Sex steroids, sex-binding globulin, and prolactin in tissues of adenocarcinoma and esophageal squamous cell carcinoma.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 79-79
Author(s):  
Oleg Ivanovich Kit ◽  
Elena Mikhaylovna Frantsiyants ◽  
Valeria Bandovkina ◽  
Evgeniy N. Kolesnikov ◽  
Roman E. Myagkov ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Sex Steroids ◽  
Tumor Biology ◽  
Free Testosterone ◽  
Adenocarcinoma Of The Esophagus ◽  
Esophageal Tumors ◽  
Hormonal Content ◽  
Resection Line

79 Background: Some researchers suggest that squamous cell carcinoma (SCC) and adenocarcinoma of the esophagus (ACE) are characterized by different pathogenesis, epidemiology and tumor biology, and therefore require different therapeutic strategies. The purpose of the study was to analyze local hormonal status in malignant esophageal tumors and surrounding tissues depending on the histogenesis. Methods: Levels of sex steroids – free testosterone (fT), estrone (E1), estriol (E3), prolactin (PRL) and sex steroid-binding globulin (SSBG) were studied by the standard ELISA methods in tumor tissue, perifocal zone and resection line of 39 patients aged 58-74 years: 27 SCC, 12 ACE, stage II, G2, pT1-2N1M0. Results: Differences were found in local hormonal content in all studied samples dependint on the tumor histotype. Levels of SSBG, PRL and E1 in ACE were higher than in SCC by 1.3, 3.3 and 1.4 times, respectively, while fT concentration was 2.4 times lower. Levels of PRL, E1 and E3 in perifocal zone of ACE compared to SCC were higher by 2.8, 3.3 and 3.1 times, and fT was 1.3 times lower. Resection line of ACE differed from that of SCC by higher tissue concentrations of SSBG – by 1.3 times, PRL – by 1.5 times, E1 – by 1.3 times, E3 – by 1.7 times and a lower level of fT – by 1.5 times. As a result, fT/E1 ratios in ACE and surrounding tissues were on average 3 times lower than in corresponding SCC samples. Conclusions: Levels of hormones in esophageal tumors and surrounding tissues depend on the histogenesis. ACE was characterized by hyperestrogenism in esophageal tissues along with a high prolactin concentration, while SCC – by hyperandrogenism with a low PRL level. Different pathogenesis of SCC and ACE was demonstrated by the fact that hormonal profile in both tumor and resection line depended on the tumor histology.

VEGF-C Expression in Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus

2007 ◽  
Vol 31 (9) ◽  
pp. 1768-1772 ◽  
Author(s):  
Christian Möbius ◽  
José Freire ◽  
Ingrid Becker ◽  
Marcus Feith ◽  
Björn L. D. M. Brücher ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adenocarcinoma Of The Esophagus

Characteristics of growth factors levels in squamous cell carcinoma and adenocarcinoma of the esophagus.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e15511-e15511
Author(s):  
Elena Mikhaylovna Frantsiyants ◽  
Oleg Ivanovich Kit ◽  
Evgeniy N. Kolesnikov ◽  
Yulia A. Pogorelova ◽  
Natalia D. Cheryarina ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factors ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adenocarcinoma Of The Esophagus

Personalized Medicine Approach for an Exceptional Response to Multiple-recurrent and Metastatic HER2-positive Oropharyngeal Squamous Cell Carcinoma

2017 ◽  
Vol 126 (4) ◽  
pp. 334-339 ◽  
Author(s):  
Nolan B. Seim ◽  
Stephen Y. Kang ◽  
Milan Bhandari ◽  
Riley G. Jones ◽  
Theodoros N. Teknos
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Chemotherapeutic Agent ◽  
Tumor Biology ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Her2 Positive ◽  
Recurrent Squamous Cell Carcinoma ◽  
Unexpected Outcomes

Introduction: Advanced stage squamous cell carcinoma of the head and neck carries an overall poor prognosis, and survivorship gains have remained relatively stagnant compared to other malignancies due to its complex tumor biology and lack of proven effective targeting agents. Methods: We present a case of an exceptional responder to molecular-targeted therapy for metastatic oropharyngeal squamous cell carcinoma using a chemotherapeutic agent FDA approved for breast cancer and targeting the HER2/Neu receptor in order to discuss the larger clinical implications. Results: The National Cancer Institute (NCI) has recently instituted the Exceptional Responders Initiative in order to identify such patients with unexpected outcomes in order to expedite the development of additional targeted therapies. This case illustrates the opportunity for cure using targeted oncogene identification in a scenario of recurrent squamous cell carcinoma with lung metastasis typically considered fatal. Conclusions: Molecular tumor analysis is an infrequently utilized tool in head and neck squamous cell carcinoma; however, as understanding of biologic mechanisms improves, additional molecular targets will become available and expand treatment opportunities such as HER2/Neu targeting. The Exceptional Responders Initiative is a unique strategy with potential to expedite progress.

Preoperative Chemoradiotherapy for Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus

CHEST Journal ◽  
2002 ◽  
Vol 122 (4) ◽  
pp. 1302-1308 ◽  
Author(s):  
Ferdinando De Vita ◽  
Natale Di Martino ◽  
Michele Orditura ◽  
Angelo Cosenza ◽  
Gennaro Galizia ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Preoperative Chemoradiotherapy ◽  
Adenocarcinoma Of The Esophagus

scholarly journals Immunosuppressive phenotype of esophagus tumors stroma

2020 ◽  
Author(s):  
Alexei Gratchev ◽  
Olga V. Kovaleva ◽  
Madina A. Rashidova ◽  
Daria V. Samoilova ◽  
Valeria V. Mochalnikova
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Data ◽  
Immunohistochemical Analysis ◽  
Good Prognosis ◽  
Disease Stage ◽  
Rank Test ◽  
Esophageal Tumors

Abstract Background Tumor associated macrophages and tumor infiltrating lymphocytes contribute significantly to the development of immunosuppressive properties of tumor. In this study we performed immunohistochemical analysis of immune cells of esophageal tumors stroma. Methods Paraffin‑embedded tissue specimens from 48 esophageal squamous cell carcinoma patients were retrospectively collected for immunohistochemical analysis of stromal cells. For staining of macrophages, CD68, CD163, CD206, PU.1 and iNOS were used. For T-cells detection CD8, CD3, FOXP3 were used. As well we performed staining for PD-L1 that can be expressed on tumor associated macrophagesand tumor cells. Clinicopathological and survival data were collected and analyzed using the χ2 and Fisher exact tests, Kaplan–Meier curves, and the log‑rank test. The correlation analysis was performed with Spearman correlation coefficient. Results The level of CD206 expression was associated with histological grade (p = 0.034), FOXP3 expression was associated with sex and age (p = 0.041, p = 0.003 respectively) and iNOS expression was associated with the disease stage (p = 0.044). In addition, FOXP3 and CD163 appeared to be markers of good prognosis (HR = 0.5407, p = 0.0462; HR = 0.4447, p = 0.0456 respectively). Significant association between PU.1 + and CD68 + macrophages (r = 0.752; P = 0.000) and between PU.1 + and CD163 + macrophages (r = 0.585; P = 0.000) was established, positive association between PU.1 and CD206 expression was also observed (r = 0.424; P = 0.001). Conclusions Large amounts of CD163 + macrophages and FOXP3+ Т-cells appear to be markers of good prognosis of esophageal squamous cell carcinoma. The number of PU.1 + macrophages strongly correlate with the number of CD68 + macrophages therefore usage of PU.1 as a potential macrophage marker can be recommended esophageal tumors.

Gender differences in hormonal statuses of patients with esophageal squamous cell carcinoma.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 85-85
Author(s):  
Evgeniy N. Kolesnikov ◽  
Oleg Ivanovich Kit ◽  
Elena Mikhaylovna Frantsiyants ◽  
Valeria Bandovkina ◽  
Margarita Kozlova ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Anterior Pituitary ◽  
Free Testosterone ◽  
Pituitary Hormones ◽  
Blood Levels ◽  
Anterior Pituitary Hormones ◽  
Local Saturation

85 Background: Esophageal squamous cell carcinoma (ESCC) is 4-8 times more frequent in men than in women, with poorer prognosis. The purpose of the study was to analyze systemic and local hormonal statuses in patients with ESCC in dependence on their gender. Methods: The study included 34 ESCC (G2, рT1-2N0-1M0) patients: 21 men and 13 women. 11 men (52.4%) had lymph node metastases. Levels of sex steroids – total (T) and free (fT) testosterone, progesterone (P4), estradiol (E2), estrone (E1), prolactin (PRL), LH, FSH and sex steroid-binding globulin (SSBG) – were studied in the peripheral blood, tumor and resection line by the standard RIA and ELISA methods. Results: Men showed a decrease in the blood T concentration by 1.4 times, P4 by 2 times, and E2 increase by 2.5 times, while women showed 1.3 times increase in T and 2 times decrease in P4. Metastases in men were accompanied by an increase in blood levels of anterior pituitary hormones: PRL by 2.5 times, LH by 2.3 times and FSH by 2.2 times compared to patients without metastases. Analysis of the local saturation with sex hormones in visually unchanged esophageal tissues of ESCC patients did not reveal any significant gender difference. However, women were characterized by a higher content of anterior pituitary hormones, PRL, LH and FSH, in esophageal tissues compared to men. Men with metastases showed local hyper-androgenization of tumor and surrounding tissues, as the fT to E1 ratio was increased. Conclusions: The results confirmed the data on T-stimulation of malignant growth in the esophagus and the possible protective effect of estrogens. The free testosterone to estrogens ratio in esophageal tissues can probably serve as one of prognostic factors for the disease course.

Plasminogen and PAI-1 activators in tissues of adenocarcinoma and squamous cell carcinoma of the esophagus

2016 ◽  
Vol 21 (4) ◽  
pp. 201-206
Author(s):  
O. I Kit ◽  
E. N Kolesnikov ◽  
E. M Frantsiyants ◽  
Larisa S. Kozlova ◽  
Yu. A Pogorelova ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Sharp Increase ◽  
Carcinoma Of The Esophagus ◽  
Tumor Tissues ◽  
Activation System ◽  
Resection Line ◽  
Pai 1

Aim. The purpose of the study was to perform the comparative analysis of the components ofplasminogen activation system - uPA and tPA, and their inhibitor PAI-1 in tissues of esophageal adenocarcinoma (EA) and squamous cell carcinoma (SCC). Tissues of removed primary both EA (n=9, st II, G2, T2-3N0-1M0-1) and SCC (n=27, st II, G2, T2-3N0-1M0-1) were studied by ELISA. Results. EA and SCC tumor tissues showed a sharp increase in both uPA forms and in PAI-1, in EA tissue there was noted a decrease in all tPA and in SCC tissue there was seen a decline in tPA-act, compared to the resection line (RL). Perifocal zone of EA showed diminished uPA-Ag, all tPA, increased uPA-act and all PAI-1, compared to the RL. uPA and PAI-1 play an important role in progression of both SCC and EA. The role of tPA requires the further studying, but in SCC perifocal zone its impact may be rather harmful than protective. tPA-Ag/tPA-act balance was increased in SCC tissue only, while in other samples it was decreased (p

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