Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus

The emergence of multi-drug resistant strains and limitations of present antimicrobial drugs have led to continuous search for natural products as curative agents for Anti-methicillin resistantinfections. The aim of this study was to evaluate antibacterial activity of an ethanolic extract from Albizia lebbeckstem bark against Anti-methicillin resistant. Methods and Results : The methods of dissemination swab on muller-hinton agar and double dilution were used to evaluate the antibacterial activity of 70 % ethanolic extract of stem bark of Albizia lebbeck.All multi-resistant strains of Staphylococcus aureus and the reference strain (ATCC 25923) were sensitive to 70 % ethanolic extract of the stem bark of Albizia lebbeck. The MBCvary from 0,49 mg/mL to 2mg/mL. Also, the phytochemical screening of this extract revealed the presence of Polyphenols, Gallic tannins, Catechin tanninsand Flavonoids. These findings confirm that an 70 % ethanolic extract from Albizia lebbeck stem bark inhibited growth of Anti-methicillin resistant at low concentration and could be utilised as an alternative Anti-methicillin resistantagent.

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Comparative Analysis of Common and Unique Targets in Drug Resistant Strains of Staphylococcus aureus

Frontier Discoveries and Innovations in Interdisciplinary Microbiology ◽

10.1007/978-81-322-2610-9_12 ◽

2016 ◽

pp. 193-205

Author(s):

Amandeep Kaur Kahlon ◽

Mahendra P. Darokar ◽

Ashok Sharma

Keyword(s):

Staphylococcus Aureus ◽

Comparative Analysis ◽

Drug Resistant ◽

Resistant Strains ◽

Drug Resistant Strains

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Antibacterial activity of combined medicinal plants extract against multiple drug resistant strains

Asian Pacific Journal of Tropical Disease ◽

10.1016/s2222-1808(15)60878-7 ◽

2015 ◽

Vol 5 ◽

pp. S151-S154

Author(s):

Rafiqul Islam ◽

Md. Shahedur Rahman ◽

Riad Hossain ◽

Nazmun Nahar ◽

Belal Hossin ◽

...

Keyword(s):

Antibacterial Activity ◽

Medicinal Plants ◽

Multiple Drug ◽

Drug Resistant ◽

Multiple Drug Resistant ◽

Resistant Strains ◽

Drug Resistant Strains ◽

Plants Extract

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Studies on the effects of 3-acetyl-4"-isovaleryltylosin against multiple-drug resistant strains of Staphylococcus aureus.

The Journal of Antibiotics ◽

10.7164/antibiotics.34.305 ◽

1981 ◽

Vol 34 (3) ◽

pp. 305-312 ◽

Cited By ~ 7

Author(s):

MASAMI TSUCHIYA ◽

KAYOKO SUZUKAKE ◽

MAKOTO HORI ◽

TSUTOMU SAWA ◽

TOMIO TAKEUCHI ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Multiple Drug ◽

Drug Resistant ◽

Multiple Drug Resistant ◽

Resistant Strains ◽

Drug Resistant Strains

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Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model

Infection and Immunity ◽

10.1128/iai.02498-14 ◽

2014 ◽

Vol 83 (1) ◽

pp. 339-345 ◽

Cited By ~ 15

Author(s):

Bao Zhong Zhang ◽

Yan Hong Hua ◽

Bin Yu ◽

Candy Choi Yi Lau ◽

Jian Piao Cai ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Immune Responses ◽

Survival Rates ◽

Passive Immunization ◽

Health Concern ◽

Drug Resistant ◽

Public Health Concern ◽

Content Type ◽

Resistant Strains ◽

Drug Resistant Strains

Staphylococcus aureusis a common pathogen found in the community and in hospitals. Most notably, methicillin-resistantS. aureusis resistant to many antibiotics, which is a growing public health concern. The emergence of drug-resistant strains has prompted the search for alternative treatments, such as immunotherapeutic approaches. To date, most clinical trials of vaccines or of passive immunization againstS. aureushave ended in failure. In this study, we investigated two ESAT-6-like proteins secreted byS. aureus,S. aureusEsxA (SaEsxA) and SaEsxB, as possible targets for a vaccine. Mice vaccinated with these purified proteins elicited high titers of anti-SaEsxA and anti-SaEsxB antibodies, but these antibodies could not preventS. aureusinfection. On the other hand, recombinant SaEsxA (rSaEsxA) and rSaEsxB could induce Th1- and Th17-biased immune responses in mice. Mice immunized with rSaEsxA and rSaEsxB had significantly improved survival rates when challenged withS. aureuscompared with the controls. These findings indicate that SaEsxA and SaEsxB are two promising Th1 and Th17 candidate antigens which could be developed into multivalent and serotype-independent vaccines againstS. aureusinfection.

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Study of bacterial pathogens causing chronic suppurative otitis media and the antibiotic susceptibility pattern of the isolates at a tertiary care centre in Kochi

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20201288 ◽

2020 ◽

Vol 6 (4) ◽

pp. 714

Author(s):

Geetha Nair ◽

Tanya Tonny Mampilly ◽

Bindhu Vasudevan ◽

J. Lancy

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Otitis Media ◽

Tertiary Care ◽

Drug Resistant ◽

Care Centre ◽

Tertiary Care Centre ◽

Suppurative Otitis Media ◽

Resistant Strains ◽

Drug Resistant Strains

Background: Chronic suppurative otitis media (CSOM) is defined as chronic inflammation of middle ear and mastoid cavity presenting with recurrent ear discharges through a tympanic membrane perforation. Complications of CSOM were frequent in pre-antibiotic era. Injudicious use of antibiotics led to the emergence of multi-drug resistant strains and complications in return. To isolate the organisms associated with CSOM in a tertiary care centre and to detect their antibiogram.Methods: In this clinical, prospective, cross sectional study, a total of 100 patients clinically diagnosed with CSOM were enrolled from January to December 2019 (1 year). Results: Of the 100 samples collected, predominant bacteria were isolated in 58 patients (58%). The most common isolate was Pseudomonas aeruginosa (29 isolates) followed by Staphylococcus aureus (24), Klebsiella species (3) and 1 isolate each of Pneumococci and Acinetobacter species. Among the 29 isolates of Pseudomonas aeruginosa, 8 (28%) were multidrug resistant. Sensitivity was 100% to imipenem followed by 97% to meropenem,79% to gentamicin, 76% to amikacin, 66% to ciprofloxacin, 41% to piperacillin tazobactam and 17% to ceftazidime. Of the 24 isolates of Staphylococcus aureus, 4 (16%) were methicillin resistant Staphylococcus aureus (MRSA).Conclusions: Pseudomonas aeruginosa was the most common isolate, of which 28% were multi drug resistant. This calls for the judicious use of antibiotics and alternative measures for treatment of drug resistant strains. Formulating an antibiotic policy based on the local antibiogram can help in preventing the emergence and spread of resistant pathogens.

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Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity

RSC Chemical Biology ◽

10.1039/d0cb00218f ◽

2021 ◽

Author(s):

Przemysław Biegański ◽

Łukasz Szczupak ◽

Manuel Arruebo ◽

Konrad Kowalski

Keyword(s):

Antibacterial Activity ◽

Pathogenic Bacteria ◽

Drug Resistant ◽

Antibacterial Drugs ◽

Recent Developments ◽

Resistant Strains ◽

Drug Resistant Strains

Recent developments in the field of organometalated antibacterial drugs and metal-based materials with antibacterial activity are reviewed. They emerge as attractive candidates for combating pathogenic bacteria including drug resistant strains.

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