Evaluating patients' satisfaction and preferences with a secondary prevention cardiovascular polypill: the Aurora Study

Aim: To evaluate the satisfaction, preferences and adherence of patients in secondary cardiovascular prevention treated with the CNIC cardiovascular polypill compared with patients treated with the separate monocomponents. Methods: Observational, cross-sectional and multicenter study. Satisfaction was evaluated by the Treatment Satisfaction Questionnaire for Medication 9 items, adherence by the Morisky-Green questionnaire and ad-hoc questions were asked regarding patient preferences. Results: Polypill patients reported higher satisfaction than patients treated with the monocomponents (77.3 vs 71.2%, p < 0.0001). 72.8% of patients treated with the monocomponents would prefer to change to the polypill. Patients treated with the polypill had significantly higher adherence than patients treated with the monocomponents (57.7 vs 41.1%) (p = 0.0027). Conclusion: Polypill patients show higher satisfaction and better adherence. Most patients receiving the monocomponents would prefer a polypill regime.

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Studying the Possibility of Optimizing the Statin Therapy Algorithm in Outpatient Practice

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2020-08-04 ◽

2020 ◽

Vol 16 (4) ◽

pp. 528-535 ◽

Cited By ~ 1

Author(s):

D. V. Nebieridze ◽

N. M. Akhmedzhanov ◽

S. A. Davitashvili ◽

A. S. Lishuta ◽

A. S. Safaryan

Keyword(s):

Secondary Prevention ◽

Statin Therapy ◽

Cardiovascular Prevention ◽

Statin Treatment ◽

Target Level ◽

Group 2 ◽

Outpatient Practice ◽

Very High ◽

Secondary Cardiovascular Prevention ◽

Group 1

The high prevalence of lipid metabolism disorders in the Russian population and their contribution to cardiovascular risk require an optimization of their pharmacotherapy in clinical practice.Aim. To study the possible benefits of statin therapy in fixed doses for primary and secondary prevention of cardiovascular disease in outpatient practice.Material and methods. Ambulatory patients (n=300) with a high or very high risk with hypercholesterolemia who had indications for statin treatment for primary or secondary prevention of cardiovascular diseases were included into a non-randomized trial. Patients were divided into 2 groups. Group 1 had a titration regimen of statins in accordance with current recommendations (group 1A [n=50] – primary cardiovascular prevention; group 1B [n=100] – secondary cardiovascular prevention). Group 2 received a titration-free statin regimen in fixed doses (group 2A [n=50] – primary cardiovascular prevention; group 2B [n=100] – secondary cardiovascular prevention). Patients were prescribed atorvastatin (10-80 mg/day) or rosuvastatin (10-40 mg/day). Group 1 patients had visits to the doctor after 1, 3, 6 and 12 months from the start of statin use, group 2 patients – after 3 and 12 months. Laboratory studies included determination of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c). Changes in lipid levels, the frequency of reaching target TC and LDL-c levels were evaluated.Results. Titration-free statins treatment (Group 2) allowed reaching the target levels of TC and LDL-c after 12 months in 73.9% and 56.3% of patients, respectively. Significant changes were found after 3 months visit. In Group 1, these indicators were slightly lower (56.8% and 53.4%, respectively), while significant changes in the LDL-c level were found later than in Group 2. More than 50% of patients taking statins for secondary prevention, reached the target level of TC and LDL-c. At the same time, when using titration-free statin therapy, such results were recorded after 3 months. Patients taking statins for primary prevention achieved the TC target level in 95.7% of cases (subgroup 2A). The frequency of reaching the LDL-c target level in the subgroups of primary prevention was slightly lower.Conclusion. The use of a titration-free statin treatment regimen allowed to more effectively control of TC and LDL-c levels in patients with high and very high cardiovascular risk compared to the traditional statin therapy regimen, and to achieve target lipid levels earlier.

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Topical 15% Resorcinol Is Associated with High Treatment Satisfaction in Patients with Mild to Moderate Hidradenitis Suppurativa

Dermatology ◽

10.1159/000515450 ◽

2021 ◽

pp. 1-4

Author(s):

Alexandre Docampo-Simón ◽

Iván Beltrá-Picó ◽

María José Sánchez-Pujol ◽

Rosa Fuster-Ruiz-de-Apodaca ◽

Juan Selva-Otaolaurruchi ◽

...

Keyword(s):

Side Effects ◽

Treatment Satisfaction ◽

Hidradenitis Suppurativa ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Satisfaction Questionnaire ◽

Global Satisfaction ◽

The Mean ◽

High Treatment

Background: Topical 15% resorcinol is commonly used in clinical practice for the treatment of nodules and abscesses in patients with hidradenitis suppurativa (HS). It has been shown to be clinically effective in some small studies, but data on satisfaction perceived by patients are lacking. The Treatment Satisfaction Questionnaire for Medication (TSQM) version 1.4 is a validated measure of patient satisfaction, evaluating four domains: effectiveness, side effects, convenience, and global satisfaction. Our objective was to obtain data from HS patients regarding resorcinol treatment satisfaction and its relationship with clinical and epidemiological variables. Methods: We performed a cross-sectional study providing TSQM version 1.4 questionnaires to HS patients who had been prescribed topical resorcinol during the previous 24 months. Results: Ninety-two patients answered the questionnaire. Eighty-five out of 92 (92.4%) were Hurley II and 7 Hurley I. The mean total score was 317.5 out of 400 (71.0 points in effectiveness, 93.6 in side effects, 79.3 in convenience, and 73.2 in global satisfaction). Total score was higher in men than in women (329.7 vs. 311.6, p = 0.026) and higher scores on convenience were seen in patients who were not overweight or obese (86.9 vs. 77.1, p = 0.016). Most patients (65, 70.6%) denied having any side effect. 78 (84.8%) of the patients would recommend the treatment. Conclusion: The results of this study suggest that HS patients treated with resorcinol 15% are very satisfied with this treatment.

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Adiposity and insulin resistance mediate the inverse association between legume intake and blood pressure in individuals: a cross-sectional analysis in secondary cardiovascular prevention

British Journal Of Nutrition ◽

10.1017/s0007114521005018 ◽

2021 ◽

pp. 1-27

Author(s):

Alinne Paula de Almeida ◽

Leidjaira Lopes Juvanhol ◽

Ângela Cristine Bersch-Ferreira ◽

Camila Ragne Torreglosa ◽

Aline Marcadenti ◽

...

Keyword(s):

Insulin Resistance ◽

Blood Pressure ◽

Cardiovascular Prevention ◽

Food Group ◽

Inverse Association ◽

Cross Sectional ◽

Beneficial Effects ◽

Tyg Index ◽

Negative Effect ◽

Secondary Cardiovascular Prevention

Abstract The legume food group has important bioactive components and amino acids that have beneficial effects on blood pressure. This study aimed to evaluate the association between legume intake and blood pressure, as well as the mediating role of cardiometabolic risk factors in patients in secondary cardiovascular prevention. Sociodemographic, anthropometric, clinical, and food intake data were collected from the baseline of the multicenter study Brazilian Cardioprotective Nutritional Program Trial - BALANCE (RCT: NCT01620398). The relationships between variables were explored through path analysis. In total, 2,247 individuals with a median age of 63.0 (45 - 91) years, 58.8% (n= 1,321) male, and 96.5% (n= 2,168) with diagnosis of hypertension were included. Negative associations were observed between histidine intake and systolic blood pressure (SBP) (SC= −0.057; p= 0.012), and between legume intake and body mass index (BMI) (SC= −0.061; p= 0.006). BMI was positively associated with TyG index (SC= 0.173; p< 0.001), SBP (SC= 0.144; p< 0.001) and diastolic blood pressure (DBP) (SC= 0.177; p< 0.001), and TyG index was positively associated with DBP (SC= 0.079; p= 0.001). A negative indirect effect was observed between the intake of legumes, SBP and DBP, mediated by BMI (SC = −0.009; p = 0.011; SC = −0.011; p = 0.010, respectively). In addition, an indirect negative effect was found between the intake of legumes and the DBP, mediated simultaneously by BMI and TyG index (SC = −0.001; p = 0.037). In conclusion, legume intake presented a negative indirect association with blood pressure, mediated by insulin resistance (TyG) and adiposity (BMI) in individuals of secondary care in cardiology.

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P5236An observational, international, cohort study to evaluate the satisfaction and preferences of patients in preventive treatment of secondary cardiovascular events with a cardiovascular polypill

European Heart Journal ◽

10.1093/eurheartj/ehz746.0209 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

J Cosin Sales ◽

J M Murcia Zaragoza ◽

H O Pereyra Rico ◽

F De La Guia Galipienso

Keyword(s):

Secondary Prevention ◽

Ad Hoc ◽

Disease Patient ◽

Economic Cost ◽

Preventive Treatment ◽

Coronary Event ◽

Current Treatment ◽

Cross Sectional ◽

Patient’S Satisfaction ◽

Single Pill

Abstract Background/Introduction The term polypill was first described, as a combination of several drugs at fixed doses in a single pill with the aim of facilitating the taking of medication to patients, increasing adherence to treatment, as well as reducing the economic cost associated with this disease. Patient satisfaction may be associated with improved clinical outcomes. To date there are no data about the satisfaction and preferences of patients with this cardiovascular polypill as a treatment for the secondary prevention of cardiovascular disease (CVD) in Spain and Belgium. Purpose To evaluate the satisfaction of patients treated with the cardiovascular polypill containing acetylsalicylic acid (ASA), atorvastatin and ramipril compared with patients treated with ASA, a statin and an ACE inhibitor separately for the secondary prevention of CVD. Adherence and preference of patients treated with the cardiovascular polypill and with the monocomponents separately were also evaluated and compared. Methods An observational, cross-sectional, cohort, multicentre study in Spain and Belgium, was carried out. All patients included were stable regarding CVD (>1 year from acute coronary event). Patients were divided into two cohorts: those treated with the cardiovascular polypill and patients treated with the monocomponents separately for a minimum of 3 months. Patients from both cohorts were paired based on gender and age (± 5 years). Data on satisfaction was collected by the TSQM-9, adherence by the Morisky-Green test and ad hoc questions were asked to determine patient preferences. Results In total 314 patients were included in Spain and 21 in Belgium who were in current treatment for the secondary prevention of CVD with a combination that included ASA, a statin and an ACEI, or who were treated with the cardiovascular polypill at least in the last 3 months. Patients with the polypill had a higher level of satisfaction with the treatment received than patients treated with the monocomponents separately (p<0.0001). In total 72.8% of patients treated with the monocomponents separately declared that they would change to the polypill. And 65.2% of patients in Spain also stated that, they would pay additional cost for the polypill to change to a single capsule. Patients treated with the polypill (57.7%) had a significantly higher adherence than patients treated with the monocomponents separately (41.1%) (p=0.0027). Conclusions The validation of patient's satisfaction and preferences is crucial for the evaluation of the cardiovascular polypill versus its monocomponents separately. Patients treated with the polypill showed a significant higher degree of satisfaction and better adherence, whereas most patients receiving the monocomponents declared that they would prefer the polypill. Acknowledgement/Funding The study was conducted with a full grant from Ferrer Internacional S.A.

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Cross-cultural validation of the Retinopathy Treatment Satisfaction Questionnaire status version (RetTSQs) in Serbian community: a cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2019-031236 ◽

2020 ◽

Vol 10 (1) ◽

pp. e031236

Author(s):

Jelena Karadzic ◽

Milenko Stojkovic ◽

Dijana Risimic ◽

Marija Bozic ◽

Nikola Slijepcevic ◽

...

Keyword(s):

Treatment Satisfaction ◽

Tertiary Care ◽

Cross Sectional Study ◽

Cross Cultural ◽

Diabetic Patients ◽

Initial Contact ◽

Sectional Study ◽

Cross Sectional ◽

Satisfaction Questionnaire ◽

Serbian Version

ObjectiveCross-cultural translation and validation of the Serbian version of the Retinopathy Treatment Satisfaction Questionnaire status version (RetTSQs).DesignCross-sectional study.SettingsThe study was conducted between June 2017 and June 2018 at tertiary care centre in Serbia, Belgrade.ParticipantsA total of 101 patients with diabetic retinopathy (DR) were included. All subjects were evaluated in two consecutive visits, the first during the initial contact to the clinic, while the second 4–6 weeks later.Main outcome measuresValidation of Serbian version of the RetTSQs was the major outcome.ResultsCronbach alpha coefficient of the subscales ranged from 0.783 (positive scale) to 0.811 (negative scale) and for all domains it was excellent at α=0.829. The intraclass correlation coefficient was greater than 0.8 for all of the subscales. Univariable analyses revealed that age, gender, education, marital status and working status did not affect the RetTSQ scores, whereas participants with non-proliferative DR reported signiﬁcantly higher treatment satisfaction (TS) than those with proliferative retinopathy (p=0.001). The group who received laser treatment scored signiﬁcantly lower than the group without it (p=0.004) regardless of type of performed laser. Positive and statistically significant correlations were found between the RetTSQ score and most of the National Eye Institute Visual Functioning Questionnaire-25 subscales.ConclusionTranslated Serbian adaptation of the RetTSQs showed adequate psychometric characteristics as an acceptable, reliable and valid questionnaire. It was well understood by Serbian diabetic patients and it promises to be used in daily clinical work as an instrument for the assessment of TS for patients with DR.

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11 / Risk factors for bone loss and peri-implantitis, and a survey on patients satisfaction. A cross sectional study

10.26226/morressier.5ad875ec2afeeb00097a3bd7 ◽

2018 ◽

Author(s):

Phoebus Tsaousoglou

Keyword(s):

Risk Factors ◽

Bone Loss ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Patients Satisfaction

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Linguistic Validation of the Endometriosis Treatment Satisfaction Questionnaire (ETSQ) in 3 Languages for Endometriosis Patients

Value in Health ◽

10.1016/j.jval.2018.04.1533 ◽

2018 ◽

Vol 21 ◽

pp. S226-S227

Author(s):

B Brandt ◽

AM Soliman ◽

T Poepsel ◽

ES Yohe Moore ◽

E McCullough ◽

...

Keyword(s):

Treatment Satisfaction ◽

Linguistic Validation ◽

Satisfaction Questionnaire

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Incidence, Characteristics and Outcomes of Large Vessel Stroke in COVID-19 Cohort: An International Multicenter Study

Neurosurgery ◽

10.1093/neuros/nyab111 ◽

2021 ◽

Author(s):

Priyank Khandelwal ◽

Fawaz Al-Mufti ◽

Ambooj Tiwari ◽

Amit Singla ◽

Adam A Dmytriw ◽

...

Keyword(s):

African Americans ◽

Multicenter Study ◽

Large Vessel ◽

Vessel Occlusion ◽

Cross Sectional ◽

Younger Age ◽

The Us ◽

The Usa ◽

Rehabilitation Facilities ◽

International Multicenter Study

Abstract BACKGROUND While there are reports of acute ischemic stroke (AIS) in coronavirus disease 2019 (COVID-19) patients, the overall incidence of AIS and clinical characteristics of large vessel occlusion (LVO) remain unclear. OBJECTIVE To attempt to establish incidence of AIS in COVID-19 patients in an international cohort. METHODS A cross-sectional retrospective, multicenter study of consecutive patients admitted with AIS and COVID-19 was undertaken from March 1 to May 1, 2020 at 12 stroke centers from 4 countries. Out of those 12 centers, 9 centers admitted all types of strokes and data from those were used to calculate the incidence rate of AIS. Three centers exclusively transferred LVO stroke (LVOs) patients and were excluded only for the purposes of calculating the incidence of AIS. Detailed data were collected on consecutive LVOs in hospitalized patients who underwent mechanical thrombectomy (MT) across all 12 centers. RESULTS Out of 6698 COVID-19 patients admitted to 9 stroke centers, the incidence of stroke was found to be 1.3% (interquartile range [IQR] 0.75%-1.7%). The median age of LVOs patients was 51 yr (IQR 50-75 yr), and in the US centers, African Americans comprised 28% of patients. Out of 66 LVOs, 10 patients (16%) were less than 50 yr of age. Among the LVOs eligible for MT, the average time from symptom onset to presentation was 558 min (IQR 82-695 min). A total of 21 (50%) patients were either discharged to home or discharged to acute rehabilitation facilities. CONCLUSION LVO was predominant in patients with AIS and COVID-19 across 2 continents, occurring at a significantly younger age and affecting African Americans disproportionately in the USA.

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Prevalence of SARS-CoV-2 Infection at the University of Barcelona during the Third COVID-19 Pandemic Wave in Spain

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18126526 ◽

2021 ◽

Vol 18 (12) ◽

pp. 6526

Author(s):

Sebastián Videla ◽

Aurema Otero ◽

Sara Martí ◽

M. Ángeles Domínguez ◽

Nuria Fabrellas ◽

...

Keyword(s):

Ad Hoc ◽

Venous Blood ◽

Herd Immunity ◽

Cross Sectional Study ◽

Rt Pcr ◽

Igg Antibody ◽

Cross Sectional ◽

Total Prevalence ◽

The University ◽

The Impact

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic started in December 2019 and still is a major global health challenge. Lockdown measures and social distancing sparked a global shift towards online learning, which deeply impacted universities’ daily life, and the University of Barcelona (UB) was not an exception. Accordingly, we aimed to determine the impact of the SARS-CoV-2 pandemic at the UB. To that end, we performed a cross-sectional study on a sample of 2784 UB members (n = 52,529). Participants answered a brief, ad hoc, online epidemiological questionnaire and provided a nasal swab for reverse transcription polymerase chain reaction (RT-PCR) SARS-CoV-2 analysis and a venous blood sample for SARS-CoV-2 IgG antibody assay. Total prevalence of SARS-CoV-2 infection (positive RT-PCR or positive IgG) was 14.9% (95%CI 13.3 to 17.0%). Forty-four participants (1.6%, 95%CI: 1.2–2.1%) were positive for SARS-CoV-2 RT-PCR. IgG against SARS-CoV-2 was observed in 12.8% (95%CI: 11.6–14.1%) of participants. Overall, while waiting for population vaccination and/or increased herd immunity, we should concentrate on identifying and isolating new cases and their contacts.

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