High serum miR-421 is associated with metabolic dysregulation and inflammation in patients with metabolic syndrome

Background. Hypercoagulation is one of the cardiovascular risk factors in patients with metabolic syndrome (MS). It results from various factors including hyperhomocysteinemia, endothelial dysfunction, non-enzymatic glycation of proteins etc.The aim of this study was to assess clinical correlates of thrombodynamics in insulin resistant and non insulin resistant men with metabolic syndrome.Methods. We investigated 79 patients with MS diagnosed in accordance with IDF criteria (2009). The main group consisted of 44 men with MS including insulin resistance. The control group consisted of 35 men with MS not including insulin resistance. In addition to routine clinical tests we performed thrombodynamics assay and measured serum levels of asymmetric dimethylarginine (ADMA) and homocysteine. Mann-Whitney U-test and Spearmen’s correlation coefficient (rs) were used for statistical analysis.Results. There was no significant difference between thrombodynamics parameters, ADMA and homocysteine levels between the two groups. In both groups thrombodynamics parameters had no correlations with body mass index, hemoglobin level, platelet count and serum ADMA level. In patients with insulin resistance clot density correlated positively with serum level of C-reactive protein (rs=0.621, p=0.007); average and initial rates of clot growth correlated positively with homocysteine level (rs=0.539, p=0.017, and rs=0.554, p=0.014, respectively). In patients with insulin resistance clot density and rates of clot growth were not interrelated with the above mentioned parameters.Conclusions. The results of the study suggest that insulin resistant men with MS are characterized by clinical correlates between thrombodynamics parameters, homocysteine and C-reactive protein levels while patients without insulin resistance have other, unestablished determinants of clot density and rates of clot growth.

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Reply to “High-sensitivity C-reactive protein and metabolic syndrome (insulin resistance syndrome) including nonalcoholic steatohepatitis”

Journal of Gastroenterology ◽

10.1007/s00535-008-2176-7 ◽

2008 ◽

Vol 43 (4) ◽

pp. 313-313

Author(s):

Masato Yoneda ◽

Yuichi Nozaki ◽

Hiroki Endo ◽

Koji Fujita ◽

Atsushi Nakajima

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Nonalcoholic Steatohepatitis ◽

High Sensitivity ◽

Insulin Resistance Syndrome ◽

C Reactive Protein ◽

Reactive Protein

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Serum Leukocyte Cell-derived Chemotaxin 2 (LECT2) Level is Associated with Osteoporosis

10.21203/rs.3.rs-985343/v1 ◽

2021 ◽

Author(s):

Qiang Wang ◽

Feng Xu ◽

Wen-Ming M. He ◽

Jiong Chen ◽

Yan-Qing Xie ◽

...

Keyword(s):

Total Cholesterol ◽

Negative Correlation ◽

Roc Curve ◽

High Sensitivity ◽

Serum Levels ◽

Mineral Density ◽

Alcoholic Fatty Liver ◽

Reactive Protein ◽

Potential Biomarker ◽

Hs Crp

Abstract BackgroundPrevious studies have shown that leukocyte cell-derived chemotaxin 2 (LECT2), a hepatokine, is associated with obesity and non-alcoholic fatty liver disease (NAFLD). It is well known that hepatokines play important roles in mediating interactions among bone, adipose tissue, and liver. We sought to examine serum LECT2 levels in subjects with osteoporosis (OP) to confirm its association with OP.MethodsFrom March 2019 to March 2020, a total of 96 adult subjects (52 OP patients and 44 controls) visiting the 2nd Spine Department of the Affiliated Hospital of School of Medicine of Ningbo University were recruited. The bone mineral density (BMD) of all subjects were assessed by dual-energy X-ray (DXA). Blood samples were collected for measurements of high-sensitivity C-reactive protein (hs-CRP), plasma glucose (PG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglycerides (TG), creatinine and uric acid. Serum LECT2 levels of total 96 participants were measured by enzyme linked immunesorbent assay (ELISA). The relationships between serum LECT2 levels and biomedical parameters were analyzed using the Spearman correlation coefficient.ResultsSerum LECT2 levels in OP patients were significantly higher than that of healthy controls (29.57 ng/mL VS 19.82 ng/mL, P < 0.01). To confirm the role LECT2 played in OP, we found a significantly negative correlation in all subjects between serum levels of LECT2 and lumbar BMD, as well as femoralneck BMD. A significantly positive correlation in all was observed between serum levels of LECT2 and TC, whereas there was a significantly negative correlation between serum levels of LECT2 and creatinine. Meanwhile, serum LECT2 levels were measured to diagnose OP patient by plotting receiver-operating characteristic (ROC) curve, the area under the ROC curve was 0.729(P < 0.01). The optimal cutoff point for LECT2 concentration to diagnose OP patient was 16.44 ng/mL.ConclusionsWe showed that serum LECT2 levels were significantly up-regulated in OP patients, and LECT2 levels were significant positively associated with total cholesterol and negatively associated with creatinine. It could be a potential biomarker for OP diagnosis.

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High serum high-sensitivity C-reactive protein concentrations are associated with relative cardiac sympathetic overactivity during the early morning period in type 2 diabetic patients with metabolic syndrome

Metabolism ◽

10.1016/j.metabol.2006.03.011 ◽

2006 ◽

Vol 55 (8) ◽

pp. 1014-1021 ◽

Cited By ~ 26

Author(s):

Yoshimasa Aso ◽

Sadao Wakabayashi ◽

Tomoki Nakano ◽

Ruriko Yamamoto ◽

Kohzo Takebayashi ◽

...

Keyword(s):

Metabolic Syndrome ◽

High Sensitivity ◽

Early Morning ◽

High Serum ◽

Diabetic Patients ◽

C Reactive Protein ◽

Type 2 Diabetic Patients ◽

Reactive Protein ◽

Type 2 Diabetic

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EVALUATION OF SERUM γ-GLUTAMYL TRANSFERASE AND ITS ASSOCIATION WITH HIGH SENSITIVITY C-REACTIVE PROTEIN AND INSULIN LEVELS IN THE PATIENTS WITH METABOLIC SYNDROME

International Journal of Medicine and Medical Research ◽

10.11603/ijmmr.2413-6077.2019.1.9693 ◽

2019 ◽

Vol 5 (1) ◽

pp. 10-16

Author(s):

R. Dharuni ◽

B. V. Maruthi Prasad ◽

H. L. Vishwanth

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

High Sensitivity ◽

Atherosclerotic Cardiovascular Disease ◽

Gamma Glutamyl Transferase ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp ◽

Glutamyl Transferase

Background. Metabolic syndrome (MS), a collection of cardiovascular risk factors, is a major worldwide public health problem. The gathered data prove that serum gamma-glutamyl transferase (γGT) activity is a true marker of atherosclerotic cardiovascular disease (CVD) and is of a prognostic importance as well as the high-sensitivity C-reactive protein (hs-CRP). Objectives. In the study, we sought to evaluate serum γGT activity, hs-CRP and insulin resistance in patients with MS. Methods. The study involved 50 persons with metabolic syndrome and 50 healthy age and sex matched controls. Fasting serum samples of all participants were investigated for γGT, hs-CRP, insulin, blood glucose, lipid profile and liver function tests. Anthropometric measurements and BMI were also calculated Results. In that case 50% showed significantly high γGT compared to the controls, 30% proved increased hs-CRP levels above >0.5 mmol/L, whereas 94% of the controls were within the reference range. 74% of cases revealed the presence of insulin resistance while 32% of the controls showed insulin resistance. High γGT levels were also observed in that case with deranged lipids levels and high BMI. Conclusions. The study suggests that the patients with MS have a higher serum γGT activity. This study also proves that hs-CRP and HOMA-IR, which are independent risk factors of CVD, are also associated with MS. The correlation between γGT and the components of MS are also found significant compared to hs-CRP. Thus, γGT can be considered as an inexpensive and authentic predictor of MS, which can be a manifestation of CVD in near future.

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Effect of a Three-month Period of Diet and pPhysical Activity on Adipokines and Inflammatory Status in Children with Metabolic Syndrome

Revista de Chimie ◽

10.37358/rc.19.1.6910 ◽

2019 ◽

Vol 70 (1) ◽

pp. 327-330

Author(s):

Ramona Stroescu ◽

Otilia Marginean ◽

Teofana Bizerea ◽

Mihai Gafencu ◽

Adrian Voicu ◽

...

Keyword(s):

Physical Activity ◽

Metabolic Syndrome ◽

Pediatric Population ◽

High Sensitivity ◽

Significant Negative Correlation ◽

Reactive Protein ◽

Inflammatory Status ◽

Diet And Physical Activity ◽

Hs Crp ◽

A Prospective Study

The prevalence of metabolic syndrome (MetS) in the young population continues to rise. This study aimed to determine whether adipokines are significant markers in defining MetS in a pediatric population and to assess the effect of a hypocaloric diet and physical activity on serum concentrations of adiponectin, leptin, and high-sensitivity C-reactive protein (hs-CRP). A prospective study was conducted over a period of 1 year, between January and December 2015, on 66 cases of obesity in children diagnosed at the Louis Turcanu Emergency Hospital for Children in Timisoara, Romania. The patients diagnosed with MetS were put on diet and physical exercise for 3 months. MetS was present in 63.6 % of obese children. There was a significant and positive correlation between MetS and both leptin and hs-CRP and a significant, negative correlation between MetS and adiponectin. After diet and physical activity, 3 patients no longer met the criteria for MetS. Leptin, adiponectin and hs-CRP concentrations statistically improved after a three-month diet and physical activity program. In conclusion, hs-CRP, leptin and adiponectin can be used as predictors of cardiovascular risk in the pediatric population. Diet and physical activity have an impact on metabolic status.

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Clinical correlates of thrombodynamics in men with metabolic syndrome: the impact of insulin resistance

Problems of Endocrinology ◽

10.14341/probl201662525-26 ◽

2016 ◽

Vol 62 (5) ◽

pp. 25-26

Author(s):

Ivan Y. Pchelin ◽

Natalia V. Hudiakova ◽

Alexander N. Shishkin

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Serum Levels ◽

Control Group ◽

C Reactive Protein ◽

Clinical Correlates ◽

Insulin Resistant ◽

Reactive Protein ◽

Significant Difference ◽

The Impact

Background. Hypercoagulation is one of the cardiovascular risk factors in patients with metabolic syndrome (MS). It results from various factors including hyperhomocysteinemia, endothelial dysfunction, non-enzymatic glycation of proteins etc.The aim of this study was to assess clinical correlates of thrombodynamics in insulin resistant and non insulin resistant men with metabolic syndrome.Methods. We investigated 79 patients with MS diagnosed in accordance with IDF criteria (2009). The main group consisted of 44 men with MS including insulin resistance. The control group consisted of 35 men with MS not including insulin resistance. In addition to routine clinical tests we performed thrombodynamics assay and measured serum levels of asymmetric dimethylarginine (ADMA) and homocysteine. Mann-Whitney U-test and Spearmen’s correlation coefficient (rs) were used for statistical analysis.Results. There was no significant difference between thrombodynamics parameters, ADMA and homocysteine levels between the two groups. In both groups thrombodynamics parameters had no correlations with body mass index, hemoglobin level, platelet count and serum ADMA level. In patients with insulin resistance clot density correlated positively with serum level of C-reactive protein (rs=0.621, p=0.007); average and initial rates of clot growth correlated positively with homocysteine level (rs=0.539, p=0.017, and rs=0.554, p=0.014, respectively). In patients with insulin resistance clot density and rates of clot growth were not interrelated with the above mentioned parameters.Conclusions. The results of the study suggest that insulin resistant men with MS are characterized by clinical correlates between thrombodynamics parameters, homocysteine and C-reactive protein levels while patients without insulin resistance have other, unestablished determinants of clot density and rates of clot growth.

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