scholarly journals Oral and Perioral Piercing Complications

2008 ◽  
Vol 2 (1) ◽  
pp. 133-136 ◽  
Author(s):  
N Escudero-Castaño ◽  
M.A Perea-García ◽  
J Campo-Trapero ◽  
Cano Sánchez ◽  
A Bascones-Martínez
Keyword(s):  
Hepatitis B ◽  
Adverse Effects ◽  
Oral Cavity ◽  
Current Knowledge ◽  
Case Series ◽  
Clinical Implications ◽  
Adolescent Population ◽  
High Incidence ◽  
Different Types ◽  
Sexual Symbolism

Background.The oral an perioral piercing has a long history as part of religious, tribal,cultural or sexual symbolism and nowdays there is a high incidence of oral and perioral piercing in the adolescent population. This practice has a long history as part of religious, tribal, cultural or sexual symbolism. This article reviews current knowledge on injuries or diseases that might be produced by piercing in the oral cavity. We propose a classification to diagnosed the pathologies related to oral an perioral piercingMethods.A search was conducted of articles in PubMed, Scielo published between 1997 and 2007, using the key words ``oral and perioral, piercing ´´, ``oral, piercing and disease”, ``recessions and oral piercing´´. It has reviewed about twentythree articles 17 were narrative reviews and 6 case seriesResults.A review was carried out on the origins of oral and perioral body piercing and its local implications, classifying the different alterations like recessions, systemic implications that it can produce in the oral and perioral cavity.Conclusion.Patients with oral and perioral piercing should be regularly followed up because of the possible development of different types of adverse effects.Clinical implications.Adverse effects of oral and perioral piercing can be systemic, with transmission of infectious diseases such as hepatitis B or C, or can be local, with alteration of oral mucosae or even of dental structures.

scholarly journals Maternal microbiome during pregnancy and their impact on the canine microbiome in neonates

2020 ◽  
Vol 51 (6) ◽  
pp. 593-604
Author(s):  
Maja Zakošek Pipan ◽  
Janko Mrkun
Keyword(s):  
Oral Cavity ◽  
Gut Microbiota ◽  
Amniotic Fluid ◽  
Current Knowledge ◽  
Bacterial Dna ◽  
Dna And Rna ◽  
Different Types ◽  
Human Neonates

The long-standing hypothesis that the neonatal microbiome is acquired during and after birth has been challenged by recent studies in humans using advanced molecular technologies, which identified bacteria and bacterial DNA and RNA in amniotic fluid, placenta, and meconium. Similar studies have recently been conducted on canine neonates, giving a description of the gut microbiota of newborn puppies and a comparison of different types of parturition on theirdevelopment. In this review, we summarize the current knowledge of microbiome and microbial alterations in the canine gut, vagina and oral cavity throughout pregnancy, and their effects on the microbiome of the placenta and the meconium in neonatal puppies. We further compare the microbiome knowledge gained in the last decade on human neonates and draw parallels with canine pregnancy and the neonatal microbiome.

scholarly journals The adverse consequences of mephedrone use: a case series

2011 ◽  
Vol 35 (6) ◽  
pp. 203-205 ◽  
Author(s):  
Kirsty Mackay ◽  
Mark Taylor ◽  
Neeraj Bajaj
Keyword(s):  
Mental Health ◽  
Mental Illness ◽  
Health Services ◽  
Adverse Effects ◽  
Case Series ◽  
Psychotic Symptoms ◽  
Clinical Implications ◽  
Recreational Drug ◽  
Low Mood ◽  
History Of

Aims and methodMephedrone is a cathinone with amphetamine-like stimulant effects, and is a commonly used recreational drug. The adverse effects of mephedrone use have not been extensively studied. All individuals who self-presented between January and June 2010 to the emergency departments and acute mental health services in Edinburgh and Falkirk with adverse effects of self-reported mephedrone use were identified.ResultsTwenty cases were identified and analysed. Severe agitation was the most common presenting problem (70%), with 40% of individuals developing psychotic symptoms and a further 20% reporting low mood and suicidality. One person died by suicide.Clinical implicationsMephedrone can produce amphetamine-like adverse psychological intoxication effects, particularly in those with a history of mental illness. Clinicians should consider advising patients on the adverse effects of mephedrone, where relevant.

Prevalence and Clinical Implications of Hepatitis B Virus Genotypes in Southern Taiwan

2003 ◽  
Vol 38 (1) ◽  
pp. 95-101 ◽  
Author(s):  
Lee C.-M. ◽  
Chen C.-H. ◽  
Lu S.-N. ◽  
Tung H.-D. ◽  
Chou W.-J. ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Implications ◽  
B Virus ◽  
Virus Genotypes ◽  
Southern Taiwan

A case series of endocrine immune-related adverse effects of checkpoint inhibitors

2018 ◽  
Author(s):  
Fotini Adamidou ◽  
Thomas Georgiou ◽  
Katerina Kafantari ◽  
Paraskevi Komzia ◽  
Anastasios Vagionas ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Checkpoint Inhibitors ◽  
Case Series

Research of matrix metalloproteinases in therapeutic dentistry

2020 ◽  
pp. 51-57
Author(s):  
L.I. Shalamay ◽  
E.Y. Nechai ◽  
A.I. Sakerina ◽  
A.G. Gabdullin
Keyword(s):  
Matrix Metalloproteinases ◽  
Oral Cavity ◽  
Catalytic Domain ◽  
Different Types ◽  
Dental Diseases ◽  
Classification Function

This article the properties of matrix metalloproteinases, their classification, function and role in the development of dental diseases are presented. The analysis of matrix metalloproteinases has been performed, which proves their important role in the physiological and pathological processes of the oral cavity. The possibility of using matrix metalloproteinases as part of one of the methods for diagnosing diseases and using them to evaluate the effectiveness of treatment has been considered. The structure of different types of metalloproteinases, as well as a model of the catalytic domain of the MMP-8 molecule has been presented.

Reactivation of hepatitis B: Pathogenesis and clinical implications

2009 ◽  
Vol 11 (2) ◽  
pp. 113-119 ◽  
Author(s):  
Anthony Post ◽  
Shweta Nagendra
Keyword(s):  
Hepatitis B ◽  
Clinical Implications

scholarly journals Autophagy Modulators in Cancer Therapy

2021 ◽  
Vol 22 (11) ◽  
pp. 5804
Author(s):  
Kamila Buzun ◽  
Agnieszka Gornowicz ◽  
Roman Lesyk ◽  
Krzysztof Bielawski ◽  
Anna Bielawska
Keyword(s):  
Cancer Research ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Nutrient Deficiency ◽  
Molecular Regulation ◽  
Regulatory Pathways ◽  
Selective Autophagy ◽  
Atg Proteins ◽  
Different Types ◽  
The Relationship

Autophagy is a process of self-degradation that plays an important role in removing damaged proteins, organelles or cellular fragments from the cell. Under stressful conditions such as hypoxia, nutrient deficiency or chemotherapy, this process can also become the strategy for cell survival. Autophagy can be nonselective or selective in removing specific organelles, ribosomes, and protein aggregates, although the complete mechanisms that regulate aspects of selective autophagy are not fully understood. This review summarizes the most recent research into understanding the different types and mechanisms of autophagy. The relationship between apoptosis and autophagy on the level of molecular regulation of the expression of selected proteins such as p53, Bcl-2/Beclin 1, p62, Atg proteins, and caspases was discussed. Intensive studies have revealed a whole range of novel compounds with an anticancer activity that inhibit or activate regulatory pathways involved in autophagy. We focused on the presentation of compounds strongly affecting the autophagy process, with particular emphasis on those that are undergoing clinical and preclinical cancer research. Moreover, the target points, adverse effects and therapeutic schemes of autophagy inhibitors and activators are presented.

scholarly journals Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2506
Author(s):  
Wamidh H. Talib ◽  
Ahmad Riyad Alsayed ◽  
Alaa Abuawad ◽  
Safa Daoud ◽  
Asma Ismail Mahmod
Keyword(s):  
Clinical Trials ◽  
Current Knowledge ◽  
Biological Activities ◽  
Experimental Studies ◽  
Therapeutic Effects ◽  
Cell Proliferation Inhibition ◽  
Different Types ◽  
Solid Foundation

Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and experimental studies have documented that melatonin could inhibit different types of cancer in vitro and in vivo. Results showed the involvement of melatonin in different anticancer mechanisms including apoptosis induction, cell proliferation inhibition, reduction in tumor growth and metastases, reduction in the side effects associated with chemotherapy and radiotherapy, decreasing drug resistance in cancer therapy, and augmentation of the therapeutic effects of conventional anticancer therapies. Clinical trials revealed that melatonin is an effective adjuvant drug to all conventional therapies. This review summarized melatonin biosynthesis, availability from natural sources, metabolism, bioavailability, anticancer mechanisms of melatonin, its use in clinical trials, and pharmaceutical formulation. Studies discussed in this review will provide a solid foundation for researchers and physicians to design and develop new therapies to treat and prevent cancer using melatonin.

scholarly journals Management of Patients under Treatment with Monoclonal Antibodies and New Biological Therapies

2021 ◽  
Vol 11 (11) ◽  
pp. 4865
Author(s):  
Marta Amigo-Basilio ◽  
Covadonga Álvarez-González ◽  
Carlos Cobo-Vázquez ◽  
Isabel Leco-Berrocal ◽  
Luis Miguel Sáez-Alcaide ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Conservative Treatment ◽  
Adverse Effects ◽  
Adverse Events ◽  
Oral Cavity ◽  
Study Design ◽  
Biological Therapy ◽  
Design Analysis ◽  
Biological Therapies ◽  
Analysis Of Cases

Objective: The aim of this study is to know the biological therapy drugs that are related to adverse events, what dental treatments are associated with the appearance of these events, their severity, and how they are resolved. Study design: Analysis of cases described in the literature on patients undergoing treatment with biological therapies who have developed adverse effects associated with these drugs. Results: Of the 62 articles reviewed, 49 describe 68 cases of MRONJ, most of which appeared in the jaw and received surgical and/or conservative treatment. Conclusions: Biological therapies can potentially develop adverse effects in the oral cavity, so strict monitoring by the dentist is necessary.

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