ESTIMATION OF SERUM COPPER AND ZINC IN ANAEMIC PATIENTS

ABSTRACTObjective: Estimation of serum zinc and copper levels in anemic patients.Methods: The study design included 30 subjects presenting to clinical laboratory, global hospitals. The subjects were divided into 2 groups. TheGroup 1 consists of 15 healthy individuals and Group 2 consists of 15 anemic patients.Results: The serum copper and zinc levels were evaluated in anemic patients. The serum copper and zinc were found to be significantly lower inanemic patients when compared with normal individuals.Conclusion: Thus, the study concludes that the serum zinc and copper in anemic patients is significantly less when compared to the control individuals.Hence, it is important to add adequate amount of zinc and copper rich food in their diet to control the prevalence of anemia.Keywords: Anemia, Zinc, Copper, Hemoglobin.

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Serum Copper and Zinc Levels of Oral Submucous Fibrosis Patients Using Areca Nut Products Reported at Isra University Hospital Hyderabad

10.53350/pjmhs211593034 ◽

2021 ◽

Vol 15 (9) ◽

pp. 3034-3036

Author(s):

Uzma Tariq ◽

Waqas Iqbal ◽

Surwaich Ali Channa ◽

Bhunesha Devi ◽

Arhama Surwaich ◽

...

Keyword(s):

Oral Submucous Fibrosis ◽

Serum Zinc ◽

Serum Copper ◽

University Hospital ◽

Areca Nut ◽

Healthy Individuals ◽

Copper And Zinc ◽

Submucous Fibrosis ◽

Zinc Levels ◽

One Year

Objective: To determine the copper and zinc levels in serum among oral submucous fibrosis patients using various areca nut products by taking healthy individuals as control at Isra University Hospital Hyderabad. Methodology: This descriptive case-control study was conducted on patients of oral submucosal fibrosis (OSMF) attending the Outpatient Department, Oral Surgery Isra Dental College, Isra university during a period of one year from November 2016 to October 2017. A total of 30 patients above 16 years of age and who were diagnosed cases of OSMF and gave history of areca nut and its commercial products consumption for more than one year were included as group (B)and in equal number healthy individuals were enrolled as control as group(A). The 6ml blood sample was collected in gel tube and then we centrifuged at 3000 rpm gravity for 10min to separate the serum from blood. The 4 to 5ml serum collected in this way was analyzed by spectrophotometric method on Hitachi 902(Roche Germany). The levels of copper and zinc were estimated from serum of both groups. All the data was collected via study proforma and analysis of the data was done by using SPSS version 20. Results: Mean age of the patients was 23.33±4.97 years and mean age of healthy controls was 22.80±4.61 years. The males were most common in both groups. Manipuri was commonest consumed areca nut (50.0%) followed by sweet scented areca nut and Gutkha 33.3% and 36.6% respectively. Mean of serum Cu in patients was lower 86±4.20 µg/dl in contrast to controls 114.0±13.8 µg/dl (p-0.0001). Average of serum Zinc was higher among patients 94.20±15.11 µg/dl as compared to controls as 68.06±17.10 µg/dl (p-0.0001). Conclusion: The average of serum copper level was observed to be significantly less and average of serum zinc significantly higher among OSMF patients using areca nut as compared to healthy individuals. These serum trace element levels could be used as potential prognostic and diagnostic markers in the OSMF patients. Key words: OSMF, Zinc, Copper, Areca nut

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Analysis of Serum and Urinal Copper and Zinc in Chinese Northeast Population with the Prediabetes or Diabetes with and without Complications

Oxidative Medicine and Cellular Longevity ◽

10.1155/2013/635214 ◽

2013 ◽

Vol 2013 ◽

pp. 1-11 ◽

Cited By ~ 30

Author(s):

Jiancheng Xu ◽

Qi Zhou ◽

Gilbert Liu ◽

Yi Tan ◽

Lu Cai

Keyword(s):

Serum Zinc ◽

Zinc Level ◽

Serum Copper ◽

Copper Level ◽

Simvastatin Treatment ◽

Copper And Zinc ◽

Urinary Copper ◽

Zinc Levels

This study investigated the association of copper and zinc levels in the serum or urine of patients living in northeast China, with either prediabetes or diabetes. From January 2010 to October 2011, patients with type 1 diabetes (T1D,n=25), type 2 diabetes (T2D,n=137), impaired fasting glucose (IFG,n=12) or impaired glucose tolerance (IGT,n=15), and age/gender matched controls (n=50) were enrolled. In the T2D group, there were 24 patients with nephropathy, 34 with retinopathy, and 50 with peripheral neuropathy. Serum copper levels were significantly higher in IFG, IGT, and T2D groups. Serum zinc level was dramatically lower, and urinary zinc level was significantly higher in both T1D and T2D subjects compared with controls. The serum zinc/copper ratio was significantly lower in all the patients with IFG, ITG, T1D, and T2D. The serum copper level was positively associated with HbA1c in T2D subjects. Simvastatin treatment in T2D patients had no significant effect on serum and urinary copper and zinc. These results suggest the need for further studies of the potential impact of the imbalanced serum copper and zinc levels on metabolic syndrome, diabetes, and diabetic complications.

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Serum Copper and Zinc Levels and Risk of Hepatocellular Carcinoma: A 1:1 Matched Case-Control Study

Current Developments in Nutrition ◽

10.1093/cdn/nzaa061_025 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1397-1397

Author(s):

Aiping Fang ◽

Huilian Zhu

Keyword(s):

Serum Zinc ◽

Serum Levels ◽

Case Control ◽

Serum Copper ◽

Copper And Zinc ◽

Copper Zinc ◽

Matched Case ◽

Zinc Levels ◽

Control Study ◽

Serum Zinc Levels

Abstract Objectives Copper and zinc have been involved in the development of liver cancer in laboratory models, yet data from epidemiological studies are limited. We investigated the association of serum levels of copper and zinc and their ratio with the risk of hepatocellular carcinoma (HCC) in a Chinese population. Methods This is a 1:1 matched case-control study conducted between September 2013 and February 2017. Each case with newly diagnosed HCC from the Guangdong Liver Cancer Cohort (GLCC) was matched to one healthy control from the Guangzhou Nutrition and Health Study by age (±1 years) and sex. Serum copper and zinc levels were quantified using inductively coupled plasma mass spectrometry. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for age, sex, body mass index, hepatitis infection, smoking status, alcohol drinking status, diabetes, and chronic inflammation. Serum levels of copper and zinc and their ratio were included in models in tertiles with cutpoints based on the distribution of the control participants. Results A total of 556 case-control pairs were included in this study. Mean (SD) age was 60.3 (7.1) years and 83.8% of the participants were men. HCC cases had significantly higher copper and lower zinc levels, and thus higher copper/zinc, than controls. Higher serum zinc levels were associated with a lower risk of HCC (ORT3 vs T1 = 0.21; 95% CI: 0.07–0.64, P for trend = 0.005). However, there was no association between serum copper levels and HCC risk (ORT3 vs T1 = 1.53; 95% CI: 0.62–3.76, P for trend = 0.375). Higher copper/zinc ratio was associated with increased risk of HCC (ORT3 vs T1 = 3.06; 95% CI: 1.08–8.70, P for trend = 0.049). Conclusions Serum zinc levels were inversely associated with the risk of HCC, suggesting a protective role of zinc in preventing HCC development. Funding Sources This work was supported by the National Natural Science Foundation of China.

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Diurnal Variation of Serum Copper and Zinc in Epileptics Receiving Anti-Convulsants

Human Toxicology ◽

10.1177/096032718600500308 ◽

1986 ◽

Vol 5 (3) ◽

pp. 195-200 ◽

Cited By ~ 9

Author(s):

A. Taylor ◽

K. Ghose

Keyword(s):

Diurnal Variation ◽

Reference Range ◽

Serum Zinc ◽

Serum Copper ◽

Copper Level ◽

Copper And Zinc ◽

Urinary Copper ◽

Zinc Concentrations ◽

Zinc Levels ◽

Patients With Epilepsy

1 Serial measurements of copper and zinc concentrations in serum were made at 06.00, 14.00, 22.00 and again at 06.00 hours in 37 male patients with epilepsy, aged between 9 and 19 years. Anti-convulsant drugs were administered at 08.00 and 20.00 hours, and standard hospital meals were allowed at 07.30, 12.00, 16.00 and 19.00 hours. 2 Similar to our previous results, eight patients (21.6%) had serum copper levels greater than the reference range (11.0–20.5 μmol/l) and this hypercupraemia was associated with carbamazapine and/or phenytoin medication. 3 No diurnal variation in serum copper level was observed. Serum copper concentration had no correlation with either 24 h urinary copper excretion or serum anti-convulsant drug levels. 4 Serum zinc concentrations were within the reference range (10–16.5 μmol/l), confirming our previous report. No relation with anti-convulsant medication or serum copper levels was found. 5 Diurnal variations in serum zinc levels with peak and trough concentrations at 06.00 and 14.00 hours, respectively, were observed. 6 It is proposed that these variations in serum zinc concentrations are a normal physiological process and is unlikely to be related to anti-convulsant drugs or epilepsy.

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