Prediction of diagnosis and treatment response in adolescents with depression using smartphone application and machine learning approaches: a pilot study (Preprint)

2020 ◽  
Author(s):  
Jae Sung Kim ◽  
Bohyun Wang ◽  
Meelim Kim ◽  
Jung Lee ◽  
Hyungjun Kim ◽  
...  
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Mobile Phone ◽  
Treatment Response ◽  
Antidepressant Treatment ◽  
Smartphone Application ◽  
Text Messages ◽  
Diagnosis And Treatment ◽  
Learning Approaches ◽  
Smart Healthcare

BACKGROUND Lack of quantifiable biomarkers is a major obstacle in making diagnosis and predicting treatment response in depression. In adolescents, increasing suicidality during antidepressant treatment further complicate the problems. Emerging healthcare systems based on digital technology are beginning to show promising results in dealing with mental health issues. OBJECTIVE Using Smart Healthcare System for Teens At Risk for Depression and Suicide (STAR-DS) smartphone application and machine learning, we sought to evaluate digital phenotypes which represent the diagnosis and treatment response of depression in adolescents. METHODS Our study included 24 adolescents (15.4±1.4 years, 17 girls) with major depressive disorder (MDD) diagnosed with K-SADS-PL and 10 healthy controls (13.8±0.6 years, 5 girls). Their depression status was evaluated using the Children’s Depression Rating Scale–Revised (CDRS-R) and CGI-S every week during the study period. After collecting the baseline data for 1 week, MDD adolescents were treated with escitalopram in an 8 week, open-label trial. Both MDD and control groups were monitored for another 4 weeks after the baseline week. We applied deep learning approach for the analysis of data. Deep Neural Network (DNN) was employed for classification and NEural network with Weighted Fuzzy Membership functions (NEWFM) for feature selection. We extracted features from directly collected data via the mobile phone (the number and total time of calls and text messages sent or received, mobile phone usage time, movement distance, amount of activity measured by gyroscope) on a daily basis. The distance from the mean value and standard deviation of each features per week were also extracted. RESULTS We could predict the diagnosis of depression with training accuracy of 96.3% and 3-fold validation accuracy of 77%. Of 24 depressed adolescents, 10 responded to antidepressant treatment. Including data on medications taken by the MDD group, we predicted the treatment response of depressed adolescents with training accuracy of 94.2% and 3-fold validation accuracy of 76%. CONCLUSIONS The STAR-DS smartphone application demonstrated preliminary evidence of predicting diagnosis and treatment response in depressed adolescents. This is the first study to predict treatment response of MDD in adolescents, examining smartphone based objective data with machine learning approaches.

scholarly journals Detection of Malicious Software by Analyzing Distinct Artifacts Using Machine Learning and Deep Learning Algorithms

Electronics ◽  
2021 ◽  
Vol 10 (14) ◽  
pp. 1694
Author(s):  
Mathew Ashik ◽  
A. Jyothish ◽  
S. Anandaram ◽  
P. Vinod ◽  
Francesco Mercaldo ◽  
...  
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Deep Learning ◽  
Support Vector ◽  
Malware Analysis ◽  
Learning Approaches ◽  
Dynamic Features ◽  
System Calls ◽  
Prevention Methods ◽  
Structural Aspects

Malware is one of the most significant threats in today’s computing world since the number of websites distributing malware is increasing at a rapid rate. Malware analysis and prevention methods are increasingly becoming necessary for computer systems connected to the Internet. This software exploits the system’s vulnerabilities to steal valuable information without the user’s knowledge, and stealthily send it to remote servers controlled by attackers. Traditionally, anti-malware products use signatures for detecting known malware. However, the signature-based method does not scale in detecting obfuscated and packed malware. Considering that the cause of a problem is often best understood by studying the structural aspects of a program like the mnemonics, instruction opcode, API Call, etc. In this paper, we investigate the relevance of the features of unpacked malicious and benign executables like mnemonics, instruction opcodes, and API to identify a feature that classifies the executable. Prominent features are extracted using Minimum Redundancy and Maximum Relevance (mRMR) and Analysis of Variance (ANOVA). Experiments were conducted on four datasets using machine learning and deep learning approaches such as Support Vector Machine (SVM), Naïve Bayes, J48, Random Forest (RF), and XGBoost. In addition, we also evaluate the performance of the collection of deep neural networks like Deep Dense network, One-Dimensional Convolutional Neural Network (1D-CNN), and CNN-LSTM in classifying unknown samples, and we observed promising results using APIs and system calls. On combining APIs/system calls with static features, a marginal performance improvement was attained comparing models trained only on dynamic features. Moreover, to improve accuracy, we implemented our solution using distinct deep learning methods and demonstrated a fine-tuned deep neural network that resulted in an F1-score of 99.1% and 98.48% on Dataset-2 and Dataset-3, respectively.

scholarly journals Analysis of the Nosema Cells Identification for Microscopic Images

Sensors ◽  
2021 ◽  
Vol 21 (9) ◽  
pp. 3068
Author(s):  
Soumaya Dghim ◽  
Carlos M. Travieso-González ◽  
Radim Burget
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Image Processing ◽  
Deep Learning ◽  
The Other ◽  
Support Vector ◽  
Learning Approaches ◽  
Microscopic Images ◽  
Trained Neural Network ◽  
Nosema Disease

The use of image processing tools, machine learning, and deep learning approaches has become very useful and robust in recent years. This paper introduces the detection of the Nosema disease, which is considered to be one of the most economically significant diseases today. This work shows a solution for recognizing and identifying Nosema cells between the other existing objects in the microscopic image. Two main strategies are examined. The first strategy uses image processing tools to extract the most valuable information and features from the dataset of microscopic images. Then, machine learning methods are applied, such as a neural network (ANN) and support vector machine (SVM) for detecting and classifying the Nosema disease cells. The second strategy explores deep learning and transfers learning. Several approaches were examined, including a convolutional neural network (CNN) classifier and several methods of transfer learning (AlexNet, VGG-16 and VGG-19), which were fine-tuned and applied to the object sub-images in order to identify the Nosema images from the other object images. The best accuracy was reached by the VGG-16 pre-trained neural network with 96.25%.

scholarly journals Comparison between Deep Learning and Tree-Based Machine Learning Approaches for Landslide Susceptibility Mapping

Water ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 2664
Author(s):  
Sunil Saha ◽  
Jagabandhu Roy ◽  
Tusar Kanti Hembram ◽  
Biswajeet Pradhan ◽  
Abhirup Dikshit ◽  
...  
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Deep Learning ◽  
Landslide Susceptibility ◽  
Learning Model ◽  
Susceptibility Mapping ◽  
Landslide Susceptibility Mapping ◽  
Learning Approaches ◽  
Statistical Measures ◽  
Deep Learning Model

The efficiency of deep learning and tree-based machine learning approaches has gained immense popularity in various fields. One deep learning model viz. convolution neural network (CNN), artificial neural network (ANN) and four tree-based machine learning models, namely, alternative decision tree (ADTree), classification and regression tree (CART), functional tree and logistic model tree (LMT), were used for landslide susceptibility mapping in the East Sikkim Himalaya region of India, and the results were compared. Landslide areas were delimited and mapped as landslide inventory (LIM) after gathering information from historical records and periodic field investigations. In LIM, 91 landslides were plotted and classified into training (64 landslides) and testing (27 landslides) subsets randomly to train and validate the models. A total of 21 landslide conditioning factors (LCFs) were considered as model inputs, and the results of each model were categorised under five susceptibility classes. The receiver operating characteristics curve and 21 statistical measures were used to evaluate and prioritise the models. The CNN deep learning model achieved the priority rank 1 with area under the curve of 0.918 and 0.933 by using the training and testing data, quantifying 23.02% and 14.40% area as very high and highly susceptible followed by ANN, ADtree, CART, FTree and LMT models. This research might be useful in landslide studies, especially in locations with comparable geophysical and climatological characteristics, to aid in decision making for land use planning.

Tagging terms in text

Terminology ◽  
2022 ◽  
Author(s):  
Ayla Rigouts Terryn ◽  
Véronique Hoste ◽  
Els Lefever
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Language Processing ◽  
Conditional Random Fields ◽  
Traditional Approach ◽  
Learning Approaches ◽  
Term Extraction ◽  
The Neural Network ◽  
Predicted Probability ◽  
Automatic Term Extraction

Abstract As with many tasks in natural language processing, automatic term extraction (ATE) is increasingly approached as a machine learning problem. So far, most machine learning approaches to ATE broadly follow the traditional hybrid methodology, by first extracting a list of unique candidate terms, and classifying these candidates based on the predicted probability that they are valid terms. However, with the rise of neural networks and word embeddings, the next development in ATE might be towards sequential approaches, i.e., classifying each occurrence of each token within its original context. To test the validity of such approaches for ATE, two sequential methodologies were developed, evaluated, and compared: one feature-based conditional random fields classifier and one embedding-based recurrent neural network. An additional comparison was added with a machine learning interpretation of the traditional approach. All systems were trained and evaluated on identical data in multiple languages and domains to identify their respective strengths and weaknesses. The sequential methodologies were proven to be valid approaches to ATE, and the neural network even outperformed the more traditional approach. Interestingly, a combination of multiple approaches can outperform all of them separately, showing new ways to push the state-of-the-art in ATE.

scholarly journals A Machine Learning View on Momentum and Reversal Trading

Algorithms ◽  
2018 ◽  
Vol 11 (11) ◽  
pp. 170 ◽  
Author(s):  
Zhixi Li ◽  
Vincent Tam
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Stock Market ◽  
Short Term Memory ◽  
Predictive Ability ◽  
Trading Strategies ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Learning Approaches ◽  
Learning Techniques

Momentum and reversal effects are important phenomena in stock markets. In academia, relevant studies have been conducted for years. Researchers have attempted to analyze these phenomena using statistical methods and to give some plausible explanations. However, those explanations are sometimes unconvincing. Furthermore, it is very difficult to transfer the findings of these studies to real-world investment trading strategies due to the lack of predictive ability. This paper represents the first attempt to adopt machine learning techniques for investigating the momentum and reversal effects occurring in any stock market. In the study, various machine learning techniques, including the Decision Tree (DT), Support Vector Machine (SVM), Multilayer Perceptron Neural Network (MLP), and Long Short-Term Memory Neural Network (LSTM) were explored and compared carefully. Several models built on these machine learning approaches were used to predict the momentum or reversal effect on the stock market of mainland China, thus allowing investors to build corresponding trading strategies. The experimental results demonstrated that these machine learning approaches, especially the SVM, are beneficial for capturing the relevant momentum and reversal effects, and possibly building profitable trading strategies. Moreover, we propose the corresponding trading strategies in terms of market states to acquire the best investment returns.

scholarly journals From Characters to Time Intervals: New Paradigms for Evaluation and Neural Parsing of Time Normalizations

2018 ◽  
Vol 6 ◽  
pp. 343-356 ◽  
Author(s):  
Egoitz Laparra ◽  
Dongfang Xu ◽  
Steven Bethard
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Comparative Analysis ◽  
State Of The Art ◽  
Learning Approaches ◽  
Semantic Parsing ◽  
Time Intervals ◽  
Semantic Composition ◽  
Previous State ◽  
New Scoring

This paper presents the first model for time normalization trained on the SCATE corpus. In the SCATE schema, time expressions are annotated as a semantic composition of time entities. This novel schema favors machine learning approaches, as it can be viewed as a semantic parsing task. In this work, we propose a character level multi-output neural network that outperforms previous state-of-the-art built on the TimeML schema. To compare predictions of systems that follow both SCATE and TimeML, we present a new scoring metric for time intervals. We also apply this new metric to carry out a comparative analysis of the annotations of both schemes in the same corpus.

Brain Signal Classification Based on Deep CNN

2020 ◽  
Vol 12 (2) ◽  
pp. 17-29
Author(s):  
Terry Gao ◽  
Grace Ying Wang
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Mental Status ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Imaging Features ◽  
Learning Approaches ◽  
Computationally Efficient ◽  
Set Up ◽  
Brain Data

It is essential to increase the accuracy and robustness of classification of brain data, including EEG, in order to facilitate a direct communication between the human brain and computerized devices. Different machine learning approaches, such as support vector machine (SVM), neural network, and linear discrimination analysis (LDA), have been applied to set up automatic subjective-classifier, and the findings for their capacities in this regard have been inconclusive. The present study developed an effective classifier for human mental status using deep learning in a convolutional neural network. In contrast to most previous studies commonly using EEG waveform or numeric value of brain signals for classification, the authors utilised imaging features generated from EEG data at alpha frequency band. A new model proposed in this study provides a simple and computationally efficient approach to distinguish mental status during resting. With training, this model could predict new 2D EEG images with above 90% accuracy, while traditional machine learning techniques failed to achieve this accuracy.

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