scholarly journals SCREENING PHYTOCHEMICAL AND ANTI-METHICILLIN RESISTANT (MRSA) ACTIVITY OF 70 % ETHANOLIC EXTRACT FROM THE STEM BARK OF ALBIZIA LEBBECK(L.) BENTH.(FABACEAE)

2018 ◽  
Vol 6 (6) ◽  
pp. 1-6
Author(s):  
Yao KANGA ◽  
CAMARA Djeneb ◽  
KOUASSI Kouadio Aubin ◽  
ZIRIHI Guédé Noël
Keyword(s):  
Antibacterial Activity ◽  
Reference Strain ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Drug Resistant ◽  
Albizia Lebbeck ◽  
Antimicrobial Drugs ◽  
Methicillin Resistant ◽  
Resistant Strains ◽  
Drug Resistant Strains

The emergence of multi-drug resistant strains and limitations of present antimicrobial drugs have led to continuous search for natural products as curative agents for Anti-methicillin resistantinfections. The aim of this study was to evaluate antibacterial activity of an ethanolic extract from Albizia lebbeckstem bark against Anti-methicillin resistant. Methods and Results : The methods of dissemination swab on muller-hinton agar and double dilution were used to evaluate the antibacterial activity of 70 % ethanolic extract of stem bark of Albizia lebbeck.All multi-resistant strains of Staphylococcus aureus and the reference strain (ATCC 25923) were sensitive to 70 % ethanolic extract of the stem bark of Albizia lebbeck. The MBCvary from 0,49 mg/mL to 2mg/mL. Also, the phytochemical screening of this extract revealed the presence of  Polyphenols, Gallic tannins, Catechin tanninsand Flavonoids. These findings confirm that an 70 % ethanolic extract from Albizia lebbeck stem bark inhibited growth of Anti-methicillin resistant at low concentration and could be utilised as an alternative Anti-methicillin resistantagent.

scholarly journals Antibacterial activity of combined medicinal plants extract against multiple drug resistant strains

2015 ◽  
Vol 5 ◽  
pp. S151-S154
Author(s):  
Rafiqul Islam ◽  
Md. Shahedur Rahman ◽  
Riad Hossain ◽  
Nazmun Nahar ◽  
Belal Hossin ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Medicinal Plants ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
Plants Extract

scholarly journals Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity

2021 ◽  
Author(s):  
Przemysław Biegański ◽  
Łukasz Szczupak ◽  
Manuel Arruebo ◽  
Konrad Kowalski
Keyword(s):  
Antibacterial Activity ◽  
Pathogenic Bacteria ◽  
Drug Resistant ◽  
Antibacterial Drugs ◽  
Recent Developments ◽  
Resistant Strains ◽  
Drug Resistant Strains

Recent developments in the field of organometalated antibacterial drugs and metal-based materials with antibacterial activity are reviewed. They emerge as attractive candidates for combating pathogenic bacteria including drug resistant strains.

scholarly journals Characterization and anti-staphylococcal activity of the essential oil from Turnera subulata Sm.

2014 ◽  
Vol 16 (3) ◽  
pp. 534-538 ◽  
Author(s):  
M.G. Fernandes ◽  
R.A. Gomes ◽  
S.G. Brito-Filho ◽  
R.N. Silva-Filho ◽  
M.F. Agra ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Essential Oil ◽  
Mass Spectra ◽  
Complex Mixture ◽  
Retention Indices ◽  
Drug Resistant ◽  
Aerial Parts ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
Broth Dilution

The present study is pioneer in analyzing the chemical composition of the essential oil from aerial parts of Turnera subulata Sm. and evaluates their antibacterial activity against a panel of drug-resistant strains of Staphylococcus aureus. The aerial parts were kiln-dried and then powdered in mechanical mill, and was subjected to hydrodistillation in a Clevenger-type apparatus. The components were analyzed using a mass spectrometrycoupled gas chromatography (GC-MS), and the identification of substances was performed by comparison of the mass spectra obtained with the mass spectra of the database of the GC-MS and retention indices . The essential oil was evaluated using the method of broth dilution at concentrations ranging from 3.125µg/mL to 3200µg/mL. It was possible to identify 45 substances (92.1%) of the essential oils, and the major components were trans-caryophyllene (6.7%), citronellol (5.6%), sphatulenol (5.3%), α-cadinol (4.3%), n-tricosano (4.3%), geraniol (4.1%) and trans-geranilacetone (3.7%), n-pentacosano (3.5%), globulol (3.4%), caryophyllene oxide (3.2%). The essential oil of T. subulata Sm. showed effective antibacterial activity for the various strains of S. aureus tested, with the MIC values between 25 µg/mL and 1600 µg/mL. The study of the essential oil of Turnera subulata Sm. showed that it consists of a complex mixture of several classes of compounds having the sesquiterpenes as major constituents followed by monoterpenes, and showed an antibacterial activity significant front the strains tested.

scholarly journals Peptide/β-Peptoid Hybrids with Ultrashort PEG-Like Moieties: Effects on Hydrophobicity, Antibacterial Activity and Hemolytic Properties

2021 ◽  
Vol 22 (13) ◽  
pp. 7041
Author(s):  
Nicki Frederiksen ◽  
Stavroula Louka ◽  
Chirag Mudaliar ◽  
Ilona Domraceva ◽  
Agrita Kreicberga ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Hemolytic Activity ◽  
Mammalian Cells ◽  
Drug Resistant ◽  
Wild Type ◽  
Reverse Phase Hplc ◽  
Reverse Phase ◽  
Ic50 Values ◽  
Resistant Strains ◽  
Drug Resistant Strains

PEGylation of antimicrobial peptides as a shielding tool that increases stability toward proteolytic degradation typically leads to concomitant loss of activity, whereas incorporation of ultrashort PEG-like amino acids (sPEGs) remains essentially unexplored. Here, modification of a peptide/β-peptoid hybrid with sPEGs was examined with respect to influence on hydrophobicity, antibacterial activity and effect on viability of mammalian cells for a set of 18 oligomers. Intriguingly, the degree of sPEG modification did not significantly affect hydrophobicity as measured by retention in reverse-phase HPLC. Antibacterial activity against both wild-type and drug-resistant strains of Escherichia coli and Acinetobacter baumannii (both Gram-negative pathogens) was retained or slightly improved (MICs in the range 2–16 µg/mL equal to 0.7–5.2 µM). All compounds in the series exhibited less than 10% hemolysis at 400 µg/mL. While the number of sPEG moieties appeared not to be clearly correlated with hemolytic activity, a trend toward slightly increased hemolytic activity was observed for analogues displaying the longest sPEGs. In contrast, within a subseries the viability of HepG2 liver cells was least affected by analogues displaying the longer sPEGs (with IC50 values of ~1280 µg/mL) as compared to most other analogues and the parent peptidomimetic (IC50 values in the range 330–800 µg/mL).

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