Cancer-Cell-Specific Mitochondria-Targeted Drug Delivery by Dual-Ligand-Functionalized Nanodiamonds Circumvent Drug Resistance

2017 ◽  
Vol 9 (13) ◽  
pp. 11780-11789 ◽  
Author(s):  
Miu Shan Chan ◽  
Ling Sum Liu ◽  
Hoi Man Leung ◽  
Pik Kwan Lo
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Cancer Cell ◽  
Targeted Drug Delivery ◽  
Targeted Drug

scholarly journals Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 59
Author(s):  
Abeer M. Beagan ◽  
Ahlam A. Alghamdi ◽  
Shatha S. Lahmadi ◽  
Majed A. Halwani ◽  
Mohammed S. Almeataq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Folic Acid ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Mesoporous Nanoparticles ◽  
Targeted Drug ◽  
Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

Biotinylated carboxymethyl chitosan/CaCO3 hybrid nanoparticles for targeted drug delivery to overcome tumor drug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 69083-69093 ◽  
Author(s):  
Jin-Long Wu ◽  
Xiao-Yan He ◽  
Pei-Yuan Jiang ◽  
Meng-Qing Gong ◽  
Ren-Xi Zhuo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Carboxymethyl Chitosan ◽  
Hybrid Nanoparticles ◽  
Cancer Drug ◽  
Tumor Drug Resistance ◽  
Anti Cancer ◽  
Targeted Drug

A tumor targeted nano-sized self-assembled drug delivery system could efficiently co-deliver an anti-cancer drug and a drug resistance inhibitor to tumor cells and achieve an improved therapeutic efficiency through inhibition of P-gp function.

scholarly journals Mini Review: Nano-Technology based Drug Deliveries

2018 ◽  
Vol 8 (6) ◽  
pp. 268-271
Author(s):  
Kuilong Wang
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Targeted Drug Delivery ◽  
Research Work ◽  
Drug Carriers ◽  
Nano Technology ◽  
Treatment Conditions ◽  
Nanoparticle Formulation ◽  
Targeted Drug

Targeted drug delivery with nano-technology has been researched and identified as being efficient across many treatment conditions. This review assesses some of the existing research work and evidence practice in using nano-technology based drug carriers. Keywords: Nano-technology, drug delivery, nanoparticle formulation, nano-technology carriers, drug resistance

scholarly journals All-optical targeted drug delivery and real-time detection of a single cancer cell

Nanophotonics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 611-622
Author(s):  
Xiaole Liu ◽  
Jie Yuan ◽  
Dong Wu ◽  
Xiaobin Zou ◽  
Qing Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Cancer Cell ◽  
Targeted Drug Delivery ◽  
Optical Method ◽  
Cell Detection ◽  
All Optical ◽  
Single Cancer ◽  
Targeted Drug ◽  
Real Time Detection

AbstractTargeted drug delivery and real-time detection both play an important role for studying the specificity of a single cancer cell and the development of anticancer drugs. However, a method that simultaneously enables safe and efficient targeted drug delivery and noninvasive, free-label cell detection is highly desirable but challenging. Here, we report an all-optical method that combines fiber optical tweezers with laser Raman microspectroscopy, which can achieve targeted drug delivery to a single cancer cell using optical manipulation in vitro quickly and accurately by a tapered fiber probe, and simultaneously record the corresponding active characteristics of the targeted cancer cell under the contact of delivered drug through a Raman spectrometer. Using the method, drug delivery and release can be flexibly controlled by turning on/off the trapping laser beam propagating in the fiber, which can avoid the complex systems and is highly autonomous and controllable. Moreover, the detection of cell activity does not require any dye calibration and processing, and it is noninvasive. In addition, for a single suspension cell, optical trapping of the cell using another fiber tip can overcome the low efficiency of targeted drug delivery and the poor stability of the Raman spectrum caused by Brownian motion of the cell. This all-optical method provides a promising approach to conduct pharmacologic studies with the reaction of cancer cell and drugs at the level of a single cell.

scholarly journals Precise Deposition of Polydopamine on Cancer Cell Membrane as Artificial Receptor for Targeted Drug Delivery

iScience ◽  
2020 ◽  
Vol 23 (12) ◽  
pp. 101750
Author(s):  
Hoda Safari Yazd ◽  
Yu Yang ◽  
Long Li ◽  
Lu Yang ◽  
Xiaowei Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Targeted Drug Delivery ◽  
Artificial Receptor ◽  
Targeted Drug

Targeted Drug Delivery in Cancer Therapy

2005 ◽  
Vol 4 (4) ◽  
pp. 363-374 ◽  
Author(s):  
Jaspreet K. Vasir ◽  
Vinod Labhasetwar
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Cancer Therapy ◽  
Success Rate ◽  
Cancer Patients ◽  
Targeted Drug Delivery ◽  
Tumor Tissue ◽  
Tumor Biology ◽  
Multi Drug Resistance ◽  
Targeted Drug

Chemotherapy has been the main modality of treatment for cancer patients; however, its success rate remains low, primarily due to limited accessibility of drugs to the tumor tissue, their intolerable toxicity, development of multi-drug resistance, and the dynamic heterogeneous biology of the growing tumors. Better understanding of tumor biology in recent years and new targeted drug delivery approaches that are being explored using different nanosystems and bioconjugates provide optimism in developing successful cancer therapy. This article reviews the possibilities and challenges for targeted drug delivery in cancer therapy.

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