scholarly journals Clinicopathological Evaluation of Disseminated Metastases of Transmissible Venereal Tumor in a Spayed Bitch

2017 ◽  
Vol 45 ◽  
pp. 6
Author(s):  
Hasan Alkan ◽  
Fatma Satilmis ◽  
Mehmet Eray Alcigir ◽  
Mehmet Bugra Kivrak ◽  
Ibrahim Aydin

Background: Although transmissible venereal tumor (TVT, transmissible venereal sarcoma, Sticker’s sarcoma) that affects dogs and other canids can be seen in many countries, it especially emerges in the countries which homeless dog population is very high. Female dogs are more susceptible than males. Transmissible venereal tumor is usually transmitted to genital organs during coitus and occasionally by social behavior such as sniffing and licking. The tumor is generally observed in the posterior part of the vagina. The tumor usually appears in various sizes, in the appearance of cauliflower, red and fragile. Metastases are rarely reported in cases with TVT. Metastases have been detected in lung, liver, tonsils, skin, lymph nodes, muscles, spleen. The diagnosis of transmissible venereal tumor is achived by considering the history of the animal, gross lesions, cytological examination and histopathology. Chemotherapy is frequently used in the treatment of TVT. In addition, radiotherapy, cryosurgery, surgical incision and immunotherapy are rarely applied for treatment. Chemical agents such as doxorubicin, vincristine sulfate, cyclophosphamide, methotrexate are preferred for chemotherapy.Case: Metastases to all mammary lobes, cervix uteri, neck, skin, gluteal muscles, the oropharyngeal region, and primary vaginal mass were described in spayed bitch, a 10-year old and mixed breed. The clinical examination manifested, fragile and hemorrhagic masses which resemble cauliflower in the vagina, neck, and inguinal region. Furthermore firm and multilobular masses in all mammary lobes, oropharyngeal region, and gluteal muscles of right leg were detected. Firstly, vaginal cytology was performed in order to confirm. In vaginal cytology, round to polyhedral shaped transmissible venereal tumor cells including cytoplasmic vacuoles and polychromatic nuclei were identified. Histopathologically, solid areas included oval- to round-shaped cells with prominent, hyperchromatic nuclei in all masses. Also, some of them comprised mitotic figures in their nuclei. In general, the tumor cells were separated by thin fibrous septa. Additionally, the cells were completely infiltrated to the mammary gland. In contrast, oropharyngeal and subdermal region of neck consisted more solid areas under the epidermis. There was lymphocyte infiltration at the periphery of the cells. For gluteal mass, TVT cells were confined in muscle bundles. Transmissible venereal tumor cases are often located in genital organs and their metastases are rarely encountered in comparison with other tumors. In this case report, metastases to cervical tissue, neck skin, oropharyngeal mucosa and gluteal muscles, mammary lobes are found.Discussion: When the sexual activity is high, the incidence of TVT increases. It especially develops in bitches in estrus. Breed, sex and age are not a cause of predisposition for TVT. Transmissible venereal tumors’ malignancy can increase in some cases, although TVT is known as a benign tumor. Prevalence of metastases was found fairly low in the studies. Metastases to mammary region, to subcutaneous region, to brain, to eye, to lung, to uterus, to ovary, to liver, to spleen have been reported. In conclusion, even if a bitch is acyclic, transmissible venereal tumor can be developed and thus the risk of its disseminated metastasis must be considered. Moreover, since the masses have not regresed for a long time, this situation may be related to severe immunosupression in the bitch.

Author(s):  
Nancy Gakahu

The history of Kenya is loaded with continuous moments when music played a key role in expressing various issues in the country. Music is one of the most important modes through which ordinary Kenyans express their wishes, identity, frustrations and aspirations. For a long time, freedom of speech in Kenya, especially on issues touching political injustice had been curtailed. However, musicians in Kenya offered an alternative means of challenging the political status quo in the country by use of musical lyrics which address injustices directly or metaphorically. What is the place of music in Kenya's political landscape? Has political music in Kenya made a difference in governance and in educating the masses on their political and social rights? Have political songs helped change the political and social climate in Kenya? These issues are examined in this chapter.


2009 ◽  
Vol 54 (No. 9) ◽  
pp. 451-454 ◽  
Author(s):  
M.I. Bhaiyat ◽  
H. Hariharan ◽  
A. Chikweto ◽  
E. Brathwaite-Sylvester ◽  
P.J.A. Burnett ◽  
...  

Concurrent lymphosarcoma and salmonellosis in a 12-year-old female neutered domestic shorthair cat in Grenada is described. Clinically, the cat was emaciated, and had a history of vomiting and diarrhea of two months duration. Clinical examination revealed a large palpable mass in the craniodorsal abdomen and fluid in the thoracic cavity. Gross lesions consisted of moderate pyothorax and pyoabdomen with variably-sized, single to multiple, soft, white masses in the mesentery adjacent to the pancreas, on the serosal surface of the stomach, and on the quadrate lobe of the liver. Histopathological findings associated with these masses were compatible with lymphosarcoma. Sheets of neoplastic round cells, some with intracytoplasmic eosinophilic granules, were found in the masses associated with the omentum, stomach, and liver. <i>Salmonella enteritidis</i> was isolated in pure culture from the thoracic fluid, collected during clinical examination, and mesenteric mass, collected during necropsy, and both isolates showed similar antimicrobial susceptibility patterns.


2017 ◽  
Vol 29 (5) ◽  
pp. 696-699 ◽  
Author(s):  
Jenna C. Dockweiler ◽  
Brieuc Cossic ◽  
Sean P. McDonough ◽  
Susan L. Fubini ◽  
Kayla M. Le ◽  
...  

An aged mixed-breed goat doe was presented with a 9-mo history of serosanguineous vaginal discharge. Vaginal speculum examination revealed serosanguineous discharge but otherwise no abnormalities. Transrectal ultrasonography showed normal ovaries and multifocal cystic lesions within the uterus. Ovariohysterectomy was recommended because of a strong suspicion of neoplasia. Multiple, non-resectable masses were noted in and around the uterus intraoperatively, and euthanasia was elected. Autopsy revealed multiple masses within the uterus, cervix, and lung parenchyma. Histologically, the masses within the uterus represented a likely collision tumor of primary adenocarcinoma and leiomyosarcoma. Our report highlights the importance of obtaining biopsy samples of all masses because the lesions described showed significantly different biological behavior. This information is vital to guide treatment and prognosis.


2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S39-S39
Author(s):  
A K Abu-Salah ◽  
S Segura ◽  
H M Cramer

Abstract Introduction/Objective SMARCA4-deficient thoracic sarcoma/carcinoma is a highly aggressive neoplasm characterized by SMARCA4 (chromatin remodeling complex) deficiency. It affects mostly smokers (85%) with a broad age range of presentation (mean age: 50 years). Most patients present with advanced disease and extensive involvement of thoracic structures. The cytomorphologic features of this entity have not been fully described. Methods/Case Report A 59-year-old female, former smoker, with a prior history of lung adenocarcinoma, presented with a new 2.8 cm right infrahilar nodule concerning for recurrence. The second patient, a 54-year-old male who is a smoker, presented with an 8.0 cm right perihilar mass extending into the right lung and mediastinum with encasement of the right main pulmonary artery. Cytologically, the smears from both aspirates were comprised of single cells and loosely cohesive clusters of ovoid to spindle cells with scant to moderate cytoplasm, stippled chromatin, and focally prominent nucleoli. Numerous mitotic figures were appreciated. Necrosis was present within the smear background. The cell block sections showed tumor cells arranged in glandular and focal papillary architecture with a myxoid background. In one case, intermediate to large-sized cells with focal cytoplasmic clearing and patchy extracellular metachromatic material were also noted. Rhabdoid morphology was not appreciated. Immunohistochemically, the tumor cells were at least focally positive for vimentin, TLE-1, SALL4, CK AE1/AE3 and TTF-1, while being negative for CK7, CK20, Napsin-A, SOX-10, p40 and neuroendocrine markers. Both tumors showed SMARCA4 (BRG1) loss of expression. Results (if a Case Study enter NA) N/A Conclusion While the cytomorphologic findings of SMARCA4-deficient thoracic sarcomas/carcinomas are not specific, the FNA diagnosis should be considered for any poorly differentiated neoplasm involving the lungs or mediastinum which should prompt an appropriate immunocytochemical work-up that includes SMARCA4/BRG1 assessment


Author(s):  
Halyna Кotsur

Petro Kalnyshevsky (1691-1803) entered the history of Ukraine as the last kish ataman of the Zaporoz’ka Sich, a talented military leader, a diplomat, an economist and a philanthropist. Personality of P. Kalnyshevsky causes heated debate until this time, despite a significant number of works (over 1650) devoted to the study of the important milestones of his life and activities. Among the masses of various topics associated with P. Kalnyshevsky, which arise periodically, is the military activity and martial art of the Zaporozhian leader, through the prism of the history of Nova Sich and the Russian-Turkish wars of the eighteenth century. The analysis of the status of the study of the figure of the Cossack ataman of the Zaporoz’n Sich P. Kalnyshevsky at the end of the XVIII – early XX centuries has shown unequal interest in this problem and ambiguous attitude towards it. We must pay tribute to the fact that it was the historical researches of the specified period that formed the basis for further objective research on the history of New Sich and the direct activities of P. Kalnyshevsky. The military activities of P. Kalnyshevsky began to be highlighted in the writings of the first historians of the Cossacks and continue to cause a research interest until nowadays. Nevertheless, there are no special studies on the identified issues in Ukrainian historiography. This issue was considered and continues to attract the attention of historians only in the context of studying the history of the Cossacks in general, or the life and activities of P. Kalnyshevsky. The historiographical analysis of the works related to the military activity of the Cossack ataman P. Kalnyshevsky made it possible to identify certain features and stages of the study of this problem. This issue didn’t attract the attention of scientists for a long time, and the available information concerned mainly the military service of the Zaporozhians during the Russo-Turkish wars. Thus, at the time of the XVIII century, we encounter small references that cover the military service of the Sich Cossacks. They are devoid of objectivity and permeated with a negative attitude towards the Cossacks, which shows the undeniable influence of imperial ideology on scientific research. There are observed some changes in the problem that we find out in the works of the second half of the nineteenth and early twentieth centuries. Historians of this era sought to deeper and more objective clarification of the issue. They used archival materials in their studies. However, the source base was provided without its critical analysis.


Author(s):  
Mithilesh Kumar Jha

Moving beyond the existing scholarship on language politics in north India which implicitly or explicitly focuses on Hindi–Urdu debates, this book examines the formation of the Maithili movement in the context of expansion of Hindi as the ‘national’ language. For a long time, the Hindi–Urdu debate has provided an important source to critically asses various facets of the nationalist movement in north India. But much emphasis on this debate has undermined simultaneous developments taking place in ‘minor’ linguistic spheres within the ‘Hindi heartland’ like Maithili, Braj, Awadhi, and Bhojpuri. This work also revisits the dynamic hierarchy through which a distinction is produced between ‘major’ and ‘minor’ languages. Significance of these ‘minor’ linguistic movements lies in the ways through which they resist such domination and appropriations while asserting their own independence. Throughout the history of the Maithili movement, what one finds is not just an opposition to Hindi’s claim of Maithili being its ‘dialect’ or the ambivalent relationship between the two. But more appropriately, one can see a double movement. The authority of Hindi has strengthened within the Maithili-speaking region even when the movement for the recognition of Maithili as an independent language has become more assertive. Another paradox of the Maithili movement has been its increasing politicization—from Hindi–Maithili ambiguities and antagonisms to territorial consciousness and finally demands for a separate statehood of Mithila, along with the persistent indifferent attitude of the masses. This work examines these processes historically since the middle of the nineteenth century until the inclusion of Maithili into the eighth schedule of the Indian Constitution in 2004.


2019 ◽  
Vol 15 (2) ◽  
pp. 125-135
Author(s):  
Tatiana S. Minaeva ◽  
Sergey S. Gulyaev

Introduction. The organization of transport links and the bridge building in cities located on the banks of wide rivers has always been one of the most important tasks of the local administration. The study of the history of bridge building allows not only to trace the process of modernization of different regions of the country, but also to help in solving similar problems of our time. Nevertheless, the history of Russian bridge building is poorly studied. The purpose of the article is to determine the characteristics and features of the organization of bridge building in big cities of the European North of Russia as a way to solve one of the problems of urban infrastructure in the early XX century. Materials and Methods. The sources for this study are the documents of the State archive of the Arkhangelsk region, published documents on the history of Vologda, articles in the local periodicals of the early XX century. The analysis of the studied problem used a systematic approach, the method of economic analysis, historical and historical-comparative methods. Results and Discussion. The building of permanent bridges was a need for the development of Arkhangelsk and Vologda. In Vologda the two wooden bridges were built in the middle of XIX century on city funds and in the future these bridges were repaired or rebuilt. The Arkhangelsk city authorities did not hurry to solve a problem of city infrastructure by own efforts and a long time they used the floating bridge. The lack of experience in the building of large bridges and the desire to save money led to the rapid destruction of the first permanent bridge in Arkhangelsk. Conclusion. The Development of trade and industry in cities of the European North of Russia, such as Arkhangelsk and Vologda, led to the expansion of their territory and the emergence over time, the so-called third parts of the cities. Despite the comparable size of the population of the districts located across the river, the process of connecting them with bridges to the rest of the city went at different rates, which depended on the attitude of the local administration to the problem of urban infrastructure.


Author(s):  
مها بنت منصور الصائغ

شهد تاريخ الأمة الإسلامية حضارة ونهضة عالمية في جميع مجالات الحياة الإنسانية، ومما كان له كبير الأثر في ذلك هو الأوقاف التي بدأت مع سيد البشرية محمد صلى الله عليه وسلم واستمرت بتنوع وشمولية إلى عصرنا الحالي؛ ولكن ما تعرضت إليه الأوقاف من إهمال وإقصاء وضياع يرجع لأسباب عديدة من أهمها غياب التوثيق الوقفي. تقوم الدراسة على تتبع مفهوم الوقف والتوثيق، والوقف في الإمارات العربية المتحدة ول سيما في إمارة الشارقة. توصلت الدراسة إلى نتائج منها: أن الأوقاف قائمة منذ زمن بعيد، وأن رغبة الواقف بالوقف وإقدامه عليها لم ينقصها سوى وثيقة، وأنه لا وثائق لها ولا مستندات، كما أن العرض الموجز لنشأة دائرة الأوقاف بالشارقة وسعيها لإحياء سنة الوقف ونشر ثقافته نراه يتضح شيئاً فشيئاً من خلال تفعيل مواد القانون والبحث حول الأنسب والأصح لحماية الأوقاف، ولم يكن هذا الاهتمام بالوقف إلا انعكاساً لتوجه الواقفين وتماشياً لرؤية الحكام وامتثالاً لنهج خير الأنام ورغبة في تكافل الأرواح وحباً للسلام. الكلمات المفتاحيّة: الوقف، التوثيق، المقارنة، الشارقة. Abstract The history of Islamic nation has witnessed a global civilization and it has had a great impact in all areas of human life, including the endowments that began with the master of humankind; Muhammad S.A.W. and it was continuing in diversity and comprehensively until our epoch. However, there are some problems related to endowment management such as negligence, exclusion and loss that due to many reasons. Among the most important reasons is the absence of endowment documentations. Therefore, the study aims to discuss the concept of endowment and documentation, as well as the endowment in United Arabic Emirates, especially in the Emirate of Sharjah. The study concluded that the practice of endowment has been existed for a long time, yet there are in need of endowment documentations. This study also found that the information related to the establishment of institution of endowment in Sharjah and its role has   spread widely to the people through the enforcement of the law and the implementation of the research related to the practice of endowment in order to sustain them in a good way. This documentation system was only a reflection of what has  stated in Shariah laws regarding the practice of endowment among the donors, so that it will be in line with the approach of good intentions and love of peace. Keywords: Endowment, Documentation, Comparison, Sharjah.   


Author(s):  
Ж.В. Васильева

вопросы взаимодействия моды и сферы искусства, аспекты сближения их позиций в области репрезентации базовых эстетических установок конца XIX – начала XX вв. долгое время оставались вне поля исследовательского внимания культурологов и искусствоведов. Между тем, для преподавания курса мировой художественной культуры (МХК) анализ динамики взаимопроникновения моды и искусства в период модерна, выявление параллелей в развитии фэшн-трендов и художественных направлений конца XIX – начала ХХ в. имеет принципиальное значение. Обосновать необходимость включения учебного материала по вестиментарным фэшн-трендам в курс МХК – наша задача. questions of interaction between fashion and art, aspects of convergence of their positions in the field of representation of basic aesthetic attitudes of the late XIX – early XX centuries for a long time remained out of the field of attention of researchers. Meanwhile, for teaching the history of world culture, the analysis of the dynamics of the interpenetration of fashion and art in the modern period, the identification of parallels in the development of fashion trends and artistic trends of the late XIX – early XX century is of fundamental importance. Our task is to justify the need to include educational material on vestigial fashion trends in the course of world art culture.


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