Characteristics of growth factors levels in squamous cell carcinoma and adenocarcinoma of the esophagus.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e15511-e15511
Author(s):  
Elena Mikhaylovna Frantsiyants ◽  
Oleg Ivanovich Kit ◽  
Evgeniy N. Kolesnikov ◽  
Yulia A. Pogorelova ◽  
Natalia D. Cheryarina ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factors ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adenocarcinoma Of The Esophagus

Phase II Trial of Docetaxel, Cisplatin, Fluorouracil, and Leucovorin as Induction for Squamous Cell Carcinoma of the Head and Neck

1999 ◽  
Vol 17 (11) ◽  
pp. 3503-3511 ◽  
Author(s):  
A. D. Colevas ◽  
C. M. Norris ◽  
R. B. Tishler ◽  
M. P. Fried ◽  
H. I. Gomolin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factors ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Performance Status ◽  
Eastern Cooperative Oncology Group ◽  
Response Rates ◽  
Clinical Response Rate ◽  
Primary Tumor Site

PURPOSE: To evaluate the toxicity and efficacy of a 4-day regimen of docetaxel, cisplatin, fluorouracil, and leucovorin (TPFL4) in patients with locoregionally advanced squamous cell carcinoma of the head and neck (SCCHN). PATIENTS AND METHODS: Thirty previously untreated patients with stage III or IV SCCHN and Eastern Cooperative Oncology Group functional status of 2 or less were treated with TPFL4. Postchemotherapy support included prophylactic growth factors and antibiotics. Patients who achieved a complete response (CR) or partial response (PR) to three cycles of TPFL4 received definitive twice-daily radiation therapy. The primary end points were toxicity and response to TPFL4. RESULTS: Eighty-five cycles were administered to 30 patients. The major acute toxicities to TPFL4 were mucositis and nausea. One patient died of neutropenic sepsis during therapy. Additional major toxicities were neutropenia, anorexia, nephropathy, neuropathy, and diarrhea. Fourteen percent of all cycles were associated with hospitalization for toxicity. The overall clinical response rate to TPFL4 was 93%, with 63% CRs and 30% PRs. Primary tumor site clinical and pathologic response rates were 93% and 68%, respectively. CONCLUSION: TPFL4 has an acceptable toxicity profile in good-performance-status patients. Modification of the 5-day TPFL regimen (TPFL5: shorter chemotherapy infusion time, earlier intervention with growth factors and antibiotics) led to fewer episodes of febrile neutropenia and hospitalization. Response rates to TPFL justify further evaluation of combinations of these agents in the context of formal clinical trials.

VEGF-C Expression in Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus

2007 ◽  
Vol 31 (9) ◽  
pp. 1768-1772 ◽  
Author(s):  
Christian Möbius ◽  
José Freire ◽  
Ingrid Becker ◽  
Marcus Feith ◽  
Björn L. D. M. Brücher ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adenocarcinoma Of The Esophagus

Sex steroids, sex-binding globulin, and prolactin in tissues of adenocarcinoma and esophageal squamous cell carcinoma.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 79-79
Author(s):  
Oleg Ivanovich Kit ◽  
Elena Mikhaylovna Frantsiyants ◽  
Valeria Bandovkina ◽  
Evgeniy N. Kolesnikov ◽  
Roman E. Myagkov ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Sex Steroids ◽  
Tumor Biology ◽  
Free Testosterone ◽  
Adenocarcinoma Of The Esophagus ◽  
Esophageal Tumors ◽  
Hormonal Content ◽  
Resection Line

79 Background: Some researchers suggest that squamous cell carcinoma (SCC) and adenocarcinoma of the esophagus (ACE) are characterized by different pathogenesis, epidemiology and tumor biology, and therefore require different therapeutic strategies. The purpose of the study was to analyze local hormonal status in malignant esophageal tumors and surrounding tissues depending on the histogenesis. Methods: Levels of sex steroids – free testosterone (fT), estrone (E1), estriol (E3), prolactin (PRL) and sex steroid-binding globulin (SSBG) were studied by the standard ELISA methods in tumor tissue, perifocal zone and resection line of 39 patients aged 58-74 years: 27 SCC, 12 ACE, stage II, G2, pT1-2N1M0. Results: Differences were found in local hormonal content in all studied samples dependint on the tumor histotype. Levels of SSBG, PRL and E1 in ACE were higher than in SCC by 1.3, 3.3 and 1.4 times, respectively, while fT concentration was 2.4 times lower. Levels of PRL, E1 and E3 in perifocal zone of ACE compared to SCC were higher by 2.8, 3.3 and 3.1 times, and fT was 1.3 times lower. Resection line of ACE differed from that of SCC by higher tissue concentrations of SSBG – by 1.3 times, PRL – by 1.5 times, E1 – by 1.3 times, E3 – by 1.7 times and a lower level of fT – by 1.5 times. As a result, fT/E1 ratios in ACE and surrounding tissues were on average 3 times lower than in corresponding SCC samples. Conclusions: Levels of hormones in esophageal tumors and surrounding tissues depend on the histogenesis. ACE was characterized by hyperestrogenism in esophageal tissues along with a high prolactin concentration, while SCC – by hyperandrogenism with a low PRL level. Different pathogenesis of SCC and ACE was demonstrated by the fact that hormonal profile in both tumor and resection line depended on the tumor histology.

scholarly journals Prognostic value of vascular endothelial growth factors A and C in oral squamous cell carcinoma

2014 ◽  
Vol 43 (7) ◽  
pp. 514-520 ◽  
Author(s):  
Mizuki Yanase ◽  
Koroku Kato ◽  
Kunio Yoshizawa ◽  
Natsuyo Noguchi ◽  
Hiroko Kitahara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Vascular Endothelial Growth Factors ◽  
Vascular Endothelial ◽  
Endothelial Growth Factors

Preoperative Chemoradiotherapy for Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus

CHEST Journal ◽  
2002 ◽  
Vol 122 (4) ◽  
pp. 1302-1308 ◽  
Author(s):  
Ferdinando De Vita ◽  
Natale Di Martino ◽  
Michele Orditura ◽  
Angelo Cosenza ◽  
Gennaro Galizia ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Preoperative Chemoradiotherapy ◽  
Adenocarcinoma Of The Esophagus

scholarly journals High frequency of simultaneous loss of p16 and p16β gene expression in squamous cell carcinoma of the esophagus but not in adenocarcinoma of the esophagus or stomach

Oncogene ◽  
1997 ◽  
Vol 15 (12) ◽  
pp. 1481-1488 ◽  
Author(s):  
Kazuhiko Hayashi ◽  
Ralf Metzger ◽  
Dennis Salonga ◽  
Kathleen Danenberg ◽  
Lawrence P Leichman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
High Frequency ◽  
Carcinoma Of The Esophagus ◽  
Adenocarcinoma Of The Esophagus ◽  
Simultaneous Loss
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