THE DIAGNOSTIC VALUE OF CONVENTIONAL TUBERCULOSIS DIAGNOSTIC PROCEDURE COMPARED WITH GENE X-PERT MTB/RIF: A CROSS-SECTIONAL STUDY

Author(s):  
KETUT SURYANA ◽  
HAMONG SUHARSONO ◽  
IDA BAGUS NGURAH RAI

Objectives: The objectives of the study were to evaluate the diagnostic value of conventional tuberculosis (TB) diagnostic procedure compared with Gene X-pert Mycobacterium tuberculosis/rifampicin (MTB/RIF). Methods: A cross-sectional study conducted from January to December 2018. The accuracy of conventional TB diagnostic procedure: TB screening, chest X-ray, and sputum Ziehl-Neelsen (ZN) staining was compared to Gene X-pert MTB/RIF using 2 × 2 table. p < 0.05 were taken as statistically significant. The collected data were processed using Statistical Package for the Social Science software version 26.0. Results: A total of 117 participants suspected TB was found 44 (37.60%) confirmed TB. Among the suspected TB cases, 86 (73.50%) were male and 31 (26.50%) were female with the mean age of 43.86±16.47 years. The sensitivity and specificity of TB screening (prolonged cough) were 84.00% and 12.00%, respectively. Chest X-ray had the sensitivity and specificity (91.00%) and (10.00%). The sensitivity and specificity of sputum ZN were 57.00% and 99.00%. Conclusions: Conventional TB diagnostic procedure has a high accuracy compared with Gene X-pert MTB/RIF. Therefore, it is still recommended as a TB diagnostic procedure routinely in era of Gene X-pert MTB/RIF, especially in Primary Health Care with limited settings.

2020 ◽  
Vol 7 (6) ◽  
Author(s):  
Sacha F de Stoppelaar ◽  
Liza Pereverzeva ◽  
Bram Hafkamp ◽  
Nikki Lips ◽  
Floor Tielbeke ◽  
...  

Abstract Suspicion of an infection without localizing signs or symptoms is a common problem. A chest x-ray (CXR) is often performed to rule out pneumonia. Our prospective cross-sectional study suggests that a CXR has no diagnostic value in patients without respiratory signs or symptoms, if a reliable medical history can be obtained.


Author(s):  
R. Behzadmehr ◽  
E. Nejadkehkha

Despite many advances in the diagnosis, screening, and rapid treatment of tuberculosis, it is still a public health concern in the world. Due to the importance of this issue in diagnosis and reduction of transmission of infection and treatment of the disease especially where this study is conducted due to the high prevalence of tuberculosis, this study was done to determine The relationship between sputum smear positivity grade and chest X-ray findings in pulmonary tuberculosis patients in a hospital in southeast of Iran. This cross-sectional study was performed on all patients with pulmonary TB referencing the health centers in Zabol city, southeast of Iran from 1 January 2015 to 30 December 2020. Sputum smear and radiographic findings of the chest X-ray were evaluated. Data was collected using a form of information and finally analyzed by SPSS 22. Out of 101 patients examined in the present study, 71 were women and 30 were men. The mean age of the patients was 62.68 ± 13.61 years. The frequency of opacity in patients with grades 1, 2, and 3 was 71.4, 78.5, and 76.5%, respectively. Frequency of cavitation in patients with Grade 1, 2 and 3 was 11.5%, 28.5% and 52.9% respectively (P value 0.001). The frequency of reticulonodular presentations in patients with grade 1, 2, and 3 was 24.2, 7.1, and 0%, respectively.  In general, the results of this study showed that, with increasing grading of smears (1+, 2+, and 3+), the frequency of cavitation presentation increased significantly and the frequency of reticulonodular presentations decreased significantly. In general, the results of this study showed that, with increasing grading of smears (, the frequency of Cavitation presentation increased significantly and the frequency of reticulonodular presentations decreased significantly. The findings of the present study can help physicians better diagnose TB.


2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Joanitah Nalunjogi ◽  
Frank Mugabe ◽  
Irene Najjingo ◽  
Pastan Lusiba ◽  
Francis Olweny ◽  
...  

The WHO END TB strategy requires ≥90% case detection to combat tuberculosis (TB). Increased TB case detection requires a more sensitive and specific screening tool. Currently, the symptoms recommended for screening TB have been found to be suboptimal since up to 44% of individuals with TB are asymptomatic. The chest X-ray (CXR) as a screening tool for pulmonary TB was evaluated in this study, as well as its incremental yield in TB diagnosis using a cross-sectional study involving secondary analysis of data of 4512 consented/assented participants ≥15 years who participated in the Uganda National TB prevalence survey between 2014 and 2015. Participants with a cough ≥2 weeks, fever, weight loss, and night sweats screened positive for TB using the symptoms screening method, while participants with a TB defining abnormality on CXR screened positive for TB by the CXR screening method. The Löwenstein-Jensen (LJ) culture was used as a gold standard for TB diagnosis. The CXR had 93% sensitivity and 65% specificity compared to LJ culture results, while symptoms had 76% sensitivity and 31% specificity. The screening algorithm involving the CXR in addition to symptoms led to a 38% increment in the yield of diagnosed tuberculosis. The number needed to screen using the CXR and symptoms screening algorithm was 32 compared to 45 when the symptoms are used alone. Therefore, the CXR in combination with symptoms is a good TB screening tool and increases the yield of diagnosed TB.


2021 ◽  
Vol 17 ◽  
Author(s):  
Mateusz Puchala ◽  
Andrzej Rydzewski ◽  
Ilona Kowalik ◽  
Małgorzata Wisłowska

Background: GPA is a necrotizing inflammation of the small vessels with granulomas. Kidney involvement deteriorated its prognosis. Objective: Comparison of GPA patients with kidney (KI) and without kidney involvement (nKI). Material and methods: We conducted a cross-sectional study of 50 consecutive adult GPA patients, 25 KI from Nephrology and 25 nKI from Rheumatology Department of Central Clinical Hospital Ministry of Interior in Warsaw. We analyzed clinical features, organ involvement, laboratory, serological, imaging, histopathological data, BVAS, treatment. Results: The mean age of KI patients was statistically older then nKI (67.3±9.5 vs 55.1±15.9, p=0.002). Generalized, severe, resistance disease was observed respectively in 92% vs 44%, p<0.001. The number of red blood cells (3.47 vs 4.41T/l, p<0.001), hemoglobin (10.0 vs 12.9g/dl, p<0.001) was lower in KI, higher mean serum creatinine (3.95 vs. 0.89mg/dl, p<0.001), lower GFR (20.1 vs. 79.3, p<0.001), higher CRP (median: 43.4 vs 2.0mg/l, p<0.001), BVAS (16.6±4.4 vs 10.1±6.2, p<0.001), c-ANCA (median: 119.0 vs 15.2CU, p=0.017). Nodules in 28% KI, in 4% nKI (p=0.048) in chest X-ray, infiltration in 43.5% KI, in 15% nKI (p=0.042) in HRCT were observed. Skin granulomas were found in 61.5% nKI vs 18.2% KI, (p=0.047). Renal biopsy revealed in KI patients focal segmental glomerulonephritis in 11.8%, crescentic glomerulonephritis in 17.6%, pauci-immune crescentic glomerulonephritis in 70.6%. Conclusions: In patients with KI more frequently we found generalized, severe, resistant GPA, higher BVAS in comparison in patients without KI. The results of laboratory parameters, were worse in patients with KI. Aggressive immunosuppressive treatment is often used in KI group.


CHEST Journal ◽  
2009 ◽  
Vol 136 (4) ◽  
pp. 40S
Author(s):  
Beverly D. Delacruz ◽  
Nerissa A. Deleon ◽  
Milagros S. Bautista ◽  
Fernando Ayuyao ◽  
Teresita Deguia

2020 ◽  
Vol 70 (6) ◽  
pp. 1847-52
Author(s):  
Khawaja Muhammad Baqir Hassan ◽  
Tathir Baqir Hassan ◽  
Shakil Sarwar ◽  
Irfan Najam Sheen ◽  
Farrukh Islam ◽  
...  

Objective: To study clinical symptoms and chest X-ray findings for evaluation of chest X-ray in management ofconfirmed cases of COVID-19 and predicting the clinical outcome. Study Design: Cross sectional study. Place and Duration of Study: The departments of Radiology & Medicine of Combined Military Hospital Malir,from Mar to May 2020. Methodology: The sample used in this study consists of 73 patients. All the standard frontal projections of chest X-ray of PCR confirmed COVID-19 patients were studied on computer and findings were noted Results: At the aggregate, the study indicates that there is no Significant Connection in between the clinicalsymptoms, their severity and chest X-ray findings. Conclusion: There is no significant connection found between the severity of clinical symptoms and chest X-rays suggesting that chest X-Ray cannot be a reliable indicator to predict the clinical outcome of the patient and has limited role in management of patient. Clinical assessment is still the main stay of the patient management.


2015 ◽  
Vol 1 (2) ◽  
pp. 19-22 ◽  
Author(s):  
Narayan Thapa ◽  
Bharat Bhandari ◽  
Bhairab Kumar Hamal

Introductions: Ureteral stones account for 20% urinary stone. Two third of ureteral stones are seen in lower third of ureter. Medical expulsive therapy is effective for such stones. This study was designed to observe the efficacy of ‘tamsulosin’ a selective alpha-1 adrenoreceptor antagonist in the management of lower ureteric stone.Methods: A cross sectional study of 70 cases of distal ureteral stones of sizes 5 to 10 mm was taken in the Department of Surgery of Shree Birendra Hospital, Nepalese Army Institute of Health Sciences (NAIHS) from January 2011 to 2013. Patients were randomly divided into tamsulosin and analgesic only groups. Stone expulsion at the end of three weeks was confirmed by X-ray or Ultrasonography.Results: Out of 70 patients, stone clearance rate in tamsulosin group was 28 in 35 cases (80%) and 21 in 35 cases (60%) in group II with analgesic only. The mean time of stone expulsion was 8.3 days in group I and 13.5 days in group II.Conclusions: In this study the use of tamsulosin in treatment of lower ureteral stones less than 10 mm was safe and effective.


Sign in / Sign up

Export Citation Format

Share Document