scholarly journals FORMULATION AND EVALUATION OF ANTIFUNGAL CREAM OF CHLORPHENESIN

2021 ◽  
pp. 76-81
Author(s):  
VEENA S. ◽  
SURINDER KAUR ◽  
GURURAJ KULKARNI
Keyword(s):  
Fungal Infections ◽  
Dosage Forms ◽  
Skin Infections ◽  
Topical Drug Delivery ◽  
Cream Formulation ◽  
Diffusion Studies ◽  
In Vitro Diffusion ◽  
Materials Used ◽  
Routes Of Drug Administration

Objective: The main aim of our research was to develop an Antifungal cream formulation consisting of Chlorphenesin for the treatment of Fungal infections. Topical route is the most suitable route for skin infections. Methods: The development of topical drug delivery systems designed to have systemic effects appears to be beneficial for a number of drugs on account of several advantages over conventional dosage forms(or) routes of drug administration. An Antifungal cream formulation consisting of Chlorphenesin was prepared. Results: The formulation was subjected to in vitro diffusion studies. Microbiological studies were performed to find out the safety of materials used in the formulation. Conclusion: The developed cream consisting of Cholrphnesin was found to be safe and effective for the treatment of fungal infection.

scholarly journals Evaluation of antipsoriatic activity of gel containing Pongamia pinnata extract on Imiquimod-induced psoriasis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Kamlesh Wadher ◽  
Shital Dabre ◽  
Anjali Gaidhane ◽  
Sagar Trivedi ◽  
Milind Umekar
Keyword(s):  
Mouse Model ◽  
Pongamia Pinnata ◽  
Gelling Agent ◽  
Proper Treatment ◽  
Phytochemical Screening ◽  
Diffusion Studies ◽  
In Vitro Diffusion ◽  
Gel Formulations ◽  
Disease And Disorders

Abstract Background Pongamia pinnata (Fabaceae) is among those categories of plants mentioned in Ayurveda and traditionally known to use in several types of disease and disorders. The objective of the present work was to investigate the anti-psoriatic activity of Pongamia pinnata leaves extracts in Herbal gel formulation. Results Hydroalcoholic leaves extract of Pongamia pinnata was first subjected to phytochemical screening and quantification of phytoconstituents. Herbal gel was prepared containing Pongamia pinnata extracts using Carbopol 934 as gelling agent. The prepared gel formulations were studied for pH, viscosity, Spreadability and in vitro diffusion studies. The imiquimod-induced psoriatic mouse model, showed a prominent anti-psoriatic activity of the extract as evident through index grading. Treatment with extract confirmed a noteworthy reduction in psoriasis in the treated groups as there was a considerable diminution in the thickness and scaling of skin. Conclusions Lack of proper treatment and disadvantages associated with allopathic medicines pave the way to extensive research in natural products with anti-psoriatic activity. The present research scientifically justified the anti-psoriatic activity of the Hydroalcoholic extracts of Pongamia pinnata leaves.

scholarly journals Overview of medically important antifungal azole derivatives.

1988 ◽  
Vol 1 (2) ◽  
pp. 187-217 ◽  
Author(s):  
R A Fromtling
Keyword(s):  
Adverse Reactions ◽  
Fungal Infections ◽  
Chemotherapeutic Agents ◽  
Skin Infections ◽  
Life Threatening ◽  
Major Chemical ◽  
Systemic Infections ◽  
Selection Of

Fungal infections are a major burden to the health and welfare of modern humans. They range from simply cosmetic, non-life-threatening skin infections to severe, systemic infections that may lead to significant debilitation or death. The selection of chemotherapeutic agents useful for the treatment of fungal infections is small. In this overview, a major chemical group with antifungal activity, the azole derivatives, is examined. Included are historical and state of the art information on the in vitro activity, experimental in vivo activity, mode of action, pharmacokinetics, clinical studies, and uses and adverse reactions of imidazoles currently marketed (clotrimazole, miconazole, econazole, ketoconazole, bifonazole, butoconazole, croconazole, fenticonazole, isoconazole, oxiconazole, sulconazole, and tioconazole) and under development (aliconazole and omoconazole), as well as triazoles currently marketed (terconazole) and under development (fluconazole, itraconazole, vibunazole, alteconazole, and ICI 195,739).

scholarly journals FORMULATION AND EVALUATION OF GEL LOADED WITH MICROSPHERES OF APREMILAST FOR TRANSDERMAL DELIVERY SYSTEM

2019 ◽  
pp. 411-417
Author(s):  
N. V. SAI PRIYANKA ◽  
P. NEERAJA ◽  
T. MANGILAL ◽  
M. RAVI KUMAR
Keyword(s):  
Research Work ◽  
Gel Strength ◽  
Gelling Agent ◽  
Stability Studies ◽  
Scanning Calorimetry ◽  
Drug Content ◽  
Diffusion Studies ◽  
In Vitro Diffusion ◽  
Drug Kinetics

Objective: The main objective of the present research work was to formulate and evaluate gel loaded with microspheres of apremilast to increase bioavailability and to reduce the dosing frequency and to improve patient compliance. Methods: Gel loaded with microspheres of apremilast was prepared by solvent evaporation method by taking different ratios of polymers. Ethyl cellulose as a polymer, dichloromethane solvent is used as drug solubility, polyvinyl alcohol as a surfactant, and sodium alginate is used as gelling agent. Prepared gel loaded with microspheres was evaluated for drug interactions by Fourier transform infrared (FTIR), differential scanning calorimetry studies, and surface morphology by scanning electron microscopy (SEM), to select effective one among all formulations. The prepared formulations (F1–F6) were evaluated for pre-formulation studies, spreadability, viscosity, pH measurement, gel strength, homogeneity, drug content, in vitro diffusion studies, drug kinetics, and finally for stability studies. Results: Differential scanning calorimeter studies confirmed that there is no drug interaction between drug and excipients. FTIR spectroscopy studies confirmed that there is compatibility between drug and excipients. Regular and spherical shape particles with smooth surface were observed in the SEM photographs. The optimized gel loaded with microspheres of F4 formulation (drug: polymer in 1:4 ratio) is more effective compared to all formulations. The prepared gel showed acceptable physical properties such as spreadability (5.86±0.54 g.cm/s), viscosity (568 cps), pH (6.33±0.55), gel strength (38 s) and drug content (90.00±0.71%). In vitro diffusion studies have shown 80.1±1.92% drug release in 10 h. Drug kinetics follows zero order kinetics and n value was found to be 0.721. Stability studies were done for 3 months. Conclusion: All the results show that the gel loaded with microspheres of apremilast can be effectively used for the treatment of psoriasis and psoriatic arthritis.

Gellan gum capped silver nanoparticle dispersions and hydrogels: cytotoxicity and in vitro diffusion studies

Nanoscale ◽  
2012 ◽  
Vol 4 (2) ◽  
pp. 563-567 ◽  
Author(s):  
S. Dhar ◽  
P. Murawala ◽  
A. Shiras ◽  
V. Pokharkar ◽  
B. L. V. Prasad
Keyword(s):  
Silver Nanoparticle ◽  
Gellan Gum ◽  
Nanoparticle Dispersions ◽  
Diffusion Studies ◽  
In Vitro Diffusion

scholarly journals Formulation and Evaluation of Topical Microemulgel Containing Terbinafine Hydrochloride

2021 ◽  
pp. 794-803
Author(s):  
Zingade Sarika G. ◽  
Nagoba Shivappa N. ◽  
Agwane Shanta G. ◽  
Swami Avinash B.
Keyword(s):  
Fungal Infections ◽  
Tween 20 ◽  
Application Site ◽  
Pharmaceutical Sciences ◽  
Terbinafine Hydrochloride ◽  
Delivery Technique ◽  
Carbopol 940 ◽  
Diffusion Studies ◽  
Transdermal Permeability

The purpose of this study is to create and test a Terbinafine hydrochloride microemulgel. Terbinafine hydrochloride is an FDA-approved antifungal medication used to treat fungal infections on the skin. It's a BCS class II medication with little bioavailability. In the realm of pharmaceutical sciences, microemulgel has evolved into one of the most intriguing topical preparations. Microemulgel as a delivery technique has several advantages over simple traditional formulations, including simplicity of administration, increased residence duration at the application site, consistent drug release with improved bioavailability, superior thermodynamic stability, and excellent transdermal permeability. Terbinafine hydrochloride microemulgels were made with carbopol 940 and HPMC as gelling agents, oleic acid as an oil, parabens as a preservative, and tween 20 as an emulgent and penetration enhancer. The appearance, spreadability, homogeneity, viscosity, pH, percent drug content, and in vitro diffusion studies of the generated microemulgel formulation were all visually checked. The findings show that developing a terbinafine-containing microemulgel is more effective, but clinical efficacy must be determined through clinical trials.

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