scholarly journals Nephrotoxicity and Chinese Herbal Medicine

2018 ◽  
Vol 13 (10) ◽  
pp. 1605-1611 ◽  
Author(s):  
Bo Yang ◽  
Yun Xie ◽  
Maojuan Guo ◽  
Mitchell H. Rosner ◽  
Hongtao Yang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Aristolochic Acid ◽  
Herbal Medicines ◽  
Kidney Injury ◽  
Medicine Use ◽  
Chinese Herbal ◽  
Aristolochic Acids ◽  
Increase Risk ◽  
Plant Alkaloids

Chinese herbal medicine has been practiced for the prevention, treatment, and cure of diseases for thousands of years. Herbal medicine involves the use of natural compounds, which have relatively complex active ingredients with varying degrees of side effects. Some of these herbal medicines are known to cause nephrotoxicity, which can be overlooked by physicians and patients due to the belief that herbal medications are innocuous. Some of the nephrotoxic components from herbs are aristolochic acids and other plant alkaloids. In addition, anthraquinones, flavonoids, and glycosides from herbs also are known to cause kidney toxicity. The kidney manifestations of nephrotoxicity associated with herbal medicine include acute kidney injury, CKD, nephrolithiasis, rhabdomyolysis, Fanconi syndrome, and urothelial carcinoma. Several factors contribute to the nephrotoxicity of herbal medicines, including the intrinsic toxicity of herbs, incorrect processing or storage, adulteration, contamination by heavy metals, incorrect dosing, and interactions between herbal medicines and medications. The exact incidence of kidney injury due to nephrotoxic herbal medicine is not known. However, clinicians should consider herbal medicine use in patients with unexplained AKI or progressive CKD. In addition, exposure to herbal medicine containing aristolochic acid may increase risk for future uroepithelial cancers, and patients require appropriate postexposure screening.

scholarly journals A proposed protocol based on integrative metabonomics analysis for the rapid detection and mechanistic understanding of sulfur fumigation of Chinese herbal medicines

RSC Advances ◽  
2019 ◽  
Vol 9 (53) ◽  
pp. 31150-31161 ◽  
Author(s):  
Dai Shengyun ◽  
Wang Yuqi ◽  
Wang Fei ◽  
Mei Xiaodan ◽  
Zhang Jiayu
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Rapid Detection ◽  
Herbal Medicines ◽  
Lonicera Japonica ◽  
Current Work ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Mechanistic Understanding

In the current work, Lonicera japonica Flos (FLJ) was selected as a model Chinese herbal medicine (CHM) and a protocol was proposed for the rapid detection of sulfur-fumigated (SF) CHMs.

scholarly journals Chinese herbal medicine use in Taiwan during pregnancy and the postpartum period: A population-based cohort study

2009 ◽  
Vol 46 (6) ◽  
pp. 787-795 ◽  
Author(s):  
Chao-Hua Chuang ◽  
Pei-Jen Chang ◽  
Wu-Shiun Hsieh ◽  
Yih-Jian Tsai ◽  
Shio-Jean Lin ◽  
...  
Keyword(s):  
Cohort Study ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Postpartum Period ◽  
Population Based ◽  
Medicine Use ◽  
Chinese Herbal

scholarly journals Effect of Traditional Chinese Herbal Medicine with Antiquorum Sensing Activity onPseudomonas aeruginosa

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Weihua Chu ◽  
Shuxin Zhou ◽  
Yan Jiang ◽  
Wei Zhu ◽  
Xiyi Zhuang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Cell Communication ◽  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Traditional Chinese Herbal Medicines

Traditional Chinese herbal medicines (TCHMs) were tested for their ability of antiquorum sensing. Water extracts ofRhubarb, Fructus gardeniae, and Andrographis paniculatashow antiquorumsensing activity when usingChromobacterium violaceumCV12472 as reporter; the sub-MIC concentrations of these TCHMs were tested against AHL-dependent phenotypic expressions of PAO1. Results showed significant reduction in pyocyanin pigment, protease, elastase production, and biofilm formation in PAO1 without inhibiting the bacterial growth, revealing that the QSI by the extracts is not related to static or killing effects on the bacteria. The results indicate a potential modulation of bacterial cell-cell communication,P. aeruginosabiofilm, and virulence factors by traditional Chinese herbal medicine. This study introduces not only a new mode of action for traditional Chinese herbal medicines, but also a potential new therapeutic direction for the treatment of bacterial infections, which have QSI activity and might be important in reducing virulence and pathogenicity of pathogenic bacteria.

scholarly journals Diagnosis and Management of Infected or Suspected Patients with Covid-19 a Study of 48 Cases in the UK

2022 ◽  
Vol 5 (1) ◽  
pp. 01-06
Author(s):  
Dan Jiang
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Herbal Medicines ◽  
Treatment Method ◽  
Individual Case ◽  
The Body ◽  
Critical Stage ◽  
Significant Information ◽  
Positive Effects ◽  
Chinese Herbal

Covid-19 is a pandemic infective disease, which has been erupting throughout the whole world from 2020 to 2021. There have been at the time of reviewing more than a hundred million cases (102,399,513) of infection, and more than 2 million deaths (2,217,005) in more than 200 countries; this information is taken from the Covid-19 daily situation report issued on 1st Feb 2021 by WHO. The pandemic was also declared as an outbreak of Public Health Emergency of International Concern on 30th Jan 2020 by WHO. No effective treatment model has yet been confirmed by conventional western medicine, but some herbal treatments used in China can be recognized as having positive results in Covid-19 cases. This pandemic disaster has been severely damaging to quality of life, disturbing social communication, economic development and the progress of humanity. Successful results were first reported from temporary hospitals (Fangcang Hospitals set up in arenas and exhibition spaces) in Wuhan, China, where more than 90% of patients treated with Chinese herbal medicine were prevented by transferring from the minor or milder stages of the disease to the severe or critical stage. In all of them the positive PCR became negative; herbs were involved in the rescue and treatment of severe and critical cases in ICU’s in hospitals as well. It was an important factor in how Covid-19 was controlled so quickly in China. The author recruited both confirmed and suspected Covid-19 patients through social media (WeChat, WhatsApp, Internet, message etc.) as a volunteer TCM consultant from March 2020, during the first Lockdown phase in UK. It was quickly realized that the appearance of the tongue provides special and significant information for identifying whether Covid-19 is present and shows its severity, from a TCM perspective, as the degree and type of dampness accumulated within the body. Herbal prescriptions were sent by post for patients’ treatment according to their clinical findings, virus exposure history and tongue information (from photos). Similar positive effects were found as in China, and treatment reports and results are summarized here. The author believes there are many herbal medicines that can be effective in controlling the Sars-Cov-2 virus, and that prescribing the appropriate formula to match each individual case is the key point for TCM control of Covid-19. Chinese herbal medicine is the most effective current treatment method that can prevent cases in the minor and ordinary stages from progressing to the severe or critical stage, and so can play a significant role in the decrease and cure of Covid-19.

scholarly journals Prediction Methods of Herbal Compounds in Chinese Medicinal Herbs

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2303 ◽  
Author(s):  
Ke Han ◽  
Lei Zhang ◽  
Miao Wang ◽  
Rui Zhang ◽  
Chunyu Wang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Virtual Screening ◽  
Chinese Herbal Medicine ◽  
Screening Method ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Prediction Methods ◽  
Chinese Herbal Medicines ◽  
Advantages And Disadvantages ◽  
Chinese Herbal

Chinese herbal medicine has recently gained worldwide attention. The curative mechanism of Chinese herbal medicine is compared with that of western medicine at the molecular level. The treatment mechanism of most Chinese herbal medicines is still not clear. How do we integrate Chinese herbal medicine compounds with modern medicine? Chinese herbal medicine drug-like prediction method is particularly important. A growing number of Chinese herbal source compounds are now widely used as drug-like compound candidates. An important way for pharmaceutical companies to develop drugs is to discover potentially active compounds from related herbs in Chinese herbs. The methods for predicting the drug-like properties of Chinese herbal compounds include the virtual screening method, pharmacophore model method and machine learning method. In this paper, we focus on the prediction methods for the medicinal properties of Chinese herbal medicines. We analyze the advantages and disadvantages of the above three methods, and then introduce the specific steps of the virtual screening method. Finally, we present the prospect of the joint application of various methods.

scholarly journals Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Yuyang Wang ◽  
Hailing Zhao ◽  
Qian Wang ◽  
Xuefeng Zhou ◽  
Xiaoguang Lu ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Diabetic Kidney Disease ◽  
Kidney Injury ◽  
Public Health Problem ◽  
Current Status ◽  
Diabetic Patients ◽  
Diabetic Kidney ◽  
Chinese Herbal

Diabetic kidney disease (DKD), a leading cause of end-stage renal disease (ESRD), has become a serious public health problem worldwide and lacks effective therapies due to its complex pathogenesis. Recent studies suggested defective autophagy involved in the pathogenesis and progression of DKD. Chinese herbal medicine, as an emerging option for the treatment of DKD, could improve diabetic kidney injury by activating autophagy. In this review, we briefly summarize underlying mechanisms of autophagy dysregulation in DKD, including AMP-activated protein kinase (AMPK), the mechanistic target of rapamycin (mTOR), and the sirtuin (Sirt) pathways, and we particularly concentrate on the current status of Chinese herbal medicine treating DKD by regulating autophagy. The advances in our understanding regarding the treatment of DKD via regulating autophagy with Chinese herbal medicine will enhance the clinical application of Chinese medicine as well as discovery of novel therapeutic agents for diabetic patients.

scholarly journals Application of Molecular Methods in the Identification of Ingredients in Chinese Herbal Medicines

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2728 ◽  
Author(s):  
Ke Han ◽  
Miao Wang ◽  
Lei Zhang ◽  
Chunyu Wang
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Future Development ◽  
Rapid Development ◽  
Herbal Medicines ◽  
Taxonomic Identification ◽  
Traditional Methods ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Speed And Accuracy

There are several kinds of Chinese herbal medicines originating from diverse sources. However, the rapid taxonomic identification of large quantities of Chinese herbal medicines is difficult using traditional methods, and the process of identification itself is prone to error. Therefore, the traditional methods of Chinese herbal medicine identification must meet higher standards of accuracy. With the rapid development of bioinformatics, methods relying on bioinformatics strategies offer advantages with respect to the speed and accuracy of the identification of Chinese herbal medicine ingredients. This article reviews the applicability and limitations of biochip and DNA barcoding technology in the identification of Chinese herbal medicines. Furthermore, the future development of the two technologies of interest is discussed.

Chinese Herbal Medicine for the Optimal Management of Polycystic Ovary Syndrome

2017 ◽  
Vol 45 (03) ◽  
pp. 405-422 ◽  
Author(s):  
Madeleine Ong ◽  
Jie Peng ◽  
Xingliang Jin ◽  
Xianqin Qu
Keyword(s):  
Herbal Medicine ◽  
Polycystic Ovary Syndrome ◽  
Chinese Herbal Medicine ◽  
Polycystic Ovary ◽  
Herbal Medicines ◽  
Ovary Syndrome ◽  
Metabolic Complications ◽  
Beneficial Effects ◽  
Chinese Herbal ◽  
Novel Approach

Polycystic ovary syndrome (PCOS) is a complex heterogeneous disorder characterized by androgen excess and ovulatory dysfunction; it is now known to be closely linked to metabolic syndrome. Recent research suggests that insulin resistance plays an important role in the pathogenesis of PCOS which may lead to the excessive production of androgens by ovarian theca cells. Currently there is no single drug that can treat both the reproductive and metabolic complications of the disorder. Existing pharmaceutical agents such as hormonal therapies have been associated with side effects and are not appropriate for PCOS women with infertility. Additionally, insulin sensitizing agents useful for treating the metabolic abnormalities in PCOS have limited efficacy for treating reproductive aspects of the disorder. Chinese herbal medicines have a long history of treating gynaecological problems and infertility and therefore may be a novel approach to the treatment of PCOS. Current research demonstrates that the compounds isolated from herbs have shown beneficial effects for PCOS and when combined in an herbal formula can target both reproductive and metabolic defects simultaneously. Therefore, further investigation into Chinese herbal medicine in the treatment of PCOS is warranted.

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