scholarly journals Merkel Cell Carcinoma: The Past, the Present, and the Future

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Inamaria Erovic ◽  
Boban M. Erovic
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Diagnostic Marker ◽  
Historical Background ◽  
Merkel Cell ◽  
The Past ◽  
Diagnostic Work ◽  
The 19Th Century ◽  
Work Up ◽  
Diagnostic Work Up

Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades. In this review, we will illustrate the historical background of the Merkel cell carcinoma beginning with the 19th century, the first description of the Merkel cell to the finding of the CK20 as a highly specific diagnostic marker and finally to the recently detected Merkel cell polyomavirus (MCPyV). Moreover, we will highlight the beginning of adjuvant therapeutic regimens with radiotherapy and chemotherapy and discuss the diagnostic work-up including imaging and histology of patients with Merkel cell carcinoma. Another very rapidly growing and interesting field of research is the development of patients' specific and tailored targeted therapy, in particular in patients with distant metastatic disease.

scholarly journals Merkel Cell Carcinoma: New Trends

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1614
Author(s):  
Ellen M. Zwijnenburg ◽  
Satish F.K. Lubeek ◽  
Johanna E.M. Werner ◽  
Avital L. Amir ◽  
Willem L.J. Weijs ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Tumor Biology ◽  
Sun Exposure ◽  
The Elderly ◽  
Treatment Modalities ◽  
Merkel Cell ◽  
Immunohistochemical Markers ◽  
Diagnostic Work ◽  
Work Up

Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin mainly seen in the elderly. Its incidence is rising due to ageing of the population, increased sun exposure, and the use of immunosuppressive medication. Additionally, with the availability of specific immunohistochemical markers, MCC is easier to recognize. Typically, these tumors are rapidly progressive and behave aggressively, emphasizing the need for early detection and prompt diagnostic work-up and start of treatment. In this review, the tumor biology and immunology, current diagnostic and treatment modalities, as well as new and combined therapies for MCC, are discussed. MCC is a very immunogenic tumor which offers good prospects for immunotherapy. Given its rarity, the aggressiveness, and the frail patient population it concerns, MCC should be managed in close collaboration with an experienced multidisciplinary team.

scholarly journals Occult Esophageal Squamous Cell Carcinoma Presenting with Multiple Bony Osteolytic Lesions Clinically Mimicking Multiple Myeloma: A Diagnostic Dilemma

2020 ◽  
Vol 12 (01) ◽  
pp. 76-78
Author(s):  
Bifica Sofia Lyngdoh ◽  
Biswajit Dey ◽  
Vandana Raphael ◽  
Iadarilang Tiewsoh
Keyword(s):  
Multiple Myeloma ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Diagnostic Dilemma ◽  
Osteolytic Lesions ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

AbstractBone metastasis as an initial presentation of esophageal carcinoma is uncommon. In the absence of typical presentations like dysphagia, these cases may lead to diagnostic dilemmas both for the clinicians and pathologists. Here, we report a case of disseminated metastasis of esophageal squamous cell carcinoma to the bone in a 47-year-old female, who presented with multiple osteolytic lesions and clinically mimicking multiple myeloma. A detailed diagnostic work-up established the diagnosis of esophageal squamous cell carcinoma.

Tl-201 Imaging in the Diagnostic Work-Up of Squamous Cell Carcinoma Metastasis of Unknown Primary Origin

2002 ◽  
Vol 27 (5) ◽  
pp. 385-386 ◽  
Author(s):  
HAKAN DEMIR ◽  
FATMA BERK ◽  
OKAN ERDINCLER ◽  
SERKAN ISGOREN ◽  
CUMALI AKTOLUN
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Unknown Primary ◽  
Primary Origin ◽  
Carcinoma Metastasis ◽  
Diagnostic Work ◽  
Work Up ◽  
Unknown Primary Origin ◽  
Diagnostic Work Up

Vascular puncture site complications - diagnosis, therapy, and prognosis

VASA ◽  
2016 ◽  
Vol 45 (6) ◽  
pp. 461-469 ◽  
Author(s):  
Wolfgang Mlekusch ◽  
Irene Mlekusch ◽  
Schila Sabeti-Sandor
Keyword(s):  
Vascular Access ◽  
Endovascular Procedures ◽  
Puncture Site ◽  
Access Site ◽  
The Past ◽  
Technical Advances ◽  
Diagnostic Work ◽  
Diagnosis Therapy ◽  
Work Up ◽  
Diagnostic Work Up

Abstract. The numbers of endovascular procedures have been noted to substantially increase over the past two decades. Besides all the technical advances and the increasing skills of more and more trained interventionists, the vascular access site still offers the possibilities and carries the risk of access site complications, which have not been changed dramatically over the past years. Guidelines on the vascular puncture procedure itself are lacking. Complications at different vascular access sites presentclinically different, require different diagnostic work up and therapy. The aim of the following review is to systematically list the most likely vascular access site complications their diagnosis and if necessary the proper treatment.

scholarly journals Staging of Cervical Lymph Nodes in Oral Squamous Cell Carcinoma: Adding Ultrasound in Clinically Lymph Node Negative Patients May Improve Diagnostic Work-Up

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90360 ◽  
Author(s):  
Rikke Norling ◽  
Birgitte Marie Due Buron ◽  
Marianne Hamilton Therkildsen ◽  
Birthe Merete Henriksen ◽  
Christian von Buchwald ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Cervical Lymph Nodes ◽  
Node Negative ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Primary thyroid squamous cell carcinoma: a challenging management problem

2021 ◽  
Vol 14 (1) ◽  
pp. e238560
Author(s):  
Joshua Agilinko ◽  
Tze Jun Kueh ◽  
Louise Smart ◽  
Muhammad Shakeel
Keyword(s):  
Squamous Cell Carcinoma ◽  
Survival Rate ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Treatment Modalities ◽  
Management Problem ◽  
Aggressive Cancer ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Primary thyroid squamous cell carcinoma (SCC) is a rare and highly aggressive cancer. Diagnostic work-up encompasses cervical ultrasonography, tissue biopsy and CT scan. Surgery, radiotherapy and chemotherapy are the available treatment modalities. With a mean survival rate of 7 months reported in the literature, our patient is alive 2 years after successful treatment of her advanced primary thyroid SCC with surgery and radiotherapy.

scholarly journals Recent advances in Merkel cell carcinoma

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1995 ◽  
Author(s):  
Caitlin G. Robinson ◽  
Daniel Tan ◽  
Siegrid S. Yu
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Disease Burden ◽  
Treatment Guidelines ◽  
Treatment Options ◽  
Merkel Cell ◽  
Conventional Chemotherapy ◽  
The Past ◽  
Improved Outcomes ◽  
Local Radiation

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that has been historically associated with limited treatment options and poor prognosis. In the past 10 years, research in MCC has progressed significantly, demonstrating improved outcomes when treating with immunotherapy, particularly PD-1/PD-L1 inhibitors, when compared with conventional chemotherapy. There is also increasing evidence of the abscopal effect, a phenomenon describing the regression of untreated, distant MCC tumors following local radiation therapy. Additionally, antibodies to Merkel cell polyomavirus oncoproteins have been found to correlate with disease burden in a subset of patients, providing a useful tool for surveillance after treatment. Guidelines for the management of MCC will likely continue to change as research on surveillance and treatment of MCC continues.

Merkel Cell Carcinoma (MCC): Treatment and Outcomes Over the Past Ten Years at a High-Volume Academic Center

2019 ◽  
Vol 105 (1) ◽  
pp. E800
Author(s):  
A. Mohammad-Zadeh ◽  
M.A. Razaq ◽  
G. Krempl ◽  
C. Henson
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
High Volume ◽  
Merkel Cell ◽  
The Past ◽  
Academic Center
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