scholarly journals Unintentional diethylene glycol poisoning following the consumption of a shared alcoholic beverage

2018 ◽  
Vol 21 (1) ◽  
Author(s):  
Muhammed Hassen ◽  
Raisa Bhikoo ◽  
Clint Johannes ◽  
Mogamat-Yazied Chothia
Keyword(s):  
Diethylene Glycol ◽  
Early Recognition ◽  
Alcoholic Beverage ◽  
Specific Treatment ◽  
Pharmaceutical Products ◽  
The Past ◽  
Toxic Alcohol ◽  
Appropriate Therapy ◽  
Diagnostic Work ◽  
Work Up

Diethylene glycol (DEG) is an uncommon cause of toxic alcohol poisoning. In the past, its ingestion in contaminated pharmaceutical products has resulted in mass outbreaks. We describe two isolated cases of unintentional DEG poisoning following the consumption of a shared alcoholic beverage and highlight the challenges that were confronted during the diagnostic work-up and management. Despite appropriate therapy, both cases had fatal outcomes, which emphasises the importance of early recognition of the condition and of instituting specific treatment.

scholarly journals Death of unknown cause? Post-mortem diagnosis of fulminant course of an EBV-associated secondary hemophagocytic lymphohistiocytosis

2021 ◽  
Author(s):  
Josia Fauser ◽  
Stefan Köck ◽  
Eberhard Gunsilius ◽  
Andreas Chott ◽  
Andreas Peer ◽  
...  
Keyword(s):  
Immune Response ◽  
Case Report ◽  
Macrophage Activation ◽  
Post Mortem ◽  
Life Threatening ◽  
Appropriate Therapy ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up ◽  
Secondary Hemophagocytic Lymphohistiocytosis

SummaryHLH is a life-threatening disease, which is characterized by a dysregulated immune response with uncontrolled T cell and macrophage activation. The often fulminant course of the disease needs a fast diagnostic work-up to initiate as soon as possible the appropriate therapy. We present herein the case of a 71-year-old patient with rapidly progressive hyperinflammatory syndrome, which post mortem resulted in the diagnosis of EBV-associated HLH. With this case report, we intend to highlight the relevance of the HScore in the diagnosis of HLH, to create a greater awareness for EBV as a trigger of HLH, and to demonstrate the importance of treating EBV-associated HLH as early as possible.

Vascular puncture site complications - diagnosis, therapy, and prognosis

VASA ◽  
2016 ◽  
Vol 45 (6) ◽  
pp. 461-469 ◽  
Author(s):  
Wolfgang Mlekusch ◽  
Irene Mlekusch ◽  
Schila Sabeti-Sandor
Keyword(s):  
Vascular Access ◽  
Endovascular Procedures ◽  
Puncture Site ◽  
Access Site ◽  
The Past ◽  
Technical Advances ◽  
Diagnostic Work ◽  
Diagnosis Therapy ◽  
Work Up ◽  
Diagnostic Work Up

Abstract. The numbers of endovascular procedures have been noted to substantially increase over the past two decades. Besides all the technical advances and the increasing skills of more and more trained interventionists, the vascular access site still offers the possibilities and carries the risk of access site complications, which have not been changed dramatically over the past years. Guidelines on the vascular puncture procedure itself are lacking. Complications at different vascular access sites presentclinically different, require different diagnostic work up and therapy. The aim of the following review is to systematically list the most likely vascular access site complications their diagnosis and if necessary the proper treatment.

Acute heart failure: diagnosis

ESC CardioMed ◽  
2018 ◽  
pp. 1911-1917 ◽  
Author(s):  
Adriaan A. Voors ◽  
Piotr Ponikowski
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Medical Condition ◽  
Specific Treatment ◽  
Length Of Hospital Stay ◽  
Clinical History ◽  
Life Threatening ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Acute heart failure is a life-threatening medical condition typically leading to urgent hospital admission. Early diagnosis is of great importance, since it will lead to earlier and better targeted treatment, leading to a decrease in length of hospital stay, and most importantly to improved clinical outcome. The initial diagnostic work-up includes a clinical history, evaluation of symptoms and signs, an electrocardiogram, chest X-ray, natriuretic peptide levels, echocardiography and perhaps lung ultrasound. After the initial work-up, a clinical classification according to blood pressure, congestion, and peripheral perfusion should be performed, since it will guide treatment. During the diagnostic work-up, treatable and life-threatening conditions always need to be considered since they need immediate and case-specific treatment.

scholarly journals Merkel Cell Carcinoma: The Past, the Present, and the Future

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Inamaria Erovic ◽  
Boban M. Erovic
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Diagnostic Marker ◽  
Historical Background ◽  
Merkel Cell ◽  
The Past ◽  
Diagnostic Work ◽  
The 19Th Century ◽  
Work Up ◽  
Diagnostic Work Up

Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades. In this review, we will illustrate the historical background of the Merkel cell carcinoma beginning with the 19th century, the first description of the Merkel cell to the finding of the CK20 as a highly specific diagnostic marker and finally to the recently detected Merkel cell polyomavirus (MCPyV). Moreover, we will highlight the beginning of adjuvant therapeutic regimens with radiotherapy and chemotherapy and discuss the diagnostic work-up including imaging and histology of patients with Merkel cell carcinoma. Another very rapidly growing and interesting field of research is the development of patients' specific and tailored targeted therapy, in particular in patients with distant metastatic disease.

scholarly journals Granulomatosis with Polyangiitis as a Cause of Sudden-Onset Bilateral Sensorineural Hearing Loss: Case Report and Recommendations for Initial Assessment

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Paul R. Ratmeyer ◽  
Benjamin R. Johnson ◽  
Luis P. Roldan ◽  
Tania L. Kraai
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Granulomatosis With Polyangiitis ◽  
Early Recognition ◽  
Sensorineural Hearing ◽  
Initial Assessment ◽  
Laboratory Evaluation ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Granulomatosis with polyangiitis (GPA) is a severe systemic vasculitis that commonly affects the paranasal sinuses, upper and lower respiratory tracts, and kidneys. GPA has also been associated with sensorineural hearing loss (SNHL), through inflammation of the cochlear apparatus. Early recognition, diagnostic laboratory evaluation, and appropriate treatment are essential to improve outcomes and achieve remission for patients with GPA. Here, we present a case of bilateral sudden sensorineural hearing loss (SSNHL) and distal symmetric polyneuropathy as the first presenting signs of GPA. A specific diagnostic work-up to rule out autoimmune inner-ear disease in patients with bilateral SSNHL is not clearly stated in the clinical practice guidelines from the American Academy of Otolaryngology-Head and Neck Surgery. The aim of this paper is to delineate an appropriate diagnostic work-up for patients with bilateral SSNHL when there is concern for autoimmune disease.

P36 DE NOVO GORD AFTER ROUX Y GASTRIC BYPASS: UNCOMMON BUT POSSIBLE – A LOOK AT THE WHY FACTORS

2019 ◽  
Vol 32 (Supplement_2) ◽  
Author(s):  
Al Saadi Hatem ◽  
Sharples Alistair ◽  
Cornes Bridie ◽  
Rao Vittal ◽  
Nagammapudur Balaji
Keyword(s):  
Gastric Bypass ◽  
De Novo ◽  
Gastric Pouch ◽  
Barium Swallow ◽  
Gastric Fistula ◽  
Ulcer Disease ◽  
The Past ◽  
Diagnostic Work ◽  
Work Up ◽  
New Onset

Abstract Background Roux Y gastric bypass (RYGB) is the preferred bariatric surgical option in patients with Gastro oesophageal reflux disease (GORD). However, de novo GORD after RYGB although uncommon is possible and present challenges in further management. Proposed mechanisms have been a large gastric pouch or a short alimentary limb. Objective Analyse anatomical causes of De Novo GORD post RYGB Methods Data of patients who presented with new onset GORD after RYGB were collected and analysed. Results Specific and remediable anatomical factors contributing to de novo GORD was found in 8 patients post RYGB (3 Males and 5 Females). Onset of symptoms ranged from 1.16-15 years. Mean age was 53.14 and mean BMI 37.39. One patient had R-Y gastric bypass for peptic ulcer disease in the past. Diagnostic work up included; Barium swallow (85.7%), CT Abdomen (42.9%), OGD (57.1%). Diagnosis of candy cane (CC) syndrome was seen in 50 % of cases (n=4) followed by Gastro-gastric fistula (n=1), gastric pouch herniation (n=1) and pouch herniation with CC syndrome (n=2). Excision of excess CC limb achieved resolution in symptoms of reflux. 4 patients are awaiting surgical anatomical correction. Conclusion De novo GORD after RYGB can be challenging. These patients need thorough anatomic and physiologic assessment to identify potentially correctable anatomical causes. A long CC, herniated gastric pouch, gastro-gastric fistula are anatomical causes identified in our study. Identification and evaluation of this sub group of patients has not been reported in the past but are likely to be increasingly encountered.

Dissociative Visual Loss in Children and Adolescents

2021 ◽  
Vol 238 (10) ◽  
pp. 1084-1091
Author(s):  
Romuald Brunner ◽  
Herbert Jägle ◽  
Stephanie Kandsperger
Keyword(s):  
Children And Adolescents ◽  
Visual Loss ◽  
Specific Treatment ◽  
Blurred Vision ◽  
Persistent Symptoms ◽  
Wide Range ◽  
Therapeutic Principles ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

AbstractPsychogenic vision disorders in children and adolescents are a common disorder primarily encountered by ophthalmologists at the onset because, as with other disorders of dissociation, the presentation suggests a neurologic or other somatic condition. Loss of visual acuity, blurred vision and visual field restriction–often described as tunnel vision–appears to be typical. The onset may be sudden, frequently related to a wide range of stressful life events (school failure, family conflicts, accidents). While the majority of these children quickly recover from their symptoms, a substantial percentage experience persistent symptoms or a fluctuating course. Due to the lack of efficacy studies of specific treatment protocols, diagnostic work-up and treatment suffer from a high degree of uncertainty. Differentiating dissociative visual loss from physical illness requires special expertise. The uncertainty of ophthalmologists and the other specialists involved in dealing with this clinical condition often delays the specialised treatment and may also trigger inadequate therapy with the iatrogenic risk of harming the patient. This article primarily describes the disorder-specific psychiatric diagnostic as well as the somatic differential diagnostic work-up and outlines the therapeutic principles of dissociative visual loss.

Das Ganglion des Hüftgelenkes als Differentialdiagnose eines pulsierenden Leistentumors

VASA ◽  
2000 ◽  
Vol 29 (1) ◽  
pp. 75-76 ◽  
Author(s):  
Paolo Claudio Cassina ◽  
Hauser ◽  
Kossmann ◽  
Brunner
Keyword(s):  
Doppler Ultrasonography ◽  
Ganglion Cyst ◽  
Correct Diagnosis ◽  
Imaging Methods ◽  
The Past ◽  
Ganglion Cysts ◽  
Duplex Doppler ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Ganglion cysts of the hip joint are uncommon synovial-lined fluid-filled juxtaarticular groin lesions. Whereas in the past the correct diagnosis was often made only at surgery there are now valuable imaging methods used for the diagnostic work-up. In experienced hands ultrasonography (US) combined with colour duplex Doppler ultrasonography (CDDS) as a real-time imaging technique easily performed at the patient’s bedside is a valid alternative to more expensive or invasive investigations. We report on a patient who presented with a ganglion cyst and in whom first supported by conventional US an aneurysm of the femoral artery was suspected. The diagnosis of a juxtaarticular ganglion was subsequently correctly made at our institution by CDDS and magnetic resonance imaging, respectively, and the cyst was exstirpated successfully. The differential diagnosis of a pulsating groin mass as well as the most useful and specific imaging methods in the diagnostic work-up in this clinical setting are discussed.

Rapidly progressive glomerulonephritis as presenting feature of systemic lupus erythematosus in a Bangladeshi male patient: a rare case report

2020 ◽  
Vol 10 (2) ◽  
pp. 137-138
Author(s):  
Samiha Haque ◽  
Ishrat Jahan ◽  
Tufayel Ahmed Chowdhury ◽  
Muhammad Abdur Rahim ◽  
Mehruba Alam Ananna ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Venous Pressure ◽  
Rapidly Progressive Glomerulonephritis ◽  
Initial Response ◽  
Systemic Lupus ◽  
Renal Manifestation ◽  
Rare Case Report ◽  
Diagnostic Work ◽  
Work Up

Rapidly progressive glomerulonephritis is one of the most dramatic and tragic presentations of lupus nephritis (LN) or renal manifestation of systemic lupus erythematosus (SLE). A 35-year-old Bangladeshi gentleman presented with worsening oedema, scanty, high colored, frothy urine and deteriorating renal function. He had puffy face, anaemia, oedema, normal jugular venous pressure (JVP), high blood pressure (150/90 mm Hg), ascites and bilateral pleural effusions. Diagnostic work-up confirmed SLE with class IV LN. His initial response to specific therapy showed improvement Birdem Med J 2020; 10(2): 137-138

Primary Tumours of the Spine: Differential Diagnosis, Epidemiology and Diagnostic Work Up

2017 ◽  
Author(s):  
Stefano Boriani ◽  
Luca Boriani
Keyword(s):  
Differential Diagnosis ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up
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