scholarly journals An atypical case of pyoderma gangrenosum in a dog

2018 ◽  
Vol 87 (6) ◽  
pp. 337-341
Author(s):  
J. Declercq
Keyword(s):  
Pyoderma Gangrenosum ◽  
Response To Treatment ◽  
Atypical Case ◽  
Excellent Response ◽  
Superficial Ulceration ◽  
Cutaneous Pain ◽  
Mixed Breed

Neutrophilic and ulcerative dermatitis is reported in a mixed breed dog. The condition was considered to be an atypical case of pyoderma gangrenosum. Clinically, it had a more superficial ulceration, a more pronounced pustular component and lacked the characteristic cutaneous pain and tenderness of the lesions. The diagnosis of pyoderma gangrenosum was made as a diagnosis of exclusion. The dog showed an excellent response to treatment with ciclosporin (Cyclavance, Virbac, Leuven, Belgium).

scholarly journals Longer Time to Reach Excellent Response to Treatment in Familial Versus Sporadic Non-medullary Thyroid Cancer (NMTC): A Matched Case-Control Study

2021 ◽  
Vol 19 (2) ◽  
Author(s):  
Susan Shafiei ◽  
Mehrdokht Sadrolodabaei ◽  
Atena Aghaei ◽  
Narjess Ayati ◽  
Samira Zare Namdar ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Response To Treatment ◽  
Control Groups ◽  
Excellent Response ◽  
Significant Difference ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Background: Familial NMTCs are supposed to be more aggressive and require more frequent treatment compared to non-familial thyroid cancer. Objectives: This matched case-control study aimed to compare the response to treatment between the matched case-control groups of familial and sporadic NMTC. Methods: This is a retrospective study in patients with familial NMTC (at least one other first-degree relative involved) who were treated with surgery, followed by radio-iodine therapy (RIT) without consideration of its familial origin. Response to treatment was compared between familial NMTC and age, sex, and TNM stage-matched non-familial NMTC (control group). Response to treatment was assessed one and two years after RIT, and time to excellent response was identified. Results: Out of 2,944 NMTC patients, 81 (2.75%) patients had familial NMTC. We compared 66 patients with familial NMTC and 66 sporadic NMTC patients. There was no significant difference in first thyroglobulin, initial and accumulative iodine dose, and additional treatments (additional surgery and radiotherapy) between patients and controls. Although no significant difference was noted in one and two years’ responses to treatment between the case and control groups, familial NMTC patients required more time to achieve excellent response (26.7 ± 24.9 versus 15.9 ± 9.0 months, P = 0.01). No significant difference was noted between familial NMTC patients with two or more than two involved relatives. Conclusions: Our study showed that if patients with familial NMTCs were treated in the same way as non-familial patients, the time to excellent response would be significantly longer, even when they have only one other involved relative.

scholarly journals Treatment of renal colic with injectable aspirin [Aspegic]

1997 ◽  
Vol 3 (2) ◽  
pp. 296-296
Author(s):  
Falih M. Al Obadi ◽  
Jinan I. Mobarak ◽  
Abdullah M. Jawad
Keyword(s):  
Adverse Effects ◽  
Emergency Treatment ◽  
Renal Colic ◽  
Response To Treatment ◽  
Complete Relief ◽  
Excellent Response ◽  
End Of Treatment

Forty-four [44] patients with severe renal colic were studied for their response to 500 mg injectable aspirin [Aspegic] administered intravenously twice daily for two days. It was found that 22.7% reported complete relief from pain after the first injection and 72.7% showed various degrees of improvement. In the overall assessment at the end of treatment, 63.6% showed an excellent response. Two patients did not show any response to treatment. Nineteen patients [43.2%] had felt or seen the stone pass out in urine, and none experienced any major adverse effects. Aspegic could be a useful drug in emergency treatment of severe renal colic

scholarly journals Pyoderma Gangrenosum-like ulceration as a presenting feature of pediatric Granulomatosis with Polyangiitis

2020 ◽  
Author(s):  
Rotem Semo Oz ◽  
Oluwakemi Onajin ◽  
Liora Harel ◽  
Rotem Tal ◽  
Tomas Dallos ◽  
...  
Keyword(s):  
Pyoderma Gangrenosum ◽  
Granulomatosis With Polyangiitis ◽  
Skin Lesions ◽  
Response To Treatment ◽  
Newly Diagnosed ◽  
Rare Presentation ◽  
Case Presentation ◽  
Appropriate Treatment ◽  
The Mean ◽  
Systemic Symptoms

Abstract Background: Granulomatosis with polyangiitis (GPA) is an anti-neutrophilic cytoplasmic antibody-associated vasculitis affecting small to medium-sized vessels and involves most commonly the kidneys and the respiratory tract. Skin involvement can be seen in up to 50% of children with GPA and is the initial presenting symptom in 7.7%. Pyoderma gangrenosum (PG)-like ulcers are rarely described as a skin manifestation in GPA and very few cases have been reported previously in children. Case presentation: We describe 3 new pediatric cases of GPA with PG-like ulcerations. The mean age at first symptom was 15 years. Two patients had PG-like ulceration as their initial presentation; additional symptoms eventually led to the diagnosis of GPA 2-24 months later. In 1 case, proteinase 3 (PR3) was negative when first tested, but converted to positive when systemic symptoms emerged, in the other 2 cases PR3 was positive at presentation. All 3 patients had prominent facial lesions. None of the patients responded to treatment with antibiotics or medications commonly used to manage PG, including corticosteroids and cyclosporine. All patients had excellent responses to rituximab. An electronic database literature review was performed and 4 previously reported cases were identified. We assessed the clinical characteristics, serology, and response to treatment of 4 previously reported and newly diagnosed cases. Conclusion: PG-like ulceration is a rare presentation of pediatric GPA which may precede classic systemic GPA symptoms. The predominance of facial ulcer, granulomatous and neutrophilic inflammation on skin biopsy and lack of response to PG treatments are characteristic of GPA-associated PG-like ulcers. Our review suggests that treatment with rituximab may be needed to improve the skin lesions. Recognizing that PG-like ulcerations can occur in pediatric GPA may result in timely diagnosis, appropriate treatment and improved prognosis.

Surgical and Medical Treatment of Pyloric and Duodenal Pythiosis in a Dog

2015 ◽  
Vol 51 (6) ◽  
pp. 385-391 ◽  
Author(s):  
David Lee Dycus ◽  
Cory Fisher ◽  
Ryan Butler
Keyword(s):  
Medical Treatment ◽  
Hepatic Cirrhosis ◽  
Response To Treatment ◽  
Billroth Ii ◽  
Partial Pancreatectomy ◽  
Persistent Vomiting ◽  
Initial Surgery ◽  
Mixed Breed ◽  
Liver Biopsies

A 5 yr old, male, neutered mixed-breed dog was referred for persistent vomiting 2 wk following a pyloric biopsy for a pyloric outflow obstruction. Histopathology at the time of initial surgery was suggestive of pythiosis. Following referral, the dog underwent radical surgical treatment with a Billroth II procedure, partial pancreatectomy, and cholecystoduodenostomy. Histopathology and serology confirmed the diagnosis of pythiosis and medical treatment consisting of itraconazole and terbinafine was started postoperatively. Serology titers were checked again at 8, 12, and 24 wk postoperatively revealing a positive response to treatment and no reoccurrence of pythiosis. Since surgery, the patient experienced waxing and waning elevations of liver values and laparoscopic liver biopsies 10 mo postoperatively revealed hepatic cirrhosis with fibrosis, bile duct hyperplasia, and chronic inflammation. This report documents successful treatment of pyloric/duodenal pythiosis and the long-term (17 mo) consequences associated with the Billroth II, partial pancreatectomy, and biliary rerouting in the dog.

Diffuse refractory esophageal spasm with excellent response to treatment with sildenafil

2021 ◽  
Author(s):  
Marina Puya Gamarro ◽  
María del Carmen López Vega ◽  
Isabel María Méndez Sánchez
Keyword(s):  
Response To Treatment ◽  
Excellent Response ◽  
Esophageal Spasm

scholarly journals Pyoderma gangrenosum-like ulceration as a presenting feature of pediatric granulomatosis with polyangiitis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Rotem Semo Oz ◽  
Oluwakemi Onajin ◽  
Liora Harel ◽  
Rotem Tal ◽  
Tomas Dallos ◽  
...  
Keyword(s):  
Pyoderma Gangrenosum ◽  
Granulomatosis With Polyangiitis ◽  
Skin Lesions ◽  
Response To Treatment ◽  
Proteinase 3 ◽  
Newly Diagnosed ◽  
Rare Presentation ◽  
Case Presentation ◽  
Appropriate Treatment ◽  
Systemic Symptoms

Abstract Background Granulomatosis with polyangiitis (GPA) is an anti-neutrophilic cytoplasmic antibody-associated vasculitis affecting small to medium-sized vessels and involves most commonly the kidneys and the respiratory tract. Skin involvement can be seen in up to 50% of children with GPA and is the initial presenting symptom in 7.7%. Pyoderma gangrenosum (PG)-like ulcers are rarely described as a skin manifestation in GPA and very few cases have been reported previously in children. Case presentation We describe 3 new pediatric cases of GPA with PG-like ulcerations. The median age at first symptom was 15 years. Two patients had PG-like ulceration as their initial presentation; additional symptoms eventually led to the diagnosis of GPA 2–24 months later. In 1 case, proteinase 3 (PR3) was negative when first tested, but converted to positive when systemic symptoms emerged; in the other 2 cases PR3 was positive at presentation. All 3 patients had prominent facial lesions. None of the patients responded to treatment with antibiotics or medications commonly used to manage PG, including corticosteroids and cyclosporine. All patients had excellent responses to rituximab. An electronic database literature review was performed and 4 previously reported cases were identified. We assessed the clinical characteristics, serology, and response to treatment of the previously reported and our newly diagnosed cases. Conclusion PG-like ulceration is a rare presentation of pediatric GPA which may precede classic systemic GPA symptoms. The predominance of facial ulcer, granulomatous and neutrophilic inflammation on skin biopsy and lack of response to PG treatments are characteristic of GPA-associated PG-like ulcers. Our review suggests that treatment with rituximab may be needed to improve the skin lesions. Recognizing that PG-like ulcerations can occur in pediatric GPA may result in timely diagnosis, appropriate treatment and improved prognosis.

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