EFFECT OF BROMELAIN AND ARNICA COMBINATION ON PERIORBITAL EDEMA AND ECCHYMOSIS IN SEPTORHINOPLASTY

Purpose: The aim of this study to investigate the effect of bromelain-arnica gel combination on periorbital edema and ecchymosis seen after open septorhinoplasty. Methods: Sixty patients who performed open septorhinoplasty with osteotomies were included to the study. These patients were allocated into two groups: in group 1, 30 patients as control and in group 2, 30 patients as study group who were treated with topical bromelain-arnica gel after surgery. Scoring of eyelid edema and peroirbital ecchymosis were evaluated on the first, third and seventh postoperative days using scale of 0 to 4 used by observers. Results: We observed that the administration of topical bromelain-arnica gel after surgery was effective clinically and statistically in decreasing the score of both edema and ecchymosis in open septorhinoplasty with ostetomies. In group 2 patients, periorbital edema and ecchymosis scores were significantly lower compared to control group (p < 0.05). Conclusions: Our results support that topical administration of bromelain and arnica gel combination provided both clinically and statistically significant reduction in periorbital edema and ecchymosis following septorhinoplasty.

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Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline

Journal of Ophthalmology ◽

10.1155/2014/452685 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 8

Author(s):

Sertan Goktas ◽

Ender Erdogan ◽

Rabia Sakarya ◽

Yasar Sakarya ◽

Mustafa Yılmaz ◽

...

Keyword(s):

Topical Administration ◽

Corneal Neovascularization ◽

Control Group ◽

Therapeutic Effects ◽

Control Groups ◽

Group 4 ◽

Percentage Area ◽

Group 3 ◽

Group 2 ◽

Group 1

Objective. To investigate the effects of topical and subconjunctival tigecycline on the prevention of corneal neovascularization.Materials and Methods. Following chemical burn, thirty-two rats were treated daily with topical instillation of 1 mg/mL tigecycline (group 1) or subconjunctival instillation of 1 mg/mL tigecycline (group 3) for 7 days. Control rats received topical (group 2) or subconjunctival (group 4) 0.9% saline. Digital photographs of the cornea were taken on the eighth day after treatment and analyzed to determine the percentage area of the cornea covered by neovascularization. Corneal sections were analyzed histopathologically.Results. The median percentages of corneal neovascularization in groups 1 and 3 were 48% (95% confidence interval (CI), 44.2–55.8%) and 33.5% (95% CI, 26.6–39.2%), respectively. The median percentages of corneal neovascularization of groups 1 and 3 were significantly lower than that of the control group (P=0.03andP<0.001, resp.). Histologic examination of samples from groups 1 and 3 showed lower vascularity than that of control groups.Conclusion. Topical and subconjunctival administration of tigecycline seems to be showing promising therapeutic effects on the prevention of corneal neovascularization. Furthermore, subconjunctival administration of tigecycline is more potent than topical administration in the inhibition of corneal neovascularization.

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Cytomorphometric and Morphological Analysis in Women with Trichomonas vaginalis Infection: Micronucleus Frequency in Exfoliated Cervical Epithelial Cells

Acta Cytologica ◽

10.1159/000431148 ◽

2015 ◽

Vol 59 (3) ◽

pp. 258-264 ◽

Cited By ~ 6

Author(s):

Zehra Safi Oz ◽

Banu Doğan Gun ◽

Mustafa Ozkan Gun ◽

Sukru Oguz Ozdamar

Keyword(s):

Epithelial Cells ◽

Trichomonas Vaginalis ◽

Control Group ◽

Study Group ◽

Control Groups ◽

The Mean ◽

The Difference ◽

Group 2 ◽

And Control ◽

Group 1

Objectives: The aim of this study was to explore the cytomorphometric and morphological effects of Trichomonas vaginalis in exfoliated epithelial cells. Study Design: Ninety-six Pap-stained cervical smears were divided into a study group and two control groups as follows: T. vaginalis cases, a first control group with inflammation, and a second control group without inflammation. Micronucleated, binucleated, karyorrhectic, karyolytic, and karyopyknotic cells and cells with perinuclear halos per 1,000 epithelial cells were counted. Nuclear and cellular areas were evaluated in 70 clearly defined cells in each smear using image analysis. Results: The frequencies of morphological parameters in the T. vaginalis cases were higher than the values of the two control groups, and the difference among groups was found to be significant (p < 0.05). The nuclear and cytoplasmic areas of epithelial cells were diminished in patients with trichomoniasis. The mean nucleus/cytoplasm ratio in T. vaginalis patients was higher than the value in the control groups, and the difference between the study group and control group 1 was significant. However, there was no statistically significant increase between the study group and control group 2. Conclusions:T. vaginalis exhibited significant changes in the cellular size and nuclear structure of the cells. The rising frequency of micronuclei, nuclear abnormalities, and changing nucleus/cytoplasm ratio may reflect genotoxic damage in trichomoniasis.

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Menopausal disorders in obese women

Kazan medical journal ◽

10.17750/kmj2017-696 ◽

2017 ◽

Vol 98 (5) ◽

pp. 696-701

Author(s):

M A Idrisova ◽

A E Esedova

Keyword(s):

Control Group ◽

Study Group ◽

Climacteric Syndrome ◽

Obese Women ◽

Point Scale ◽

Healthy Women ◽

Kupperman Index ◽

Symptom Complex ◽

Group 2 ◽

Group 1

Aim. To study menopausal disorders in women suffering from obesity. Methods. The study included 165 women in physiological postmenopausal state. Women were divided into two groups: group 1 (study group) included 87 women with obesity, group 2 (control group) consisted of 78 women without obesity. With the use of modified menopausal index (the Kupperman index) the severity of climacteric disorders was assessed. Severity of neurovegetative, metabolic-endocrine and psychoemotional symptoms was assessed according to 4-point scale (from 0 to 3 points). The number of points in each group was summarized and a modified menopausal index was obtained. Results. It was revealed that in women with obesity severe (in 24 females, 27.5%) and moderate (in 39 patients, 44.5%) climacteric syndrome was prevalent, in patients from the control group such forms were 1.5-2 times less frequent - in 11 (14.2%) and 28 (36.2%) patients, respectively. A deeper analysis of the entire symptom complex of climacteric syndrome revealed that severe and moderate forms of neurovegetative manifestations were 2 times more common in patients with obesity, in contrast to healthy women (in 7.8% and 4.5%, 21.5% and 12.3%, respectively). Severe forms of psychoemotional manifestations were also observed 2.6 times more often in women with obesity. Conclusion. Severity of menopausal disorders depends on obesity presence, the data obtained demonstrated that, against the background of obesity, climacteric syndrome tends to have prolonged course with predominance of severe and moderate forms.

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Could edaravone prevent gentamicin ototoxicity? An experimental study

Human & Experimental Toxicology ◽

10.1177/0960327116639360 ◽

2016 ◽

Vol 36 (2) ◽

pp. 123-127 ◽

Cited By ~ 5

Author(s):

M Turan ◽

E Ciğer ◽

S Arslanoğlu ◽

H Börekci ◽

K Önal

Keyword(s):

Guinea Pigs ◽

Hearing Threshold ◽

Control Group ◽

Study Group ◽

Threshold Values ◽

Once Daily ◽

Significant Difference ◽

Brainstem Response ◽

Group 2 ◽

Group 1

Objectives: Clinical application of gentamicin may cause nephrotoxicity and ototoxicity. Our study is the first study to investigate the protective effects of edaravone against the gentamicin-induced ototoxicity. We investigated the protective effect of intraperitoneal (i.p.) edaravone application against gentamicin-induced ototoxicity in guinea pigs. Methods: Fourteen guinea pigs were divided into two equal groups consisting of a control group and a study group. One-hundred sixty milligrams per kilogram subcutaneous gentamicin and 0.3 mL i.p. saline were applied simultaneously once daily to seven guinea pigs in the control group (group 1). One-hundred sixty milligrams per kilogram gentamicin was applied subcutaneously and 3 mg/kg edaravone was applied intraperitoneally once daily for 7 days simultaneously to seven guinea pigs in the study group (group 2). Following the drug application, auditory brainstem response measurements were performed for the left ear on the 3rd and 7th days. Results: Hearing threshold values of the group 1 and group 2 measured in the 3rd day of the study were detected as 57.14 ± 4.88 and 82.86 ± 7.56, respectively. This difference was statistically significant ( p < 0.05). Hearing threshold values of the group 1 and group 2 measured in the 7th day of the study were detected as 87.14 ± 4.88 and 62.86 ± 4.88, respectively. This difference was statistically significant ( p < 0.05). Conclusion: A statistically significant difference between the average threshold values of edaravone-administered group 2 and that of group 1 without edaravone was found. These differences show that systemic edaravone administration could diminish ototoxic effects of gentamicin and the severity of the hearing loss.

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Ultrasound-guided tip location of midline catheters

The Journal of Vascular Access ◽

10.1177/1129729820907250 ◽

2020 ◽

Vol 21 (5) ◽

pp. 764-768

Author(s):

Stefano Elli ◽

Mauro Pittiruti ◽

Valentina Pigozzo ◽

Luigi Cannizzo ◽

Luciano Giannini ◽

...

Keyword(s):

Venous Thrombosis ◽

Subclavian Vein ◽

Control Group ◽

Study Group ◽

Axillary Vein ◽

Ultrasound Guided ◽

Catheter Tip ◽

Group 2 ◽

And Control ◽

Group 1

Introduction: Midline catheters are widely used in clinical practice. Proper placement of midline catheter tip is usually assessed only by aspirating blood and flushing with normal saline without resistance. Purpose: To describe the ultrasound-guided tip location for midline catheters and its feasibility and to compare incidence of catheter-related venous thrombosis associated with or without ultrasound tip localization. Methods: The ultrasound-guided tip location is described step by step. Feasibility of the technique and incidence of catheter-related venous thrombosis were measured (study group) and compared with two historical groups: study group, 20-cm midline catheters inserted with ultrasound-guided tip location; group 1, 25-cm midline catheters inserted without ultrasound-guided tip location and group 2, 20-cm midline catheters inserted without ultrasound-guided tip location. Results: In the study group, ultrasound-guided tip location was easily feasible in 98.9% of patients. Incidence of catheter-related venous thrombosis was 2.42% in control group 1, 9% in control group 2 and 2.62% in the study group. Discussion: In the study group and control group 1, the tip was placed in the axillary vein, about 3 cm distal to the clavicle and in the subclavian vein. In control group 2, the tip was probably located at the transition between the axillary and the subclavian vein. It is possible that such position may have been associated with an increased incidence of catheter-related venous thrombosis. Conclusion: The ideal position of the tip of a midline catheter might be inside the axillary vein, about 3 cm distal to the axillary-subclavian transition or inside the subclavian vein. Ultrasound-guided tip location is safe, inexpensive, easy and potentially useful during midline catheters insertion.

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THE USING OF POLYPRENOL-CONTAINING DRUG IN PATIENTS WITH ACUTE CORONARY SYNDROME

Siberian Medical Journal ◽

10.29001/2073-8552-2018-33-2-21-25 ◽

2018 ◽

Vol 33 (2) ◽

pp. 21-25

Author(s):

E. I. Tsoi ◽

E. V. Vyshlov ◽

V. B. Trusov

Keyword(s):

Acute Coronary Syndrome ◽

Standard Therapy ◽

Control Group ◽

Study Group ◽

Double Blind ◽

Coronary Syndrome ◽

Group 3 ◽

Group 2 ◽

The Right ◽

Group 1

The article shows the results of the study using drug Ropren in the patients with acute coronary syndrome. Ropren is a plant drug containing polyprenols — dolichol precursors which take part in dolichol phosphate pathway. The pathology in this pathway leads to disbalance and glycoprotein deficiency. This is the reason of large group of diseases. This study is randomized double blind placebo controlled (No. NCT03122340 at ClinicalTrials.gov). Patients (n=68) with ACS taking standard therapy including atorvastatin 40 mg/day were randomized into to 2 groups: group 1 (n=34) took Ropren 8 drops 3 times per day for 3 week, then 5 drops 3 times per day for 5 weeks; group 2 (n=34) took placebo in the same dose regimen. After two — month therapy there was a positive dynamic (decreasing) in the level of interleukin-6 in the study group whereas in the control group there was no statistically significant change: 4.36 (2.61, 8.95) and 5.5 (3.3; 8.4) pg/ml, respectively (p<0.05). In the group of patients taking Ropren the reduction or cessation of statin was required significantly less than in the placebo group: 3 (8.8%) vs 9 (26.5%), respectively. One patient from the first group had a side effect in the form of gravity in the right hypochondrium. That is why the administration of Ropren in addition to standard therapy is reasonable in patients with ACS.

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The use of injectable chondroitin sulfate in combination with dosed physical exercise for the treatment of patients with hand osteoarthritis

Modern Rheumatology Journal ◽

10.14412/1996-7012-2020-3-79-83 ◽

2020 ◽

Vol 14 (3) ◽

pp. 79-83

Author(s):

L. V. Vasilyeva ◽

E. F. Evstratova ◽

E. Yu. Suslova

Keyword(s):

Physical Exercise ◽

Chondroitin Sulfate ◽

Control Group ◽

Study Group ◽

Hand Osteoarthritis ◽

American College Of Rheumatology ◽

Discontinuation Of Treatment ◽

Group 2 ◽

Magnetic Therapy ◽

Group 1

Objective: to evaluate the efficiency and the safety of treatment with injectable chondroitin sulfate (ICS) in combination with dosed physical exercise (exercise therapy (ET)) for hand osteoarthritis (HOA).Patients and methods. A study group consisted of 68 patients with HOA; the diagnosis of which was established in accordance with the 1991 American College of Rheumatology (ACR) criteria. The investigators identified two groups: 1) 36 women and 4 men; mean age, 62.2±3.4 years (a study group); 2) 20 women and 8 men; mean age, 61.7±6.5 years (a control group). Group 1 patients received treatment with 25 intramuscular ICS (Chondroguard) injections per cycle and underwent ET under the guidance of a trainer. In the first 3–5 days, the patients could take nonsteroidal anti-inflammatory drugs (NSAIDs). Group 2 patients were prescribed a magnetic therapy cycle (alternating pulsed magnetic field, 15–20-minute hand exposure, a total of 10 sessions). They could also take NSAIDs within the first 3–5 days. A visual analogue scale (VAS, mm) was used to analyze hand pain severity over time: at baseline, at 3 weeks, and at 3 months after the start of treatment.Results and discussion. The dynamics of VAS joint pain was statistically more significant in Group 1 than in Group 2: 69.1±2.83 and 71.1±2.15 mm at baseline; 42.6±1.16 and 57.14±1.96 mm at 3 weeks (p<0.05), and 36.4±2.96 and 62.8±3.26 mm at 3 months (p<0.001). Similarly, Group 1 versus Group 2 showed a greater improvement in indicators, such as a decrease in the duration of morning stiffness in the hands and an increase in their grip strength. No adverse reactions requiring discontinuation of treatment or special therapy were noted in both groups.Conclusion. The investigation showed the advantage of ICS used in combination with ET over magnetotherapy in the treatment of patients with HOA.

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Are There Cochlear Dead Regions Involved in Hearing Loss after Cisplatin Ototoxicity?

Audiology and Neurotology ◽

10.1159/000502250 ◽

2019 ◽

Vol 24 (5) ◽

pp. 253-257 ◽

Cited By ~ 1

Author(s):

Christiane Schultz ◽

Patricia Helena Pecora Liberman ◽

Maria Valéria Schmidt Goffi-Gomez

Keyword(s):

Hearing Loss ◽

Hearing Aids ◽

Absolute Threshold ◽

Control Group ◽

Study Group ◽

Chemotherapy Treatment ◽

Cross Sectional ◽

Group 2 ◽

Cochlear Dead Regions ◽

Group 1

Background: The most common complaint of patients affected by chemotherapy-induced hearing loss is difficulty understanding speech in noisy environments despite the use of hearing aids. Cochlear dead regions, those areas with damaged or absent inner hair cells and dendrites, may account for this type of hearing loss. However, it is unknown whether this condition is associated with cisplatin agents. Objective: The aim of this study was to determine whether cisplatin is associated with hearing loss and cochlear dead regions. Methods: This prospective cross-sectional study was conducted in patients participating in routine audiological monitoring during and after chemotherapy treatment. Adults undergoing audiological evaluation who had completed chemotherapy treatment were invited to participate. Patients were divided into 3 groups according to pure tone thresholds. Group 1 patients had thresholds over 70 dB (HL) at 2,000 Hz and higher frequencies. Group 2 patients had thresholds below 70 dB (HL) up to 2,000 Hz. Patients in the control group had normal thresholds at all frequencies. The threshold equalizing noise test (TEN[HL]) was used to identify cochlear dead regions by repeating thresholds in the presence of TEN noise played from a compact disc. The presence of cochlear dead regions was established when the masked threshold was 10 dB or greater above the TEN level and 10 dB or greater above the absolute threshold at any frequency. Results: Twelve patients were included in study group 1, 10 patients in study group 2, and 7 patients in the control group. Cochlear dead regions were present in all patients with hearing loss and in none of the control group. For groups 1 and 2, mean differences between absolute and masked thresholds were 21 and 16 dB at 500 Hz; 22 and 15 dB at 1,000 Hz; 31 and 17 dB at 2,000 Hz; 32 and 20 dB at 3,000 Hz; and 31 and 21 dB at 4,000 Hz, respectively. Nevertheless, analysis of variance testing with Bonferroni analysis showed a difference between groups 1 and 2 only at 2,000, 3,000, and 4,000 Hz. Conclusion: We found unresponsive or dead cochlear regions in patients who had undergone cisplatin chemotherapy even among patients with mild to moderate hearing loss.

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Grape or grain but never the twain? A randomized controlled multiarm matched-triplet crossover trial of beer and wine

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqy309 ◽

2019 ◽

Vol 109 (2) ◽

pp. 345-352 ◽

Cited By ~ 9

Author(s):

Jöran Köchling ◽

Berit Geis ◽

Stefan Wirth ◽

Kai O Hensel

Keyword(s):

Alcohol Intoxication ◽

Included Study ◽

Alcohol Concentration ◽

Alcoholic Beverages ◽

Control Group ◽

Study Group ◽

Open Label ◽

Randomized Controlled ◽

Group 2 ◽

Group 1

ABSTRACT Background Alcohol-induced hangover constitutes a significant, yet understudied, global hazard and a large socio-economic burden. Old folk wisdoms such as “Beer before wine and you'll feel fine; wine before beer and you'll feel queer” exist in many languages. However, whether these concepts in fact reduce hangover severity is unclear. Objectives The aim of this study was to investigate the influence of the combination and order of beer and wine consumption on hangover intensity. Methods In this multiarm, parallel randomized controlled matched-triplet crossover open-label interventional trial, participants were matched into triplets and randomly assigned according to age, gender, body composition, alcohol drinking habits, and hangover frequency. Study group 1 consumed beer up to a breath alcohol concentration (BrAC) ≥0.05% and then wine to BrAC ≥0.11% (vice versa for study group 2). Control group subjects consumed either only beer or only wine. On a second intervention day (crossover) ≥1 wk later, study-group subjects were switched to the opposite drinking order. Control-group subjects who drank only beer on the first intervention received only wine on the second study day (and vice versa). Primary endpoint was hangover severity assessed by Acute Hangover Scale rating on the day following each intervention. Secondary endpoints were factors associated with hangover intensity. Results Ninety participants aged 19–40 y (mean age 23.9), 50% female, were included (study group 1 n = 31, study group 2 n = 31, controls n = 28). Neither type nor order of consumed alcoholic beverages significantly affected hangover intensity (P > 0.05). Multivariate regression analyses revealed perceived drunkenness and vomiting as the strongest predictors for hangover intensity. Conclusions Our findings dispel the traditional myths “Grape or grain but never the twain” and “Beer before wine and you'll feel fine; wine before beer and you'll feel queer” regarding moderate-to-severe alcohol intoxication, whereas subjective signs of progressive intoxication were confirmed as accurate predictors of hangover severity. This trial was prospectively registered at the Witten/Herdecke University Ethics Committee as 140/2016 and retrospectively registered at the German Clinical Trials Register as DRKS00015285.

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Otoacoustic emissions in detection of pre-clinical noise induced cochlear damage in military personnel

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20150901 ◽

2015 ◽

Vol 1 (2) ◽

pp. 58 ◽

Cited By ~ 1

Author(s):

Abhijeet Bhatia

Keyword(s):

Hearing Loss ◽

Military Personnel ◽

Otoacoustic Emissions ◽

Noise Exposure ◽

Control Group ◽

Study Group ◽

Control Groups ◽

Cochlear Damage ◽

Group 2 ◽

Group 1

Background: Objective of current study to analyse the utility of TEOAEs and DPOAEs to detect cochlear damage due to chronic exposure to firearm noise in Indian military personnel at a preclinical stage. Military personnel are exposed to firearm noise and need to be assessed for cochlear damage periodically.Methods: This cross sectional study was conducted from May 2004 to Apr 2005. Indian army soldiers and general civilian population were included in the study. The TEOAE and DPOAE parameters of two control groups (civilians, no noise exposure, no HL: control group 1; soldiers, noise exposed, hearing loss: Control group 2) were compared with the study group (soldiers, noise exposure, no hearing loss: Study group).Results: TEOAE amplitudes of the study group varied significantly from those of both the control groups at almost all frequencies. Overall amplitude too followed a similar trend. However, although the DPOAE amplitude of the study group was less than that of control group 1, the difference was not significant. The DPOAE amplitude of study group varied significantly from control group 2.Conclusions: TEOAEs proved to be useful to distinguish between green ears and ears chronically exposed to impulse noise with and without hearing loss. But DPOAEs proved to be useful in distinguishing only between normal hearing from hearing loss ears.

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