scholarly journals REVIEW ARTICLE ON PULSATILE DRUG DELIVERY SYSTEM

2021 ◽  
pp. 48-59
Author(s):  
VENKATASWAMY R ◽  
LAVANYA NALLAGUNTLA
Keyword(s):  
Drug Delivery ◽  
Technology Development ◽  
Review Article ◽  
The Body ◽  
Night Time ◽  
Survey Article ◽  
Unit System ◽  
Multiple Unit ◽  
Osmotic System ◽  
Pulsatile Drug Delivery

Pulsatile drug delivery systems (PDDS) are acquiring a lot of interest as they deliver the medication at the perfect place at the perfect time and in the perfect amount, subsequently giving spatial and transient delivery and increasing patient consistency. These systems are designed by the circadian rhythm of the body. The primary reasoning for the utilization of pulsatile arrival of the medications is the place where a consistent medication release is not desired. A pulse must be planned so that a complete and rapid medication release is accomplished after the lag time. A different system such as capsular system, osmotic system, single-and multiple unit system dependent on the utilization of soluble or erodible polymer coating, and the utilization of rupturable films has been managed in the article. It sums up the most recent technology development, formulation parameter, and delivery profiles of this system. PDDS is helpful for the medications having chronopharmacological conduct where night-time dosing is required, such as anti-arrhythmic, anti-ulcerative, and anti-asthmatic, and so on The momentum survey article talked about the explanations behind the advancement of the PDDS, benefits, limitation, mechanism of medication release, need for pulsatile drug delivery, a disease that requires pulsatile technology, classification, and future parts of PDDS.

Pulsatile Drug Delivery Systems: An Overview

2009 ◽  
Vol 2 (3) ◽  
pp. 605-614
Author(s):  
Ramesh D. Parmar ◽  
Rajesh K. Parikh ◽  
G. Vidyasagar ◽  
Dhaval V. Patel ◽  
Chirag J. Patel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Night Time ◽  
Technological Developments ◽  
Pulsatile Drug Delivery ◽  
Formulation Parameters ◽  
The Right

Pulsatile  Drug  Delivery  Systems  are  gaining  a  lot  of  interest  as  they  deliver  the  drug  at  the  right  place  at  the  right  time  and  in  the  right  amount,  thus  providing  spatial  and  temporal  delivery  and  increasing  patient  compliance.  These  systems  are  designed  according  to  the  circadian  rhythm  of  the  body.  The  principle  rationale  for  the  use  of  pulsatile  release  of  the  drugs is where  a  constant  drug  release  is  not  desired.  A  pulse  has  to  be  designed  in  such  a  way  that  a  complete  and  rapid  drug  release  is  achieved  after  the  lag  time.  Various  systems  like  capsular  systems,  osmotic  systems,  single-  and  multiple-unit  systems  based  on  the  use  of  soluble  or  erodible  polymer  coating  and  use  of  rupturable  membranes  have  been  dealt  with  in  the  article.  It  summarizes  the  latest  technological  developments,  formulation  parameters,  and  release  profiles  of  these  systems.  These  systems  are  beneficial  for  the  drugs  having  chronopharmacological  behavior  where  night  time  dosing  is  required,  such  as  anti-arhythmic  and  anti-asthmatic.

scholarly journals Recent Trends in Chronopharmaceutics, Pulsatile Drug Delivery System

2019 ◽  
pp. 41-49
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Correct Position ◽  
Unit System ◽  
Recent Trends ◽  
Osmotic System ◽  
Pulsatile Drug Delivery ◽  
Fast Release

Pulsatile Drug Delivery Systems (PDDS) are getting considerable interest in delivering a drug at the correct position, at the correct time, and in the correct quantity, thus offering temporal, spatial, and intelligent delivery with improving patient compliance. These systems are intended to meet body's biological rhythm. Here, the delivery of drugs is assisted by the rhythm of disease. The main reason for the using pulsatile drug release is when the continuous drug release is not required. A PDDS must be designed in such a way that after the lag time a complete and fast release of drugs is achieved. The article deals with various systems such as osmotic system, capsular system, single and multi-unit system based on the utilization of erodible or soluble polymer coating and using of rupturable membrane. These systems are favorable to drugs with chronopharmacological behaviors such as drugs used to treat rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. The current review paper focus on the causes for pulsatile drug delivery system design, types of illness requiring pulsatile release, classification, benefits, and restriction of this drug delivery system

A Concise Insight on Pulsatile Drug Delivery System: An Outlook towards its Development

2021 ◽  
Vol 14 (5) ◽  
pp. 5577-5587
Author(s):  
Om M Bagade ◽  
Snehal S Sutar ◽  
Priyanka E Doke
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Patient Compliance ◽  
Delivery System ◽  
The Body ◽  
Multiple Unit ◽  
Pulsatile Drug Delivery ◽  
Pulsatile Delivery ◽  
Time Specific ◽  
The Right

In pharmaceutical science, the pulsatile drug delivery system gains more attraction because of their number of benefits over the other dosage forms. In these systems, the drug is released at right time at the right site of action, and in the right amount, it is the most beneficial and important characteristic of the PDDS system due to that the patient compliance is increased, and the drug release is after a well-defined lag time.  Moreover, this system is designed according to the circadian rhythm of the body. Because the disease has a predictable cyclic rhythm, such as Arthritis, diabetes mellitus, asthma, peptic ulcer, hypertension, cardiovascular disease the PDDS is more effective than other dosage forms.This system is a more time-specific and site-specific drug delivery system. In this system the drug is released as a pulse. The mechanism of PDDS is first diffusion then erosion and then osmosis. For the drug having a high first-pass effect and having a high risk of toxicity and side effects, these systems can be very useful. And to reduce dosing frequency and improve patient compliance this system is very helpful. There are various methods present like, single-unit systems and multiple-unit systems – which included capsular system, pulsatile delivery by osmosis, pulsatile delivery by erosion of membrane, delivery by rupture of membrane, etc.  

scholarly journals Drug Delivery Technology Development in Canada

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 541
Author(s):  
Wasan ◽  
Badea
Keyword(s):  
Drug Delivery ◽  
Technology Development ◽  
The Body ◽  
Special Issue ◽  
Academic Institutions ◽  
Formulation Development ◽  
Drug Release Profile ◽  
History Of ◽  
Biotechnology Companies ◽  
Site Targeting

Canada has a long and rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community. Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. It may involve rational site-targeting, or facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of the presence of the drug in the body. Drug delivery is often approached through a drug's chemical formulation, medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form development and selection of route of administration; the latter sometimes even being considered part of the definition. Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and adherence. Over the past 30 years, numerous Canadian-based biotechnology companies have been formed stemming from the inventions conceived and developed within academic institutions. Many have led to the development of important drug delivery products that have enhanced the landscape of drug therapy in the treatment of cancer to infectious diseases.  This Special Issue serves to highlight the progress of drug delivery within Canada. We invited articles on all aspects of drug delivery sciences from pre-clinical formulation development to human clinical trials that bring to light the world-class research currently undertaken in Canada for this Special Issue.

scholarly journals Advanced characterizations of nanoparticles for drug delivery: investigating their properties through the techniques used in their evaluations

2017 ◽  
Vol 6 (4) ◽  
pp. 355-372 ◽  
Author(s):  
Syed Mahmood ◽  
Uttam Kumar Mandal ◽  
Bappaditya Chatterjee ◽  
Muhammad Taher
Keyword(s):  
Drug Delivery ◽  
Advanced Characterization ◽  
Data Interpretation ◽  
Review Article ◽  
The Body ◽  
Drug Molecule ◽  
Drug Molecules ◽  
Preparation Techniques

AbstractNanomedicine has achieved a huge success in delivering a wide variety of drug molecules into the target site of the body. In this respect, the characterization of nanoformulation is very important to investigate the drug molecule together with its carrier as a nanoform during formulation, storage, and in vivo transport through the body. This review article summarizes important advanced characterization techniques of nanoformulation with respect to their theories, use of required instrumental parameters, sample preparation techniques, data interpretation, etc., to exploit them for the best possible results. This review article also sheds a glimpse to the shortcomings of these techniques together with further advancements required in future.

PULSATILE DRUG DELIVERY A PROGRAMMED POLYMERIC DEVICE

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (05) ◽  
pp. 5-22
Author(s):  
S Rawat ◽  
◽  
S Bisht ◽  
P Kothiyal
Keyword(s):  
Drug Delivery ◽  
Peptic Ulcer ◽  
Circadian Rhythm ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
The Body ◽  
Latin Literature ◽  
Dose Frequency ◽  
Pulsatile Drug Delivery ◽  
The Right

Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place, at the right time and in the right amount, thus providing spatial, temporal and smart delivery and increasing patient compliance. The use of pulsatile release of the drugs is desirable where constant drug release is not desired. These systems are designed according to the circadian rhythm of the body. According to Latin literature circa means about and Diem means day. This could be advantageous for many drugs or therapies including asthma, peptic ulcer & arthritis etc. To correlate with our biological needs, “precisely timed drug delivery,” which could be accomplished with “programmable dosage forms,” is desirable. Precisely timed drug delivery may maximize therapeutic efficacy, minimize dose frequency, and may reduce toxicity. This paper outlines the concepts that have been proposed to release drugs in a pulsed manner from pharmaceutical device.

scholarly journals Recent developments on zinc(ii) metal–organic framework nanocarriers for physiological pH-responsive drug delivery

MedChemComm ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 2038-2051 ◽  
Author(s):  
Weicong Liu ◽  
Ying Pan ◽  
Weiwei Xiao ◽  
Hongjia Xu ◽  
Dong Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Review Article ◽  
The Body ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Stimulus Responsive ◽  
Recent Developments ◽  
Metal Organic ◽  
Organic Framework

In this review article, we discuss the diverse stimuli achieved upon outside activation from single pH-stimulus-responsive or/and multiple pH-stimuli-responsive viewpoints in the body.

scholarly journals Chrono pharmacotherapy: A pulsatile Drug Delivery

2015 ◽  
Vol 1 (1) ◽  
pp. 25
Author(s):  
Huma Hameed ◽  
Arwa Khalid ◽  
Fazala Khalid ◽  
Rabeea Khan ◽  
Akhtar Rasul
Keyword(s):  
Drug Delivery ◽  
Circadian Rhythms ◽  
Antihypertensive Drugs ◽  
Systemic Delivery ◽  
Night Time ◽  
Colon Targeting ◽  
Therapeutic Outcomes ◽  
Zero Order Release ◽  
Pulsatile Drug Delivery ◽  
Pulsatile Delivery

Chronopharmacotherapy refers to a treatment in which controlled drug delivery is achieved according to circadian rhythms of disease by enhancing therapeutic outcomes and minimizing side effects. Colon targeting has gained great importance not only for the treatment of local diseases such as Crohn’s disease, inflammatory bowel disease and ulcerative colitis but also very important in systemic delivery of proteins/peptides, antiasthmatic drugs, antidiabetic agents and antihypertensive drugs, which mostly show their efficacy based on circadian rhythms of the body.Colon drug delivery is one of the difficult approaches to achieve the targeted and desired outcomes through pulsatile drug delivery by avoiding dose dumping.The main reasonbehind the use of pulsatile delivery is provision ofconstant drug release where a zero-order release is notpreferred. Chronopharmacotherapy in colon targeting play its role bymany systems such ascapsular systems, pulsatile system and osmotic systems, which are based on use of rupturable membranes and biodegradable polymers.The objective of this review article is to provide latest knowledge about drugs with chrono-pharmacological behavior entails night time dosing specially to the colon.

scholarly journals PULSATILE DRUG DELIVERY SYSTEM-A TECHNIQUE OF DELIVERING DRUG IN ACCORDANCE WITH BIOLOGICAL CLOCK - A REVIEW

2021 ◽  
Vol 9 (4) ◽  
pp. 101-124
Author(s):  
Chiluvuru Vani ◽  
◽  
K. Srinivas Reddy ◽  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biological Clock ◽  
Biological Rhythms ◽  
Immediate Release ◽  
Dosage Forms ◽  
The Body ◽  
Solid Dosage ◽  
Pulsatile Drug Delivery

Over last 30 years pulsatile drug delivery system has achieved a lot of importance in drug delivery technology. And the reason why this pulsatile drug delivery is gaining importance is because of its strategy of delivering drug molecule at right place, right time. There are certain diseases which are controlled by biological clock of our body and follow circadian rhythms like congestive heart failure, asthma, rheumatoid arthritis ,osteoarthritis, inflammatory disorders and other hormonal disorders, for this type of diseases conventional solid dosage forms like immediate release tablets or modified dosage forms like sustained, controlled release tablets cant give the required therapeutic response and also for such diseases delivering the drug at right time in right amount is very important. And that task is accomplished by this pulsatile drug delivery system. These pulsatile drug delivery framework is planned by the organic mood i.e., biological rhythms of the body, and medication conveyance is worked with by as per disease cadence. The rule for the utilization of pulsatile drug delivery of the medications is the place where a consistent drug discharge isnt wanted. The principle for the utilization of pulsatile release of the medications is the place where a steady drug discharge isnt wanted, yet drug release must be planned in such a way that, quick medication discharge is accomplished after the lag time. Current review examined the clarifications for improvement of pulsatile drug delivery framework in accordane with body circadian rhythm, kinds of the illness during which pulsatile discharge is required, order, assessments, benefits, impediments.

scholarly journals Chronopharmaceutical Drug Delivery Systems: A Comprehensive Review

2021 ◽  
Vol 69 (2) ◽  
Author(s):  
Vipin Gupta ◽  
Prashant Kumar
Keyword(s):  
Drug Delivery ◽  
Circadian Rhythms ◽  
Drug Delivery Systems ◽  
Early Morning ◽  
Internal Clock ◽  
Delivery Systems ◽  
The Body ◽  
Peak Time ◽  
Night Time ◽  
Pharmaceutical Dosage Forms

Chronopharmaceutical drug delivery systems release drug at a rhythm that ideally matches the biological requirement of a given disease therapy or prevention. The sound knowledge of the biological processes and their functions utilized in biomedical and pharmaceutical sciences is necessary for effective design and evaluation of pharmaceutical dosage forms. Circadian phase master the circadian clock of the body, the supra chiasmatic nucleus is known to regulate the endogenous circadian rhythms present inside the human body and the peak evidences of some diseases are reported as per circadian rhythm. The secretion of melatonin, a hormone, released by the pineal gland during darkness, help to reset the internal clock, which regulates the timing of different body functions. In certain diseases like asthma, airway resistance increases progressively in early morning, also release of adrenaline and noradrenaline in the morning causes rise in the blood pressure. In hypercholesterolemia, cholesterol synthesis is higher during the night time than day light; in diabetes mellitus blood sugar level is higher in the day time; myocardial insufficiency occurs early in the morning, and many others. The present review addresses the approaches to chronopharmaceuticals, identifies existing technologies, and study of recent chronopharmaceutical drug delivery systems for management of various chronic diseases like diabetes, hypertension and various types of cancers according to the circadian rhythms of diseases in order to optimize therapeutic outcomes and reduce side effects. Recently chronopharmaceutical drug delivery systems are attaining huge importance in the field of pharmaceutical technology for product development because they are proved to reduce dosing frequency, toxicity and also they deliver the drug in particular disease as and when required considering the peak time of the disease, offering better patient compliance.

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