scholarly journals Pattern of analgesic use in hospitalized children at a pediatric general ward in a tertiary care teaching hospital

2019 ◽  
Vol 9 (1) ◽  
pp. 199-201
Author(s):  
Dr. Puja ◽  
D.C. Dhasmana ◽  
Saurabh Kohli ◽  
Vipin Chander
Keyword(s):  
Tertiary Care ◽  
General Ward ◽  
Fixed Dose ◽  
Hospitalized Children ◽  
Microsoft Excel ◽  
Inflammatory Agent ◽  
Icd 10 ◽  
Dose Combination ◽  
Analgesic Use ◽  
Who Indicators

Background: analgesic use is common in adults but their use in children has not been extensively studied. This observational study was envisaged to study prevalence and pattern of analgesic use in hospitalized children in pediatric general ward. Methods: 120 patients were included in the study. Disease was classified as per ICD-10 and medicines used were classified according to ATC classification. WHO indicators for rationality was used. Descriptive statistics was used to present the data i.e. percentage; proportions, frequency, mean and standard deviation using Microsoft excel worksheet. Result: A total of 791 drugs from different classes were prescribed to 120 patients with a mean of 6.6 + 2.68 drugs described per patient during their stay in the hospital. 81 analgesics were prescribed. 25 were prescribed as fixed dose combination. Paracetamol was the most commonly prescribed non steroidal anti-inflammatory agent. Keywords: analgesics, children, fixed dose combinations

scholarly journals EFFECTIVENESS AND SAFETY ASSESSMENT OF FIXED DOSE COMBINATION OF NON-STEROIDAL ANTIINFLAMMATORY DRUGS PRESCRIBED FOR ORTHOPEDIC PATIENTS

2019 ◽  
pp. 70-73
Author(s):  
NILAY SOLANKI ◽  
ALPA GOR ◽  
BIRAJ PARMAR
Keyword(s):  
Adverse Effects ◽  
Tertiary Care ◽  
The Other ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Antiinflammatory Drugs ◽  
Dose Combination ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Orthopedic Patients

Objective: Many Fix Dose Combinations (FDCs) being introduced in India are usually irrational. The most pressing concern with irrational FDCs is that they expose patients to unnecessary risk of adverse drug reactions, for instance, pediatric formulations of nimesulide+paracetamol. Despite their wide clinical use, their gastro-intestinal toxicity is a major limitation. The aim of the present work was to evaluate the efficacy and safety of FDCs in non-steroidal anti-inflammatory drugs in the orthopedic department at a tertiary care teaching hospital. To study the effectiveness and safety parameters of fixed-dose combinations of Non-Steroidal Anti-inflammatory Drugs. Methods: This prospective, observational study was conducted among 150 out-patients of the orthopedic ward over a period of July 2013 to December 2013(Each combination with 50 patients). Three fixed-dose combinations utilized were paracetamol+diclofenac, paracetamol+ibuprofen and paracetamol+nimesulide. The effectiveness was analyzed by using Visual Analogue Scale (VAS) and Disease Activity Scale (DAS) and the safety criteria were analyzed by using the WHO probability scale and Naranjo scale. 150 orthopedic patients attending Out Patient Department were included. 50 participants for each of the combinations of fixed-dose combination (FDCs) of NSAIDs. Results: Out of 150 patients 33 patients developed adverse effects, and 17(51.51%) adverse effects due to the combination of Paracetmol+Nimuselide, 11(33.34%) adverse effects due to the Paracetamol+Ibuprofen and 5 (15.15%) were due to the combination of Paracetamol+Diclofenac. The maximum effectiveness (3.55±0.208) showed in the combination of paracetamol+diclofenac compared to the other two combinations. Conclusion: It was concluded from this study that the effectiveness and safety profile of PCM+DICLO is better than the other two FDCs.

scholarly journals TO STUDY THE DRUG USE PATTERN IN PRIMARY OPEN ANGLE GLAUCOMA IN A TERTIARY CARE TEACHING

2017 ◽  
Vol 10 (2) ◽  
pp. 198
Author(s):  
Deepalatha C ◽  
Leela Pratyusha Mb
Keyword(s):  
Drug Use ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Tertiary Care ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Open Angle ◽  
Duration Of Treatment ◽  
Care Teaching ◽  
Dose Combination

Objective: To study the drug utilization pattern in patients suffering from primary open-angle glaucoma (POAG) in a tertiary care teaching hospital.Methods: It is a prospective study done on 50 patients of POAG (comprising of individuals belonging to any age group). This study was carried for a period of 2-month, and the data included patient’s demographic details and the drugs prescribed. Data were analyzed for drug use pattern.Results: After screening the prescriptions of patients, it was found out that out of total 50 prescriptions, 30 were males, and 20 were females. Out of50 prescriptions, prostaglandins (58%) were most commonly prescribed. β-blockers (16%) were also prescribed. Fixed dose combination constituted60% of the prescriptions. Instructions about the route, frequency, and duration of treatment were present in all prescriptions. Drugs prescribed by their generic names were 18.75% and about 81.25% of the drugs were prescribed by their brand names.Conclusions: Fixed drug combination of timolol and dorzolamide was the most frequently prescribed combination. Prescribers must be aware ofimportance of prescribing drugs with generic names.Keywords: Primary open-angle glaucoma, Intraocular pressure, Fixed dose combination.

scholarly journals A study on the prescription pattern of antifungal drugs in the Dermatology Department of a tertiary care teaching hospital in Southern Kerala

2018 ◽  
Vol 8 (1) ◽  
pp. 100
Author(s):  
Parvathy Gopimohan ◽  
Sudha M. J. ◽  
Rathish T. Pillai ◽  
Ramani P. T.
Keyword(s):  
Fungal Infection ◽  
Tertiary Care ◽  
Cost Effective ◽  
Antifungal Drugs ◽  
Fixed Dose ◽  
Dermatology Department ◽  
Prescription Pattern ◽  
Number Of Patients ◽  
Dose Combination ◽  
Cutaneous Fungal Infection

Background: Skin disorders form 2% of total Out Patient Department consultations worldwide. But no such data is available from India. Studying prescription pattern is a component of medical audit that help prescribers to provide rational and cost-effective medical care. This study is about the prescription pattern of antifungals in this institution and will help in developing local policies for appropriate use of antifungal drugs. The objective was to study the prescription pattern of antifungals in dermatological diseases.Methods: This is a retrospective study conducted from 1st June 2017 to 30th November 2017 in Dermatology Department. Prescriptions included all newly diagnosed patients with cutaneous fungal infection of both sex who attended Dermatology OPD. Factors considered were sociodemographic parameters, number of patients with combination and monotherapy, number of single topical agents and Fixed Dose Combination (FDC) details of prescribing indicators.Results: 1500 prescriptions were analysed; 500 prescriptions were of fungal infection. 40.2% of the patients were in 18-35 years age group. There were a greater number of males (59.6%) than females (40.4%).Conclusions: The most common oral antifungal used was fluconazole. Terbinafine and clotrimazole were the most commonly used topical agents.

scholarly journals Cost variation analysis of parenteral antibiotics in Indian pharmaceutical market

2019 ◽  
Vol 8 (11) ◽  
pp. 2535
Author(s):  
Prasan R. Bhandari ◽  
Apeksha Bhandary
Keyword(s):  
Tertiary Care ◽  
Fixed Dose ◽  
Price Difference ◽  
Price Variation ◽  
Medical Specialties ◽  
Cost Variation ◽  
Maximum Price ◽  
Minimum Price ◽  
Dose Combination ◽  
The Cost

Background: The objective of the present study was to analyse price differences between parenteral antibiotics available in a tertiary care teaching hospital.Methods: The study was done in the Department of Pharmacology of S. D. M. College of Medical Sciences, Dharwad, Karnataka. Latest volume of current index of medical specialties or Indian Drug Review was used to analyze the prices of parenteral antibiotics.Results: Overall, prices of 17 single drug antibiotics available in 37 strengths marketed and 8 fixed-dose combinations available in 16 strength marketed were analyzed. It was observed that the maximum cost variation among the single ingredient parenteral antibiotic was with cefpirome 1000 mg. The price difference being Rs. 283 and the cost variation being 90.7%. The minimum price variation was seen with Ampicillin 100 mg of Rs. 4.3 and the cost variation being 40.2%. Additionally the highest price difference was also seen teicoplanin 400 mg i.e., Rs. 610 and its cost variation being 68.5%. Among the fixed-dose combination (FDC’s) the maximum price variation was observed in the combination of cefoperazone+sulbactum 1000+1000 of Rs. 340. Whereas the cost variation of the same was 212.5 %. The minimum price variation among the FDC’s was of the combination of ceftriaxone 250 mg + tazobactum 31.25 mg Rs. 3.3 and its cost variation being 7.9 %.Conclusions: Pharmacoeconomics facets must be taken into deliberation by healthcare practitioners while prescribing antibiotics to the patients for infectious disease treatment. This will assist compliance, reduce antibiotic resistance and treatment failure.

scholarly journals Assessment of rational use of fixed dose combinations in hypertension in a tertiary care teaching hospital in north India

2018 ◽  
Vol 5 (5) ◽  
pp. 1263 ◽  
Author(s):  
Rohini Gupta ◽  
Apoorva Malhotra ◽  
Pavan Malhotra
Keyword(s):  
Tertiary Care ◽  
Drug Combinations ◽  
North India ◽  
Fixed Dose ◽  
Cross Sectional ◽  
Jammu And Kashmir ◽  
Rational Use ◽  
Dose Combination ◽  
Come Into The Market ◽  
Dual Drug

Background: Fixed-dose combination (FDC) agents could be considered as an effective therapy in chronic illnesses like hypertension, which have multifactorial etiology. At present, many FDCs have come into the market without being assessed for their efficacy, safety and rationality by the drug regulatory authorities. The objective of the present study was to assess the rational use of fixed dose drug combinations in hypertension.Methods: It was a cross-sectional observational study conducted in the cardiology outpatient department of ASCOMS and H, Sidhra, Jammu, Jammu and Kashmir from February 2016 to July 2016. In the study 92 prescriptions of hypertensive patients who were on anti-hypertensive fixed-dose drug combinations (FDCs) were recruited after thoroughly evaluated for inclusion and exclusion criteria. Data obtained includes the demographic profile of the patients, pattern of the prescribed FDCs in hypertension, evaluation of the rationality of the FDCs based upon the comprehensive seven-point criteria developed by Panda et al.Results: In the present study, about sixteen different anti-hypertensive FDCs were observed in the prescriptions of 92 patients during six-month period. It was observed that about 93.75% of FDCs were dual drug combinations. Among the dual drug combinations, most commonly used combination was Olmesartan (ARB; Angiotensin receptor blocker) + Amlodipinine (Calcium channel blocker) in 17.4% of patients. It was also observed that among the 16 different anti-hypertensive fixed dose combinations analysed, 12 FDCs (75%) were found to be rational and 4 FDCs (25%) were found to be irrational.Conclusions: In the present study it was found that 75% of the FDCs prescribed were rational and 25% were irrational. Therefore, before marketing the FDCs proper assessment of their efficacy, safety and rationality should be done.

scholarly journals PRESCRIBING PATTERN OF ANTIBIOTICS AMONG OUTDOOR PATIENTS IN MEDICINE DEPARTMENT OF TERTIARY CARE HOSPITAL IN NORTHERN INDIA

2020 ◽  
pp. 43-46
Author(s):  
SUMAN LATA ◽  
VIJAY KHAJURIA ◽  
VINEETA SAWHNEY ◽  
SANJAY SHAH
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Antibiotic Use ◽  
Fixed Dose ◽  
Care Hospital ◽  
Prescribing Pattern ◽  
Medicine Department ◽  
Medical College ◽  
Northern India ◽  
Dose Combination

Objective: The objective of the present study was to examine the prescribing pattern of antibiotics in the outpatient department of medicine in a tertiary care hospital. Methods: This prospective observational study was conducted in department of pharmacology in collaboration with department of medicine of Govt Medical College Kathua for a period of one month. Prescription of all patients attending medicine OPD who were prescribed antibiotics was analysed. Results: A total of 450 prescription of OPD patients were analysed. Out of these 200 prescriptions of patients had antibiotics prescribed. 98% of prescriptions had oral antibiotics and other 2% were prescribed injectable antibiotics. 70 % of prescriptions were on the single antibiotic and in 30% of prescriptions, fixed-dose combination were prescribed. Cefpodoxime antibiotic was most commonly prescribed in the cephalosporin group, followed by amoxy-clavulanic acid, azithromycin. Irrational prescribing of antibiotics was 34% and it was quite high in our study. Conclusions: Cefpodoxime was most commonly prescribed in cephalosporin group among all antibiotics. Irrational prescribing was quite high in present study. Our result calls for the urgency of refresher courses like stewardship programmes regarding antibiotic use to avoid irrational usage.

scholarly journals Knowledge, attitude and practice regarding use of fixed dose combination drugs among young prescribers a tertiary care teaching hospital in rural Bengal, India

2019 ◽  
Vol 8 (7) ◽  
pp. 1479
Author(s):  
Ananya Mandal ◽  
Sonai Mandal ◽  
Somenath Das
Keyword(s):  
Patient Compliance ◽  
Synergistic Effects ◽  
Tertiary Care ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Cross Sectional ◽  
Medical College ◽  
Prescribing Practice ◽  
Dose Combination ◽  
Graduate Trainees

Background: Use of fixed dose combination (FDCs) is a double edged sword with scope for irrational prescribing on one hand and improved pharmacotherapy and patient compliance on the other hand. Irrational FDCs are being marketed aggressively and often young prescribers including Post Graduate Trainees fall prey to the lure of FDCs. This was a Knowledge-Attitude-Practice study regarding of FDC use among the resident doctors working at a tertiary care medical college of rural Bengal.Methods: This was a cross-sectional, questionnaire based study including 50 resident doctors who were asked to fill a 10-question questionnaire on FDCs anonymously.Results: Ninety two percent of the study participants were aware of the FDCs. The most commonly perceived advantages were better patient compliance and synergistic effects. Most (96%) cited problems of titrating dosages and problems of more side effects. Only 37.6% knew about the banned FDCs. Preferred FDCs among them were antibiotics (94%), cough syrups (80%) and NSAIDs (68%). Residents of dermatology, orthopaedics, surgery and medicine most commonly prescribed FDCs. Sources of knowledge regarding FDCs were CME (92%), medical representative (76%), colleagues (72%), internet (68%), journals (48%) and textbooks (36%).Conclusions: The study showed that most participants were aware of the FDCs and also aware of the problems with irrational FDC use. Knowledge regarding banned drugs was poor as was the rationality of such combinations. More CMEs and inter department group discussions could be conducted to improve awareness and FDC prescribing practice among young prescribers.

scholarly journals RATIONALITY ASSESSMENT OF ZINC FORMULATIONS AVAILABLE IN INDIA

2017 ◽  
Vol 9 (8) ◽  
pp. 200
Author(s):  
Krishnan Vengadaragava Chary ◽  
Rithu Bhaskaran
Keyword(s):  
Tertiary Care ◽  
Daily Intake ◽  
Essential Medicine ◽  
Fixed Dose ◽  
Care Hospital ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Study Results ◽  
Dose Combination ◽  
Sectional Analysis

Objective: To critically analyze the essentiality and irrational zinc preparations available in Indian market. Methods: This was conducted as cross-sectional analysis by department of pharmacology of our tertiary care hospital between June and December 2016. Data regarding various formulations of zinc were retrieved from current index of medical sciences and drug India database. Rationality assessment was done using prescribed guidelines and approved formulations of zinc by Central drug standard control organisation. Essentiality was checked using National list of essential medicine India, 2013 and latest version of WHO list essential medicine bulletin. Dosage regulation was assessed using Indian pharmacopeia guidelines, National institute of nutrition, India recommendation and upper daily intake toxicity intake, United States of America (USA)Results: Our study results showed wide variation in the number of zinc preparation. Total number of formulation available in the market is 335. Among zinc preparation, the preparation that contains 20 mg of zinc as recommended by various guidelines is 10 in number. About 325 preparations of zinc are added with one or more nutraceuticals. None of these fixed dose combination of zinc containing preparation is recommended as essential fixed regimen.Conclusion: Zinc has lot of relevance in treating recurrent diarrhoeal illness, especially in paediatric cases; however legal, regulatory and educational measures should be followed to curtail all the irrational zinc prescription development, promotion, marketing and prescription.

Evaluation of Post-Surgical Antibiotic Utility Patterns in an Indian Tertiary Care Teaching Hospital

2017 ◽  
Vol 10 (5) ◽  
pp. 3853-3857
Author(s):  
Azad Moidul Islam ◽  
Ankit Acharya ◽  
Satish Kumar B P ◽  
Faruk Azad Kibria ◽  
Renukaa Aradhya Chitti ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Tertiary Care ◽  
Surgical Site Infections ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Care Hospital ◽  
Rational Use ◽  
Breast Infection ◽  
Dose Combination ◽  
Surgery Department

Rationale use of antibiotic prophylaxis is essential to reduce the incidence of surgical site infections and cost inefficiency. However, inappropriateness of antibiotic prophylaxis administration is still commonly observed in surgical hospitals. A prospective and observational study was carried out in 111 patients at tertiary care hospital in India. Among the 111 study population enrolled in the study, the majority of study populations were males 70.270% and the females were about 29.729%. Among the 111 study populations enrolled in the study, the majority of the subjects belonged to the age group ≥18 years (88%) and followed by 13-17 years (7%) and 1-12 years (4%). Among 111 patients included in the study, the majority of patients were found ulcer (18%) and followed by hernia (12%), appendicitis (9.9%), head injury (4.5%), burn (3.6%), abscess (3.6%), cystitis (2.7%), hemorrhoids (2.7%), cholelithiasis (2.7%), cancer (3.6%), breast infection (1.81%), miscellaneous (4.5%). Among 111 subjects enrolled in the study, the majority of the subjects (74) had surgery (66%) and 37 subjects did not get surgery (33.33%). Among 111 subjects included in the study, the majority of subjects stayed (5-10days) in the hospital for 11 to 31 days. In 78 (70%) cases, there was no drug interaction and only 33 (30%) subjects showed drug interactions at mild to moderate level. In 66 subjects, antibiotics were prescribed in fixed dose combination. In 45 subjects, antibiotic were prescribed by generic name and 35 subjects got antibiotics from both fixed dose combination and generic version. Within 111 subjects, majority of subjects got rational use of antibiotics (85 subjects, 76%) and irrational use of antibiotic found in 26 subjects (23%). This study confirms that the use of antibiotic prophylaxis needs to be continuously focused in surgery department in order to improve rational use of antibiotic prophylaxis to decrease morbidity and cost. 

Sign in / Sign up

Export Citation Format

Share Document