scholarly journals Correction of iron deficiency in the clinical picture of internal medicine

2021 ◽  
Vol 17 (3) ◽  
pp. 64-70
Author(s):  
Z.P. Mandziy ◽  
O.H. Boichuk ◽  
V.V. Myhovych
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Malignant Tumors ◽  
Clinical Manifestations ◽  
The Body ◽  
Comprehensive Approach ◽  
Deficiency Anemia ◽  
Peptic Ulcers ◽  
Liposomal Form ◽  
Systematic Analysis

Background. The purpose was to theoretically and practically substantiate the existing approaches to the problem of prevalence, causes, clinical manifestations, as well as diagnosis and use of the latest methods of treatment of iron deficiency anemia (IDA) based on studying scientific ideas. Materials and methods. We used systematic analysis, synthesis, and generalization of scientific and medical literature to make it possible to consider modern views on the problem of IDA among different populations in terms of its epidemiology, etiology, presentation of iron metabolism in the body, and pathogenetic mechanisms of clinical and laboratory symptoms as well as modern methods of laboratory diagnosis of anemia and conclusions on a comprehensive approach to the treatment and prevention. Results. The most common blood disease is iron deficiency anemia. Iron deficiency occurs as a result of a mismatch between the body’s needs for iron and its intake or loss. According to the WHO, more than half of the population in different countries suffers from iron deficiency anemia. It covers all age groups but is most common in children, adolescents, and pregnant women. The symptoms of anemia are pale skin, fatigue, dizziness, shortness of breath, loss of consciousness, dysfunction of many organs. The most common causes of iron deficiency anemia are bleeding from wounds or peptic ulcers, hemorrhoidal bleeding, excessive blood loss during menstruation, uterine fibroids, ulcerative colitis, malignant tumors, gastrectomy, and others. In this disease, the iron depot in the body decreases. According to data from domestic and foreign scientists, as well as the WHO, IDA of varying severity is observed in 20 % of the population. The treatment of IDA should first eliminate the cause of bleeding, prescribe a protein-enriched diet, vitamins, and trace elements. In many countries, the prevention and treatment of anemia are becoming a social challenge. The presence of iron deficiency reduces the quality of life of patients, disrupts their ability to work, causes functional disorders of many organs and systems. To prevent and eliminate iron deficiency, a whole group of iron-containing drugs is successfully used, the range of which is constantly replenishing and updating, as well as a comprehensive approach to treatment with modern iron drugs is discussing. Conclusions. The main pathological and physiological conditions that lead to the development of iron deficiency in different population groups are analyzed. Therefore, the treatment of IDA is aimed not only at eliminating anemia as a symptom, but also at eliminating iron deficiency and replenishing its reserves in the body, which can be achieved by taking a liposomal form of iron.

scholarly journals A systematic analysis of global anemia burden from 1990 to 2010

Blood ◽  
2014 ◽  
Vol 123 (5) ◽  
pp. 615-624 ◽  
Author(s):  
Nicholas J. Kassebaum ◽  
Rashmi Jasrasaria ◽  
Mohsen Naghavi ◽  
Sarah K. Wulf ◽  
Nicole Johns ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Systematic Analysis ◽  
Key Points ◽  
Common Etiology ◽  
Age And Sex

Key Points Anemia accounted for 8.8% of the total disability from all conditions in 2010. Children <5 years and women still have the highest burden. Although iron-deficiency anemia is the most common etiology globally, other leading causes of anemia vary widely by geography, age, and sex.

Iron Homeostasis and Disorders in Dogs and Cats: A Review

2011 ◽  
Vol 47 (3) ◽  
pp. 151-160 ◽  
Author(s):  
Jennifer L. McCown ◽  
Andrew J. Specht
Keyword(s):  
Iron Deficiency ◽  
Iron Overload ◽  
Iron Homeostasis ◽  
Diagnostic Testing ◽  
Clinical Manifestations ◽  
Essential Element ◽  
The Body ◽  
Deficiency Anemia ◽  
Enzyme Systems ◽  
Living Organisms

Iron is an essential element for nearly all living organisms and disruption of iron homeostasis can lead to a number of clinical manifestations. Iron is used in the formation of both hemoglobin and myoglobin, as well as numerous enzyme systems of the body. Disorders of iron in the body include iron deficiency anemia, anemia of inflammatory disease, and iron overload. This article reviews normal iron metabolism, disease syndromes of iron imbalance, diagnostic testing, and treatment of either iron deficiency or excess. Recent advances in diagnosing iron deficiency using reticulocyte indices are reviewed.

scholarly journals Kandidias Oral pada Penderita Anemia Defisiensi Besi (Fe) dan Penetalaksanaannya

2012 ◽  
Vol 19 (1) ◽  
pp. 77
Author(s):  
Sri Budiarti Wongsohardjono
Keyword(s):  
Body Weight ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Oral Candidiasis ◽  
Dorsal Surface ◽  
Body Weight Loss ◽  
Microcytic Anemia ◽  
The Body ◽  
Deficiency Anemia ◽  
Normal Limits

Background: Iron deficiency anemia is a microcytic anemia caused by chronic blood loss dueto such problems as excessive menstrual flow, gastrointestinal bleeding, gasterektomi or malabsorption that reduces the absorption of Fe. Predisposing factors that lead to the disruption of the ecology of oral candidiasis or oral microbiological changes can be due to malnutrition (iron deficiency, folic acid, vitamin B12) and the very old age. Objective: To report a case of iron deficiency anemia with oral candidiasis and its management. Case Report: A 69-year man in the reference by peer demonstrated swollen gums, mouth pain and difficulty in swallowing. A moth ago he was hospitalized and boarded for a week but no change, his body weight loss was 25kg. paleconjunctiva and face, droliing, looked weak. The body temperature was 370 C; the BP measurement was: 125/80mmHg; with body weight was 50kg; right and left submandibular  lymph nodes become enlarging and soreness palpatiom. Symmetrical face. Right and left lip corners are angular kheilitis, cheek mucosa, palate hyperemia, gingival stipling was disappeared, hyperemia, dorsal surface smooth tongue, hyperemia, depapilasi, OHI: bad; thick saliva, hypersalivation. A lot of dental caries and the remaining roots. Management: Examination of the saliva with KOH solution looked a hyphe. Routine blood tests and profile of fe all within normal limits except RBC was 3,37.106 / uL; HGB: 11.0 g / dl; HCT: 32.2%, Fe 29.00 u g / dl (below normal). Treatment with 3% perhidrol mouthwash, Nyistatin solution 3 x daily. Zegase tablet 2x daily. Paracetamol tablets if necessary. Conclusion sixteen days later the patient recovered.

THEORETICAL ASPECTS OF TREATMENT OF IRON DEFICIENCY ANEMIA IN CHILDREN (review)

2021 ◽  
pp. 32-39
Author(s):  
Н.А. САДИЕВА ◽  
А.Э. МАМЕДОВА
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
The Body ◽  
Deficiency Anemia ◽  
Treatment Protocols

В публикации авторы представили теоретический обзор распространения анемии у детей во всем мире, в том числе и в Азербайджане, роли железа в организме, причинах возникновения железодефицитной анемии и его классификации, особенностях проведения ферротерапии у детей, классификации железосодержащих средств применяемых в Азербайджане, протоколах лечения ЖДА у детей во всем мире, в том числе и в Азербайджане. In the publication the authors presented a theoretical review of the spread of anemia in children worldwide, including Azerbaijan, the role of iron in the body, the causes of iron deficiency anemia and its classification, the peculiarities of ferrotherapy in children, the classification of iron-containing agents used in Azerbaijan, the treatment protocols for iron deficiency in children worldwide, including in Azerbaijan.

Iron Deficiency Anemia in Cancer Patients

2012 ◽  
Vol 08 (02) ◽  
pp. 74
Author(s):  
Mark Janis ◽  
Keyword(s):  
Iron Deficiency ◽  
Cancer Patients ◽  
Iron Deficiency Anemia ◽  
Iron Transport ◽  
The Body ◽  
Deficiency Anemia ◽  
Functional Iron Deficiency ◽  
Iron Stores ◽  
Iv Iron ◽  
Absolute Iron Deficiency

Anemia is highly prevalent, affecting approximately 40 % of cancer patients, and results in a significant decrease in health-related quality of life while also being associated with shorter cancer survival times. A recent survey of 15,000 cancer patients in Europe found that 39 % were anemic at the time of enrolment. In addition, anemia is a recognized complication of myelosuppressive chemotherapy, and it has been estimated that, in the US, around 1.3 million cancer patients who are not anemic at the time of diagnosis will develop anemia during the course of their disease. The etiology of anemia in cancer patients is variable and often multifactorial, and may be the result of an absolute or a functional iron deficiency. Cancer produces an enhanced inflammatory state within the body—causing hepcidin levels to increase and erythropoietin production to decrease—and results in a reduction in erythropoiesis due to impaired iron transport. This type of anemia is known as functional iron deficiency, where the body has adequate iron stores but there are problems with mobilization and transport of the iron. Absolute iron deficiency is when both iron stores and iron transport are low. The National Comprehensive Cancer Network (NCCN) treatment guidelines for cancer-related anemia recommend intravenous (IV) iron products alone for iron repletion in cancer patients with absolute iron deficiency, and erythropoiesis-stimulating agents (ESAs) in combination with IV iron in cancer patients (currently undergoing palliative chemotherapy) with functional iron deficiency. Although IV iron has been demonstrated to enhance the hematopoietic response to ESA therapy, the use of supplemental iron has not yet been optimized in oncology. Here we discuss the significance of iron deficiency anemia in cancer patients and the need to implement tools to properly diagnose this condition, and we provide an overview of the management strategies and recommendations for patients with iron deficiency anemia as outlined in the NCCN guidelines.

Macrophage Iron, Hepcidin, and Atherosclerotic Plaque Stability

2007 ◽  
Vol 232 (8) ◽  
pp. 1014-1020 ◽  
Author(s):  
Jerome l. Sullivan
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Atherosclerotic Plaque ◽  
Animal Studies ◽  
Iron Concentration ◽  
Normal Subjects ◽  
Lesion Size ◽  
The Body ◽  
Deficiency Anemia ◽  
Iron Depletion

Hepcidin has emerged as the key hormone in the regulation of iron balance and recycling. Elevated levels increase iron in macrophages and inhibit gastrointestinal iron uptake. The physiology of hepcidin suggests an additional mechanism by which iron depletion could protect against atherosclerotic lesion progression. Without hepcidin, macrophages retain less iron. Very low hepcidin levels occur in iron deficiency anemia and also in homozygous hemochromatosis. There is defective retention of iron in macrophages in hemochromatosis and also evidently no increase in atherosclerosis in this disorder. In normal subjects with intact hepcidin responses, atherosclerotic plaque has been reported to have roughly an order of magnitude higher iron concentration than that in healthy arterial wall. Hepcidin may promote plaque destabilization by preventing iron mobilization from macrophages within atherosclerotic lesions; the absence of this mobilization may result in increased cellular iron loads, lipid peroxidation, and progression to foam cells. Marked downregulation of hepcidin (e.g., by induction of iron deficiency anemia) could accelerate iron loss from intralesional macrophages. It is proposed that the minimally proatherogenic level of hepcidin is near the low levels associated with iron deficiency anemia or homozygous hemochromatosis. Induced iron deficiency anemia intensely mobilizes macrophage iron throughout the body to support erythropoiesis. Macrophage iron in the interior of atherosclerotic plaques is not exempt from this process. Decreases in both intralesional iron and lesion size by systemic iron reduction have been shown in animal studies. It remains to be confirmed in humans that a period of systemic iron depletion can decrease lesion size and increase lesion stability as demonstrated in animal studies. The proposed effects of hepcidin and iron in plaque progression offer an explanation of the paradox of no increase in atherosclerosis in patients with hemochromatosis despite a key role of iron in atherogenesis in normal subjects.

Determinants of Iron Deficiency Anemia Among Pregnant Females Visiting Tertiary Care Hospitals, Lahore

2021 ◽  
Author(s):  
Anam Junaid ◽  
Iqra Masood ◽  
Ms Khansa ◽  
Shahnai Basharat ◽  
Morad Yaser Al Mostafa
Keyword(s):  
Socioeconomic Status ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Low Socioeconomic Status ◽  
Tertiary Care ◽  
Red Meat ◽  
The Body ◽  
Deficiency Anemia ◽  
Low Socioeconomic ◽  
Tertiary Care Hospitals

Iron deficiency anemia refers to the anemia caused by insufficient iron stores within the body. The main cause of anemia in obstetrics is iron deficiency, which has a worldwide prevalence estimated between 20%–80% and constitutes mainly female population.  Objective: To find out the determinants of iron deficiency anemia amongst pregnant women visiting Tertiary Care Hospitals, Lahore. Methods: A cross-sectional study was conducted at Sir Ganga Ram Hospital, Lahore. A sample of 245 pregnant female patients was selected through non-probability convenient sampling technique. Data were collected with the pre-tested questionnaires. SPSS version 21.0 was used for data analysis. Results: Amongst social determinants, socioeconomic status had a signifcant effect on iron defciency anemia; as 82% women belonged to low socioeconomic status. Among dietary determinants, less consumption of red meat was a major factor affecting IDA as 95% women were not consuming red meat more than two times a day thus contributing to overall iron defciency. Amongst clinical factors, lack of thorough clinical checkup before conception was a major factor as 79% women did not have regular clinical checkup before pregnancy. Conclusions: Major determinants linked with IDA were dietary habits and practices such as preferring vegetables over meat, less overall consumption of red meat and excessive consumption of tea and coffee. Other determinants affecting IDA include low socioeconomic status, little or no gap between pregnancies and lack of knowledge and education concerning dietary practices during pregnancy.   

scholarly journals ANALYSIS OF ST SEGMENT CHANGES IN PATIENTS OF SEVERE IRON DEFICIENCY ANEMIA BELONGING TO SOUTH REGION OF BIHAR STATE: A CROSS SECTIONAL STUDY

2021 ◽  
pp. 1-3
Author(s):  
Rajni Kant ◽  
Deepmala Sinha ◽  
Shishir Kumar Mahto
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Cardiovascular Health ◽  
The Body ◽  
Deficiency Anemia ◽  
Cross Sectional ◽  
Functional Changes ◽  
Body Tissues ◽  
St Segment ◽  
Bihar State

Anemia is one of the commonest blood disorders with a significant degree of morbidity and mortality. It has multi factorial etiology with iron deficiency being the most common cause contributing around 50% of the World’s total anemia burden. Prevalence is significantly high in people of low socio economic groups with preponderance in female gender. Irrespective of the causes, iron deficiency anemia results into low hemoglobin in the blood which ultimately decreases oxygen delivery to the body tissues. This adversely affects the cardiovascular hemodynamics putting extra workload on heart. If anemia persists for longer duration, various structural and functional changes take place in the heart. These changes are thereby depicted in Electrocardiographic (ECG) recordings. Studies have shown that including many changes in ECG recordings of patients with iron deficiency anemia, ST segment changes in the form of ST segment depression are important findings. As the people belonging to south region of Bihar state come from low socioeconomic group and are at nutritionally deprived condition, they are very much vulnerable to suffer from iron deficiency anemia. The present study was aimed to observe ST segment changes in patients of severe iron deficiency anemia from this region. 160 subjects were included in our study satisfying the inclusion criteria, out of which 150 subjects finally completed the study (65 males and 85 females). A total of 70 patients (46.67%) were having Hb concentration levels less than 8.0 g/dl and they fell in the severe or very severe grade of anemia. We found in our study that 38 subjects i.e. 25.33% (n = 150) had ST segment depression as one of the various ECG changes. We also observed that these changes were directly correlated with the severity of iron deficiency anemia. We concluded from our study that cardiac ischemia was resulted in the patients of iron deficiency anemia which was ascribed in the form of ST segment depression in ECG recordings. Specific and emergent measures must be taken to deal with iron deficiency anemia in order to mitigate its deleterious effects on cardiovascular health.

scholarly journals Serum Concentration of Hepcidin as an Indicator of Iron Reserves in Children

2018 ◽  
Vol 37 (4) ◽  
pp. 456-464 ◽  
Author(s):  
Jelena Ćulafić ◽  
Jovanka Kolarović ◽  
Lato Pezo ◽  
Velibor Čabarkapa ◽  
Stanislava Nikolić ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Concentration ◽  
Iron Deficiency Anemia ◽  
Iron Metabolism ◽  
Transferrin Saturation ◽  
The Body ◽  
Deficiency Anemia ◽  
Control Group ◽  
Hepcidin Level ◽  
Serum Hepcidin

SummaryBackground:Anemia represents a significant cause of maternal and perinatal mortality, as well as child mortality. The aim of the research was to determine the serum concentration of hepcidin in children aged 6 months to 2 years and adolescents aged 11 to 19 years which suffer from iron deficiency anemia and compare it with the serum concentration of hepcidin in the control groups, as well as to determine its connection with the parameters of the iron metabolism.Methods:The research included 173 examinees, 89 of them suffered from iron deficiency anemia and 84 did not suffer from iron deficiency anemia (the latter represented the control group). Blood samples were collected from all study participants. The samples were analyzed for complete blood count and parameters of iron metabolism. ELISA method was used for establishing serum hepcidin levels.Results:The research showed that the concentration of hepcidin is statistically lower in children (4.4 ng/mL) and adolescents (4.1 ng/mL) who suffer from iron deficiency anemia in comparison with the control group (14 ng/mL, 10 ng/mL, respectively). The positive correlation between serum hepcidin level and iron in the serum, ferritin, the mean corpuscular volume and transferrin saturation was confirmed, but the negative one occurred in serum hepcidin level, transferrin and reticulocytes.Conclusions:The age of the examinees does not influence the level of serum hepcidin which makes it a more sensitive indicator of the level of iron in the body. Besides this, serum hepcidin is a reliable biological marker for the assessment of iron deficiency anemia.

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