Primary follicular mucinosis: excellent response to treatment with photodynamic therapy

2008 ◽  
Vol 22 (3) ◽  
pp. 393-394 ◽  
Author(s):  
M Fernández-Guarino ◽  
A Harto Castaño ◽  
R Carrillo ◽  
P Jaén
Keyword(s):  
Photodynamic Therapy ◽  
Response To Treatment ◽  
Excellent Response

scholarly journals New opportunities in the treatment of cutaneous lymphoid hyperplasia

2020 ◽  
Vol 23 (1) ◽  
pp. 17-22
Author(s):  
O. Yu. Olisova ◽  
E. M. Anpilogova
Keyword(s):  
Photodynamic Therapy ◽  
Complete Remission ◽  
Partial Remission ◽  
Laboratory Testing ◽  
Skin Lesions ◽  
Lymphoid Hyperplasia ◽  
Response To Treatment ◽  
Safe Method ◽  
Modified Assessment

Here, we present the results of our research regarding the efficacy of photodynamic therapy (PDT) in cutaneous lymphoid hyperplasia (CLH). We observed five patients with CLH. The diagnoses were confirmed both clinically and through laboratory testing. The response to treatment was defined by the index of the modified assessment of the severity of the skin lesions scale (mSWAT). PDT (665 10 nm) with topical photosensitizer application was performed once a week. The PDT course consisted of 4 2 sessions. After the therapy, complete remission was achieved in four patients (80%; mSWAT 95100%) and partial remission in one patient (20%; mSWAT 63%). Thus, PDT proved to be an effective and safe method for treating CLH.

scholarly journals Longer Time to Reach Excellent Response to Treatment in Familial Versus Sporadic Non-medullary Thyroid Cancer (NMTC): A Matched Case-Control Study

2021 ◽  
Vol 19 (2) ◽  
Author(s):  
Susan Shafiei ◽  
Mehrdokht Sadrolodabaei ◽  
Atena Aghaei ◽  
Narjess Ayati ◽  
Samira Zare Namdar ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Response To Treatment ◽  
Control Groups ◽  
Excellent Response ◽  
Significant Difference ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Background: Familial NMTCs are supposed to be more aggressive and require more frequent treatment compared to non-familial thyroid cancer. Objectives: This matched case-control study aimed to compare the response to treatment between the matched case-control groups of familial and sporadic NMTC. Methods: This is a retrospective study in patients with familial NMTC (at least one other first-degree relative involved) who were treated with surgery, followed by radio-iodine therapy (RIT) without consideration of its familial origin. Response to treatment was compared between familial NMTC and age, sex, and TNM stage-matched non-familial NMTC (control group). Response to treatment was assessed one and two years after RIT, and time to excellent response was identified. Results: Out of 2,944 NMTC patients, 81 (2.75%) patients had familial NMTC. We compared 66 patients with familial NMTC and 66 sporadic NMTC patients. There was no significant difference in first thyroglobulin, initial and accumulative iodine dose, and additional treatments (additional surgery and radiotherapy) between patients and controls. Although no significant difference was noted in one and two years’ responses to treatment between the case and control groups, familial NMTC patients required more time to achieve excellent response (26.7 ± 24.9 versus 15.9 ± 9.0 months, P = 0.01). No significant difference was noted between familial NMTC patients with two or more than two involved relatives. Conclusions: Our study showed that if patients with familial NMTCs were treated in the same way as non-familial patients, the time to excellent response would be significantly longer, even when they have only one other involved relative.

scholarly journals Treatment of renal colic with injectable aspirin [Aspegic]

1997 ◽  
Vol 3 (2) ◽  
pp. 296-296
Author(s):  
Falih M. Al Obadi ◽  
Jinan I. Mobarak ◽  
Abdullah M. Jawad
Keyword(s):  
Adverse Effects ◽  
Emergency Treatment ◽  
Renal Colic ◽  
Response To Treatment ◽  
Complete Relief ◽  
Excellent Response ◽  
End Of Treatment

Forty-four [44] patients with severe renal colic were studied for their response to 500 mg injectable aspirin [Aspegic] administered intravenously twice daily for two days. It was found that 22.7% reported complete relief from pain after the first injection and 72.7% showed various degrees of improvement. In the overall assessment at the end of treatment, 63.6% showed an excellent response. Two patients did not show any response to treatment. Nineteen patients [43.2%] had felt or seen the stone pass out in urine, and none experienced any major adverse effects. Aspegic could be a useful drug in emergency treatment of severe renal colic

Diffuse refractory esophageal spasm with excellent response to treatment with sildenafil

2021 ◽  
Author(s):  
Marina Puya Gamarro ◽  
María del Carmen López Vega ◽  
Isabel María Méndez Sánchez
Keyword(s):  
Response To Treatment ◽  
Excellent Response ◽  
Esophageal Spasm

scholarly journals Photodynamic therapy for cancer of the pancreas – The story so far

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Stephen G. Bown
Keyword(s):  
Clinical Trials ◽  
Photodynamic Therapy ◽  
Clinical Studies ◽  
Early Stage ◽  
Response To Treatment ◽  
Normal Pancreas ◽  
Invasive Treatment ◽  
College Hospital ◽  
Stage Of Development ◽  
And Function

AbstractPancreatic cancer has long been a leading cause of cancer death. Few patients are suitable for surgery and for those who are not, the response to treatment is generally poor. No more than about 10% survive for more than a year. Recent research has focused on focal treatment for local disease control. This review covers the development of one of the most promising options, photodynamic therapy (PDT).This review covers pre-clinical and clinical studies. Laboratory work was designed to understand the effect of PDT on the normal pancreas and surrounding tissues and on transplanted cancers in the hamster pancreas to ensure safety prior to clinical application. Essentially all clinical studies have been undertaken in University College Hospital, London. Phase-I studies used the photosensitisers mTHPC and verteporfin in patients with localised but inoperable cancers.Laboratory results showed that normal pancreas, bile duct, liver, stomach and major blood vessels could tolerate PDT without any unacceptable effects on the structure and function of these organs. Necrosis that healed safely was documented in transplanted cancers. The clinical trials showed that focal necrosis could be produced in inoperable cancers with acceptable levels of complications, but considerable refinements of treatment delivery and monitoring are required before the technique will be ready for assessment in controlled clinical trials.PDT is showing promise for the minimally invasive treatment of localised pancreatic cancers, but it is still at an early stage of development. Much more work will be necessary to optimise techniques for applying PDT to these cancers and for combining it with other therapeutic options such as chemotherapy.

scholarly journals Six Years of Experience in Photodynamic Therapy for Basal Cell Carcinoma: Results and Fluorescence Diagnosis from 191 Lesions

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
M. Fernández-Guarino ◽  
A. Harto ◽  
B. Pérez-García ◽  
A. Royuela ◽  
P. Jaén
Keyword(s):  
Photodynamic Therapy ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Therapeutic Option ◽  
Complete Response ◽  
Histological Type ◽  
Response To Treatment ◽  
Treatment Protocols ◽  
Fluorescence Diagnosis

Background.Photodynamic therapy (PDT) has become a therapeutic option for basal cell carcinoma (BCC) in the last decade. Objectives.To study the results and predictors of BCC response to treatment with PDT and to evaluate fluorescence diagnosis of BCC.Methods.A descriptive, retrospective, and observational study was carried out. Patients with biopsy-confirmed BCC who were treated with methyl aminolevulinate and red light according to standard treatment protocols (2 sessions separated by 2 weeks, 630 nm, 37 J/cm2, 8 minutes, Aktilite) were selected. Response was scored as clinically complete and incomplete and the patients were followed up every three months.Results. Data from 191 BCC in 181 patients with a mean age of 69.55 years and a mean follow-up period of 34.4 months were collected. The overall response was 74% of the BCC treated, with the best response in superficial BCC with a 95% of complete response. The regression analysis revealed that the superficial histological type was the primary factor predictive of a complete response.Conclusions.In the treatment of BCC with PDT, the most significant factor for predicting response is the histological type.

scholarly journals An atypical case of pyoderma gangrenosum in a dog

2018 ◽  
Vol 87 (6) ◽  
pp. 337-341
Author(s):  
J. Declercq
Keyword(s):  
Pyoderma Gangrenosum ◽  
Response To Treatment ◽  
Atypical Case ◽  
Excellent Response ◽  
Superficial Ulceration ◽  
Cutaneous Pain ◽  
Mixed Breed

Neutrophilic and ulcerative dermatitis is reported in a mixed breed dog. The condition was considered to be an atypical case of pyoderma gangrenosum. Clinically, it had a more superficial ulceration, a more pronounced pustular component and lacked the characteristic cutaneous pain and tenderness of the lesions. The diagnosis of pyoderma gangrenosum was made as a diagnosis of exclusion. The dog showed an excellent response to treatment with ciclosporin (Cyclavance, Virbac, Leuven, Belgium).

scholarly journals Diffuse Optical Spectroscopy Monitoring of Experimental Tumor Oxygenation after Red and Blue Light Photodynamic Therapy

Photonics ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 19
Author(s):  
Anna Orlova ◽  
Yulia Perevalova ◽  
Ksenia Pavlova ◽  
Natalia Orlinskaya ◽  
Aleksandr Khilov ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Growth ◽  
Oxygen Saturation ◽  
Blue Light ◽  
Optical Spectroscopy ◽  
Tumor Oxygenation ◽  
Response To Treatment ◽  
Tumor Growth Inhibition ◽  
Diffuse Optical Spectroscopy ◽  
Observation Period

Photodynamic therapy (PDT) is an effective technique for cancer treatment based on photoactivation of photosensitizer accumulated in pathological tissues resulting in singlet oxygen production. Employment of red (660 nm) or blue (405 nm) light differing in typical penetration depth within the tissue for PDT performance provides wide opportunities for improving PDT protocols. Oxygenation dynamics in the treated area can be monitored using diffuse optical spectroscopy (DOS) which allows evaluating tumor response to treatment. In this study, we report on monitoring oxygenation dynamics in experimental tumors after PDT treatment with chlorin-based photosensitizers using red or blue light. The untreated and red light PDT groups demonstrate a gradual decrease in tumor oxygen saturation during the 7-day observation period, however, the reason is different: in the untreated group, the effect is explained by the excessive tumor growth, while in the PDT group, the effect is caused by the blood flow arrest preventing delivery of oxygenated blood to the tumor. The blue light PDT procedure, on the contrary, demonstrates the preservation of the blood oxygen saturation in the tumor during the entire observation period due to superficial action of the blue-light PDT and weaker tumor growth inhibition. Irradiation-only regimes show a primarily insignificant decrease in tumor oxygen saturation owing to partial inhibition of tumor growth. The DOS observations are interpreted based on histology analysis.

scholarly journals 1,213 Cases of Treatment of Facial Acne Using Indocyanine Green and Intense Pulsed Light in Asian Skin

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Kui Young Park ◽  
Ji Young Kim ◽  
Moo Yeol Hyun ◽  
Won Jong Oh ◽  
Se Yeong Jeong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Patient Satisfaction ◽  
Indocyanine Green ◽  
Intense Pulsed Light ◽  
Response To Treatment ◽  
Light Sources ◽  
Pulsed Light ◽  
Patient Satisfaction Scores ◽  
Excellent Improvement ◽  
Facial Acne

Background. Photodynamic therapy (PDT) has been used for acne, with various combinations of photosensitizers and light sources.Objective. We evaluated the effectiveness and safety of indocyanine green (ICG) and intense pulsed light (IPL) in the treatment of acne.Materials and Methods. A total of 1,213 patients with facial acne were retrospectively reviewed. Patients received three or five treatments of ICG and IPL at two-week intervals. Clinical response to treatment was assessed by comparing pre- and posttreatment clinical photographs and patient satisfaction scores.Results. Marked to excellent improvement was noted in 483 of 1,213 (39.8%) patients, while minimal to moderate improvement was achieved in the remaining 730 (60.2%) patients. Patient satisfaction scores revealed that 197 (16.3%) of 1,213 patients were highly satisfied, 887 (73.1%) were somewhat satisfied, and 129 (10.6%) were unsatisfied. There were no significant side effects.Conclusion. These results suggest that PDT with ICG and IPL can be effectively and safely used in the treatment of acne.

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