Advanced Therapies in Medicine and its diffusion in the online mass media: a bibliometric analysis of Tissue Engineering.

BACKGROUND Tissue engineering (TE) constitutes a multidisciplinary field aiming to construct artificial tissues to regenerate end-staged organs. Its development has taken placed since the last decade of the 20th century, entailing a clinical revolution. In this sense, TE research groups have worked and shared relevant information in the mass media era. Thus, it would be interesting to study the online dimension of TE research and to compare it with traditional measures of scientific impact. OBJECTIVE To evaluate TE online dimension from 2012 to 2018 by using metadata obtained from the Web of Science (WoS) and Altmetrics and to develop a prediction equation for the impact of TE documents from Almetrics scores. METHODS We have analyzed 23,719 TE documents through descriptive and statistical methods. First, TE temporal evolution was exposed for WoS and fifteen online platforms (News, Blogs, Policy, Twitter, Patents, Peer review, Weibo, Facebook, Wikipedia, Google, Reddit, F1000, Q&A, Video and Mendeley readers). The 10 most-cited TE original articles were ranked according to WoS citations and the Altmetric Attention Score. Second, in order to better comprehend TE online framework, a correlation and factorial analysis were performed based on the suitable results previously obtained for the Bartlett Sphericity and Kaiser-Meyer-Olkin tests. Finally, the liner regression model was applied to elucidate the relation between academy and online media and to construct a prediction equation for TE from Altmetrics data. RESULTS TE dynamic shows an upward trend in WoS citations, Twitter, Mendeley Readers and Altmetric Scores. However, WoS and Altmetrics rankings for the most cited documents clearly differs. When compared, the best correlation results were obtained for Mendeley readers and WoS (ρ=0.71). In addition, the factorial analysis identified six factors that could explain the previously observed differences between TE academy, and the online platforms evaluated. At this point, the mathematical model constructed is able to predict and explain more than the 40% of TE WoS citations from Altmetrics scores. CONCLUSIONS The scientific information related to the construction of bioartificial tissues increasingly reaches society through different online media. Because of the focus of TE research importantly differs when the academic institutions and online platforms are compared, it could be stated that basic and clinical research groups, academic institutions and health politicians should take it into account in a coordinated effort oriented to the design and implementation of adequate strategies for information diffusion and population health education.

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A Bibliometric Analysis of the Global Trend of Using Alginate, Gelatine, and Hydroxyapatite for Bone Tissue Regeneration Applications

Polymers ◽

10.3390/polym13040647 ◽

2021 ◽

Vol 13 (4) ◽

pp. 647

Author(s):

Mohamed Saiful Firdaus Hussin ◽

Aludin Mohd Serah ◽

Khairul Azri Azlan ◽

Hasan Zuhudi Abdullah ◽

Maizlinda Izwana Idris ◽

...

Keyword(s):

Tissue Engineering ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Bibliometric Analysis ◽

Research Work ◽

The United States ◽

Research Area ◽

Bone Tissue Regeneration ◽

Future Research ◽

Starting Point

Collecting information from previous investigations and expressing it in a scientometrics study can be a priceless guide to getting a complete overview of a specific research area. The aim of this study is to explore the interrelated connection between alginate, gelatine, and hydroxyapatite within the scope of bone tissue and scaffold. A review of traditional literature with data mining procedures using bibliometric analyses was considered to identify the evolution of the selected research area between 2009 and 2019. Bibliometric methods and knowledge visualization technologies were implemented to investigate diverse publications based on the following indicators: year of publication, document type, language, country, institution, author, journal, keyword, and number of citations. An analysis using a bibliometric study found that 7446 papers were located with the keywords “bone tissue” and “scaffold”, and 1767 (alginate), 185 (gelatine), 5658 (hydroxyapatite) papers with those specific sub keywords. The number of publications that relate to “tissue engineering” and bone more than doubled between 2009 (1352) and 2019 (2839). China, the United States and India are the most productive countries, while Sichuan University and the Chinese Academy of Science from China are the most important institutions related to bone tissue scaffold. Materials Science and Engineering C is the most productive journal, followed by the Journal of Biomedical Materials Research Part A. This paper is a starting point, providing the first bibliometric analysis study of bone tissue and scaffold considering alginate, gelatine and hydroxyapatite. A bibliometric analysis would greatly assist in giving a scientific insight to support desired future research work, not only associated with bone tissue engineering applications. It is expected that the analysis of alginate, gelatine and hydroxyapatite in terms of 3D bioprinting, clinical outcomes, scaffold architecture, and the regenerative medicine approach will enhance the research into bone tissue engineering in the near future. Continued studies into these research fields are highly recommended.

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Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration

Journal of The Royal Society Interface ◽

10.1098/rsif.2006.0179 ◽

2006 ◽

Vol 4 (14) ◽

pp. 413-437 ◽

Cited By ~ 467

Author(s):

Anthony D Metcalfe ◽

Mark W.J Ferguson

Keyword(s):

Tissue Engineering ◽

Regenerative Process ◽

Model Systems ◽

Viral Gene ◽

Skin Substitutes ◽

Recent Advances ◽

Advanced Therapies ◽

Skin Replacement ◽

Organ Repair ◽

Complete Regeneration

Advanced therapies combating acute and chronic skin wounds are likely to be brought about using our knowledge of regenerative medicine coupled with appropriately tissue-engineered skin substitutes. At the present time, there are no models of an artificial skin that completely replicate normal uninjured skin. Natural biopolymers such as collagen and fibronectin have been investigated as potential sources of biomaterial to which cells can attach. The first generation of degradable polymers used in tissue engineering were adapted from other surgical uses and have drawbacks in terms of mechanical and degradation properties. This has led to the development of synthetic degradable gels primarily as a way to deliver cells and/or molecules in situ , the so-called smart matrix technology. Tissue or organ repair is usually accompanied by fibrotic reactions that result in the production of a scar. Certain mammalian tissues, however, have a capacity for complete regeneration without scarring; good examples include embryonic or foetal skin and the ear of the MRL/MpJ mouse. Investigations of these model systems reveal that in order to achieve such complete regeneration, the inflammatory response is altered such that the extent of fibrosis and scarring is diminished. From studies on the limited examples of mammalian regeneration, it may also be possible to exploit such models to further clarify the regenerative process. The challenge is to identify the factors and cytokines expressed during regeneration and incorporate them to create a smart matrix for use in a skin equivalent. Recent advances in the use of DNA microarray and proteomic technology are likely to aid the identification of such molecules. This, coupled with recent advances in non-viral gene delivery and stem cell technologies, may also contribute to novel approaches that would generate a skin replacement whose materials technology was based not only upon intelligent design, but also upon the molecules involved in the process of regeneration.

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A Bibliometric Analysis of Covid-19 Research using VOSviewer

Indonesian Journal of Science and Technology ◽

10.17509/ijost.v5i2.24522 ◽

2020 ◽

Vol 5 (2) ◽

pp. 209-216 ◽

Cited By ~ 9

Author(s):

Ida Hamidah ◽

Sriyono Sriyono ◽

Muhammad Nur Hudha

Keyword(s):

Mass Media ◽

Bibliometric Analysis ◽

Reference Point ◽

Topic Area ◽

Bibliometric Mapping ◽

Search Results ◽

Search Result ◽

Bibliometric Review ◽

Scopus Database ◽

Number Of Publications

The new Coronavirus (namely Covid-19) discovered in 2019 in Wuhan has sickened more than three million people in worldwide. Because Covid-19 is spreading so fast and killing so many people, it has encouraged researchers to conduct research and publish it in various mass media, including journals. This study aims to analyze the scope of Covid-19 research using a bibliometric review. To obtain information about Covid-19 studies, the Scopus database was used. Topic areas with titles, keywords, and abstract criteria in Covid-19 studies were used as a reference for extracting search results. Search result extraction was done using VOSviewer. After that, the results of bibliometric mapping were analyzed further. A total of 3,513 articles were found in the Scopus database accessed on April 25, 2020. There was a significant increase in the number of publications on Covid-19 from 2019 to 2020. Among all countries, China contributed the most publications. Meanwhile, the keywords coronavirus, pandemic, and impact turned out to be the area's most widely discussed. Through VOSViewer we analyzed how many articles have been published about Covid-19 and its relationships to a topic area. This review certainly can provide a reference point for further research related to the Covid-19 outbreak.

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Biomaterials Development for Application in Tissue Engineering: Literature Review

JOURNAL OF BIOENGINEERING AND TECHNOLOGY APPLIED TO HEALTH ◽

10.34178/jbth.v4i2.164 ◽

2021 ◽

Vol 4 (2) ◽

pp. 76-80

Author(s):

Taís dos Santos Costa

Keyword(s):

Tissue Engineering ◽

Literature Review ◽

Bacterial Cellulose ◽

Human Skin ◽

Tissue Regeneration ◽

Skin Diseases ◽

Wide Applicability ◽

Functional Systems ◽

Advanced Therapies ◽

Active Substances

The search for tissue regeneration has attracted a lot of attention due to its wide applicability, and great potential to solve several problems in advanced therapies. Currently, functional systems have been widely used as therapeutic solutions in the treatment of some skin diseases, whether chronic, acquired, or as a consequence of accidents and burns. It is possible due to the feasibility of releasing and/or acting in loco of some active substances with properties and characteristics very similar to human skin. In this sense, this work aimed to carry out a literature review research regarding the development of new biomaterials, including hydrated membranes composed of biopolymers such as keratin and bacterial cellulose.

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Information and scientific impact of Advanced Therapies in the age of mass media: an Altmetrics-based analysis of Tissue Engineering. (Preprint)

10.2196/preprints.25383 ◽

2020 ◽

Author(s):

Antonio Santisteban Espejo ◽

Miguel Ángel Martín Piedra ◽

Julia Morán Sánchez ◽

José Antonio Moral Muñoz ◽

Ana Isabel Pacheco Serrano ◽

...

Keyword(s):

Tissue Engineering ◽

Mass Media ◽

Prediction Equation ◽

Factorial Analysis ◽

Online Media ◽

Research Groups ◽

Academic Institutions ◽

Scientific Impact ◽

Online Platforms ◽

The Impact

BACKGROUND Tissue engineering (TE) constitutes a multidisciplinary field aiming to construct artificial tissues to regenerate end-staged organs. Its development has taken placed since the last decade of the 20th century, entailing a clinical revolution. In this sense, TE research groups have worked and shared relevant information in the mass media era. Thus, it would be interesting to study the online dimension of TE research and to compare it with traditional measures of scientific impact. OBJECTIVE To evaluate TE online dimension from 2012 to 2018 by using metadata obtained from the Web of Science (WoS) and Altmetrics and to develop a prediction equation for the impact of TE documents from Almetrics scores. METHODS We have analyzed 23,719 TE documents through descriptive and statistical methods. First, TE temporal evolution was exposed for WoS and fifteen online platforms (News, Blogs, Policy, Twitter, Patents, Peer review, Weibo, Facebook, Wikipedia, Google, Reddit, F1000, Q&A, Video and Mendeley readers). The 10 most-cited TE original articles were ranked according to WoS citations and the Altmetric Attention Score. Second, in order to better comprehend TE online framework, a correlation and factorial analysis were performed based on the suitable results previously obtained for the Bartlett Sphericity and Kaiser-Meyer-Olkin tests. Finally, the liner regression model was applied to elucidate the relation between academy and online media and to construct a prediction equation for TE from Altmetrics data. RESULTS TE dynamic shows an upward trend in WoS citations, Twitter, Mendeley Readers and Altmetric Scores. However, WoS and Altmetrics rankings for the most cited documents clearly differs. When compared, the best correlation results were obtained for Mendeley readers and WoS (ρ=0.71). In addition, the factorial analysis identified six factors that could explain the previously observed differences between TE academy, and the online platforms evaluated. At this point, the mathematical model constructed is able to predict and explain more than the 40% of TE WoS citations from Altmetrics scores. CONCLUSIONS The scientific information related to the construction of bioartificial tissues increasingly reaches society through different online media. Because of the focus of TE research importantly differs when the academic institutions and online platforms are compared, it could be stated that basic and clinical research groups, academic institutions and health politicians should take it into account in a coordinated effort oriented to the design and implementation of adequate strategies for information diffusion and population health education.

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Marine origin materials on biomaterials and advanced therapies to cartilage tissue engineering and regenerative medicine

Biomaterials Science ◽

10.1039/d1bm00809a ◽

2021 ◽

Author(s):

Duarte Nuno Carvalho ◽

Rui Reis ◽

T. H. Silva

Keyword(s):

Tissue Engineering ◽

Articular Cartilage ◽

Regenerative Medicine ◽

Cartilage Tissue Engineering ◽

The Body ◽

Cartilage Tissue ◽

Repair Capacity ◽

Marine Origin ◽

The Past ◽

Advanced Therapies

The body´s self-repair capacity is limited, including injuries on articular cartilage zones. Over the past few decades, tissue engineering and regenerative medicine (TERM) have focused the studies on the development...

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The Top 100 Cited Articles in Osteonecrosis of the Femoral Head: a Bibliometric Analysis

10.21203/rs.3.rs-436593/v1 ◽

2021 ◽

Author(s):

Yumin Zhang ◽

Yakang Wang ◽

Juan Chen ◽

Qianyue Cheng ◽

Binfei Zhang ◽

...

Keyword(s):

Shock Wave ◽

Tissue Engineering ◽

Femoral Head ◽

Total Hip Arthroplasty ◽

Bibliometric Analysis ◽

Hip Arthroplasty ◽

Core Decompression ◽

Extracorporeal Shock Wave ◽

The Usa ◽

China And Japan

Abstract Background: The number of articles of clinical and basic research for osteonecrosis of the femoral head (ONFH) is increasing, to our knowledge, there is still a lack of bibliometric analysis on ONFH articles. The purpose of this study was to identify the top 100 cited (T100) articles related to ONFH research and analyze the characteristics and qualities of these articles.Methods: The T100 articles on ONFH were retrieved from the Web of Science database. The information about each article including citations, titles, authors, journals, countries, institutions, and keywords, was recorded for bibliometric analysis. Results: The T100 articles related to ONFH were mainly published from 1991 to 2010 (n=70), and originated from 24 countries. The USA, China, and Japan were the most productive countries in this regard. The most prolific institution was the University of Pennsylvania from the USA with 6 publications and 742 citations. The most-cited article was published in 1995 by Professor Steinberg ME. The five most frequently occurring keywords were “femoral head”, “osteonecrosis”, “core decompression”, “total hip arthroplasty” and “follow up”. The keywords like "bone tissue engineering" and "extracorporeal shock wave" have emerged in recent years.Conclusions: The USA, China, and Japan contributed greatly in terms of the T100 articles. The outcomes of core decompression and total hip arthroplasty gathered most research interests. In recent years, bone tissue engineering and extracorporeal shock wave have become new trends. However, the mechanism of ONFH is still unclear.

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Personalized Bone Reconstruction and Regeneration in the Treatment of Craniosynostosis

Applied Sciences ◽

10.3390/app11062649 ◽

2021 ◽

Vol 11 (6) ◽

pp. 2649

Author(s):

Federica Tiberio ◽

Ilaria Cacciotti ◽

Paolo Frassanito ◽

Giuseppina Nocca ◽

Gianpiero Tamburrini ◽

...

Keyword(s):

Tissue Engineering ◽

Drug Delivery Systems ◽

Congenital Defects ◽

Bone Fixation ◽

Technological Advances ◽

Biomimetic Scaffolds ◽

Advanced Therapies ◽

Skull Growth ◽

Manufacturing Techniques ◽

Resolving Functional

Craniosynostosis (CS) is the second most prevalent craniofacial congenital malformation due to the premature fusion of skull sutures. CS care requires surgical treatment of variable complexity, aimed at resolving functional and cosmetic defects resulting from the skull growth constrain. Despite significant innovation in the management of CS, morbidity and mortality still exist. Residual cranial defects represent a potential complication and needdedicated management to drive a targeted bone regeneration while modulating suture ossification. To this aim, existing techniques are rapidly evolving and include the implementation of novel biomaterials, 3D printing and additive manufacturing techniques, and advanced therapies based on tissue engineering. This review aims at providing an exhaustive and up-to-date overview of the strategies in use to correct these congenital defects, focusing on the technological advances in the fields of biomaterials and tissue engineering implemented in pediatric surgical skull reconstruction, i.e., biodegradable bone fixation systems, biomimetic scaffolds, drug delivery systems, and cell-based approaches.

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