Kawasaki Disease and Atopic Diseases: A Systematic Review and Meta-Analysis of Observational Studies

2021 ◽  
pp. 1-9
Author(s):  
Zihan Wang ◽  
Jintao Zhang ◽  
Hao Yan ◽  
Liang Dong
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Kawasaki Disease ◽  
Observational Studies ◽  
Allergic Conjunctivitis ◽  
Meta Analysis ◽  
Allergic Diseases ◽  
Cardiovascular Disorder ◽  
Atopic Diseases ◽  
Cross Sectional

<b><i>Introduction:</i></b> The etiology of Kawasaki disease (KD), an inflammatory and cardiovascular disorder, remains largely unexplained after more than 50 years of intensive research. In recent years, the association between KD and atopic diseases had been explored by some observational studies. We systematically reviewed and summarized the literature on the relationship between KD and atopic diseases. <b><i>Methods:</i></b> MEDLINE and EMBASE were searched to identify observational studies on the association between KD and atopic diseases from inception to May 2021. Odds ratio (OR) was pooled using random-effects models. Heterogeneity was assessed using the <i>I</i><sup>2</sup> and Cochran Q statistics. Primary outcomes were to compare the prevalence of KD among individuals with atopic diseases to nonatopic disease controls and the prevalence of atopic diseases among individuals with KD to non-KD controls. <b><i>Results:</i></b> Thirteen studies, including 12,651 cases and 170,708 controls, were included in this meta-analysis. In cross-sectional studies, KD was associated with allergic rhinitis (<i>n</i> = 6; OR, 1.69; 95% CI, 1.52–1.87), asthma (<i>n</i> = 3; OR, 1.72; 95% CI, 1.38–2.14), allergic conjunctivitis (<i>n</i> = 2; OR, 1.95; 95% CI, 1.68–2.27), and atopic dermatitis (<i>n</i> = 3; OR, 1.35; 95% CI, 1.22–1.49). In case-control and cohort studies, KD was associated with allergic rhinitis (<i>n</i> = 3; OR, 1.35; 95% CI, 1.28–1.43), asthma (<i>n</i> = 8; OR, 1.40; 95% CI, 1.19–1.65), allergic conjunctivitis (<i>n</i> = 1; OR, 1.74; 95% CI, 1.45–2.09), and atopic dermatitis (<i>n</i> = 3; OR, 1.39; 95% CI, 1.26–1.53). <b><i>Conclusion:</i></b> KD diagnosed was associated with four common atopic diseases. Among the four allergic diseases, allergic conjunctivitis and asthma have the highest correlation with KD, which may provide a direction for exploring the etiology of KD.

scholarly journals Increased Risk of Asthma and Allergic Rhinitis in Patients With a Past History of Kawasaki Disease: A Systematic Review and Meta-Analyses

2021 ◽  
Vol 9 ◽  
Author(s):  
Wei-Te Lei ◽  
Chih-Wei Hsu ◽  
Po-Cheng Chen ◽  
Ping-Tao Tseng ◽  
Ho-Chang Kuo ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Kawasaki Disease ◽  
Past History ◽  
Meta Analysis ◽  
Allergic Diseases ◽  
Previous Diagnosis ◽  
Increased Risk ◽  
History Of ◽  
Meta Analyses

Background: Allergic diseases are frequently observed in children with Kawasaki disease (KD). However, the evidence supporting the association between KD and allergies has been conflicting. The objective of the current study is to examine the association between KD and allergic diseases.Methods: We conducted an electronic search using PubMed, Embase, and the Cochrane through 24 July 2021. The inclusion criteria consisted of studies that examined the prevalence of allergic diseases in children with a previous diagnosis of KD and in a comparison group. We pooled studies by using a random effects model. The effects of KD on the subsequent risk of allergic diseases were expressed as odds ratio (OR) with 95% confidence intervals (CI).Results: We included a total of four studies that assessed the effect of KD on asthma, allergic rhinitis, and atopic dermatitis vs. non-KD children (KD individuals for asthma, four studies, n = 8,474; allergic rhinitis, four studies, n = 8,474; atopic dermatitis, three studies, n = 8,330). The overall prevalence of asthma, allergic rhinitis, and atopic dermatitis was 9.12, 27.63, and 6.55% among patients with previous KD. The meta-analysis showed a significantly increased risk of asthma (OR:1.437, CI: 1.067–1.937) and allergic rhinitis (OR: 1.726, CI: 1.291–2.307) in patients with KD, compared with the control groups. However, patients with KD did not have a significantly different level of risk of atopic dermatitis (OR: 1.243, 95% CI: 0.857–1.802).Conclusion: This meta-analysis supports that individuals with KD are more likely to have asthma and allergic rhinitis compared to controls.

scholarly journals The Role of Allergens in Atopic Dermatitis

2020 ◽  
Author(s):  
Suna Asilsoy ◽  
Serdar Al
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Skin Lesions ◽  
Atopic Diseases ◽  
Chronic Skin ◽  
Genetic And Environmental Factors ◽  
Inhalant Allergens ◽  
Chronic Skin Disease

Atopic dermatitis (AD) is a chronic skin disease caused by genetic and environmental factors. Often it begins in early childhood. It is located at the first step of the process we refer to as atopic march. This feature is a precursor of the development of other allergic diseases such as asthma and allergic rhinitis. Especially in patients with atopy of food and inhalant allergens, the occurrence of other atopic diseases is more common. Although the role of these sensitivities in AD is controversial, it has been determined that some patients may trigger eczematous skin lesions. In this report, the role of allergens in atopic dermatitis are reviewed in the light of current literature.

scholarly journals Clinical manifestations of atopy in children up to two years of age

2011 ◽  
Vol 68 (8) ◽  
pp. 690-695 ◽  
Author(s):  
Nevenka Ilic ◽  
Vesna Velickovic ◽  
Dragoljub Djokic ◽  
Nebojsa Rankovic ◽  
Gordana Kostic ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Developed Countries ◽  
Specific Ige ◽  
Food Allergies ◽  
Atopic Diseases ◽  
Ige Antibodies ◽  
Total Ige

Background/Aim. Atopic diseases such as atopic dermatitis, allergic rhinitis and asthma have had increased prevalence during the past decade and nowadays occur in every third child in developed countries. The aim of the study was to determine frequency and type of atopic diseases at the age of two, as well as the importance the total IgE antibodies concentrations have in diagnosis and prognosis of the disease. Methods. The study involved 175 children up to two years of age. Allergy-like symptoms were found after surveying their parents and pediatric medical records. Using the fluorescence immunossay (FIA) method, total IgE antibodies concentrations and specific IgE antibodies (Phadiatop infant) were determined on an Immunocap 100 Dyagnostic System. Results. One or more allergy-like symptoms accounted for 57.7% of findings in children under the age of two, whilst in 19.4% the existence of IgE-related allergic diseases was found. Atopic diseases usually have clinical manifestations of atopic dermatitis (11.4%), IgE-bound wheezing/asthma (10.8%) and food allergies (7.4%), and to much lesser extent those of allergic rhinitis (3.4%) and urticaria (1.7%). The significantly higher total IgE antibodies concentrations were found in children with allergy-like symptoms (p < 0.0005) (cut-off 15.15 kU/L, sensitivity 76.5% specificity 71.6%). Conclusion. Almost 20% of two-year-old children have any of clinically manifested allergic diseases, with atopic dermatitis and IgE wheeze/asthma being predominant. The higher total IgE antibodies concentration is a good marker for sensitization in children with allergy-like symptoms.

Children with allergic diseases have an increased subsequent risk of migraine upon reaching school age

2018 ◽  
Vol 66 (7) ◽  
pp. 1064-1068 ◽  
Author(s):  
Chang-Ching Wei ◽  
Cheng-Li Lin ◽  
Te-Chun Shen ◽  
An-Chyi Chen
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Disease ◽  
Allergic Conjunctivitis ◽  
Cumulative Effect ◽  
Allergic Diseases ◽  
School Age ◽  
Increasing Trend ◽  
History Of ◽  
Subsequent Risk

The association between migraine and allergy has remained a subject of debate for more than a century. To systemically investigate the interaction between children with antecedent allergic diseases and their future risks of migraine on reaching school age, we recruited 16,130 children aged 7–18 with migraine diagnosed between 2000 and 2008, and 64,520 matched controls without a history of migraine. The ORs of migraine were calculated for the association with allergic diseases diagnosed before migraine diagnosis. The allergic diseases included atopic dermatitis, allergic conjunctivitis, allergic rhinitis (AR), and asthma. Children with preceding allergic diseases had a greater subsequent risk of migraine than the controls. Among the four evaluated diseases, AR had the highest adjusted OR (aOR) of 2.17 (95% CI 2.09 to 2.26). Children with all four allergic diseases had the highest aOR of 3.59 (95% CI 2.91 to 4.44). Further, an increasing trend of aORs was observed with more allergic disease-associated medical consulting. Our study indicates that children with allergic diseases are at increased subsequent risk of migraine when they reach school age, and the risk shows a cumulative effect of more allergic diseases and more allergy-related healthcare.

O Uso dos Probióticos nas Doenças Alérgicas: Revisão de Literatura/The Use of Probiotics on Allergic Diseases: Literature Review

1970 ◽  
Vol 4 (2) ◽  
pp. 108-119
Author(s):  
Isabela Maria Anselmo Ribeiro Simões ◽  
Helba Heliane Toledo ◽  
José Henrique Pereira Pinto
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Food Allergy ◽  
Literature Review ◽  
Scientific Community ◽  
Allergic Diseases ◽  
Progressive Increase ◽  
Atopic Diseases ◽  
Significant Clinical Improvement ◽  
Probiotic Strains

Nas últimas décadas, observou-se o aumento progressivo das doenças alérgicas e assim, novas alternativas preventivas e de tratamento têm sido buscadas. Neste âmbito, é notável o crescimento no número de pesquisas na comunidade científica destinadas a investigar se a suplementação com substancias probióticas seria capaz de reduzir a incidência e severidade das atopias clínicas, bem como seus possíveis efeitos como estratégia de tratamento. O artigo consistiu em uma revisão bibliográfica com o objetivo de analisar a eficácia dos probióticos nas atopias clínicas como asma, rinite alérgica, dermatite atópica e alergia alimentar, bem como seus efeitos. Apesar de relatos consistentes apontarem que cepas probióticas específicas quando usadas em  determinados casos produzem melhora clínica significante, ainda se faz de extrema importância novos estudos, visando verificar e esclarecer precisamente os demais efeitos produzidos, incluindo efeitos colaterais, determinação de uma dosagem adequada, bem como a população alvo.Palavras-chave: probióticos, alergia, hipersensibilidade. ABSTRACTIn the last decades, it was observed a progressive increase of allergic diseases and consequently researchers are looking for new preventive and alternative treatments. In this context it is remarkable the growth of researcher in the scientific community,aiming to investigate whether the supplementation with probiotics substances would be able to reduce the incidence and severity of clinical atopy and its effects as a treatment strategy. The study consisted of a literature review with the aim of evaluate the clinical efficacy of probiotics in atopic diseases such as asthma, allergic rhinitis, atopic dermatitis and food allergy as well as its effects.Despite consistent reports suggest that specific probiotic strains when used in certain cases produce significant clinical improvement, it is still extremely important to have new studies in order to verify and clarify precisely other effects, including side effects, the appropriate dosage as well as the target population.Keywords: probiotics, allergy, hypersensitivity.

scholarly journals Association between atopic disease and anemia in pediatrics: a cross-sectional study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Kiyon Rhew ◽  
Jung Mi Oh
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Logistic Regression ◽  
Pediatric Patients ◽  
Inflammatory Diseases ◽  
Atopic Disease ◽  
Cross Sectional Study ◽  
Atopic Diseases ◽  
Sectional Study ◽  
Cross Sectional

Abstract Background Atopic diseases, such as atopic dermatitis, allergic rhinitis, and asthma, are inflammatory diseases common in pediatric patients. This study investigated whether these inflammatory atopic diseases were associated with anemia in pediatrics. Methods A cross-sectional study was conducted using a pediatric dataset from the Health Insurance Review and Assessment Service (HIRA) of South Korea in 2016. Multivariable logistic regression, adjusting for demographic covariates was used for analyse the association between atopic disease and iron deficiency anemia (IDA). Results A total of 846,718 pediatric patients were included in the study. Of these, 19,594 (2.31%) had a diagnosis of IDA. The logistic regression analyses including covariates revealed there were association between atopic disease and IDA. The adjusted OR (aOR) of IDA was 1.42 (95% CI, 1.37–1.47) for atopic dermatitis, 1.25 (95% CI, 1.21–1.29) for allergic rhinitis, and 1.71 (95% CI, 1.65–1.76) for asthma. IDA was more prevalent in patients with multiple comorbid atopic diseases, with aOR of 1.30 (95% CI, 1.25–1.35), 1.81 (95% CI, 1.73–1.89), and 2.58 (95% CI, 2.43–2.73) for 1, 2, or 3 atopic diagnoses. There was no evidence of multicollinearity among covariates. Conclusions Our findings suggest that atopic disease was associated with IDA. Further study is needed to clarify the distinction between IDA and/or AI to better understand the cause of anemia in patients with inflammatory diseases.

scholarly journals Impact of Environmental Factors on the Prevalence Changes of Allergic Diseases in Elementary School Students in Ulsan, Korea: A Longitudinal Study

2020 ◽  
Vol 17 (23) ◽  
pp. 8831
Author(s):  
Jiho Lee ◽  
Seokhyun Yun ◽  
Inbo Oh ◽  
Min-ho Kim ◽  
Yangho Kim
Keyword(s):  
Physical Activity ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Elementary School Students ◽  
Allergic Conjunctivitis ◽  
Allergic Diseases ◽  
School Students ◽  
Weekly Physical Activity ◽  
Low Levels

We examined the effect of long-term changes in environmental factors on the prevalence of allergic diseases in elementary school students in Ulsan, Korea. This longitudinal study was conducted among 390 students who were enrolled from three elementary schools in Ulsan in both the first (2009–2010) and second survey (2013–2014). The International Study of Asthma and Allergies in Childhood questionnaire was used to determine the prevalence of allergic diseases and hazardous environmental factors. Generalized estimating equations (GEE) were used to investigate the impact of environmental factors on the change in the prevalence of allergic diseases. The survey revealed that an increased risk of allergic rhinitis was associated with exposure to secondhand smoke, the remodeling of a room, the replacement of wallpaper or flooring, the use of a humidifier, and irritation symptoms of air pollution. Atopic dermatitis was associated with the relocation to or repairs of a new house, and allergic conjunctivitis was associated with low levels of weekly physical activity, the use of insecticides, and irritation symptoms of air pollution. The results indicate that (1) allergic rhinitis and atopic dermatitis are associated with indoor pollution, (2) allergic conjunctivitis is associated with exposure to indoor chemical compounds and low levels of weekly physical activity. This study suggested that the proper evaluation and decrease in the number of environmental risk factors could effectively manage allergic diseases.

Atopie als Vorbote von Autoimmunerkrankungen - Nicht aus dem (zweiten) Blick verlieren

2018 ◽  
Vol 6 (2) ◽  
pp. 85-86
Author(s):  
David Brandt
Keyword(s):  
Allergic Rhinitis ◽  
Large Scale ◽  
Past History ◽  
Systemic Vasculitis ◽  
Allergic Diseases ◽  
Control Group ◽  
Atopic Diseases ◽  
Cross Sectional ◽  
Large Scale Study ◽  
History Of

Background: Kawasaki disease (KD) is an acute, systemic vasculitis in children, with an etiology that is not completely understood. It is assumed that the development of KD is mediated by an immunologic response. Several reports from East Asia have found a higher prevalence of atopic diseases among patients with KD, but a large-scale study of a non-Asian population regarding this correlation is still lacking. The purpose of this article was to achieve this goal. Methods: We conducted a cross-sectional, large-scale study to estimate the correlation of KD with allergic diseases. The medical history of 1,187,757 Israeli teenagers (aged 16-20 years during the years 1998-2013) was retrieved. The study population was divided into 3 groups according to a past history of noncomplicated and complicated KD and a control group. The prevalence of allergic diseases among these groups was further investigated. Results: The prevalence of atopic diseases in the 3 study groups was presented (asthma in 11.4, 8.1 and 3.5%, respectively; angioedema/urticaria in 7.1, 0 and 0.46%, respectively; allergic rhinitis in 20, 12.1 and 6.7%, respectively). In noncomplicated KD, a statistically significant link to asthma [odds ratio (OR) 2.4; p = 0.048] and a borderline significant link to allergic rhinitis (OR 1.9; p = 0.06) were found. In KD complicated with cardiac disease, statistically significant links were found for all the allergic conditions, asthma (OR 3.5; p = 0.003), allergic rhinitis (OR 3.5; p < 0.001) and angioedema/urticaria (OR 16.48; p < 0.001). Conclusion: KD is associated with allergic diseases. This association increases with the severity of the disease.

scholarly journals Prevalence and associated factors of allergic diseases in school children and adolescents aged 6-7 and 13-14 years old from two rural areas in Colombia

2021 ◽  
Vol 49 (3) ◽  
pp. 153-161
Author(s):  
Sergio Moreno-López ◽  
Lucia C. Pérez-Herrera ◽  
Daniel Peñaranda ◽  
Diana C. Hernández ◽  
Elizabeth García ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Latin American ◽  
Rural Areas ◽  
Associated Factors ◽  
Maternal Education ◽  
Pediatric Population ◽  
Allergic Diseases ◽  
Cross Sectional ◽  
School Aged Children

Introduction: The prevalence of allergic diseases is increasing worldwide, affecting about 30% of the population in low to middle-income countries. Research trends on allergic diseases within rural pediatric populations of Latin American countries is scarce. This study aimed to determine the prevalence of allergic diseases (allergic rhinitis, asthma, and atopic dermatitis) and their associated factors using the International Study of Asthma and Allergies in Childhood-III (ISAAC-III) questionnaire in school-aged children from two rural municipalities in Colombia.Materials and methods: This is a cross-sectional study. The ISAAC-III questionnaire was applied to school-aged children attending elementary schools in the municipalities of Soracá and Palmas del Socorro during 2018. The questionnaires were applied to adolescents aged 13–14 years and the parents of 6–7 years old children. Associations were estimated via bivariate and multivariate analysis. Results: Among 261 school-aged children (58.2% adolescents), the prevalence of allergic dis-eases was: allergic rhinitis 11.49% (95% CI: 8.05–15.78), asthma 8.81% (95% CI: 5.82–12.7), and atopic dermatitis 6.13% (95% CI: 3.69–9.53). Associated factors for allergic rhinitis included: female sex (PR: 2.68, 95% CI: 1.17–5.26), asthma (PR: 4.69, 95% CI: 1.96–8.31), atopic dermatitis (PR: 3.55, 95% CI: 1.09–7.83), and higher maternal education (PR: 4.16, 95% CI: 1.45–8.25).Conclusions: The prevalence of allergic diseases in this rural pediatric population was lower compared with that of the previous reports from urban populations. Associated factors found in this study support previous studies. Research addressing modifiable environmental associ-ations is so far scarce in Latin America; further studies are needed to reduce the burden of these diseases in rural populations.

scholarly journals Prevalence of bronchial asthma, allergic rhinitis, atopic dermatitis in children in Lesnoy area of Sverdlovsk region

2012 ◽  
Vol 9 (3) ◽  
pp. 14-17
Author(s):  
N A Volkova ◽  
E K Beltyukov
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Age Groups ◽  
International Study ◽  
Allergic Diseases ◽  
Preschool Age ◽  
Atopic Diseases ◽  
Younger Age ◽  
Further Development

A research of prevalence of allergic diseases in children from 0 to 6 years has been carried out using a standardized program «International Study of Asthma and Allergies in Childhood» (ISAAC) in town Lesnoy in 2010. Background. To define the prevalence and structure of atopic diseases in different age groups in children of preschool age in town Lesnoy. Methods. Standardized program «International Study of Asthma and Allergies in Childhood» (ISAAC). Results. Formation of atopic march is defined, in early age — atopic dermatitis and later respiratory form of allergy. Conclusion. Treatment of atopic dermatitis as risk factor of further development of allergic rhinitis and bronchial asthma can promote preventive maintenance of respiratory forms of allergy in children of younger age.

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