Systematic review and meta-analysis of surgery for hilar cholangiocarcinoma with arterial resection (Preprint)
BACKGROUND With the advances in multimodality treatment in the recent years, an analysis of the outcome of vascular resections in surgery of hilar cholangiocarcinoma is lacking. OBJECTIVE The aim of this meta-analysis is to summarize the currently available evidence on outcomes of patients undergoing arterial resection for the treatment of hilar cholangiocarcinoma. METHODS A systematic literature search in the databases PubMed/Medline, Cochrane Library, Cinahl and the trial registries ClinicalTrials.gov and WHO ICTRP will be carried out. RESULTS Pre-defined outcomes are mortality (100-day and in-hospital), morbidity (Clavien-Dindo classification, any type of complication), vascular complications (thrombosis or stenosis of the portal vein or hepatic artery, pseudoaneurysms), liver failure, postoperative bleeding, duration of surgery, reoperation rate, length of hospital stay, survival time, actuarial survival (2-, 3- and 5-year survival), complete/incomplete resection rates, histologic arterial invasion and lymph node positivity (number of positive lymph nodes and lymph node ratio). CONCLUSIONS Our findings will enable us to present the current evidence on feasibility, safety and oncological effectiveness of surgery for hilar cholangiocarcinoma with arterial resection. These data will support healthcare professionals in their clinical decision-making. CLINICALTRIAL PROSPERO ID 223396