SCHISTOSOMIASIS Recent Progresses in Synthesis and Evaluation of Bioactive Compounds with Molluscicidal Activity - Molluscicidal Activity of Synthetic and Natural Products

2014 ◽  
pp. 196-230
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Molluscicidal Activity

scholarly journals Chemical Diversity and Biological Activity of Secondary Metabolites Isolated from Indonesian Marine Invertebrates

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1898
Author(s):  
Fauzia Izzati ◽  
Mega Ferdina Warsito ◽  
Asep Bayu ◽  
Anggia Prasetyoputri ◽  
Akhirta Atikana ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Marine Natural Products ◽  
Biological Function ◽  
Marine Invertebrates ◽  
Biological Activities ◽  
Structural Diversity ◽  
Chemical Diversity ◽  
Soft Corals ◽  
High Chemical

Marine invertebrates have been reported to be an excellent resource of many novel bioactive compounds. Studies reported that Indonesia has remarkable yet underexplored marine natural products, with a high chemical diversity and a broad spectrum of biological activities. This review discusses recent updates on the exploration of marine natural products from Indonesian marine invertebrates (i.e., sponges, tunicates, and soft corals) throughout 2007–2020. This paper summarizes the structural diversity and biological function of the bioactive compounds isolated from Indonesian marine invertebrates as antimicrobial, antifungal, anticancer, and antiviral, while also presenting the opportunity for further investigation of novel compounds derived from Indonesian marine invertebrates.

scholarly journals Essential Oils and Their Bioactive Compounds in the Control of Gastrointestinal Nematodes of Small Ruminants

2018 ◽  
Vol 46 (1) ◽  
pp. 14 ◽  
Author(s):  
Weibson Paz Pinheiro André ◽  
Wesley Lyeverton Correia Ribeiro ◽  
Lorena Mayana Beserra de Oliveira ◽  
Iara Tersia Freitas Macedo ◽  
Fernanda Cristina Macedo Rondon ◽  
...  
Keyword(s):  
Natural Products ◽  
Essential Oils ◽  
Bioactive Compounds ◽  
Small Ruminant ◽  
Anthelmintic Activity ◽  
Gastrointestinal Nematodes ◽  
In Vivo Tests ◽  
Anthelmintic Effect

Background: Gastrointestinal nematodes are one of the major health and economic problem of sheep and goats in the world. The control of these nematodes is carried out conventionally with synthetic anthelminths, which favored the selection of gastrointestinal nematode (GIN) populations multiresistant to anthelmintics. The emergence of anthelmintic resistance has stimulated the search for new alternatives to control small ruminant GIN, standing out the use of plants and their bioactives compounds, such as essential oils (EO). The objective of this review was to present the main characteristics and anthelmintic activity of EO, their isolated compounds and drug delivery systems in the control of GIN.Review: Essential oils are a complex blend of bioactive compounds with volatile, lipophilic, usually odoriferous and liquid substances. EO are composed of terpenes, terpenoids, aromatic and aliphatic constituents. EO has various pharmacological activities of interest in preventive veterinary medicine such as antibacterials, antifungals, anticoccicids, insecticides and anthelmintics. In vitro and in vivo tests are used to validate the anthelmintic activity of EO on GIN. In vitro tests are low cost screening tests that allow the evaluation of the anthelmintic activity of a large amount of bioactive compounds on eggs, first (L1) and third stage larvae (L3), and adult nematodes. The antiparasitic effect of EO is related to its main compound or to the interaction of the compounds. These bioactive compounds penetrate the cuticle of the nematodes by transcuticular diffusion, altering the mechanisms of locomotion, besides causing cuticular lesions. Following in vitro evaluation, the acute and sub-chronic toxicity test should be performed to assess the toxicity of the bioactive compounds and to define the dose to be used in in vivo tests. In vivo tests are more reliable because the anthelmintic effectiveness of bioactive compounds is evaluated after the metabolization process. The metabolization process of the bioactive compounds can generate metabolites that exhibit or not anthelmintic effectiveness. The in vivo tests assessing the anthelmintic effectiveness of bioactive compounds in sheep and goats are the fecal egg count reduction test and the controlled test.  OE promoted reduction of egg elimination in faeces which may be related to cuticular and reproductive alterations in GIN, and reduction of parasite burden in in vivo tests. Due to the promising results obtained with OE in the in vivo tests, interest has been aroused in using nanotechnology as an alternative to increase the bioavailability of OE and consequently, potentializing its anthelmintic effect, reducing the dose and  toxicity of the biocompounds. In addition to nanotechnology, the isolation and chemical modification of compounds isolated from OE have been employed to obtain new molecules with anthelmintic action and understand the mechanism of action of EO on the small ruminant GIN.Conclusion: The use of EO and their compound bioactive in the control of resistant populations of GIN is a promising alternative. The adoption of strategies in which natural products can replace synthetic anthelmintics, such as in dry periods and use synthetic anthelmintics in the rainy season when the population in refugia in the pasture is high, thus reducing the dissemination of GIN resistant populations. As perspective, the evaluation of pharmacokinetics and pharmacodynamics of these natural products should be performed so that one defines treatment protocols that optimize the anthelmintic effect.

Ginger: A systematic review of clinical trials and recent advances encapsulation of their bioactive compounds

2022 ◽  
Author(s):  
Loleny Tavares ◽  
Slim SMAOUI ◽  
Cristian Pinilla ◽  
Hajer Ben Hlima ◽  
Helio Lopes Barros
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Natural Products ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Health Benefits ◽  
Recent Advances

Recently, studies on natural products have considerably increased due to their exceptional biological activities and health benefits. Subsequently, their pharmacological attributes have played an immense role in detecting natural and...

Medicinal Plants and Their Bioactive Compounds for the Management and Treatment of Gout

2021 ◽  
pp. 267-287
Author(s):  
Bui Thanh Tung
Keyword(s):  
Natural Products ◽  
Uric Acid ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Inflammatory Arthritis ◽  
Natural Compound ◽  
Complex Form ◽  
Compound Structure ◽  
Anti Inflammatory

Gout is a complex form of arthritis which is characterized by sudden, severe attacks of pain, swelling, redness, and tenderness in the joints. Gout is a type of inflammatory arthritis that is triggered by the crystallization of uric acid within the joints and is often associated with hyperuricemia. Natural products offer many options to reduce the progress and symptoms of diseases, including gout. Natural compound structure including lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids have anti-inflammatory, antioxidant, and XO activities. In this chapter, the authors present medicinal plants and isolated compounds which are used to prevent and reduce the pathogenesis of gout.

scholarly journals Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3890 ◽  
Author(s):  
Laurence K. Jennings ◽  
Neyaz M. D. Khan ◽  
Navdeep Kaur ◽  
Daniel Rodrigues ◽  
Christine Morrow ◽  
...  
Keyword(s):  
Natural Products ◽  
Cytotoxic Activity ◽  
Bioactive Compounds ◽  
Indole Alkaloids ◽  
Marine Species ◽  
Chemical Study ◽  
Central Core ◽  
Chemical Investigation ◽  
Chemical Profiles ◽  
New Metabolites

As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and chemical profiles. The first chemical investigation of this marine species led to the discovery of two new bisindole alkaloids of the topsentin family, together with six other known indole alkaloids. Missing the usual central core featured by the representatives of these marine natural products, the new metabolites may represent key biosynthetic intermediates for other known bisindoles. These compounds were found to exhibit weak cytotoxic activity against HeLa tumour cells, suggesting a specificity towards previously screened carcinoma and leukaemia cells.

Biosynthesis of bioactive natural products from Basidiomycota

2019 ◽  
Vol 17 (5) ◽  
pp. 1027-1036 ◽  
Author(s):  
Hsiao-Ching Lin ◽  
Ranuka T. Hewage ◽  
Yuan-Chun Lu ◽  
Yit-Heng Chooi
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Biosynthetic Pathways ◽  
Bioactive Natural Products ◽  
Wide Range

The club fungi, Basidioycota, produce a wide range of bioactive compounds. Here, we describe recent studies on the biosynthetic pathways and enzymes of bioactive natural products from these fungi.

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