scholarly journals Molecular Design and Applications of Self-Assembling Surfactant-Like Peptides

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Chengkang Tang ◽  
Feng Qiu ◽  
Xiaojun Zhao
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Molecular Design ◽  
Structural Characteristics ◽  
Protein Stabilization ◽  
The Self ◽  
Geometrical Shape ◽  
Self Assembling ◽  
Hydrophobic Moiety ◽  
Potential Applications

Self-assembling surfactant-like peptides have been explored as emerging nanobiomaterials in recent years. These peptides are usually amphiphilic, typically possessing a hydrophobic moiety and a hydrophilic moiety. The structural characteristics can promote many peptide molecules to self-assemble into various nanostructures. Furthermore, properties of peptide molecules such as charge distribution and geometrical shape could also alter the formation of the self-assembling nanostructures. Based on their diverse self-assembling behaviours and nanostructures, self-assembling surfactant-like peptides exhibit great potentials in many fields, including membrane protein stabilization, drug delivery, and tissue engineering. This review mainly focuses on recent advances in studying self-assembling surfactant-like peptides, introducing their designs and the potential applications in nanobiotechnology.

Self-Assembling Peptides: Implications for Patenting in Drug Delivery and Tissue Engineering

2011 ◽  
Vol 5 (1) ◽  
pp. 24-51 ◽  
Author(s):  
Pradeep Kumar ◽  
Viness Pillay ◽  
Girish Modi ◽  
Yahya E. Choonara ◽  
Lisa C. du Toit ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembling

Beyond Fmoc: a review of aromatic peptide capping groups

2020 ◽  
Vol 8 (5) ◽  
pp. 863-877 ◽  
Author(s):  
Adam D. Martin ◽  
Pall Thordarson
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Structure And Function ◽  
Short Peptides ◽  
Peptide Structure ◽  
Energy Materials ◽  
Self Assembling ◽  
And Function

Self-assembling short peptides have widespread applications in energy materials, tissue engineering, sensing and drug delivery. In this review we discuss the effect of functional N-terminal capping groups on peptide structure and function.

scholarly journals Synthesis and gelation properties of poly(2-alkyl-2-oxazoline) based thermo-gels

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 66438-66443 ◽  
Author(s):  
Adam L. Fisher ◽  
Julia M. H. Schollick ◽  
Dirk G. A. L. Aarts ◽  
Martin C. Grossel
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Potential Applications

Novel thermo-gelling polymers based on poly(2-alkyl-2-oxazoline)s grafted onto a polar carboxymethylcellulose backbone gel are reported which have potential applications in areas such as drug delivery and tissue engineering.

Chitosan Polyelectrolyte Complexes for Use in Tissue Engineering and Drug Delivery

2007 ◽  
Vol 539-543 ◽  
pp. 577-582
Author(s):  
Silvia Bubeníková ◽  
Igor Lacík ◽  
Dušan Bakoš ◽  
Lucia Vodná
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Reaction Time ◽  
Drug Delivery Systems ◽  
Chondroitin Sulphate ◽  
Delivery Systems ◽  
Medical Field ◽  
Polyelectrolyte Complexes ◽  
Potential Applications ◽  
Cross Linker

The paper presents the first part of the work focused on preparation of biodegradable chitosan microcapsules with tailored properties for potential applications in medical field as drug temporary carriers. In this paper, we aimed to prepare chitosan and chondroitin sulphate microcapsules using TPP as the second cross-linker and investigate the formation of the capsule membrane and its permeability in dependence on conditions of polyionic complexation. As a model, TPP was used to assess an influence of concentration and reaction time on the microcapsule formation. The method of inverse SEC was used for pores size and permeability limit of capsules assessment. For chitosan/CHS/TPP capsules, the distribution of pores size in the membrane is rather broad, which can be suitable for applications in tissue engineering and drug delivery systems.

Synthesis and Self-Assembly of a Peptide - Amphiphile as a Drug Delivery Vehicle

2013 ◽  
Vol 66 (1) ◽  
pp. 23 ◽  
Author(s):  
Soo Jung Son ◽  
Margaret A. Brimble ◽  
Sunghyun Yang ◽  
Paul W. R. Harris ◽  
Tom Reddingius ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glutamic Acid ◽  
Long Range ◽  
Self Assembly ◽  
The Self ◽  
Long Range Order ◽  
Delivery Vehicle ◽  
Peptide Amphiphile ◽  
Drug Delivery Vehicle ◽  
Hydrophobic Moiety

The formation of functional liposomes by the self assembly of a peptide–amphiphile that comprises the neuroprotective tripeptide motif glycyl-prolyl-glutamic acid linked to a hydrophobic moiety is reported. The self-assembled peptide–lipid conjugate displays long range order and can be dispersed as nanometre sized particles.

scholarly journals Chitosan Based Self-assembled Nanoparticles in Drug Delivery

2018 ◽  
Author(s):  
Carlos Peniche ◽  
Hazel Peniche ◽  
Javier Pérez
Keyword(s):  
Drug Delivery ◽  
Chitosan Nanoparticles ◽  
Biological Properties ◽  
Polyelectrolyte Complexes ◽  
Non Invasive ◽  
Self Assembling ◽  
Hydrophobic Moiety ◽  
Specificity And Sensitivity ◽  
Self Assembled ◽  
Routes Of Drug Administration

Chitosan is a cationic polysaccharide usually obtained by alkaline deacetylation of chitin poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive and non-toxic. These excellent biological properties make chitosan a good candidate as platform for developing drug delivery systems with improved biodistribution, increased specificity and sensitivity, and reduced pharmacological toxicity. In particular, chitosan nanoparticles have been found appropriate for non-invasive routes of drug administration: oral, nasal, pulmonary and ocular routes. These applications are facilitated by the absorption-enhancing effect of chitosan. Many different procedures have been proposed for obtaining chitosan nanoparticles. Particularly, the introduction of hydrophobic moieties into chitosan molecules by grafting to generate a hydrophobic-hydrophilic balance promoting self-assembling is a current and appealing approach. The grafting agent can be a hydrophobic moiety to form micelles that can entrap lipophilic drugs or it can be the drug itself. Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of polyelectrolyte complexes with polyanions. This paper reviews the main approaches developed for preparing chitosan nanoparticles by self-assembling by both procedures and illustrates the state of the art of their application in drug delivery.

Recent advances of self-assembling peptide-based hydrogels for biomedical applications

Soft Matter ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. 1704-1715 ◽  
Author(s):  
Jieling Li ◽  
Ruirui Xing ◽  
Shuo Bai ◽  
Xuehai Yan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
3D Bioprinting ◽  
Biological Applications ◽  
Antitumor Therapy ◽  
Self Assembling ◽  
Recent Advances

The review introduces several methods for fabrication of robust peptide-based hydrogels and their biological applications in the fields of drug delivery and antitumor therapy, antimicrobial and wound healing materials, and 3D bioprinting and tissue engineering.

Preparation and Characterization of Poly(Vinyl Alcohol)(PVA)/Hydroxyapatite (HA) Nanofibrous Scaffolds

2011 ◽  
Vol 284-286 ◽  
pp. 459-463 ◽  
Author(s):  
Yuan Yuan Qi ◽  
Bin Liu ◽  
Xing Bin Yan
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Tensile Strength ◽  
Drug Delivery Systems ◽  
Poly Vinyl Alcohol ◽  
Elongation At Break ◽  
Nanofibrous Scaffolds ◽  
Potential Applications

Nanofibrous scaffolds of PVA and HA were prepared by electrospinning. SEM showed the scaffolds had porous nanofibrous morphology, and the diameter of the fibers was in the range of 200-1000 nm. FTIR and XRD showed the presence of HA in the scaffolds. The mechanical properties of the scaffolds changed by the adding content of HA. For the nanoscaffolds with 2wt % HA, the ultimate tensile strength and the elongation at break was 7.5 MPa and 17%. The PVA/HA nanoscaffolds prepared by electrospinning indicated good properties, and had a potential applications in bone tissue engineering and drug delivery systems.

scholarly journals 4D Printing: Materials, Technologies, and Future Applications in the Biomedical Field

2020 ◽  
Vol 12 (24) ◽  
pp. 10628
Author(s):  
Ankur Bajpai ◽  
Anna Baigent ◽  
Sakshika Raghav ◽  
Conchúr Ó. Brádaigh ◽  
Vasileios Koutsos ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Smart Materials ◽  
Artificial Organs ◽  
4D Printing ◽  
Medical Treatments ◽  
Aerospace Manufacturing ◽  
Potential Applications ◽  
Biomedical Field ◽  
Research Investments

4D printing can be defined as the fabrication of structures using smart materials that allow the final object to change its shape, properties, or function in response to an external stimulus such as light, heat, or moisture. The available technologies, materials, and applications have evolved significantly since their first development in 2013, with prospective applications within the aerospace, manufacturing, and soft robotic industries. This review focuses on the printing technologies and smart materials currently available for fabricating these structures. The applications of 4D printing within biomedicine are explored with a focus on tissue engineering, drug delivery, and artificial organs. Finally, some ideas for potential uses are proposed. 4D printing is making its mark with seemingly unlimited potential applications, however, its use in mainstream medical treatments relies on further developments and extensive research investments.

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