Squamous cell versus adenocarcinoma of the esophagus

2013 ◽  
pp. 212-222
Author(s):  
Christina L Roland
Keyword(s):  
Squamous Cell ◽  
Adenocarcinoma Of The Esophagus ◽  
Cell Versus

scholarly journals Insulin-like Growth Factor Receptor 1 (IGF1R) Gene Copy Number Is Associated With Survival in Operable Non–Small-Cell Lung Cancer: A Comparison Between IGF1R Fluorescent In Situ Hybridization, Protein Expression, and mRNA Expression

2010 ◽  
Vol 28 (13) ◽  
pp. 2174-2180 ◽  
Author(s):  
Rafal Dziadziuszko ◽  
Daniel T. Merrick ◽  
Samir E. Witta ◽  
Adelita D. Mendoza ◽  
Barbara Szostakiewicz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Protein Expression ◽  
Squamous Cell ◽  
Copy Number ◽  
Gene Copy Number ◽  
Growth Factor Receptor ◽  
Gene Copy ◽  
Cell Versus

PurposeThe purpose of this study was to characterize insulin-like growth factor-1 receptor (IGF1R) protein expression, mRNA expression, and gene copy number in surgically resected non–small-cell lung cancers (NSCLC) in relation to epidermal growth factor receptor (EGFR) protein expression, patient characteristics, and prognosis.Patients and MethodsOne hundred eighty-nine patients with NSCLC who underwent curative pulmonary resection were studied (median follow-up, 5.3 years). IGF1R protein expression was evaluated by immunohistochemistry (IHC) with two anti-IGF1R antibodies (n = 179). EGFR protein expression was assessed with PharmDx kit. IGF1R gene expression was evaluated using quantitative reverse transcription polymerase chain reaction (qRT-PCR) from 114 corresponding fresh-frozen samples. IGF1R gene copy number was assessed by fluorescent in situ hybridization using customized probes (n = 181).ResultsIGF1R IHC score was higher in squamous cell carcinomas versus other histologies (P < .001) and associated with stage (P = .03) but not survival (P = .46). IGF1R and EGFR protein expression showed significant correlation (r = 0.30; P < .001). IGF1R gene expression by qRT-PCR was higher in squamous cell versus other histologies (P = .006) and did not associate with other clinical features nor survival (P = .73). Employing criteria previously established for EGFR copy number, patients with IGF1R amplification/high polysomy (n = 48; 27%) had 3-year survival of 58%, patients with low polysomy (n = 87; 48%) had 3-year survival of 47% and patients with trisomy/disomy (n = 46; 25%) had 3-year survival of 35%, respectively (P = .024). Prognostic value of high IGF1R gene copy number was confirmed in multivariate analysis.ConclusionIGF1R protein expression is higher in squamous cell versus other histologies and correlates with EGFR expression. IGF1R protein and gene expression does not associate with survival, whereas high IGF1R gene copy number harbors positive prognostic value.

VEGF-C Expression in Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus

2007 ◽  
Vol 31 (9) ◽  
pp. 1768-1772 ◽  
Author(s):  
Christian Möbius ◽  
José Freire ◽  
Ingrid Becker ◽  
Marcus Feith ◽  
Björn L. D. M. Brücher ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adenocarcinoma Of The Esophagus

Characteristics of growth factors levels in squamous cell carcinoma and adenocarcinoma of the esophagus.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e15511-e15511
Author(s):  
Elena Mikhaylovna Frantsiyants ◽  
Oleg Ivanovich Kit ◽  
Evgeniy N. Kolesnikov ◽  
Yulia A. Pogorelova ◽  
Natalia D. Cheryarina ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factors ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adenocarcinoma Of The Esophagus

Sex steroids, sex-binding globulin, and prolactin in tissues of adenocarcinoma and esophageal squamous cell carcinoma.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 79-79
Author(s):  
Oleg Ivanovich Kit ◽  
Elena Mikhaylovna Frantsiyants ◽  
Valeria Bandovkina ◽  
Evgeniy N. Kolesnikov ◽  
Roman E. Myagkov ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Sex Steroids ◽  
Tumor Biology ◽  
Free Testosterone ◽  
Adenocarcinoma Of The Esophagus ◽  
Esophageal Tumors ◽  
Hormonal Content ◽  
Resection Line

79 Background: Some researchers suggest that squamous cell carcinoma (SCC) and adenocarcinoma of the esophagus (ACE) are characterized by different pathogenesis, epidemiology and tumor biology, and therefore require different therapeutic strategies. The purpose of the study was to analyze local hormonal status in malignant esophageal tumors and surrounding tissues depending on the histogenesis. Methods: Levels of sex steroids – free testosterone (fT), estrone (E1), estriol (E3), prolactin (PRL) and sex steroid-binding globulin (SSBG) were studied by the standard ELISA methods in tumor tissue, perifocal zone and resection line of 39 patients aged 58-74 years: 27 SCC, 12 ACE, stage II, G2, pT1-2N1M0. Results: Differences were found in local hormonal content in all studied samples dependint on the tumor histotype. Levels of SSBG, PRL and E1 in ACE were higher than in SCC by 1.3, 3.3 and 1.4 times, respectively, while fT concentration was 2.4 times lower. Levels of PRL, E1 and E3 in perifocal zone of ACE compared to SCC were higher by 2.8, 3.3 and 3.1 times, and fT was 1.3 times lower. Resection line of ACE differed from that of SCC by higher tissue concentrations of SSBG – by 1.3 times, PRL – by 1.5 times, E1 – by 1.3 times, E3 – by 1.7 times and a lower level of fT – by 1.5 times. As a result, fT/E1 ratios in ACE and surrounding tissues were on average 3 times lower than in corresponding SCC samples. Conclusions: Levels of hormones in esophageal tumors and surrounding tissues depend on the histogenesis. ACE was characterized by hyperestrogenism in esophageal tissues along with a high prolactin concentration, while SCC – by hyperandrogenism with a low PRL level. Different pathogenesis of SCC and ACE was demonstrated by the fact that hormonal profile in both tumor and resection line depended on the tumor histology.

Preoperative Chemoradiotherapy for Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus

CHEST Journal ◽  
2002 ◽  
Vol 122 (4) ◽  
pp. 1302-1308 ◽  
Author(s):  
Ferdinando De Vita ◽  
Natale Di Martino ◽  
Michele Orditura ◽  
Angelo Cosenza ◽  
Gennaro Galizia ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Preoperative Chemoradiotherapy ◽  
Adenocarcinoma Of The Esophagus

scholarly journals High frequency of simultaneous loss of p16 and p16β gene expression in squamous cell carcinoma of the esophagus but not in adenocarcinoma of the esophagus or stomach

Oncogene ◽  
1997 ◽  
Vol 15 (12) ◽  
pp. 1481-1488 ◽  
Author(s):  
Kazuhiko Hayashi ◽  
Ralf Metzger ◽  
Dennis Salonga ◽  
Kathleen Danenberg ◽  
Lawrence P Leichman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
High Frequency ◽  
Carcinoma Of The Esophagus ◽  
Adenocarcinoma Of The Esophagus ◽  
Simultaneous Loss

Prognostic differences between early squamous-cell and adenocarcinoma of the esophagus

1997 ◽  
Vol 10 (3) ◽  
pp. 179-184 ◽  
Author(s):  
A. H. Hölscher ◽  
E. Bollschweiler ◽  
W. Schröder ◽  
C. Gutschow ◽  
J. Siewert
Keyword(s):  
Squamous Cell ◽  
Adenocarcinoma Of The Esophagus
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