scholarly journals Vitamin D, Testosterone, and Thyroid Status in Young Men at Different Seasons

2021 ◽  
Vol 77 (3) ◽  
Author(s):  
Vladimir Bondarenko ◽  
Olga Goncharova ◽  
Andriy Minukhin ◽  
Evgeniy Skornyakov
Keyword(s):  
Vitamin D ◽  
Thyroid Stimulating Hormone ◽  
Semen Parameters ◽  
Winter Period ◽  
Seasonal Fluctuations ◽  
Summer Period ◽  
Thyroid Status ◽  
General Group ◽  
Vitamin D Levels ◽  
Different Seasons

There are evidences that seasonal fluctuations in vitamin D levels coincide with annual rhythms of testosterone levels, and hypothyroidism may be a predictor of hypoandrogenism. The aim of the study was to establish the levels of vitamin D (vit. D), testosterone (T), thyroid stimulating hormone (TSH) and free thyroxine (T4f) in young people with pathospermia and normospermia in the spring-summer and autumn-winter periods. Materials and methods. The data of 58 men aged 23-44 years, who are in a sterile marriage, were analyzed: 24 were examined in the spring-summer period, 34 - in the autumn-winter period. BMI, levels of T, TSH, T4fandvit. Dwere investigated. Results. In the general group of men, the frequency of D - hypovitaminosis was higher in those examined in the autumn-winter period. Vit D levels were significantly lower with pathospermia than with normospermia. BMI did not significantly affect the level of vit.D in the blood.A direct correlation between vit. D and T in men with patho- and normospermiahas not been established, although such a correlation took place in the general group of the surveyed. The average TSH values ​​in the group examined in the spring-summer period did not significantly differ in the group with patho- and normospermia, and in those examined in the autumn-winter period, against the background of pathospermia, there was a decrease in T4f values ​​and an increase in TSH. 13.6% of this subgroup had laboratory signs of subclinical hypothyroidism. Conclusions: In men of the general group, without taking into account the state of the spermatogenic function of the testicles, examined in the autumn-winter period, there is a significant increase in the frequency of D-hypovitaminosis compared with a similar group of men in whom the level of vitamin D blood was determined in the spring-summer period. Regardless of the examination period, patients with pathospermia show a decrease in the average levels of vitamin D and testosterone compared to men with normal semen parameters. The frequency of vitamin D deficiency in patients with pathospermia significantly increases in the autumn-winter period. Disorders of spermatogenesis in men can be associated with the hypofunctional state of the thyroid gland against the background of the existing deficiency of vitamin D in the autumn-winter period.

scholarly journals Effect of Hypovitaminosis D on Lipid Profile in Hypothyroid Patients in Saudi Arabia

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Awad S. Alsamghan ◽  
Safar A. Alsaleem ◽  
Mohammed A. S. Alzahrani ◽  
Ayyub Patel ◽  
Ayaz K. Mallick ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Total Cholesterol ◽  
Cell Function ◽  
Early Stage ◽  
Thyroid Stimulating Hormone ◽  
Vitamin D Levels ◽  
Hypothyroid Patients ◽  
Tsh Levels

Background. Hypothyroidism is believed to be associated with dyslipidemia and is considered a risk factor for the development of atherosclerotic cardiovascular diseases (ASCVD). Vitamin D, due to its steroid hormone action, retains cell function and controls the metabolism of lipids. Therefore, the present study was carried out to show the association of the risk factors of ASCVD and deficiency of thyroid hormones and vitamin D levels since no previous studies have been performed on Saudi patients before. Methodology. A retrospective cohort study was carried out on 400 hypothyroid patients. Medical records of those patients were followed up and were classified as normal and hypothyroid patients according to their thyroid-stimulating hormone levels. TSH, vitamin D, and lipid profiles were determined using the ELISA technique. Result. Total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels were significantly higher in hypothyroid patients than those in the normal group. We have found a significant correlation between TSH levels and the risk factors of ASCVD (total cholesterol, triglycerides, and LDL-C). Moreover, a significant correlation between vitamin D levels and the risk factors of ASCVD (total cholesterol, triglycerides, and LDL-C) has been found. In addition, there is a correlation between deficiency of Vit D and low-TSH levels (95% CI 1.092–4.05) indicating a higher risk for the development of ASCVD among those patients. Conclusion. Hypothyroid and vitamin D-deficient patients must be screened regularly at an early stage to predict and also to prevent cardiovascular diseases. Moreover, an adequate supply of vitamin D and TH should be given to those patients to prevent cardiovascular diseases at an early stage.

scholarly journals P007: Association between serum biomarkers and frailty level in seniors with minor injurys

CJEM ◽  
2016 ◽  
Vol 18 (S1) ◽  
pp. S80-S81
Author(s):  
N. Allain-Boulé ◽  
J. Lebon ◽  
M. Sirois ◽  
M. Aubertin-Leheudre ◽  
M. Émond
Keyword(s):  
Vitamin D ◽  
Thyroid Stimulating Hormone ◽  
Serum Biomarkers ◽  
Sexual Hormones ◽  
Clinical Frailty Scale ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Vitamin D Levels ◽  
Minor Injuries ◽  
Age And Sex

Introduction: Frailty is associated with mobility & physical impairment in seniors with minor injuries. Serum biomarkers have also been suggested as potential markers of these impairments in clinical studies. No study has examined if serum biomarkers could contribute to the diagnosis of frailty in seniors with minor injuries. Objectives: To explore the association between several serum biomarkers (Ferritin, Creatinine, Vitamin D, Albumin, Glucose, Estradiol, Testosterone, Thyroid Stimulating Hormone (TSH), Insulin-Growth Factor (IGF-1) C-reactive protein (CRP)) and frailty level in seniors treated in emergency department (ED) for minor injuries. Methods: Cross-sectional study within the larger CETI cohort. It includes 142 seniors discharged home from 4 EDs after treatment of minor injuries. Their frailty status was measured by the Canadian Study of Health & Aging-Clinical Frailty Scale (CSHA-CFS). Biomarkers were obtained from blood samples. Pearson’s correlations (r) were performed to examine the relation between serum biomarkers and frailty levels. Partial correlation controlled for age and sex, were also performed. Results: Due to inclusion criteria, no patient was severely frail. Overall, these preliminary analyses seem to indicate that robust patients tended to have lower Glucose & Vitamin D levels (-0.264 ≤ r ≤ -0.230; p < 0.05), higher Estradiol (r = 0,230; p < 0.05) & Testosterone (r = 0,295; p < 0.05), while prefrail/frail patients tended to have higher Glucose & Vitamin D levels (0,235 ≤ r ≤ 0,238; p < 0.05), lower Estradiol levels (r = -0,235; p < 0.05) & more elevated Ferritin levels. Due to the small number of patients, controlling for age and sex lead to non-significant results of the most associations. Conclusion: Pre-frail/frail seniors presenting to EDs with minor injuries tend to have higher Ferritin, Glucose & Vitamin D levels as well as lower sexual hormones levels than robust individuals. Larger samples are needed in order to elucidate which biomarkers could be most useful to identify frail seniors needing clinical attention and to assess a possible association with mobility impairments in this population.

352 The Relation Between Semen Parameters and Plasma 25 (OH) Vitamin D Levels in Infertil Men

2017 ◽  
Vol 14 (1) ◽  
pp. S103-S104
Author(s):  
K. Ertas ◽  
G. Turan ◽  
O. Cakir ◽  
E. Kandirali ◽  
E. Serefoglu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Semen Parameters ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Vitamin D-containing supplements for children between 1–3 years of age: Are they essential for bone health?

2015 ◽  
Vol 28 (1-2) ◽  
Author(s):  
Emel Torun ◽  
Feyza Ustabas Kahraman ◽  
Nurcan Keskin Osmanoğlu ◽  
Mehmet Kucukkoc ◽  
Tugrul Donmez ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
Vitamin D Levels ◽  
Different Seasons ◽  
Medical Reports ◽  
Calcium And Phosphorus ◽  
Low Levels ◽  
Phosphorus Levels ◽  
Group 1

Abstract: We aim to evaluate how vitamin D-containing supplements affect the vitamin D status of children 1–3 years old and to assess the variation of the vitamin D concentrations across different seasons.This retrospective study included a review of medical reports of 1035 patients (aged 1–3 years) who presented to our hospital between October 2011 and October 2013. The children were divided into 3 groups: Group 1: those supplemented with vitamin DGender distribution was not statistically different between the three groups (p=0.38). The children who had taken vitamin D-containing supplements had significantly higher vitamin D levels compared with the children who were given no vitamin D supplementation (p<0.001). Children with no vitamin D supplementation had significantly lower calcium and phosphorus levels compared with Groups 1 and 2. Vitamin D levels were affected by vitamin D supplementation (f=16.125, p<0.001) but not by season (f=0.699, p=0.650).The children aged 1–3 years who did not receive vitamin D-containing supplements had insufficient vitamin D and low levels of calcium and phosphorus. Vitamin D levels were affected by vitamin D supplementation but not by season.

scholarly journals Efficacy of Vitamin-D Supplement on Thyroid Profile in Children with Graves’ Disease

2020 ◽  
Vol 8 (B) ◽  
pp. 798-801
Author(s):  
Winra Pratita ◽  
Karina Sugih Arto ◽  
Nindia Sugih Arto
Keyword(s):  
Vitamin D ◽  
Thyroid Hormone ◽  
Vitamin D Deficiency ◽  
Thyroid Disease ◽  
Vitamin D Supplementation ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Vitamin D Levels ◽  
Thyroid Profile ◽  
Vitamin D Supplement

BACKGROUND: Many studies have shown low Vitamin-D level as a risk factor for autoimmune diseases, especially multiple sclerosis and thyroid disease. Graves’ disease (GD) is an autoimmune disease caused by autoantibodies that stimulate thyroid-stimulating hormone (TSH) receptors by increasing thyroid hormone synthesis and secretion. Several studies report that many patients with autoimmune thyroid disease including GD have low Vitamin-D status. AIM: The objective of the study was to evaluate the effect of Vitamin-D supplement on GD patients on improvement in thyroid hormone levels. METHODS: Open random clinical trial was conducted in GD patients to determine changes in thyroid hormone to achieving normal levels between those receiving methimazole plus Vitamin-D supplementation compared with those who only received methimazole. Patients were checked for TSH receptor antibody, thyroid profile and Vitamin-D level before treatment and rechecked for thyroid profile and Vitamin-D level 3 months after treatment. t-test used to compare the drug efficacy (p < 0.05) in two groups. RESULTS: From 25 children with GD accompanied by Vitamin-D deficiency with an average value of Vitamin-D was 16 ng/mL. GD children who receive methimazole with Vitamin-D supplement had elevated TSH levels in the 3rd month of therapy that was significantly different compared to GD children who received methimazole only (p = 0.00), and the increase of TSH was also followed by an increase in Vitamin-D levels. CONCLUSION: All children with GD had Vitamin D deficiency, and the addition of Vitamin-D supplement to GD therapy would improve TSH faster than children who did not receive Vitamin-D supplement.

scholarly journals Treatment With Cholecalciferol Leads to Increase Of Selected Semen Parameters in Young Infertile Males: Results of a 6-month Interventional Study

2021 ◽  
pp. S99-S107
Author(s):  
I. Bartl ◽  
M. Ondrušová ◽  
M. Kužma ◽  
P. Jackuliak ◽  
A. Gažová ◽  
...  
Keyword(s):  
Vitamin D ◽  
Semen Analysis ◽  
Sperm Concentration ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Sperm Parameters ◽  
Semen Parameters ◽  
Serum Vitamin D ◽  
Vitamin D Levels

High incidence of infertility along with low vitamin D levels was detected in otherwise healthy young men. The aim is to observe the effect of vitamin D supplementation on semen parameters as assessed by semen analysis in infertile men. In total, 45 men (mean age 36.6 years) in consecutive order were included, of whom 34 finished the study. Subjects were supplemented by vitamin D (cholecalciferol) 2500 IU/day. Vitamin D levels were assessed by HPLC. Semen analysis was performed strictly following 2010 WHO guidelines. Study periods were baseline and month 6. During follow-up, 20 %, 7.4 %, 22 % and 0.7 % increase in serum vitamin D levels, progressive sperm motility, sperm concentration and sperm morphology, respectively, were observed (all p<0.05). At follow-up end, 9 patients (26 %) reached normal sperm parameters of whom 2 fertilized their partner. There was no correlation between vitamin D and semen parameters observed. This study proves that vitamin D supplementation is possibly a modulator of sperm parameters in vitamin D deficient, otherwise healthy men. Although a direct relationship between vitamin D and sperm parameters was not observed obtaining adequate vitamin D levels could likely play a role in the male factor of infertility.

scholarly journals Vitamin D status, bone mineral density and body mass index in patients with newly diagnosed postmenopausal osteoporosis and healthy menopausal women

2019 ◽  
pp. 18-28
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Postmenopausal Osteoporosis ◽  
Control Group ◽  
Winter Period ◽  
Mineral Density ◽  
Vitamin D Levels ◽  
Menopausal Women ◽  
Calcium Phosphorus ◽  
D 12

This study aims to assess vitamin D levels in women with postmenopausal osteoporosis and healthy women going through menopause. Two groups of menopausal women took part in the study – 41 women with osteoporosis and 22 without osteoporosis. The levels of vitamin D, parathormone, alkaline phosphatase, calcium and phosphorus were examined during the autumn-winter period. Calcium, phosphorus and alkaline phosphatase were established within the reference range in both groups. A negative correlation with increase of parathormone levels among the patients with osteoporosis and vitamin D deficiency was found (r = -0.46, p<0.01). 16 women with osteoporosis (39%) were with normal levels of vitamin D, 14 (34,1%) were with insufficiency and 11 (26,9%) with deficiency. Within the control group, 8 women (36,4%) were with normal levels of vitamin D, 12 (54,5%) were with insufficiency and 2 (9,1%) with deficiency.

Absence of a relationship between thyroid hormones and vitamin D levels

2016 ◽  
Vol 29 (6) ◽  
Author(s):  
Ping Zhou ◽  
Jinny Cai ◽  
Morri Markowitz
Keyword(s):  
Vitamin D ◽  
Thyroid Hormones ◽  
Serum Levels ◽  
Population Based ◽  
Thyroid Stimulating Hormone ◽  
Normal Group ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
The Mean

AbstractVitamin D is an immune modulator that may play a role in thyroid related autoimmunity.We analyzed a US population based dataset to determine the relationship between serum 25-hydroxyvitamin D (25OHD) and thyroid hormones while assessing the effects of autoimmunity and BMI.25OHD did not correlate significantly with any thyroid related measure. 25OHD levels stratified by thyroid antibody status were not statistically different between antibody positive and negative groups. The mean 25OHD levels of lean, overweight, and obese groups defined by BMI were lower than those of the normal group. Only the mean thyroid stimulating hormone (TSH) value in the obese group was significantly higher than the normal group.We conclude that thyroid related measures and 25OHD serum levels are not related.

scholarly journals Is there a relationship between serum vitamin D and semen parameters? A cross-sectional sample of the Iranian infertile men

2021 ◽  
Vol 31 (1) ◽  
Author(s):  
Hossein Hajianfar ◽  
Elham Karimi ◽  
Negar Mollaghasemi ◽  
Sheyda Rezaei ◽  
Arman Arab
Keyword(s):  
Vitamin D ◽  
Sperm Count ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Semen Parameters ◽  
Cross Sectional ◽  
Normal Morphology ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Semen Volume

Abstract Background Recent studies suggest that serum vitamin D may be associated with semen parameters. In the present cross-sectional study, we attempted to investigate the association between serum vitamin D levels and semen parameters among Iranian sub-fertile men. Results A total of 350 infertile men recruited for this cross-sectional study using a simple random sampling method with a mean age of 34.77 years old, body mass index of 26.67 kg/m2, serum vitamin D of 20.17 ng/ml, semen volume of 3.82 mL, sperm count of 44.48 (106/mL), sperm total motility of 38.10 %, and morphologically normal sperm of 7.0 %. After controlling for potential confounders, serum vitamin D was positively associated with semen volume (β = 0.63, 95 % CI: 0.06, 1.20), sperm count (β = 14.40, 95 % CI: 4.56, 24.25), sperm total motility (β = 18.12, 95 % CI: 12.37, 23.86), and sperm normal morphology (β = 1.95, 95 % CI: 1.07, 2.83). Conclusions The present findings suggest that higher serum vitamin D levels are positively associated with higher semen volume, sperm count, sperm total motility, and normal morphology rate. These findings, however, do not specify a cause-and-effect relationship, and there is a need for further research in this area to understand whether vitamin D supplementation can improve semen parameters.

Does sufficient 25-hydroxyvitamin D mean lower metabolic risk for women?

2020 ◽  
Vol 13 (4) ◽  
pp. 311-318
Author(s):  
Zeynep Cetin ◽  
Ozden Baser ◽  
Derya Koseoglu ◽  
Merve Catak
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Metabolic Diseases ◽  
Thyroid Stimulating Hormone ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
Calcium Phosphorus ◽  
25 Hydroxy Vitamin D ◽  
25 Hydroxyvitamin D ◽  
25 Oh Vitamin D

OBJECTIVE: There are conflicting results regarding the relationship between metabolic diseases and vitamin D deficiency. We aimed to show the possible relationship between 25-hydroxy (OH) vitamin D levels and obesity, insulin resistance and hyperlipidemia in women. MATERIALS AND METHODS: Three hundred fifty seven female were included retrospectively. Body mass index (BMI) was determined with body weight (kg)/height (m2) formula. Fasting plasma glucose, insulin, lipid profile, calcium, phosphorus, parathormone, 25 hydroxy vitamin D, thyroid stimulating hormone were evaluated. Insulin resistance was calculated with homeostatic model values for insulin resistance (HOMA-IR). Patients were grouped according to 25 (OH) vitamin D levels and BMIs. RESULTS: 25 (OH) vitamin D was negative correlated with BMI, insulin and HOMA-IR, (respectively r = –0.156, –0.128, –0.123 and p = 0.003, 0.015, 0.020). It is positive correlated with HDL and HDL/LDL ratio (respectively r = 0.183, 0.185 and p = 0.003, <0.001) HDL-C was higher in 25(OH) vitamin D sufficient group. After multivariate analysis, 25 (OH) vitamin D was still positively related with HDL and HDL/LDL ratio (respectively r = 0.127, 0.118 and p = <0.05). CONCLUSION: 25 (OH) Vitamin D is relationship with HDL, HDL/LDL ratio and invers relationship obesity. The normal 25 (OH) vitamin D supports the reduction of metabolik risk.

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