Safety of uSCIT-MPL-4: prevalence and risk factors of systemic reactions in real life

Immunotherapy ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 783-794
Author(s):  
Marco Caminati ◽  
Alessandra Arcolaci ◽  
Massimo Guerriero ◽  
Giuseppina Manzotti ◽  
Mariangiola Crivellaro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Real Life ◽  
Systemic Reactions

scholarly journals Cumulative Risks from Stressor Exposures and Personal Risk Factors in the Workplace: Examples from a Scoping Review

2021 ◽  
Vol 18 (11) ◽  
pp. 5850
Author(s):  
Mary A. Fox ◽  
Richard Todd Niemeier ◽  
Naomi Hudson ◽  
Miriam R. Siegel ◽  
Gary Scott Dotson
Keyword(s):  
Risk Factors ◽  
Risk Assessment ◽  
Scoping Review ◽  
Multiple Stressors ◽  
Cumulative Risk ◽  
Real Life ◽  
Personal Factors ◽  
Exposure Limits ◽  
Personal Risk ◽  
Personal Risk Factors

Protecting worker and public health involves an understanding of multiple determinants, including exposures to biological, chemical, or physical agents or stressors in combination with other determinants including type of employment, health status, and individual behaviors. This has been illustrated during the COVID-19 pandemic by increased exposure and health risks for essential workers and those with pre-existing conditions, and mask-wearing behavior. Health risk assessment practices for environmental and occupational health typically do not incorporate multiple stressors in combination with personal risk factors. While conceptual developments in cumulative risk assessment to inform a more holistic approach to these real-life conditions have progressed, gaps remain, and practical methods and applications are rare. This scoping review characterizes existing evidence of combined stressor exposures and personal factors and risk to foster methods for occupational cumulative risk assessment. The review found examples from many workplaces, such as manufacturing, offices, and health care; exposures to chemical, physical, and psychosocial stressors combined with modifiable and unmodifiable determinants of health; and outcomes including respiratory function and disease, cancers, cardio-metabolic diseases, and hearing loss, as well as increased fertility, menstrual dysfunction and worsened mental health. To protect workers, workplace exposures and modifiable and unmodifiable characteristics should be considered in risk assessment and management. Data on combination exposures can improve assessments and risk estimates and inform protective exposure limits and management strategies.

Incidence and risk factors for dupilumab associated ocular adverse events: a real‐life prospective study

2020 ◽  
Author(s):  
A.T. Touhouche ◽  
M. Cassagne ◽  
E. Bérard ◽  
F. Giordano‐Labadie ◽  
A. Didier ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adverse Events ◽  
Prospective Study ◽  
Real Life

scholarly journals Adverse drug reactions associated with treatment in patients with chronic rheumatic diseases in childhood: a retrospective real life review of a single center cohort

2020 ◽  
Vol 60 (1) ◽  
Author(s):  
Manar Amanouil Said ◽  
Liana Soido Teixeira e Silva ◽  
Aline Maria de Oliveira Rocha ◽  
Gustavo Guimarães Barreto Alves ◽  
Daniela Gerent Petry Piotto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Model ◽  
Children And Adolescents ◽  
Adverse Drug Reactions ◽  
Rheumatic Diseases ◽  
Real Life ◽  
Drug Reactions ◽  
Wide Range ◽  
Disease Modifying ◽  
Chronic Rheumatic Diseases

Abstract Background Adverse drug reactions (ADRs) are the sixth leading causes of death worldwide; monitoring them is fundamental, especially in patients with disorders like chronic rheumatic diseases (CRDs). The study aimed to describe the ADRs investigating their severity and associated factors and resulting interventions in pediatric patients with CRDs. Methods A retrospective, descriptive and analytical study was conducted on a cohort of children and adolescents with juvenile idiopathic arthritis (JIA), juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM). The study evaluated medical records of the patients to determine the causality and the management of ADRs. In order to investigate the risk factors that would increase the risk of ADRs, a logistic regression model was carried out on a group of patients treated with the main used drug. Results We observed 949 ADRs in 547 patients studied. Methotrexate (MTX) was the most frequently used medication and also the cause of the most ADRs, which occurred in 63.3% of patients, followed by glucocorticoids (GCs). Comparing synthetic disease-modifying anti-rheumatic drugs (sDMARDs) vs biologic disease-modifying anti-rheumatic drugs (bDMARDs), the ADRs attributed to the former were by far higher than the latter. In general, the severity of ADRs was moderate and manageable. Drug withdrawal occurred in almost a quarter of the cases. In terms of risk factors, most patients who experienced ADRs due to MTX, were 16 years old or younger and received MTX in doses equal or higher than 0.6 mg/kg/week. Patients with JIA and JDM had a lower risk of ADRs than patients with JSLE. In the multiple regression model, the use of GCs for over 6 months led to an increase of 0.5% in the number of ADRs. Conclusions Although the ADRs highly likely affect a wide range of children and adolescents with CRDs they were considered moderate and manageable cases mostly. However, triggers of ADRs need further investigations.

scholarly journals Longitudinal Asthma Patterns in Italian Adult General Population Samples: Host and Environmental Risk Factors

2020 ◽  
Vol 9 (11) ◽  
pp. 3632
Author(s):  
Sara Maio ◽  
Sandra Baldacci ◽  
Marzia Simoni ◽  
Anna Angino ◽  
Stefania La Grutta ◽  
...  
Keyword(s):  
Risk Factors ◽  
General Population ◽  
Multinomial Logistic Regression ◽  
Population Sample ◽  
Real Life ◽  
Persistent Asthma ◽  
Asthma Diagnosis ◽  
Longitudinal Patterns ◽  
Asthma Symptoms ◽  
Passive Smoke

Background: Asthma patterns are not well established in epidemiological studies. Aim: To assess asthma patterns and risk factors in an adult general population sample. Methods: In total, 452 individuals reporting asthma symptoms/diagnosis in previous surveys participated in the AGAVE survey (2011–2014). Latent transition analysis (LTA) was performed to detect baseline and 12-month follow-up asthma phenotypes and longitudinal patterns. Risk factors associated with longitudinal patterns were assessed through multinomial logistic regression. Results: LTA detected four longitudinal patterns: persistent asthma diagnosis with symptoms, 27.2%; persistent asthma diagnosis without symptoms, 4.6%; persistent asthma symptoms without diagnosis, 44.0%; and ex -asthma, 24.1%. The longitudinal patterns were differently associated with asthma comorbidities. Persistent asthma diagnosis with symptoms showed associations with passive smoke (OR 2.64, 95% CI 1.10–6.33) and traffic exposure (OR 1.86, 95% CI 1.02–3.38), while persistent asthma symptoms (without diagnosis) with passive smoke (OR 3.28, 95% CI 1.41–7.66) and active smoke (OR 6.24, 95% CI 2.68–14.51). Conclusions: LTA identified three cross-sectional phenotypes and their four longitudinal patterns in a real-life setting. The results highlight the necessity of a careful monitoring of exposure to active/passive smoke and vehicular traffic, possible determinants of occurrence of asthma symptoms (with or without diagnosis). Such information could help affected patients and physicians in prevention and management strategies.

scholarly journals Prevalence and impact of risk factors for poor asthma outcomes in a large, specialist-managed patient cohort: a real-life study

2019 ◽  
Vol Volume 12 ◽  
pp. 297-307 ◽  
Author(s):  
Gábor Tomisa ◽  
Alpár Horváth ◽  
Zsuzsanna Szalai ◽  
Veronika Müller ◽  
Lilla Tamási
Keyword(s):  
Risk Factors ◽  
Real Life ◽  
Life Study ◽  
Patient Cohort ◽  
Asthma Outcomes ◽  
Real Life Study

Natural history of systemic reactions and risk factors in children and adults with Hymenoptera venom allergy

2020 ◽  
Vol 29 (2) ◽  
pp. 26-33
Author(s):  
Darío Antolín-Amérigo ◽  
Berta Ruiz-León ◽  
A. Vega-Castro ◽  
Belén de la Hoz Caballer
Keyword(s):  
Risk Factors ◽  
Natural History ◽  
Hymenoptera Venom ◽  
Venom Allergy ◽  
Hymenoptera Venom Allergy ◽  
Systemic Reactions ◽  
History Of

scholarly journals P1822 Exercise stress echo in the preventive assessment of the coronary heart disease: experience in the real life practice

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
F Acquistapace
Keyword(s):  
Risk Factors ◽  
Cost Effectiveness ◽  
Real Life ◽  
Exercise Stress ◽  
Primary Role ◽  
Cost Effectiveness Ratio ◽  
Multiple Risk Factors ◽  
Stress Echo ◽  
Artery Disease ◽  
Primary Evaluation

Abstract The predictive of the functional tests compared to the anatomical tests in the diagnosis of coronary artery disease (CAD) is still debated. Cost-effectiveness ratio play a primary role in the best application of clinical practice.Methods 3200 pts (1600 men and 1600 women) were selected during a medical and cardiological screening. Two groups. The first one: evaluation or absence of events and the second one: presence of CAD. Evaluated datas: risk factors (FRC) and presence of clinical parameters limiting the predictive value of the Stress ECG from Effort (EE) such as: ECG’s abnormalities, branch blocks, hypertrophic, cardiomyopathy, gender. FRC evaluated parameters: hypertension 2080 (65.5%: 1040m; 1040f), hypercholesterolemia 1084 (37%: 592m; 592f), smoking 595 (18.6%: 298m; 297f), familiarity 1088 (34%: 1038m; 1042f), anxiety, depression, dystonia 1210 (37.8%: 430m-35% | 780f-65%), diabetes 320 (10%: 176m-55% 144f-45%).Results 900 pts were subjected to ESE: 540m 360w. Outcome at 1 year of CAD for mortality due to myocardial infarction, hospitalization for unstable angina major complications (CM): no pts. After ESE coronary angiography (CG) followed in 60 pts (7%): revascularizations (PTCA/CABG) 8 (1%: all men). ESE/CG correspondence in 100%. Comparison of CAD without revascularizations, ie diffuse atheromasia with sub-critical stenosis 35 (4%: 9m-25%, 26f-75%) all in primary evaluation without events and all hypertensive, evaluable as vasospastic ischemia (ie: x syndrome). Nobody pts was exposed to further radioactive stress procedures.Conclusions the functional test with ESE is confirmed as a valid tool, in term of cost-effectiveness also, in the screening and follow-up of CAD. Women and pts with multiple risk factors are different in the development of CAD. They are more exposed to the risk of an unappropriated and useless investigations, also radioactive. In general, ESE improves the prognosis and cost- effectiveness ratio in management of the pts with CAD.

scholarly journals ABC Classification of Risk Factors in Production Supply Chains with Uncertain Data

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Aleksandar Vujović ◽  
Aleksandar Đorđević ◽  
Ranka Gojković ◽  
Milan Borota
Keyword(s):  
Risk Factors ◽  
Risk Management ◽  
Supply Chain ◽  
Good Practice ◽  
Uncertain Data ◽  
Real Life ◽  
Frequency Of Occurrence ◽  
Management Problem ◽  
Extreme Risk

The problem of classification of risk factors in an uncertain environment is part of the risk management problem, which has a critical effect on the competitive advantage of production supply chain. The severities of consequences, their relative importance, and the frequency of occurrence of risk factors are defined by risk management team, depending on their experience and the results of good practice. Fuzzy rating of the severities of consequences and the frequency of occurrence of risk factors are described by linguistic expressions, which are modeled by triangular fuzzy numbers. The risk values, obtained by the materialization of the identified risk factors, are given precisely with the usage of fuzzy algebra rules. The classification criterion is defined as the distance between current risk value and extreme risk values. The proposed model enables determination of the priorities of risk factors. It is illustrated by an example with real-life data from a production supply chain in auto industry.

scholarly journals What must we know about cardiovascular prevention in medical school freshmen?

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
Y Venevtseva ◽  
ELENA Golubeva ◽  
LEV Putilin
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Heart Rate ◽  
Medical Students ◽  
Screen Time ◽  
Body Height ◽  
Real Life ◽  
Male Students ◽  
First Year ◽  
Normal Range

Abstract Funding Acknowledgements Type of funding sources: None. Background/Introduction. Medical students have been found to report high levels of perceived stress that may be influenced on health status and academic performance. Digital era and e-learning produce novel risk factors for cardiovascular disease (CVD) including arterial hypertension. In real life clinical practice in large healthy populations it is quite difficult to follow guidelines for hypertension screening due to the time deficit. Purpose. The aim of the study was to examine prevalence of CVD risk factors and impact of casual blood pressure on cognitive function in 1st and 6th year medical male students. Methods. Cross-sectional study was conducted during the period from 2014 to 2020. 222 first year (age (M ± m) 18.5 ± 0.1 years) and 207 6th year male medical students (age 23.5 ± 0.3 years) completed 45-item questionnaire about habitual life-behavior and performed 9 cognitive tasks. Blood pressure (BP) was self-measured by electronic device just prior to testing. Results. In freshmen mean body height was (M ± m) 180.3 ± 0.5 cm; weight – 76.8 ± 1.1 kg, body mass index (BMI) – 23.6 ± 0.3 kg/m2; heart rate – 82.1 ± 0.9 bpm; casual systolic BP (SBP) -131.9 ± 2.3 and diastolic BP (DBP) – 77.6 ± 0.6 mm Hg. 6th year male students had similar height (179.6 ± 0.5 cm), but were heavier (80.5 ± 1.0 kg; p < 0.01; BMI =24.9 ± 0.3 kg/m2; p < 0.01). Heart rate (78.7 ± 0.8 bpm; p < 0.05) and casual SBP (126.7 ± 0.8 mm Hg; p < 0.05) were lower. No difference was found in DBP (77.8 ± 0.6 mm Hg). Excessive body weight was detected in 16.6 % of 1st and in 36.2 % of 6th year students, obesity – in 8.5 and 6.8 % of students. 3 first year males and 1 – from 6th year group had morbid obesity (BMI > 40.0). Low physical activity reported 22.1% and 29.9%. Current smokers were 16.1 % of 1st and 33.3 % of 6th year students, but only 9.4 and 18.8 % smoked permanently. Casual SBP lay in high normal range in 27.4 % of 1st and in 34.3% of 6th year, and above 140 mm Hg – in 21.5 and 14%. Correlation analysis revealed in both groups significant positive correlations SBP and DBP to weight and BMI, SBP to height (p < 0.05) and screen time (p < 0.01) and DBP - to heart rate. Only in freshmen SPB was related to cognitive functions: 17-18 year’s ones with elevated BP made tests faster may be due to their greater arousal, whereas 19-20 year’s – slower, but had better working vision memory. Only in 17-18 year group existed negative association SBP to subjective vision value and smoking status. Conclusions. Modern medical male students are at high risk of CVD: casual BP within the normal range was only in 49 % of 1st and in 48 % of 6th year students, 25 % of freshmen and 43 % of 6th year males were overweight or obese, and one quarter was physically inactive. Besides healthy lifestyle and nutrition promotion quite necessary is also to limit screen time.

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