scholarly journals Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity

2021 ◽  
Author(s):  
Przemysław Biegański ◽  
Łukasz Szczupak ◽  
Manuel Arruebo ◽  
Konrad Kowalski
Keyword(s):  
Antibacterial Activity ◽  
Pathogenic Bacteria ◽  
Drug Resistant ◽  
Antibacterial Drugs ◽  
Recent Developments ◽  
Resistant Strains ◽  
Drug Resistant Strains

Recent developments in the field of organometalated antibacterial drugs and metal-based materials with antibacterial activity are reviewed. They emerge as attractive candidates for combating pathogenic bacteria including drug resistant strains.

scholarly journals SCREENING PHYTOCHEMICAL AND ANTI-METHICILLIN RESISTANT (MRSA) ACTIVITY OF 70 % ETHANOLIC EXTRACT FROM THE STEM BARK OF ALBIZIA LEBBECK(L.) BENTH.(FABACEAE)

2018 ◽  
Vol 6 (6) ◽  
pp. 1-6
Author(s):  
Yao KANGA ◽  
CAMARA Djeneb ◽  
KOUASSI Kouadio Aubin ◽  
ZIRIHI Guédé Noël
Keyword(s):  
Antibacterial Activity ◽  
Reference Strain ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Drug Resistant ◽  
Albizia Lebbeck ◽  
Antimicrobial Drugs ◽  
Methicillin Resistant ◽  
Resistant Strains ◽  
Drug Resistant Strains

The emergence of multi-drug resistant strains and limitations of present antimicrobial drugs have led to continuous search for natural products as curative agents for Anti-methicillin resistantinfections. The aim of this study was to evaluate antibacterial activity of an ethanolic extract from Albizia lebbeckstem bark against Anti-methicillin resistant. Methods and Results : The methods of dissemination swab on muller-hinton agar and double dilution were used to evaluate the antibacterial activity of 70 % ethanolic extract of stem bark of Albizia lebbeck.All multi-resistant strains of Staphylococcus aureus and the reference strain (ATCC 25923) were sensitive to 70 % ethanolic extract of the stem bark of Albizia lebbeck. The MBCvary from 0,49 mg/mL to 2mg/mL. Also, the phytochemical screening of this extract revealed the presence of  Polyphenols, Gallic tannins, Catechin tanninsand Flavonoids. These findings confirm that an 70 % ethanolic extract from Albizia lebbeck stem bark inhibited growth of Anti-methicillin resistant at low concentration and could be utilised as an alternative Anti-methicillin resistantagent.

scholarly journals Antibacterial activity of combined medicinal plants extract against multiple drug resistant strains

2015 ◽  
Vol 5 ◽  
pp. S151-S154
Author(s):  
Rafiqul Islam ◽  
Md. Shahedur Rahman ◽  
Riad Hossain ◽  
Nazmun Nahar ◽  
Belal Hossin ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Medicinal Plants ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
Plants Extract

Recent Developments and Novel Drug Delivery Strategies for the Treatment of Tuberculosis

2019 ◽  
Vol 12 (3) ◽  
pp. 4524-4530
Author(s):  
Yonas Brhane ◽  
Tesfaye Gabriel ◽  
Tigist Adane ◽  
Yemisrach Negash ◽  
Henok Mulugeta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mycobacterium Tuberculosis Complex ◽  
Drug Resistant ◽  
Tuberculosis Complex ◽  
Innovative Drug ◽  
Recent Developments ◽  
Resistant Strains ◽  
Delivery Strategies ◽  
Drug Resistant Strains ◽  
Novel Drug

Tuberculosis (TB) is a contagious infectious illness caused by species having a place with the Mycobacterium tuberculosis complex. The clinical management of tuberculosis still remains a difficult task. Treatment of TB with anti-tubercular drugs becomes the only option available. Hence, the goals of treatment are ensure cure without relapse, prevent death, impede transmission, and prevent emergence of drug resistant strains. This review describes the latest developments and innovative drug delivery strategies for treatment of TB in order to improve the therapeutic efficacy and reduce toxic effect of anti-tubercular agents and enhance patient compliance with concomitant decrease in drug interaction. Among different novel drug delivery systems Niosomes, Liposomes, Dendrimers, Cyclodextrins, Microencapsulation, Alginates and Hydrogels have been described as new drug delivery strategies of anti-tubercular agents. 

scholarly journals Pharmacological Inhibition of the ClpXP Protease Increases Bacterial Susceptibility to Host Cathelicidin Antimicrobial Peptides and Cell Envelope-Active Antibiotics

2012 ◽  
Vol 56 (4) ◽  
pp. 1854-1861 ◽  
Author(s):  
Shauna M. McGillivray ◽  
Dan N. Tran ◽  
Nitya S. Ramadoss ◽  
John N. Alumasa ◽  
Cheryl Y. Okumura ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Pathogenic Bacteria ◽  
Therapeutic Strategy ◽  
Cell Envelope ◽  
Bacterial Species ◽  
Drug Resistant ◽  
Host Defenses ◽  
Content Type ◽  
Resistant Strains ◽  
Drug Resistant Strains

ABSTRACTThe ClpXP protease is a critical bacterial intracellular protease that regulates protein turnover in many bacterial species. Here we identified a pharmacological inhibitor of the ClpXP protease, F2, and evaluated its action inBacillus anthracisandStaphylococcus aureus. We found that F2 exhibited synergistic antimicrobial activity with cathelicidin antimicrobial peptides and antibiotics that target the cell well and/or cell membrane, such as penicillin and daptomycin, inB. anthracisand drug-resistant strains ofS. aureus. ClpXP inhibition represents a novel therapeutic strategy to simultaneously sensitize pathogenic bacteria to host defenses and pharmaceutical antibiotics.

scholarly journals Characterization and anti-staphylococcal activity of the essential oil from Turnera subulata Sm.

2014 ◽  
Vol 16 (3) ◽  
pp. 534-538 ◽  
Author(s):  
M.G. Fernandes ◽  
R.A. Gomes ◽  
S.G. Brito-Filho ◽  
R.N. Silva-Filho ◽  
M.F. Agra ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Essential Oil ◽  
Mass Spectra ◽  
Complex Mixture ◽  
Retention Indices ◽  
Drug Resistant ◽  
Aerial Parts ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
Broth Dilution

The present study is pioneer in analyzing the chemical composition of the essential oil from aerial parts of Turnera subulata Sm. and evaluates their antibacterial activity against a panel of drug-resistant strains of Staphylococcus aureus. The aerial parts were kiln-dried and then powdered in mechanical mill, and was subjected to hydrodistillation in a Clevenger-type apparatus. The components were analyzed using a mass spectrometrycoupled gas chromatography (GC-MS), and the identification of substances was performed by comparison of the mass spectra obtained with the mass spectra of the database of the GC-MS and retention indices . The essential oil was evaluated using the method of broth dilution at concentrations ranging from 3.125µg/mL to 3200µg/mL. It was possible to identify 45 substances (92.1%) of the essential oils, and the major components were trans-caryophyllene (6.7%), citronellol (5.6%), sphatulenol (5.3%), α-cadinol (4.3%), n-tricosano (4.3%), geraniol (4.1%) and trans-geranilacetone (3.7%), n-pentacosano (3.5%), globulol (3.4%), caryophyllene oxide (3.2%). The essential oil of T. subulata Sm. showed effective antibacterial activity for the various strains of S. aureus tested, with the MIC values between 25 µg/mL and 1600 µg/mL. The study of the essential oil of Turnera subulata Sm. showed that it consists of a complex mixture of several classes of compounds having the sesquiterpenes as major constituents followed by monoterpenes, and showed an antibacterial activity significant front the strains tested.

scholarly journals Peptide/β-Peptoid Hybrids with Ultrashort PEG-Like Moieties: Effects on Hydrophobicity, Antibacterial Activity and Hemolytic Properties

2021 ◽  
Vol 22 (13) ◽  
pp. 7041
Author(s):  
Nicki Frederiksen ◽  
Stavroula Louka ◽  
Chirag Mudaliar ◽  
Ilona Domraceva ◽  
Agrita Kreicberga ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Hemolytic Activity ◽  
Mammalian Cells ◽  
Drug Resistant ◽  
Wild Type ◽  
Reverse Phase Hplc ◽  
Reverse Phase ◽  
Ic50 Values ◽  
Resistant Strains ◽  
Drug Resistant Strains

PEGylation of antimicrobial peptides as a shielding tool that increases stability toward proteolytic degradation typically leads to concomitant loss of activity, whereas incorporation of ultrashort PEG-like amino acids (sPEGs) remains essentially unexplored. Here, modification of a peptide/β-peptoid hybrid with sPEGs was examined with respect to influence on hydrophobicity, antibacterial activity and effect on viability of mammalian cells for a set of 18 oligomers. Intriguingly, the degree of sPEG modification did not significantly affect hydrophobicity as measured by retention in reverse-phase HPLC. Antibacterial activity against both wild-type and drug-resistant strains of Escherichia coli and Acinetobacter baumannii (both Gram-negative pathogens) was retained or slightly improved (MICs in the range 2–16 µg/mL equal to 0.7–5.2 µM). All compounds in the series exhibited less than 10% hemolysis at 400 µg/mL. While the number of sPEG moieties appeared not to be clearly correlated with hemolytic activity, a trend toward slightly increased hemolytic activity was observed for analogues displaying the longest sPEGs. In contrast, within a subseries the viability of HepG2 liver cells was least affected by analogues displaying the longer sPEGs (with IC50 values of ~1280 µg/mL) as compared to most other analogues and the parent peptidomimetic (IC50 values in the range 330–800 µg/mL).

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