Current Trends and Future Strategies for the Global Impact of COVID-19 Pandemic

Coronaviruses ◽  
2021 ◽  
Vol 02 ◽  
Author(s):  
Ashutosh Chauhan ◽  
Ankit Kumar ◽  
Sandeep Goyal ◽  
Sunil Kumar Joshi ◽  
Deepak Kumar Semwal
Keyword(s):  
Relevant Information ◽  
Current Status ◽  
Stage Of Development ◽  
Current Trends ◽  
Global Pandemic ◽  
Future Challenges ◽  
Preclinical Trials ◽  
The Usa ◽  
Novel Coronavirus ◽  
Treatment Procedures

ABSTRACT: Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) might have originated from the recombination of a Pangolin-CoV-like virus with a Bat-CoV-RaTG13-like virus and then transmitted to the human at Wuhan city of China. On February 11, 2020, the WHO announced a name for the new coronavirus disease as COVID-19. Finally, the WHO declared the novel coronavirus outbreak a global pandemic on March 11, 2020. Within a few months, SARS-CoV-2 had spread across the world in 220 Countries, areas or territories. The main objective of this work is to review the existing knowledge about COVID-19, its updated status, available treatment procedures and future challenges. The available literature based on the COVID-19 was thoroughly reviewed and concise evidence-based information was explored for the public interest. Various authentic databases like PubMed, Scopus, and Google Scholar together with the official sites of some Govt. Organizations were carefully searched for all relevant information about the current status of COVID-19 including the published research on coronavirus. More than 68 million people are already infected including around 20% severely ill with almost 1.5 million casualties due to this virus and expected to infect approximate 70% population worldwide. Currently, maximum confirmed cases and death are reported in the USA. The epicentre of the pandemic was initially shifted from China to Europe then to the USA, Brazil and now India. In between, understanding of pathogenesis and mode of transmission has been developed; repurposing drugs are being validated and development of a new vaccine is underway. The study concludes that there is no established treatment available for COVID-19, although 26 clinical and 139 preclinical trials are underway to develop vaccines globally. Although three vaccines are in advance stage of development, their efficacy and adverse effect yet to be validated and recorded. Recently, Pfizer vaccine has been started vaccination for emergency uses in England and Bahrain, and the United State of America will start it soon. Meanwhile, prevention, rigorous global containment and quarantine efforts are practiced worldwide to control its spread.

scholarly journals The spatiotemporal estimation of the risk and the international transmission of COVID-19: a global perspective

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yuan-Chien Lin ◽  
Wan-Ju Chi ◽  
Yu-Ting Lin ◽  
Chun-Yeh Lai
Keyword(s):  
South Korea ◽  
Relevant Information ◽  
The United States ◽  
Global Perspective ◽  
Imported Case ◽  
Global Pandemic ◽  
Exponential Decrease ◽  
Risk Simulation ◽  
Novel Coronavirus ◽  
The Relationship

AbstractAn ongoing novel coronavirus outbreak (COVID-19) started in Wuhan, China, in December 2019. Currently, the spatiotemporal epidemic transmission, prediction, and risk are insufficient for COVID-19 but we urgently need relevant information globally. We have developed a novel two-stage simulation model to simulate the spatiotemporal changes in the number of cases and estimate the future worldwide risk. Simulation results show that if there is no specific medicine for it, it will form a global pandemic. Taiwan, South Korea, Hong Kong, Japan, Thailand, and the United States are the most vulnerable. The relationship between each country's vulnerability and days before the first imported case occurred shows an exponential decrease. We successfully predicted the outbreak of South Korea, Japan, and Italy in the early stages of the global pandemic based on the information before February 12, 2020. The development of the epidemic is now earlier than we expected. However, the trend of spread is similar to our estimation.

scholarly journals On the novel coronavirus (COVID-19): a global pandemic

2020 ◽  
Vol 9 (1) ◽  
pp. 103-114 ◽  
Author(s):  
James Louis-Jean ◽  
Magdonald Aime
Keyword(s):  
Relevant Information ◽  
Influenza Viruses ◽  
The Novel ◽  
Genetic Characteristics ◽  
Respiratory Illnesses ◽  
Global Issues ◽  
Global Pandemic ◽  
Animal Contact ◽  
Exposure Risks ◽  
Novel Coronavirus

Coronaviruses (COVS) are viruses transmitted through droplets of sputum from an infected person. Analyses identify COVS as zoonotic pathogens, possibly resulting from human-animal contact at animal markets. They share overlapping genetic characteristics with the avian influenza viruses from China. COVS released from humans through droplets of sputum and may land on various surfaces, which poses exposure risks; as studies have shown the virus can exist intact for a relatively long period of time (several days). The recent highly pathogenic COVS outbreak (COVID-19) emerged in Wuhan, China in 2019, include Severe Acute Respiratory Syndrome (SARS-COVS). This highly transmittable disease causes pneumonia and severe respiratory illnesses similar to SARS and MERS; it has a global mortality rate of about 6.13%. The virus has rapidly become a global pandemic, causing major global issues, including health, economic, and age-preference, among other issues. This text summarizes the nature of the emerging COVID-19 global pandemic while analyzing several factors concerning the etiology of the virus. This is done in an urgent effort to educate and provide relevant information about the virus.

Outbreak of respiratory infection: nCoV-2019 current status and its impact on global health

2020 ◽  
Vol 16 ◽  
Author(s):  
Saurabh Kumar ◽  
Sandeep Kumar ◽  
Adil Karim ◽  
Kamlesh Bisht ◽  
Abdul Ghani ◽  
...  
Keyword(s):  
T Cells ◽  
Clinical Symptoms ◽  
Cytotoxic T Cells ◽  
Respiratory Illness ◽  
Current Status ◽  
Global Pandemic ◽  
High Infection ◽  
Epidemiology Data ◽  
Rapid Transmission ◽  
Novel Coronavirus

: Novel Coronavirus-2019 (nCoV-2019) emerged as a potentially infectious respiratory disease caused by newly discovered β-coronavirus. nCoV-19 has emerged as a global pandemic due to the rapid transmission and high infection rate commonly involved in acute respiratory illness. Literature search includes various databases like Google Scholar, PubMed, ScienceDirect, and Scopus for studies published using a different combination of keywords “coronavius”, “COVID-19”, “SARS”, “MERS”, “antiviral drugs”, “vaccines”, and “immunity”. We collected epidemiology data from the Worldometer portal (data available till 9 October, 2020). Fever, dry cough, dyspnea, sore throat, or fatigue are common clinical symptoms of the infection. Cytotoxic T-cells and T-helper cells Cytotoxic T cells (CD8+) accounts for maximum (approximately 80%) of total infiltrate in the pulmonary region of the affected nCoV individuals and acts as a significant contributor in the clearance of the infection. This review intends to outline the literature concerning the mode of actual transmission, immune response, and possible therapeutic approach against the virus.

scholarly journals Counting on COVID-19 vaccine: Insights into the current strategies, progress and future challenges

2021 ◽  
Author(s):  
Ramesh Kandimalla ◽  
Pratik Chakraborthy ◽  
Jayalakshmi Vallamkondu ◽  
Anupama Chaudhary ◽  
Sonalinandini Samanta ◽  
...  
Keyword(s):  
Present Report ◽  
Current Status ◽  
Local Administration ◽  
Protective Mechanism ◽  
Promising Candidate ◽  
Protein Subunits ◽  
Vaccine Candidates ◽  
Vaccination Strategies ◽  
Future Challenges ◽  
Novel Coronavirus

Emergence of a novel coronavirus viz., severe acute respiratory syndrome coronavirus (SARS-CoV-2) in late 2019 and its subsequent substantial spread, produced coronavirus disease 2019 (COVID-19) pandemic worldwide. Given its unprecedented infectivity and pathogenicity, COVID-19 pandemic had a devastating impact on human health and its clinical management. It led to development and speedy trials of several vaccine candidates against SARS-CoV-2 at an exceptional pace; as a result, several COVID-19 vaccines were made commercially available in the 2021 first half. Although, several COVID-19 vaccines showed promising results, crucial in-sights into their epidemiology, protective mechanism and propensity of reinfection are not largely reviewed. In the present report, we provided insights into the prospects of vaccination against COVID-19 and assessed diverse vaccination strategies including DNA, mRNA, protein subunits, vector-based, live attenuated, and inactivated whole/viral particle-based vaccines, imi-tating COVID-19 infection. Next, we reviewed major aspects of various available vaccines ap-proved by the WHO and by local administration to use against COVID-19. Moreover, we com-prehensively assessed the success of these approved vaccines and also their untoward effects in-cluding the possibility of reinfection. We also provided an update on the vaccines that are under development and could be the promising candidate. Conclusively, we provided insights into the COVID-19 vaccine epidemiology, their potency and propensity for SARS-CoV-2 reinfection, while a careful review of their current status, strategies, success and future challenges was also presented.

New Viral Infection COVID-19: Current Status, Challenges and Possible Treatments

2020 ◽  
Vol 18 ◽  
Author(s):  
Vipan Kumar ◽  
Amruta Suryan ◽  
Jyoti Singh ◽  
Sandeep Kumar ◽  
Pradeep Kamboj ◽  
...  
Keyword(s):  
Treatment Options ◽  
Antiviral Agents ◽  
Viral Envelope ◽  
Current Status ◽  
Effective Vaccine ◽  
Plasma Therapy ◽  
Immunomodulatory Agents ◽  
Global Pandemic ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Since December 2019, the prevalence of novel coronavirus infection (named as COVID-19 by WHO on Feb 11, 2020) has become a growing healthcare concern worldwide. On March 11, 2020, the WHO declared COVID-19 a global pandemic. As no specific approved treatment options are available for the COVID-19 infection, several existing antiviral drugs in combination with others have become mainstay therapy. The targets for the treatment of the infection include viral targets such as polymerases, spike glycoproteins, membrane proteins, and viral envelope and host targets such as host proteases and host receptors. Antiviral agents, immunomodulatory agents, and empiric broad-spectrum antibiotics can be used as treatment therapies for the infection. Convalescent plasma therapy has also been proposed as an effective treatment for COVID-19. Additionally, many studies are ongoing to develop a potent and effective vaccine that completely blocks SARS-CoV-2. Nevertheless, prevention of spreading of the virus remains the first and foremost step towards controlling and managing the coronavirus infection.

scholarly journals Counting on COVID-19 Vaccine: Insights into the Current Strategies, Progress and Future Challenges

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1740
Author(s):  
Ramesh Kandimalla ◽  
Pratik Chakraborty ◽  
Jayalakshmi Vallamkondu ◽  
Anupama Chaudhary ◽  
Sonalinandini Samanta ◽  
...  
Keyword(s):  
Present Report ◽  
World Health ◽  
Current Status ◽  
Protective Mechanisms ◽  
Protein Subunits ◽  
Vaccine Candidates ◽  
Vaccination Strategies ◽  
Future Challenges ◽  
Novel Coronavirus ◽  
Health Organization

The emergence of a novel coronavirus viz., severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019 and its subsequent substantial spread produced the coronavirus disease 2019 (COVID-19) pandemic worldwide. Given its unprecedented infectivity and pathogenicity, the COVID-19 pandemic had a devastating impact on human health, and its clinical management has been a great challenge, which has led to the development and speedy trials of several vaccine candidates against SARS-CoV-2 at an exceptional pace. As a result, several COVID-19 vaccines were made commercially available in the first half of 2021. Although several COVID-19 vaccines showed promising results, crucial insights into their epidemiology, protective mechanisms, and the propensities of reinfection are not largely reviewed. In the present report, we provided insights into the prospects of vaccination against COVID-19 and assessed diverse vaccination strategies including DNA, mRNA, protein subunits, vector-based, live attenuated, and inactivated whole/viral particle-based vaccines. Next, we reviewed major aspects of various available vaccines approved by the World Health Organization and by the local administrations to use against COVID-19. Moreover, we comprehensively assessed the success of these approved vaccines and also their untoward effects, including the possibility of reinfection. We also provided an update on the vaccines that are under development and could be promising candidates in the future. Conclusively, we provided insights into the COVID-19 vaccine epidemiology, their potency, and propensity for SARS-CoV-2 reinfection, while a careful review of their current status, strategies, success, and future challenges was also presented.

scholarly journals Global assessment of environment, health and economic impact of the novel coronavirus (COVID-19)

2020 ◽  
Author(s):  
Samuel Asumadu Sarkodie ◽  
Phebe Asantewaa Owusu
Keyword(s):  
Health System ◽  
Environmental Health ◽  
Economic Impact ◽  
Environmental Sustainability ◽  
Future Research ◽  
Economic Dimension ◽  
Innovation Research ◽  
Global Pandemic ◽  
The Usa ◽  
Novel Coronavirus

AbstractThe institution of social distancing and punitive measures to contain the spread of COVID-19 through human-to-human transmission has environmental, health and economic impact. While the global pandemic has led to the enhancement of the health system and decline of emissions, economic development appears deteriorating. Here, we present the global environmental, health and economic dimension of the effect of COVID-19 using qualitative and empirical assessments. We report the health system policies, environmental sustainability issues, and fiscal, monetary and exchange rate measures introduced during lockdown across countries. While air pollution is reported to have declined, municipal and medical waste is increasing. The COVID-19 global pandemic uncertainty ranks the UK as the country with the highest uncertainty level among 143 countries. The USA has introduced 100% of pre-COVID-19 crisis level GDP, the highest policy cut-rate among 162 countries. Science, innovation, research and development underpin COVID-19 containment measures implemented across countries. Our study demonstrates the need for future research to focus on environment-health-economic nexus—a trilemma that has a potential trade-off.

Plastic Surgery in the Time of COVID-19

2020 ◽  
Author(s):  
David Chi ◽  
Austin D. Chen ◽  
Miguel I. Dorante ◽  
Bernard T. Lee ◽  
Justin M. Sacks
Keyword(s):  
Health Care Systems ◽  
Lessons Learned ◽  
Difficult Decision ◽  
Global Pandemic ◽  
Life Saving ◽  
The World ◽  
Future Challenges ◽  
Care Systems ◽  
To Come ◽  
Novel Coronavirus

Abstract Background The novel coronavirus disease 2019 (COVID-19) has swept the world in the last several months, causing massive disruption to existing social, economic, and health care systems. As with all medical fields, plastic and reconstructive surgery has been profoundly impacted across the entire spectrum of practice from academic medical centers to solo private practice. The decision to preserve vital life-saving equipment and cancel elective procedures to protect patients and medical staff has been extremely challenging on multiple levels. Frequent and inconsistent messaging disseminated by many voices on the national stage often conflicts and serves only to exacerbate an already difficult decision-making process. Methods A survey of relevant COVID-19 literature is presented, and bioethical principles are utilized to generate guidelines for plastic surgeons in patient care through this pandemic. Results A cohesive framework based upon core bioethical values is presented here to assist plastic surgeons in navigating this rapidly evolving global pandemic. Conclusion Plastic surgeons around the world have been affected by COVID-19 and will adapt to continue serving their patients. The lessons learned in this present pandemic will undoubtedly prove useful in future challenges to come.

Infections caused by medical products at longterm nursing care

2020 ◽  
pp. 7-10
Author(s):  
Hardy Thorsten Panknin
Keyword(s):  
Nursing Care ◽  
Nursing Staff ◽  
Nosocomial Infections ◽  
The Elderly ◽  
Relevant Information ◽  
Medical Products ◽  
The Disabled ◽  
The Usa ◽  
Therapeutic Measures

Nosocomial infections in the elderly, often suffering from many ailments, patients in homes for the disabled and the old are among the problematic diseases that specialized nursing staff and doctors have to deal with more often in such institutions. Review work from the USA introduces relevant information about infectious risks, as well as possible preventive and therapeutic measures.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

Sign in / Sign up

Export Citation Format

Share Document