Prevalence of redetectable positive SARS-CoV-2 nucleic acid in recovered COVID-19 patients: a systematic review and meta-analysis

Background: The prevalence of positive SARS-CoV-2 nucleic acid in recovered COVID-19 patients has attracted attention. We aimed to investigate the repositive rate of SARS-CoV-2 and the clinical features of discharged COVID-19 patients. Methods: In this systematic review and meta-analysis, we searched PubMed, Embase, Web of Science, China National Knowledge Internet, Wanfang Data, China BioMedical Literature, VIP, and Google Scholar. Fixed or random-effect models were used to determine effect estimates. Results: Eleven studies were included. The pooled positive rate of viral RNA in discharged patients was 11% (95% CI 7-15; I2=90.4%). The median days from discharge to repositivity were 7 to 8 days. Coughing was the most common clinical symptom, occurring in 16% (95% CI 11-20; I2=0%) of patients at readmission. Chest CT and laboratory indicators of positive retest (PR) patients showed significant recovery trends. The prevalence of comorbidities between the PR patients and the negative retest patients were not significant (OR 0.86 [95% CI 0.38–1.95]; p=0.002; I2=76.5%). No close contacts were positive for SARS-CoV-2 RNA. Conclusion: PR patients were uncommon. The repositive result was likely due to the incomplete clearance of virus from a previous disease course. PR patients were less likely to be contagious. However, close monitoring and quarantine after discharge from the hospital are necessary. Registration: The protocol has been registered on PROSPERO, registration ID: CRD42021239650 Keywords: COVID-19, SARS-CoV-2, discharged patients, positive retest rate

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Systematic review on risk factors of rotator cuff tears

Journal of Orthopaedic Surgery ◽

10.1177/2309499016684318 ◽

2017 ◽

Vol 25 (1) ◽

pp. 230949901668431 ◽

Cited By ~ 15

Author(s):

Andrew Arjun Sayampanathan ◽

Tan Hwee Chye Andrew

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Rotator Cuff ◽

Meta Analysis ◽

Random Effect ◽

Female Gender ◽

Analysis Data ◽

Rotator Cuff Tears ◽

Dominant Hand ◽

Random Effect Models

Purpose: Rotator cuff tears (RCTs) occur commonly, especially among certain groups of individuals. In this meta-analysis, we aim to identify risk factors for RCTs. Methods: We searched MEDLINE for 210 articles. Seventeen articles were selected for systematic review, of which 10 were eligible for meta-analysis. Data was analysed with Review Manager 5.3, using Mantel–Haenszel statistics and random effect models. Results: A total of 6653 individuals were analysed. The odds of sustaining a RCT on the dominant hand was 2.30 times more than the non-dominant hand (95% confidence interval (CI): 1.01–5.25, Z = 1.99, p = 0.05; Heterogenity: τ2 = 0.38, χ2 = 8.84, df = 2 ( p = 0.01), I2 = 77%). The odds of an individual aged 60 years and above sustaining a RCT was 5.07 times higher than an individual less than 60 years old (95% CI: 2.45–10.51, Z = 4.37, p < 0.001; Heterogenity: τ2 = 0.47, χ2 = 25.24, df = 3 ( p < 0.001), I2 = 88%). Female gender was not a significant association, with an odds ratio of 0.98 when compared to the male gender (95% CI: 0.66–1.45, Z = 0.09, p = 0.93; Heterogenity: τ2 = 0.20, χ2 = 44.24, df = 5 ( p < 0.001), I2 = 89%). Conclusions: Hand dominance and older age are associated with RCTs. More studies are required for further assessment of associations and risk factors of RCTs.

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Mortality rate and predictors of Stroke: A Meta-Analysis and Systematic Review

10.21203/rs.2.16369/v1 ◽

2019 ◽

Author(s):

Amanual Getnet Mersha ◽

Tadesse Melaku Abegaz ◽

Mohammed Assen Seid ◽

Eyob Alemayehu Gebreyohannes ◽

Akshaya Srikanth Bhagavath ◽

...

Keyword(s):

Systematic Review ◽

Risk Factor ◽

Observational Studies ◽

Meta Analysis ◽

Random Effect ◽

Stroke Mortality ◽

Stroke Event ◽

Meta Analyses ◽

Random Effect Models ◽

Overall Mortality

Abstract Background Global data on stroke mortality remained to be sparse. In light of this, we aimed to conduct a Meta-analysis and systematic review of observational studies to estimate the mortality of stroke and to identify risk factors that predispose patients for stroke-related death.Methods This study was conducted based on the Meta-Analyses of Observational Studies in Epidemiology (MOOSE) guidelines. Overall mortality, in-hospital and 30- day mortality due to stroke were the primary outcome measures of the study. The meta-analysis was performed using Stata (Version 14, Stata Corp, College Station, Texas). Random-effect models were used for estimating pooled effects.Findings Overall, thirty two studies assessed overall mortality due to stroke. A total number of 2,885, 126 patients were recruited for the study. Pooled estimate indicated that the overall mortality of stroke was reported to be 20% (19%-22%). Whereas, the 30-day and In-hospital mortality were found to be 18% (16%-20%) and 16% (16%-19%), respectively. A subgroup analysis revealed that Africa registered the highest stroke-related death 29% (23%-36%). Hypertension was found to be an important risk factor for mortality secondary to stroke 61.9% (52.8%-71.1%).Conclusion Overall mortality of stroke was estimated to be twenty percent. The burden of stroke mortality was prominent in Africa region. Hypertension remained to be an independent risk factor for stroke mortality. Mortality of stroke can be minimized by establishing stroke centers that promptly deliver emergency management of stroke event.

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PENGARUH KONSUMSI SERAT DENGAN PENGURANGAN RISIKO KANKER KOLON DI NEGARA BARAT: STUDI META ANALISIS

Jurnal Kesehatan Masyarakat Andalas ◽

10.24893/jkma.v12i2.473 ◽

2018 ◽

Vol 12 (2) ◽

pp. 97

Author(s):

Masrul Masrul

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Cancer Patients ◽

Meta Analysis ◽

Random Effect ◽

Western Countries ◽

Colorectal Cancer Patients ◽

Published Research ◽

Random Effect Models ◽

Reduced Risk

The association between dietary fibre and colorectal cancer risk is controversial. This systematic review and meta-analysis was performed to determine fibre consumption reduced risk of colorectal cancer patients in western countries.The authors conducted a meta-analysis of published research articles on fibre consumption reduced risk of colorectal cancer patients in western countries published between January 2000 and January 2018 in the online article databases of PubMed, ProQuest and EBSCO. Pooled relative risk (PRR) were calculated with fixed and random-effect models. Data were processed using Stata version 14.2 (Stata Corporation). This study reviewed 405 articles. There are 7 studies conducted a systematic review and continued with Meta-analysis. The results showed fibre consumption reduced risk of colorectal cancer patients in western countries (RR = 0.83 [95% CI 0.75-0.93]). This analysis confirmed fibre consumption reduced risk of colorectal cancer patients in western countries.

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Tamsulosin for treatment of unilateral distal ureterolithiasis: a systematic review and metaanalysis

CJEM ◽

10.2310/8000.2013.131012 ◽

2014 ◽

Vol 16 (03) ◽

pp. 229-242 ◽

Cited By ~ 6

Author(s):

Christian Malo ◽

Jean-Sébastien Audette-Côté ◽

Marcel Émond ◽

Alexis F. Turgeon

Keyword(s):

Systematic Review ◽

Data Extraction ◽

Meta Analysis ◽

Random Effect ◽

The United States ◽

Expulsion Rate ◽

Relative Risks ◽

The Mean ◽

Mean Time ◽

Random Effect Models

ABSTRACT Objectives: The lifetime prevalence of ureterolithiasis is approximately 13% for men and 7% for women in the United States. Tamsulosin, an α-antagonist, has been used as therapy to facilitate the expulsion of lithiasis. Whether it is a good treatment for distal lithiasis remains controversial. We conducted a systematic review and meta-analysis to evaluate the effect of tamsulosin on the passage of distal ureterolithiasis. Methods: A systematic search was conducted using MEDLINE, EMBASE, and Cochrane Central. Trial eligibility was evaluated by two investigators. All randomized controlled trials (RCTs) comparing tamsulosin to standard therapy or placebo for the treatment of a single distal ureterolithiasis ≤ 10 mm in adult patients with renal colic confirmed by radiographic imaging were included. Data extraction was conducted in duplicate. Primary outcome was the expulsion rate, and secondary outcomes were the mean time for ureterolithiasis expulsion, analgesic requirements, and side effects. Mantel-Haenszel random effect models were used, and heterogeneity was assessed using I2 statistics. Data were presented with relative risks (RRs). Results: The search strategy identified 685 articles, of which 22 studies were included. Combined results suggested a benefit for the expulsion of ureterolithiasis (≥ 10 mm) when tamsulosin was used compared to a standard treatment (RR 1.50 [95% CI 1.31–1.71], I2 = 70%). A decrease in the average time of expulsion of the ureterolithiasis of 3.33 days in favour of tamsulosin was observed (95% CI −4.23, −2.44], I2 = 67%). Conclusion: Tamsulosin increases the rate of spontaneous passage of distal ureterolithiasis (≤ 10 mm).

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Dietary Fibre Protective against Colorectal Cancer Patients in Asia: A Meta-Analysis

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2019.265 ◽

2019 ◽

Vol 7 (10) ◽

pp. 1723-1727 ◽

Cited By ~ 1

Author(s):

Masrul Masrul ◽

Ricvan Dana Nindrea

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Cancer Patients ◽

Publication Bias ◽

Dietary Fibre ◽

Meta Analysis ◽

Random Effect ◽

Colorectal Cancer Patients ◽

Published Research ◽

Random Effect Models

BACKGROUND: The association between dietary fibre and colorectal cancer risk is controversial. AIM: This systematic review and meta-analysis were performed to determine the dietary fibre protective against colorectal cancer patients in Asia. METHODS: The authors conducted a meta-analysis of published research articles on dietary fibre protective against colorectal cancer patients in Asia published between January 2000 and March 2019 in the online article databases of PubMed, ProQuest and EBSCO. Pooled odds ratios (OR) were calculated with fixed and random-effect models. Publication bias was visually evaluated by using funnel plots and statistically assessed through Egger’s and Begg’s tests. Data were processed using Review Manager 5.3 (RevMan 5.3) and Stata version 14.2 (Stata Corporation). RESULTS: This study reviewed 405 articles. There are 10 studies conducted a systematic review and continued with Meta-analysis of relevant data with several sample 49,964 patients. The results showed dietary fibre protective against colorectal cancer patients in Asia (OR = 0.66 [95% CI 0.56-0.77, p=0.008]). There was significant publication bias for studies included in dietary fibre protective against colorectal cancer patients in Asia. CONCLUSION: This analysis confirmed dietary fibre protective against colorectal cancer patients in Asia.

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Global Prevalence of Posttraumatic Stress Disorder (PTSD) during and after Coronavirus Pandemic: A Study Protocol for a Systematic Review and Meta-Analysis

Iranian Journal of Psychiatry ◽

10.18502/ijps.v15i3.3819 ◽

2020 ◽

Author(s):

Maryam Salmanian ◽

Mona Salehi ◽

Zahra Hooshyari

Keyword(s):

Systematic Review ◽

Web Of Science ◽

Stress Disorder ◽

Meta Analysis ◽

Random Effect ◽

Future Studies ◽

Global Prevalence ◽

Care Workers ◽

Prevalence Estimates ◽

Random Effect Models

Objective: Studies conducted on severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19 epidemics have shown PTSD can occur during and after infectious diseases. However, more studies are needed to explore PTSD during and after COVID-19 outbreak. The objective of this study is to provide a protocol of systematic review and meta-analysis to report the global prevalence of PTSD during and after coronavirus pandemics among general population, health care workers, survivors, or patients with coronaviruses. Method: We include all studies that reported the prevalence of PTSD during and after coronavirus pandemics and search databases, including Web of Science, PubMed, Scopus, Embase, and Google Scholar from first of November 2002 to May 18, 2020. Two authors independently use relevant checklists to quality assessment of the included studies and extract data. We use the graphical methods and fixed or random effect models to aggregate prevalence estimates. Also, we will assess heterogeneity between the included studies using the I2 heterogeneity statistic and use subgroup and sensitivity analysis to assess the sources of heterogeneity. Discussion: We infer that PTSD is a common experience during and after infectious disease pandemics, especially COVID-19. The findings of this study can be used by health policymakers and other stakeholders and will provide a path to future studies.

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A Systematic Review and Meta-Analysis on Catastrophic Cost incurred by Tuberculosis Patients and their Households

10.1101/2021.02.27.21252453 ◽

2021 ◽

Author(s):

Ramy Mohamed Ghazy ◽

Haider M. El Saeh ◽

Shaimaa Abdulaziz ◽

Esraa Abdellatif Hammouda ◽

Amira Elzorkany ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Random Effect ◽

Significant Proportion ◽

Catastrophic Health Expenditure ◽

World Health ◽

Total Cost ◽

Quantitative Synthesis ◽

Health Organization ◽

Random Effect Models

AbstractBackgroundAs one of the World Health Organization (WHO) End Tuberculosis (TB) Strategy is to reduce the proportion of TB affected families that face catastrophic costs to 0% by 2020. This systematic review and meta-analysis aimed to estimate the pooled proportion of TB affected households who face catastrophic cost.MethodA search of the online database through September 2020 was performed. A total of 5114 articles were found, of which 29 articles got included in quantitative synthesis. Catastrophic cost is defined if total cost related to TB exceeded 20% of annual pre-TB household income. R software was used to estimate the pooled proportion at 95% confidence intervals (CIs) using the fixed/random-effect models.ResultThe proportion of patients faced catastrophic cost was 43% (95% CI 34-52, I2 = 99%); 32% (95% CI 29 – 35, I2 = 70%) among drug sensitive, and 80% (95% CI 74-85, I2 = 54%) among drug resistant, and 81% (95%CI 78-84%, I2 = 0%) among HIV patients. Regarding active versus passive case finding the pooled proportion of catastrophic cost was 12% (95% CI 9-16, I2 = 95%) versus 42% (95% CI 35-50, I2 = 94%). The pooled proportion of direct cost to the total cost was 45% (95% CI 39-51, I2 = 91%). The pooled proportion of patients facing catastrophic health expenditure (CHE) at cut of point of 10% of their yearly income was 45% (95% CI 35-56, I2 = 93%) while at 40% of their capacity to pay was 63% (95% CI 40-80, I2 = 96%).ConclusionDespite the ongoing efforts, there is a significant proportion of patients facing catastrophic cost, which represent a main obstacle against TB control.PROSPERO registrationCRD42020221283

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Detection of three pandemic causing coronaviruses from non-respiratory samples: systematic review and meta-analysis

Scientific Reports ◽

10.1038/s41598-021-95329-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Chandan Mishra ◽

Suneeta Meena ◽

Jitendra Kumar Meena ◽

Suman Tiwari ◽

Purva Mathur

Keyword(s):

Systematic Review ◽

Detection Rate ◽

Meta Analysis ◽

Total Sample ◽

Urine Samples ◽

Pathogenic Potential ◽

Clinical Specimens ◽

Qrt Pcr ◽

Corona Virus ◽

Positive Rate

AbstractSARS-CoV-2 has posed an unprecedented challenge to the world. Pandemics have been caused previously by viruses of this family like Middle East Respiratory Corona Virus (MERS CoV), Severe Acute Respiratory Syndrome Corona Virus (SARS CoV). Although these viruses are primarily respiratory viruses, but they have been isolated from non-respiratory samples as well. Presently, the detection rate of SARS‐CoV‐2 RNA from different clinical specimens using Real Time Reverse Transcriptase Polymerized Chain Reaction (qRT‐PCR) after onset of symptoms is not yet well established. Therefore, the aim of this systematic review was to establish the profile of detecting SARS‐CoV‐2, MERS CoV, SARS CoV from different types of clinical specimens other than the respiratory using a standard diagnostic test (qRT‐PCR). A total of 3429 non-respiratory specimens were recorded: SARS CoV (total sample—802), MERS CoV (total sample—155), SARS CoV-2 (total sample—2347). Out of all the samples studied high positive rate was seen for saliva with 96.7% (14/14; 95% CI 87.6–100.0%) for SARS CoV and 57.5% (58/250; 95% CI − 1.2 to 116.2%) for SARS CoV-2, while low detection rate in urine samples for SARS CoV-2 with 2.2% (8/318; 95% CI 0.6–3.7%) and 9.6% (12/61; 95% CI − 0.9 to 20.1%) for SARS CoV but there was relatively higher positivity in urine samples for MERS CoV with detection rate of 32.4% (2/38; 95% CI − 37.3 to 102.1%). In Stool sample positivity was 54.9% (396/779; 95% CI 41.0–68.8%), 45.2% (180/430; 95% CI 28.1–62.3%) and 34.7% (4/38; 95% CI − 29.5 to 98.9%) for SARS CoV-2, MERS CoV, and SARS CoV, respectively. In blood sample the positivity was 33.3% (7/21; 95% CI 13.2–53.5%), 23.7% (42/277; 95% CI 10.5–36.9%) and 2.5% (2/81; 95% CI 0.00–5.8%) for MERS CoV, SARS CoV-2 and SARS CoV respectively. SARS‐CoV‐2 along with previous two pandemic causing viruses from this family, were highly detected stool and saliva. A low positive rate was recorded in blood samples. Viruses were also detected in fluids along with unusual samples like semen and vaginal secretions thus highlighting unique pathogenic potential of SARS‐CoV‐2.

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Complications of Outpatient and Inpatient Renal Biopsy: A Systematic Review and Meta-Analysis

Diagnostics ◽

10.3390/diagnostics11040651 ◽

2021 ◽

Vol 11 (4) ◽

pp. 651

Author(s):

Shih-Yi Lin ◽

Cherry Yin-Yi Chang ◽

Cheng-Chieh Lin ◽

Wu-Huei Hsu ◽

I.-Wen Liu ◽

...

Keyword(s):

Systematic Review ◽

Renal Biopsy ◽

Meta Analysis ◽

Random Effect ◽

Bleeding Risk ◽

Complication Rates ◽

Bleeding Events ◽

Cochrane Database ◽

Renal Biopsies ◽

Inpatient Settings

Background: The evidence indicates that the optimal observation period following renal biopsy ranges between 6 and 8 h. This systematic review and meta-analysis explored whether differences exist in the complication rates of renal biopsies performed in outpatient and inpatient settings. Methods: We searched the MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews from 1985 to February 2020. Two reviewers independently selected studies evaluating the bleeding risk from renal biopsies performed in outpatient and inpatient settings and reviewed their full texts. The primary and secondary outcomes were risks of bleeding and major events (including mortality) following the procedure, respectively. Subgroup analysis was conducted according to the original study design (i.e., prospective or retrospective). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random effect meta-analysis. Heterogeneity was assessed using the I2 test. Results: Data from all 10 eligible studies, which included a total of 1801 patients and 203 bleeding events, were included for analysis. Renal biopsies in outpatient settings were not associated with a higher bleeding risk than those in inpatient settings (OR = 0.81; 95% CI, 0.59–1.11; I2 = 0%). The risk of major events was also comparable across both groups (OR = 0.45; 95% CI, 0.16–1.29; I2 = 4%). Conclusions: Similar rates of bleeding and major events following renal biopsy in outpatient and inpatient settings were observed.

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Pretherapeutic Imaging for Axillary Staging in Breast Cancer: A Systematic Review and Meta-Analysis of Ultrasound, MRI and FDG PET

Journal of Clinical Medicine ◽

10.3390/jcm10071543 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1543

Author(s):

Morwenn Le Boulc’h ◽

Julia Gilhodes ◽

Zara Steinmeyer ◽

Sébastien Molière ◽

Carole Mathelin

Keyword(s):

Systematic Review ◽

Sensitivity And Specificity ◽

Meta Analysis ◽

False Negative ◽

Significant Proportion ◽

False Negative Rate ◽

True Positive Rate ◽

Axillary Staging ◽

Positron Emission ◽

Positive Rate

Background: This systematic review aimed at comparing performances of ultrasonography (US), magnetic resonance imaging (MRI), and fluorodeoxyglucose positron emission tomography (PET) for axillary staging, with a focus on micro- or micrometastases. Methods: A search for relevant studies published between January 2002 and March 2018 was conducted in MEDLINE database. Study quality was assessed using the QUality Assessment of Diagnostic Accuracy Studies checklist. Sensitivity and specificity were meta-analyzed using a bivariate random effects approach; Results: Across 62 studies (n = 10,374 patients), sensitivity and specificity to detect metastatic ALN were, respectively, 51% (95% CI: 43–59%) and 100% (95% CI: 99–100%) for US, 83% (95% CI: 72–91%) and 85% (95% CI: 72–92%) for MRI, and 49% (95% CI: 39–59%) and 94% (95% CI: 91–96%) for PET. Interestingly, US detects a significant proportion of macrometastases (false negative rate was 0.28 (0.22, 0.34) for more than 2 metastatic ALN and 0.96 (0.86, 0.99) for micrometastases). In contrast, PET tends to detect a significant proportion of micrometastases (true positive rate = 0.41 (0.29, 0.54)). Data are not available for MRI. Conclusions: In comparison with MRI and PET Fluorodeoxyglucose (FDG), US is an effective technique for axillary triage, especially to detect high metastatic burden without upstaging majority of micrometastases.

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