Association of Monocyte Chemotactic Protein-1 and Dickkopf-1 with Body Composition and Physical Performance in Community-Dwelling Older Adults in Singapore

This study aimed to assess the impact of malnutrition on the 5-year evolution of physical performance, muscle mass and muscle strength in participants from the SarcoPhAge cohort, consisting of community-dwelling older adults. The malnutrition status was assessed at baseline (T0) according to the “Global Leadership Initiatives on Malnutrition” (GLIM) criteria, and the muscle parameters were evaluated both at T0 and after five years of follow-up (T5). Lean mass, muscle strength and physical performance were assessed using dual X-ray absorptiometry, handgrip dynamometry, the short physical performance battery test and the timed up and go test, respectively. Differences in muscle outcomes according to nutritional status were tested using Student’s t-test. The association between malnutrition and the relative 5-year change in the muscle parameters was tested using multiple linear regressions adjusted for several covariates. A total of 411 participants (mean age of 72.3 ± 6.1 years, 56% women) were included. Of them, 96 individuals (23%) were diagnosed with malnutrition at baseline. Their muscle parameters were significantly lower than those of the well-nourished patients both at baseline and after five years of follow-up (all p-values < 0.05), except for muscle strength in women at T5, which was not significantly lower in the presence of malnutrition. However, the 5-year changes in muscle parameters of malnourished individuals were not significantly different than those of well-nourished individuals (all p-values > 0.05).

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Short Physical Performance Battery (SPPB) score as a discriminator of dynapenic abdominal obesity among community-dwelling older adults

Geriatric Nursing ◽

10.1016/j.gerinurse.2021.02.016 ◽

2021 ◽

Vol 42 (2) ◽

pp. 467-472

Author(s):

Elane Priscila Rosa dos Santos ◽

Caroline Fátima Ribeiro Silva ◽

Daniela Gonçalves Ohara ◽

Areolino Pena Matos ◽

Ana Carolina Pereira Nunes Pinto ◽

...

Keyword(s):

Older Adults ◽

Physical Performance ◽

Abdominal Obesity ◽

Community Dwelling ◽

Short Physical Performance Battery ◽

Community Dwelling Older Adults

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Prospective associations of plasma growth differentiation factor 15 with physical performance and cognitive functions in older adults

The Journals of Gerontology Series A ◽

10.1093/gerona/glac020 ◽

2022 ◽

Author(s):

Lingxiao He ◽

Philipe de Souto Barreto ◽

Juan Luis Sánchez Sánchez ◽

Yves Rolland ◽

Sophie Guyonnet ◽

...

Keyword(s):

Older Adults ◽

Grip Strength ◽

Physical Performance ◽

Cognitive Functions ◽

Community Dwelling ◽

Cognitive Score ◽

Growth Differentiation Factor 15 ◽

Clinically Significant ◽

One Year ◽

Community Dwelling Older Adults

Abstract Background Growth differentiation factor 15 (GDF15) has been associated with several age-related disorders, but its associations with functional abilities in community-dwelling older adults are not well studied. Methods The study was a secondary analysis on 1096 community-dwelling older adults (aged 69 to 94 years) recruited from the Multidomain Alzheimer’s Preventive Trial. Plasma GDF15 was measured one year after participants’ enrolment. Annual data of physical performance (grip strength and short physical performance battery [SPPB]) and global cognitive functions (mini-mental state examination [MMSE] and a composite cognitive score) were measured for four years. Adjusted mixed-effects linear models were performed for cross-sectional and longitudinal association analyses. Results A higher GDF15 was cross-sectionally associated with a weaker grip strength (β = -1.1E-03, 95%CI [-2.0E-03, -1.5E-04]), a lower SPPB score (β = -3.1E-04, 95%CI [-5.4E-04, -9.0E-05]) and worse cognitive functions (β = -2.4E-04, 95%CI [-3.3E-04, -1.6E-04] for composite cognitive score; β = -4.0E-04, 95%CI [-6.4E-04, -1.6E-04] for MMSE). Participants with higher GDF15 demonstrated greater longitudinal declines in SPPB (β = -1.0E-04, 95%CI [-1.7E-04, -2.0E-05]) and composite cognitive score (β = -2.0E-05, 95%CI [-4.0E-05, -3.6E-06]). The optimal initial GDF15 cutoff values for identifying participants with minimal clinically significant decline after one year were 2189 pg/mL for SPPB (AUC: 0.580) and 2330 pg/mL for composite cognitive score (AUC: 0.587). Conclusions Plasma GDF15 is cross-sectionally and longitudinally associated with lower-limb physical performance and global cognitive function in older adults. Circulating GDF15 alone has limited capacity of discriminating older adults who will develop clinically significant functional declines.

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PP022-MON BODY COMPOSITION AND PHYSICAL FUNCTION IN HEALTHY COMMUNITY-DWELLING OLDER ADULTS IN SWEDEN, A CROSS-SECTIONAL STUDY

Clinical Nutrition ◽

10.1016/s0261-5614(13)60334-9 ◽

2013 ◽

Vol 32 ◽

pp. S131

Author(s):

A. Lindblad ◽

S. Dahlin-Ivanoff ◽

I. Bosaeus ◽

E. Rothenberg

Keyword(s):

Older Adults ◽

Body Composition ◽

Physical Function ◽

Cross Sectional Study ◽

Community Dwelling ◽

Sectional Study ◽

Cross Sectional ◽

Healthy Community ◽

Community Dwelling Older Adults

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Pilot Study: Predictive Measures of Self-Reported Confidence Levels and Physical Performance Related to Fall Risk in Community Dwelling Older Adults

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2016.08.402 ◽

2016 ◽

Vol 97 (10) ◽

pp. e129

Author(s):

Beth Bright ◽

Jamison Staley ◽

Lauren Tirey ◽

Steven Vrchota ◽

Katie Watson

Keyword(s):

Older Adults ◽

Pilot Study ◽

Physical Performance ◽

Fall Risk ◽

Community Dwelling ◽

Confidence Levels ◽

Community Dwelling Older Adults

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Physical Performance difference in Community Dwelling Older Adults with Successful Ageing, Usual Ageing and Mild Cognitive Impairment

Jurnal Sains Kesihatan Malaysia ◽

10.17576/jskm-2018-16si-33 ◽

2018 ◽

Vol 16 (Special Issue) ◽

pp. 221-222

Author(s):

Rajwinder Kaur Hardev Singh ◽

Devinder Kaur Ajit Singh ◽

Suzana Shahar

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Physical Performance ◽

Community Dwelling ◽

Performance Difference ◽

Successful Ageing ◽

Community Dwelling Older Adults

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Body Composition in Community-Dwelling Older Adults Before and After SARS-CoV-2 Infection: A Longitudinal Prospective Study in a Rural Village Struck by the Pandemic

Journal of Primary Care & Community Health ◽

10.1177/21501327211047781 ◽

2021 ◽

Vol 12 ◽

pp. 215013272110477

Author(s):

Oscar H. Del Brutto ◽

Robertino M. Mera ◽

Denisse A. Rumbea ◽

Pedro Pérez ◽

Bettsy Y. Recalde ◽

...

Keyword(s):

Physical Activity ◽

Older Adults ◽

Body Composition ◽

Regression Models ◽

Community Dwelling ◽

The Body ◽

Study Results ◽

The Impact ◽

Community Dwelling Older Adults

Background: Information on the body composition of inhabitants of remote communities during the SARS-CoV-2 pandemic is limited. Using a longitudinal population-based study design, we assessed the association between SARS-CoV-2 infection and changes in body composition. Methods: Community-dwelling older adults living in a rural Ecuadorian village received body composition determinations before and 1 year after the pandemic as well as serological tests for detection of SARS-CoV-2 antibodies. The independent association between SARS-CoV-2 infection and abnormalities in body composition at follow-up was assessed by fitting linear mixed models for longitudinal data. Results: Of 327 enrolled individuals, 277 (85%) received baseline and follow-up body composition determinations, and 175 (63%) of them became SARS-CoV-2 seropositive. Overall, diet and physical activity deteriorated during the follow-up. Multivariate random-effects generalized least squares regression models that included the impact of time and seropositivity on follow-up body composition, showed that neither variable contributed to a worsening in body composition. Multivariate logistic regression models disclosed that the serological status at follow-up cannot be predicted by differences in body composition and other baseline covariates. Conclusions: Study results suggest no increased susceptibility to SARS-CoV-2 infection among older adults with abnormal body composition and no significant changes as a result of worse physical activity and dietary habits or seropositivity during the length of the study. Together with a previous study in the same population that showed decrease in hand-grip strength after SARS-CoV-2, results confirm that dynapenia (and not sarcopenia) is associated with SARS-CoV-2 infection in older adults.

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