scholarly journals Pulsed ultrasound for bone regeneration – outcomes and hurdles in the clinical application: a systematic review

2021 ◽  
Vol 42 ◽  
pp. 281-311
Author(s):  
R Puts ◽  
◽  
L Vico ◽  
N Beilfuß ◽  
M Shaka ◽  
...  
Keyword(s):  
Systematic Review ◽  
Patient Compliance ◽  
Clinical Application ◽  
Clinical Studies ◽  
Bone Fractures ◽  
Small Animal ◽  
The Elderly ◽  
Pulsed Ultrasound ◽  
Double Blind ◽  
Non Union

Impaired bone-fracture healing is associated with long-term musculoskeletal disability, pain and psychological distress. Low-intensity pulsed ultrasound (LIPUS) is a non-invasive and side-effect-free treatment option for fresh, delayed- and non-union bone fractures, which has been used in patients since the early 1990s. Several clinical studies, however, have questioned the usefulness of the LIPUS treatment for the regeneration of long bones, including those with a compromised healing. This systematic review addresses the hurdles that the clinical application of LIPUS encounters. Low patient compliance might disguise the effects of the LIPUS therapy, as observed in several studies. Furthermore, large discrepancies in results, showing profound LIPUS effects in regeneration of small-animal bones in comparison to the clinical studies, could be caused by the suboptimal parameters of the clinical set-up. This raises the question of whether the so-called “acoustic dose” requires a thorough characterisation to reveal the mechanisms of the therapy. The adequate definition of the acoustic dose is especially important in the elderly population and patients with underlying medical conditions, where distinct biological signatures lead to a delayed regeneration. Non-industry-funded, randomised, double-blind, placebo-controlled clinical trials of the LIPUS application alone and as an adjuvant treatment for bones with complicated healing, where consistent control of patient compliance is ensured, are required.

scholarly journals NSAID Use and Effects on Pediatric Bone Healing: A Review of Current Literature

Children ◽  
2021 ◽  
Vol 8 (9) ◽  
pp. 821
Author(s):  
Stephanie Choo ◽  
Julia A. V. Nuelle
Keyword(s):  
Systematic Review ◽  
Bone Healing ◽  
Clinical Studies ◽  
Pain Control ◽  
Bone Fractures ◽  
Long Bone ◽  
Evidence Based ◽  
Skeletally Immature ◽  
Inflammatory Drugs ◽  
The Impact

This systematic review evaluates and synthesizes the available peer-reviewed evidence regarding the impact of non-steroidal anti-inflammatory drugs (NSAIDs) on fracture healing in skeletally immature patients. Evidence supports the use of NSAIDs in this patient population for adequate pain control without increasing the risk of nonunion, particularly in long bone fractures and pseudoarthrosis after spine fusion. However, further clinical studies are needed to fill remaining gaps in knowledge, specifically with respect to the spectrum of available NSAIDs, dosage, and duration of use, in order to make broad evidence-based recommendations regarding the optimal use of NSAIDs during bone healing in skeletally immature patients.

Facilitation of fracture repair using low-intensity pulsed ultrasound

2000 ◽  
Vol 13 (04) ◽  
pp. 158-164 ◽  
Author(s):  
W. T. Wong ◽  
K. L. Bennell ◽  
J. M. McMeeken ◽  
J. D. Wark ◽  
S. J. Warden
Keyword(s):  
Bone Fractures ◽  
Delayed Union ◽  
Fracture Repair ◽  
Pulsed Ultrasound ◽  
Non Union ◽  
Veterinary Practice ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Fresh Fracture ◽  
Practical Implications

SummaryA recent application of ultrasound (US) therapy is to bone fractures. In two randomized controlled trials in humans, specific dosed US accelerated fresh tibial and radial fracture repair by 38%. When applied to delayed- and non-unions the same dosed US resulted in union in over 80% of cases. Similar US may augment fracture repair in veterinary practice. This paper reviews US dosages applied during fracture repair and their effect on bone healing. It concludes by discussing the clinical and practical implications of these findings to veterinary practice and the need for further research into this electrotherapeutic modality.Low-intensity pulsed ultrasound has been shown to facilitate fresh fracture repair, reduce the incidence of delayed-union and initiate healing of fractures displaying delayedand non-union. This paper discusses these findings and their implications to veterinary practice.

scholarly journals Malocclusion influence on balance and posture: a systematic review.

2015 ◽  
Vol 13 ◽  
pp. 320
Author(s):  
Tatiane Garcia Stancker ◽  
Andréia Cristina de Oliveira Silva ◽  
Hugo Pasin Neto ◽  
Cristiane Delgado Alves Rodrigues
Keyword(s):  
Systematic Review ◽  
Temporomandibular Joint ◽  
Clinical Application ◽  
Systematic Reviews ◽  
Clinical Studies ◽  
Dynamic Balance ◽  
Body Balance ◽  
The Subject ◽  
Masticatory System ◽  
The Relationship

Introduction: Malocclusion can be defined as an imbalance between the masticatory system and neuromuscular Temporomandibular joint. It is considered as a result of the sum of genetic, environmental and postural elements therefore of multifactorial origin. Objective: To review the existing literature if malocclusion influence in posture and balance of the subject. Methods: This is a systematic review, which searched up clinical studies, published between 2009 and 2014 in English, Portuguese and Spanish, in the databases SciELO, PubMed, Lilacs and Sience Direct, using the keywords malocclusion/posture and malocclusion/body balance. Studies were included that had to evaluate the posture and/or balance in patients with malocclusion, were excluded systematic reviews and studies that did not correspond to the proposed theme. Results: In addition to the articles found in all databases, the corpus generated by the literature consisted of 828 records; 13 of them responded to the proposed theme. About the selected literature, eight studies showed significant results regarding the relationship between malocclusion and posture, and two as malocclusion and body balance. Conclusion: it was concluded that malocclusion is associated with the posture of the changes, since the balance, only two studies presented this outcome and was in a considered positive for the worsening of static equilibrium, but with no clinical application, and another positive for improves dynamic balance.

Effect of Pycnogenol on Blood Pressure: Findings From a PRISMA Compliant Systematic Review and Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled, Clinical Studies

Angiology ◽  
2019 ◽  
Vol 71 (3) ◽  
pp. 217-225 ◽  
Author(s):  
Federica Fogacci ◽  
Giuliano Tocci ◽  
Amirhossein Sahebkar ◽  
Vivianne Presta ◽  
Maciej Banach ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Clinical Trials ◽  
Clinical Studies ◽  
Randomized Clinical Trials ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Double Blind ◽  
Double Blind Placebo ◽  
The Impact

Results of previous clinical trials evaluating the effect of pycnogenol supplementation on blood pressure (BP) are controversial. Therefore, we aimed to assess the impact of pycnogenol on BP through a systematic review of literature and meta-analysis of available randomized, double-blind, placebo-controlled clinical studies (randomized clinical trials [RCTs]). Literature search included SCOPUS, PubMed-Medline, ISI Web of Science, and Google Scholar databases up to January 10, 2019 to identify RCTs investigating the impact of pycnogenol on BP. Two investigators independently extracted data on study characteristics, methods, and outcomes. This systematic review and meta-analysis is registered in International Prospective Register of Systematic Reviews (PROSPERO) under number CRD42018112172. Overall, the impact of pycnogenol on BP was reported in 7 trials involving 626 participants. Meta-analysis did not suggest any significant improvement in systolic BP (weighted mean difference [WMD]: −0.028 mm Hg; 95% confidence interval [CI]: −0.182 to 0.127; P = .726; I2 = 46%), diastolic BP (WMD: −0.144 mm Hg; 95% CI: −0.299 to 0.010; P = .067; I2 = 0%), mean arterial pressure (WMD: −0.091 mm Hg; 95% CI: −0.246 to 0.063; P = .246; I2 = 0%), and pulse pressure (WMD: −0.003 mm Hg; 95% CI: −0.151 to 0.158; P = .966; I2 = 0%) following pycnogenol treatment. Results persisted in the leave-one-out sensitivity analysis. Therefore, the present meta-analysis does not suggest any significant effect of pycnogenol on BP.

scholarly journals Prevalence of dementia among elderly Brazilians: a systematic review

2011 ◽  
Vol 129 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Susana Dytz Fagundes ◽  
Marcus Tolentino Silva ◽  
Maria Fernanda Reis Silva Thees ◽  
Maurício Gomes Pereira
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
The Elderly ◽  
Population Based ◽  
Significant Rise ◽  
Qualitative Synthesis ◽  
Double Blind ◽  
Cross Sectional ◽  
Prevalence Studies ◽  
Prevalence Of Dementia

CONTEXT AND OBJECTIVE: The rapid growth of the elderly population in Brazil has implied a significant rise in the number of individuals with dementia. The real prevalence of this disease needs to be ascertained in order to establish appropriate measures for improving the quality of life of those affected. The aim of this study was to estimate the prevalence of dementia among elderly Brazilians (> 60 years) through a systematic review of high-quality, population-based, double-blind studies published between 1990 and 2010. DESIGN AND SETTING: Systematic review of prevalence studies. The manuscript was produced in the School of Medicine, Universidade de Brasília. METHODS: Database searches for articles were conducted in Medline (Medical Literature Analysis and Retrieval System Online), Embase (Excerpta Medica database), Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) and theses and dissertations, using specific keywords. Quality was assessed according to eight criteria for sampling and measurement of findings. RESULTS: Out of 112 articles identified, eleven were included in the qualitative synthesis. In five higher-quality studies from São Paulo, the prevalence rates ranged from 5.1 to 19.0%. No meta-analysis was presented because of heterogeneity among the studies. Poor, illiterate, female and very elderly individuals were the groups most affected. CONCLUSION: The findings from this review did not reflect the reality of the whole country. Although the results brought some information on the prevalence and distribution of dementia in Brazil, cross-sectional studies with consistent methodology are needed

The ComPact UniLock 2.0/2.4 system and its clinical application in small animal orthopedics

2005 ◽  
Vol 18 (02) ◽  
pp. 83-93 ◽  
Author(s):  
K. Voss ◽  
P. M. Montavon ◽  
M. A. Keller
Keyword(s):  
Clinical Application ◽  
Locking Plate ◽  
Bone Fractures ◽  
Small Animal ◽  
Spinal Fractures ◽  
Clinical Applications ◽  
Long Bone ◽  
Long Bone Fractures ◽  
Locking Plate System ◽  
Plate System

SummaryThis study describes the titanium ComPact UniLock 2.0/2.4™ locking plate system (Stratec Medical, Oberdorf, Switzerland) and reports its application in nine selected clinical cases. The system was found useful for a variety of indications. Three categories of clinical applications are illustrated. They include (a) long bone fractures, (b) cervical spinal fractures and instabilities and (c) joint instabilities and luxations. A brief introduction to the system has already been published (1).

scholarly journals The Efficacy of Remdesivir Drug to Control the Recently Emerged Novel Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2): A Review Study

2020 ◽  
pp. 1-8
Author(s):  
Humera Batool ◽  
Mizba Baksh ◽  
Khatja Batool ◽  
Zainab Rafique ◽  
Sibghatullah Shahab ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Studies ◽  
Controlled Trial ◽  
Phase Iii ◽  
Future Research ◽  
Double Blind ◽  
Clinical Phase ◽  
Large Patient ◽  
Phase Iii Trials ◽  
Clinical Benefits

Introduction: Remdesivir is among the investigational drugs which show some promising effect against COVID-19, it may be due to its broad-spectrum antiviral action against some RNA viruses. To date very few clinical studies have been conducted on the use of remdesivir to the treatment of COVID-19. The main objective of the present study was, to conduct a review on the effect of Remdesivir to the treatment of COVID-19. To the best of our knowledge, this is the first systematic review on the effect of remdesivir drug to the treatment of COVID-19. Methodology: We have searched PubMed, for published studies on assessing the effect of remdesivir drug among patients with confirmed COVID-19. The main search terms used were “COVID-19” or “SARS-CoV-2”, “remdesivir”, and “systematic review”. Results: Only 11 research articles were found eligible for enclosure in this systematic review, among selected studies only two were randomized, placebo-controlled trial of intravenous remdesivir. Data on the efficacy of remdesivir in the patients with confirmed COVID-19 from clinical Phase-III trials are still pending. Recently, in the latter half of May month, results of two hospital based randomized, double-blind, placebo-controlled phase III trials studies were reported, both the studies found that remdesivir was efficient in the treatment of patients with confirmed COVID-19. However, Wang et al., (2020) found that remdesivir treatment was not significantly associated with clinical benefits. Conclusion: From the systematic review, the use of remdesivir to cure patients with confirms COVID-19 was found promising; however, further clinical studies with large patient size need to be considered. The efficacy and safety of remdesivir in the treatment of COVID-19 will require to be emphasized in future research studies.

Sign in / Sign up

Export Citation Format

Share Document