scholarly journals Myocardial protection in cardiac surgery: how limited are the options? A comprehensive literature review

Authorea ◽  
2020 ◽  
Author(s):  
Abigail Whittaker ◽  
Maryam Aboughdir ◽  
Samiha Mahbub ◽  
Amer Harky
Author(s):  
Philippa Royston-White ◽  
Imran Janmohamed ◽  
Daniyal Ansari ◽  
Abigail Whittaker ◽  
Maryam Aboughadir ◽  
...  

Author(s):  
Amer Harky ◽  
Mihika Joshi ◽  
Shubhi Gupta ◽  
Wan Yi Teoh ◽  
Francesca Gatta ◽  
...  

Perfusion ◽  
2020 ◽  
pp. 026765912094265
Author(s):  
Abigail Whittaker ◽  
Maryam Aboughdir ◽  
Samiha Mahbub ◽  
Amna Ahmed ◽  
Amer Harky

For patients undergoing cardiopulmonary bypass, myocardial protection is a key for successful recovery and improved outcomes following cardiac surgery that requires cardiac arrest. Different solutions, components and modes of delivery have evolved over the last few decades to optimise myocardial protection. These include cold and warm and blood and crystalloid solution through antegrade, retrograde or combined cardioplegia delivery approach. However, each method has its own advantages and disadvantages, posing a challenge to establish a gold-standard cardioplegic solution with an optimised mode of delivery for enhanced myocardial protection during cardiac surgery. The aim of this review is to provide a brief history of the development of cardioplegia, explain the electrophysiological concepts behind myocardial protection in cardioplegia, analyse the current literature and summarise existing evidence that warrants the use of varying cardioplegic techniques. We provide a comprehensive and comparative overview of the effectiveness of each technique in achieving optimal cardioprotection and propose novel techniques for optimising myocardial protection in the future.


Author(s):  
Adam Lee ◽  
Adam Bajinting ◽  
Abby Lunneen ◽  
Colleen M. Fitzpatrick ◽  
Gustavo A. Villalona

AbstractReports of incidental pneumomediastinum in infants secondary to inflicted trauma are limited. A retrospective review of infants with pneumomediastinum and history of inflicted trauma was performed. A comprehensive literature review was performed. Three infants presented with pneumomediastinum associated with inflicted trauma. Mean age was 4.6 weeks. All patients underwent diagnostic studies, as well as a standardized evaluation for nonaccidental trauma. All patients with pneumomediastinum were resolved at follow-up. Review of the literature identified other cases with similar presentations with related oropharyngeal injuries. Spontaneous pneumomediastinum in previously healthy infants may be associated with inflicted injuries. Clinicians should be aware of the possibility of an oropharyngeal perforation related to this presentation.


Oikos ◽  
2016 ◽  
Vol 19 (40) ◽  
pp. 137
Author(s):  
Roberto Horta

RESUMENEl objetivo de este artículo es el de analizar el concepto “desempeño exportador”, concepto muy usado en la literatura relacionada con los negocios internacionales, a los efectos de aportar a su conceptualización y medición. Para ello, se efectúa una amplia revisión de la literatura y se analizan los avances realizados por los investigadores a los efectos de aportar a las dimensiones y formas de medir este concepto. Se concluye que se trata de un concepto en el cual siguen existiendo diversos enfoques, aunque existen avances importantes en la forma de operacionalizar el desempeño exportador.Palabras clave: conceptualización, desempeño exportador, negocios internacionales.Conceptualization of export performance: analysis of developments in the literature of international business ABSTRACTThe aim of this paper is to analyze the concept of "export performance" concept very use in the literature of international business, in order to contribute to its conceptualization and measurement. For this, a comprehensive literature review is performed and the progress made by researchers to contribute to the dimensions and ways of measuring this concept is discussed. Concluded that it is a concept which still exist several approaches, although there are significant advances in how to operationalize export performance.Keywords: conceptualization, export performance, international business.Conceptualização do desempenho exportador: a análise dos avanços na literatura dos negócios internacionais RESUMO O objetivo deste artigo é analisar o conceito de "desempenho exportador", conceito utilizado amplamente na literatura sobre negócios internacionais, aos efeitos de contribuir para a conceituação e medição. Para fazer isso, se faz uma extensa revisão da literatura e analisam-se os avanços realizados pelos pesquisadores aos efeitos de contribuir nas dimensões e formas de medir este conceito. Conclui-se que se trata de um conceito no qual continuam existindo diversas abordagens, apesar dos avanços significativos na forma de operacionalizar o desempenho exportador.Palavras-chave: conceituação, desempenho exportador, negócios internacionais.


2019 ◽  
Vol 19 (16) ◽  
pp. 1298-1368 ◽  
Author(s):  
Ankit Jain ◽  
Poonam Piplani

: Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological properties, which could play a major role in the common mechanisms associated with various disorders like cancer, infections, inflammation, convulsions, oxidative stress and neurodegeneration. Structural modification of this scaffold could be helpful in the generation of new therapeutically useful agents. Although research endeavors are moving towards the growth of synthetic analogs of triazole, there is still a lot of scope to achieve drug discovery break-through in this area. Upcoming therapeutic prospective of this moiety has captured the attention of medicinal chemists to synthesize novel triazole derivatives. The authors amalgamated the chemistry, synthetic strategies and detailed pharmacological activities of the triazole nucleus in the present review. Information regarding the marketed triazole derivatives has also been incorporated. The objective of the review is to provide insights to designing and synthesizing novel triazole derivatives with advanced and unexplored pharmacological implications.


Author(s):  
Mariek Vanden Abeele

Recent empirical work suggests that phubbing, a term used to describe the practice of snubbing someone with a phone during a face-to-face social interaction, harms the quality of social relationships. Based on a comprehensive literature review, this chapter presents a framework that integrates three concurrent mechanisms that explain the relational impact of phubbing: expectancy violations, ostracism, and attentional conflict. Based on this framework, theoretically grounded propositions are formulated that may serve as guidelines for future research on these mechanisms, the conditions under which they operate, and a number of potential issues that need to be considered to further validate and extend the framework.


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