Analysis of Prognostic Factors Affecting Short-term and Long-term Outcomes of Gastric Cancer Resection

Background/Aims: Identification of nutritional indicators to predict short-term and long-term outcomes is necessary to provide appropriate treatment to patients with gastric cancer. Methods: We designed an analysis of a multicenter dataset of patients with gastric cancer who underwent gastrectomy between 2010 and 2014. We enrolled 842 eligible patients who had stage II/III gastric cancer. The area under the curve (AUC) values were compared among prognostic nutritional index (PNI), calculated as 10 × albumin g/dL + 0.005 × total lymphocyte count/mm3, and its constituents, and the predictive value of preoperative PNI for postoperative short-term and long-term outcomes was evaluated. Results: Preoperative PNI exhibited higher AUC values (0.719) for 1-year survival than its constituents, and the optimal cutoff value was 47. The disease-free and overall survival of patients in the PNI-low group were significantly shorter compared with those in the PNI-high group. The prognostic difference between the PNI-high and PNI-low groups was significantly greater in the subgroup of patients who underwent total gastrectomy. Clinically relevant postoperative complications were more frequently observed in the PNI-low group. Conclusions: The preoperative PNI is a useful predictor reflecting the incidence of complications after gastrectomy and the prognosis of patients with stage II/III gastric cancer.

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Long-term outcomes and prognostic factors of patients with advanced gastric cancer treated with S-1 plus cisplatin combination chemotherapy as a first-line treatment

International Journal of Clinical Oncology ◽

10.1007/s10147-013-0610-1 ◽

2013 ◽

Vol 19 (4) ◽

pp. 656-661 ◽

Cited By ~ 4

Author(s):

Shigenori Kadowaki ◽

Azusa Komori ◽

Yukiya Narita ◽

Sohei Nitta ◽

Kazuhisa Yamaguchi ◽

...

Keyword(s):

Gastric Cancer ◽

Prognostic Factors ◽

Advanced Gastric Cancer ◽

Combination Chemotherapy ◽

Line Treatment ◽

Long Term Outcomes ◽

First Line ◽

First Line Treatment

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Neutrophil-to-lymphocyte ratio (NLR) to predict the short-term and long-term outcomes of gastric cancer patients.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e15560 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e15560-e15560

Author(s):

Ryoichi Miyamoto ◽

Satoshi Inagawa ◽

Naoki Sano ◽

Sosuke Tadano ◽

Masayoshi Yamamoto

Keyword(s):

Gastric Cancer ◽

Cancer Patients ◽

Predictive Value ◽

Disease Free Survival ◽

Perioperative Outcomes ◽

Survival Times ◽

Long Term Outcomes ◽

Short Term ◽

Gastric Cancer Patients

e15560 Background: Preoperative NLR was well known as highly repeatable, cost-effective and widely available long-term postoperative prognostic marker of gastric cancer patients. However, the utility of preoperative NLR to predict short-term outcomes in gastric cancer patients remains unclear. In this study, we addressed whether the preoperative NLR is a predictive value of short-term outcome in gastric cancer patients. Methods: We retrospectively evaluated 154 consecutive gastric cancer patients. Mean NLR was calculated, and 3.5 was set as cut-off value. The patient characteristics and perioperative outcomes were respectively compared. In addition, median survival times (MSTs) were also compared. In terms of stage II/III (UICC 7th) gastric cancer patients, median disease-free survival times (MDFSTs) were compared between the two groups. Results: The patients were then divided into two groups: low-NLR group (n = 110) and high-NLR group (n = 44). Among low-NLR group and high-NLR group, significant differences were respectively observed in preoperative symptoms [56 (51%) vs. 31 (70%); p = 0.027] and perioperative outcomes including postoperative complications [3 (2.7%) vs. 5 (11.3%); p = 0.015], intraoperative blood loss (158 ± 168 g vs. 232 ± 433 g; p = 0.022), and intraoperative blood transfusion [0 vs. 3 (6.8%); p = 0.042]. MSTs and MDFSTs were significantly differed (812 vs. 594 days; p = 0.04, 848 vs. 475 days; p = 0.03, respectively). Conclusions: The present study indicated that preoperative NLR influenced not only long-term outcomes but also perioperative outcomes in gastric cancer patients. Preoperative NLR is also a useful predictive value of short-term outcomes in gastric cancer patients.

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