scholarly journals Pregnancy benefit of acupuncture on in vitro fertilization: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Shiyan Yan ◽  
Xiaoyu Liu ◽  
Zhenqing Pu ◽  
Yuhan Lin ◽  
Zhiyi Xiong ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Random Effect ◽  
Random Effect Model ◽  
Live Birth Rate ◽  
Current Evidence ◽  
Control Group ◽  
Vitro Fertilization ◽  
Statistical Heterogeneity ◽  
Significant Difference

Background: The evidence of acupuncture for in vitro fertilization (IVF) remains debatable. Objectives: To evaluate the efficacy of acupuncture on embryo transfer in women undergoing IVF. Search Strategy: PubMed, MEDLINE, Web of Science, EMBASE, CENTRAL, Wanfang, Chinese National Knowledge Infrastructure, VIP were searched up to 6 September 2021. Selection Criteria: Randomized controlled trials (RCTs) of acupuncture evaluating IVF’s effects were included. Data Collection and Analysis: Clinical pregnancy rate (CPR) and live birth rate (LBR) were quantitatively summarized by the random-effect model. Variations in pooled estimates were examined by subgroup analyses and I2 was measured to quantify statistical heterogeneity. Main Results: Forty-nine eligible RCTs representing 9422 women undergoing IVF for pregnant success were identified. Pooled CPR and LBR showed a significant difference between acupuncture and control groups (odds ratio [OR]=1.65, 95% confidence interval [CI]: 1.45 to 1.88; OR=1.34, 95% CI: 1.08 to 1.66). Subgroup analysis showed a benefit of traditional acupuncture for women aged < 35 years (CPR: OR=1.57, 95% CI: 1.23 to 2.03; LBR: OR=1.34, 95% CI:1.23 to 1.48), treatment with  3 sessions (CPR: OR=2.37, 95% CI: 1.46 to 3.85; LBR: OR=1.99, 95% CI:1.52 to 2.60), and lower baseline control group rates of CPR (CPR: OR=2.14, 95% CI: 1.22 to 2.13; LBR: OR=2.23, 95% CI:1.07 to 4.62). Heterogeneity across studies were found (CPR: I2=47.4, p <0.001; LBR: I2=62.9, p <0.001). Conclusions: Although benefits of acupuncture in CPR and LBR among IVF women existed, no robust associations were found and which might be limited by the heterogeneity of current evidence

scholarly journals The effectiveness of collaborative infertility counseling (CIC) on pregnancy outcome in infertile women undergoing in vitro fertilization: A randomized controlled trial

2019 ◽  
Author(s):  
Mahboobeh Rasoulzadeh Bidgoli ◽  
robab latifnejad roudsari ◽  
ali montazeri
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Treatment Success ◽  
Intervention Group ◽  
Control Group ◽  
Vitro Fertilization ◽  
Infertile Women ◽  
Significant Difference ◽  
And Control

Abstract Background: Infertility is an emotional tension which influences the whole aspects of relationships in infertile couples. A main objective of infertility treatments is elevation of pregnancy rate. The present study aimed to examine the effect of collaborative counseling on pregnancy rate in infertile women, undergoing in vitro fertilization in Mashhad, Iran. Methods: In this clinical trial, 60 women with primary infertility were selected from an infertility research center and were randomly allocated into intervention (n=29) and control (n=31) groups. The intervention group received individual counseling, based on the collaborative reproductive healthcare model with collaboration of a midwife, a gynecologist and a clinical psychologist in five sessions during a two-month period. The control group received routine care. Positive pregnancy test was considered as a criterion of treatment success at the end of the study. Data were analyzed using statistical tests including independent samples t-test. Results: There was no significant difference in pregnancy rate between intervention and control groups (P = 0.298). Also, there were no significant differences in follicle and embryo numbers between two groups. However, a significant difference was observed between two groups in terms of oocyte numbers where the intervention group had more oocyte (P = 0.014). Conclusion: Overall the findings indicated that the collaborative infertility counseling did not improve treatment success in infertile women undergoing in vitro fertilization

scholarly journals Effect of intrauterine granulocyte-colony stimulating factor administration on in vitro fertilization outcome in women with moderate-to-severe endometriosis: An RCT

2021 ◽  
pp. 733-740
Author(s):  
Ladan Kashani ◽  
Ashraf Moini ◽  
Tayebeh Esfidani ◽  
Nazila Yamini ◽  
Shima Mohiti
Keyword(s):  
In Vitro Fertilization ◽  
Clinical Pregnancy ◽  
Control Group ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Vitro Fertilization ◽  
Infertile Women ◽  
Significant Difference ◽  
Stimulating Factor

Background: Nearly 25-50% of infertile women have endometriosis. There are reports of disorders in the expression of granulocyte colony-stimulating factor (G-CSF) receptors in women with endometriosis. Objective: To examine the effect of intrauterine administration of G-CSF in in vitro fertilization (IVF) cycles on the fertility rate of infertile women with moderate-to-severe endometriosis. Materials and Methods: This clinical trial was conducted on 66 infertile women with moderate-to-severe endometriosis, undergoing IVF and intracytoplasmic sperm injection (ICSI). The participants were allocated into two groups via simple randomization: the G-CSF (n = 27) and control (n = 39) groups. In the G-CSF intervention group, on the oocyte pick-up day, immediately after an ovarian puncture, 300 μg of G-CSF was injected through a transcervical catheter under abdominal ultrasound guide to visualize flushing into the uterine cavity. Women in the control group received no intervention. The two groups were evaluated for clinical pregnancy. Results: No significant difference was noted in the demographic characteristics of the two groups. The rate of clinical pregnancy was 28.2% in the control group and 25.9% in the G-CSF group, indicating no significant difference (p = 0.83). Conclusion: The results showed that the intrauterine injection of G-CSF had no effects on pregnancy in women with stage-3/4 endometriosis undergoing IVF. Key words: G-CSF, In vitro fertilization, Endometriosis, Pregnancy.

scholarly journals The effect of acupuncture on the day of embryo transfer on the in vitro fertilization outcomes: An RCT

2020 ◽  
Author(s):  
Alamtaj Samsami Dehghani ◽  
Kaynoosh Homayouni ◽  
Zahra Kanannejad ◽  
Zeinab Kanannejad
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Pregnancy Rates ◽  
Control Group ◽  
Vitro Fertilization ◽  
Significant Difference ◽  
Before And After ◽  
Mother And Child ◽  
Child Hospital

Background: Acupuncture is an adjunct therapy to support infertile women received in vitro fertilization (IVF) treatment; however, the efficacy of this approach needs more evaluation. Objective: This randomized clinical trial (RCT) study aimed to evaluate the influence of acupuncture on reproductive outcomes in women undergoing IVF treatment. Materials and Methods: The study was carried out on 186 participants who had undergone IVF treatment in the Mother and Child Hospital between September 2015 and February 2016. Subjects were randomly divided into three groups: Acupuncture 25 min before embryo transfer (ET) (ACU1 group, n = 62), acupuncture 25 min before and after ET (ACU2 group, n = 62), and ET without acupuncture (control group, n = 62). Pregnancy rates (biochemical, clinical, and ongoing) were evaluated and compared between groups. Results: There were significant differences between the ACU1 group and the control group regarding biochemical (p = 0.005), clinical (p = 0.006), and ongoing (p = 0.007) pregnancies. Also, our results showed that two-session acupuncture (ACU2) lead to a significant reduction in frequency of biochemical (p = 0.002), clinical (p = 0.003), and ongoing (p = 0.01) pregnancy rates when compared to the one-session acupuncture (ACU1). No significant difference was found between the ACU2 and control groups regarding the aforementioned terms (p = 0.50). Conclusion: Acupuncture 25 min before ET significantly increased the IVF outcomes in women undergoing IVF compared with no acupuncture. Repeating acupuncture 25 min after ET did not improve the IVF outcome. Key words: Acupuncture, Embryo transfer, In vitro fertilization, Pregnancy rate.

scholarly journals The clinical outcome of Dienogest treatment followed by in vitro fertilization and embryo transfer in infertile women with endometriosis

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Hiroshi Tamura ◽  
Hiroaki Yoshida ◽  
Hiroyuki Kikuchi ◽  
Mai Josaki ◽  
Yumiko Mihara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
In Vitro Fertilization ◽  
Clinical Outcome ◽  
Control Group ◽  
Vitro Fertilization ◽  
Infertile Women ◽  
Significant Difference ◽  
Ivf Et ◽  
Follicular Fluids

Abstract Background Endometriosis is considered to be the most intractable cause of female infertility. Administering any type of treatment for endometriosis before in vitro fertilization and embryo transfer (IVF-ET) is an important strategy for improving the IVF-ET outcomes for infertile women with endometriosis. In fact, treatment with a gonadotropin-releasing hormone (GnRH) agonist just before IVF-ET has been reported to improve the clinical outcome in endometriosis patients. However, the benefit of Dienogest (DNG), a synthetic progestin, treatment just before IVF-ET remains unclear. Methods Sixty-eight infertile women with Stage III or IV endometriosis (ovarian endometrial cyst < 4 cm) were recruited for this study. The subjects were divided into 2 groups: a DNG group (n = 33) and a control group (n = 35). DNG was administered orally every day for 12 weeks prior to the conventional IVF-ET cycle in the DNG group. Standard controlled ovarian hyperstimulation with the GnRH agonist long protocol was performed in the control group. The numbers of mature follicles and retrieved oocytes, fertilization rates, implantation rates, and clinical pregnancy rate were compared between the two groups. In addition, the concentrations of inflammatory cytokines, oxidative stress markers, and antioxidants in follicular fluids were also measured. Results The numbers of growing follicles, retrieved oocytes, fertilized oocytes, and blastocysts were significantly lower in the DNG group than in the control group. The fertilization and blastocyst rates were also lower in the DNG group than in the control group. Although there was no significant difference in the implantation rate between the groups, the cumulative pregnancy rate and live birth rate were lower in the DNG group than in the control group. There was no significant difference in the abortion rate. Our results failed to show that DNG reduces the inflammatory cytokine levels and oxidative stress in follicular fluids. Conclusions Administering DNG treatment just before IVF-ET did not provide any benefits to improve the clinical outcomes for infertile women with endometriosis.

scholarly journals Does Acupuncture Have Any Benefit in the IVF Treatment of Couples with Unexplained Infertility; A Prospective Randomized Controlled Trial

2019 ◽  
pp. 1
Author(s):  
Songul Ece Gonen ◽  
Pınar Kadirogullari ◽  
Kerem Doga Seckin ◽  
Bunyamin Borekci
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Controlled Trial ◽  
Unexplained Infertility ◽  
Controlled Study ◽  
Control Group ◽  
Study Group ◽  
Vitro Fertilization ◽  
Significant Difference

<p><strong>Objective:</strong> We aimed to investigate the effect of acupuncture performed as an adjuvant therapy to in vitro fertilization, on pregnancy rates by performing acupuncture on the day of embryo transfer, one hour before the procedure and one hour after the procedure.</p><p><strong>Study Design:</strong> In this open-label randomized prospective controlled study, 60 unexplained infertility patients enrolled for in vitro fertilization treatment were randomized by a computer-based number generator for acupuncture performance and no-treatment. All patients received rFSH (Gonal-F®) for ovulation induction and the antagonist Cetrorelix (Cetrotide®) to prevent premature ovulation. Ovulation was triggered by using hCG (Ovitrelle®) and egg collection was done after 36-48 hours. In the study group, acupuncture was performed by intradermal needling, bilaterally with a sterile needle, both one hour before and one hour after the embryo transfer. Acupuncture was not performed on the control group. The results of the treatment were evaluated 12 days after embryo transfer.</p><p><strong>Results:</strong> Thirty patients were randomized into the study group and 30 patients were randomly placed in the control group. Although there was no statistically significant difference between groups in terms of β-hCG positivity, it was 43.3% in the study group and 36.7% in the control group (p&gt;0.05).</p><p><strong>Conclusion:</strong> The success rate of in vitro fertilization was higher in terms of pregnancy rate in the patient group who received acupuncture procedure as well, but the difference was not statistically significant. This may be due to the type of acupuncture procedure selected or insufficient sample size. As a result, further studies involving larger numbers of participants and using different acupuncture techniques are needed.</p>

scholarly journals HYSTEROSCOPY BEFORE IN VITRO FERTILIZATION

2018 ◽  
pp. 76
Author(s):  
Dejan Mitić ◽  
Radomir Živadinović ◽  
Marin Bašić ◽  
Aleksandra Petrić ◽  
Milan Trenkić ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Negative Impact ◽  
Similar Rate ◽  
Control Group ◽  
Pathological State ◽  
Vitro Fertilization ◽  
Group I ◽  
Significant Difference

In the last decade, success after in vitro fertilization process (IVF) has remained at a similar rate despite all the improvements implemented in the stimulation protocols and laboratory techniques. Hysteroscopy is a method becoming more widely used with patients after a failed IVF cycle, considering a large incidence of uterus cavum pathological states which have a negative impact on the favorable outcome. Numerous studies have provided different results on the IVF outcome with hysteroscopy performed prior to this treatment in cases with no uterus cavum pathology. The aim of the research was to examine the effect of both diagnostic and surgical hysteroscopy on the outcome of IVF.  Hysteroscopy was performed with 74 patients 30 to 50 days prior to IVF and in 33 of them (group I) some pathological state was noticed, which was treated during the same procedure. The control group (group III) included 151 patients who had IVF performed with no prior hysteroscopy. There is no statistically significant difference in the rate of post hysteroscopy implantation between I and II group when compared to the control group (20.62% vs 23.28% vs 17.31%), nor in the rate of clinical pregnancies (45.45% vs 46.34% vs 34.44%). Following the correctional treatment of uterus cavum pathological states, implantation and pregnancy rates remain at a level comparable to hysteroscopically normal medical findings. Statistically significant higher pregnancy rate is present in group I after the first IVF cycle, compared to the next IVF in the same group and in comparison to the next IVF cycle in the control group (60.00% vs 27.91%, p<0.05). Hysteroscopy is a simple and safe method allowing nearly identical rate of clinical pregnancies after a surgical treatment of uterus cavum pathological states when compared to the control group, but statistically much higher pregnancy rate if the order of IVF procedure is being compared. In cases of normal ultrasound findings and negative hysteroscopical findings, performing hysteroscopy prior to IVF does not provide significantly better results. Therefore, its routine execution is not recommended.

scholarly journals The effectiveness of a collaborative infertility counseling (CIC) on pregnancy outcome in women undergoing in vitro fertilization: a randomized trial

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Mahboobeh Rasoulzadeh Bidgoli ◽  
Robab Latifnejad Roudsari ◽  
Ali Montazeri
Keyword(s):  
In Vitro Fertilization ◽  
Randomized Trial ◽  
Pregnancy Rate ◽  
Intervention Group ◽  
Fertility Treatment ◽  
Control Group ◽  
Vitro Fertilization ◽  
Group Randomized Trial ◽  
Significant Difference

Abstract Background The optimal objective of infertility treatments is to increase pregnancy rate. The aim of this study was to assess the effectiveness of a collaborative counseling program on pregnancy rate in women undergoing in vitro treatment. Methods This was a parallel group randomized trial on a sample of 60 women attending to an infertility research center affiliated to Mashhad University of Medical Sciences for fertility treatment. Women were randomly assigned to an intervention or a control group. Then, a five-session program offered to the intervention group while the control group received nothing expect the usual care. The primary outcome for the study was positive pregnancy test at the end of study. Statistical analyses including independent samples t-test were performed to explore the data. Results The outcome analysis showed that there were no significant differences in pregnancy rate between the intervention and the control groups (P = 0.298). Also, there were no significant differences in follicle and embryo numbers between two groups. However, a significant difference was observed between two groups in terms of oocyte numbers where the intervention group had more oocyte (P = 0.014). Conclusion Overall the findings indicated that the collaborative infertility counseling did not improve treatment success in infertile women undergoing in vitro fertilization. Trial registration IRCT201110267915N1. Registered 2014.07.25-Retrospectively registered (http://en.irct.ir/trial/8359).

scholarly journals Features of neurological and psychomotoral development of premature children born by IVF and naturally

2021 ◽  
pp. 24-31
Author(s):  
N. A. Druzhrnina ◽  
D. R. Merzlyakova ◽  
R. Z. Akhmetshin ◽  
N. R. Khafizova ◽  
G. P. Shiryaeva ◽  
...  
Keyword(s):  
Body Weight ◽  
In Vitro Fertilization ◽  
Premature Infants ◽  
Reproductive Technologies ◽  
Speech Development ◽  
Psychomotor Development ◽  
Control Group ◽  
Vitro Fertilization ◽  
Significant Difference

Introduction. The use of in vitro fertilization methods plays an important role in overcoming the childlessness of families, but they must be combined with the success of nursing premature newborns to increase the effectiveness of assisted reproductive technologies. Children with very or extremely low body weight are at risk of increased rates of infant mortality and disability. The study of the state of health and the analysis of the psychomotor/neurological status of such children is extremely important due to the study of the possibilities of reducing the frequency of negative outcomes.Aim. A study during the first 3 years of neurological/psychomotor development in premature infants diagnosed with extremely low/very low body weight, born as a result of in vitro fertilization and naturally.Materials and methods. Studies of neurological/psychomotor development in premature infants have been carried out. The study included 189 infants diagnosed with prematurity at birth. The studies were carried out on the basis of the intensive care unit and the department of prematurity and neonatal pathology at the Republican Children’s Clinical Hospital (Ufa). Then, for 3 years, regular observation was carried out in the follow-up room in the same institution. Dynamic assessment of neurological and psychomotor status was performed using the Clinical Adaptive Test and Clinical linguistic and auditory milestone scales, as well as Gross Motor testing.Results and discussion. It was found that the incidence of neurological morbidity related to developmental delay is significantly higher in children born as a result of in vitro fertilization than in those conceived naturally. Thus, the number of children lagging behind in speech development at the age of up to 1 year is 59.1/59.6 and 52.1/52.3% when diagnosed with very low and extremely low body weight.Conclusion. The dynamics of the average coefficient of speech development in children conceived artificially did not reach (less than 75) normal values by the age of 3, and in the control group, the coefficient of speech development was normalized. There is no significant difference between very low and extremely low body weight children.

scholarly journals Miscarriage Rates due to Endometriosis: A Retrospective Cohort Study

2020 ◽  
pp. 1
Author(s):  
Pinar Calis ◽  
Gizem Isik ◽  
Dilara Duygulu ◽  
Nuray Bozkurt ◽  
Deniz Karcaaltincaba
Keyword(s):  
Cohort Study ◽  
In Vitro Fertilization ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Control Group ◽  
Pathology Report ◽  
Miscarriage Rate ◽  
Vitro Fertilization ◽  
Significant Difference

<p><strong>OBJECTIVE:</strong> To find the differences of miscarriage rates between pregnant patients with and without endometriosis. </p><p><strong>STUDY DESIGN:</strong> The retrospective cohort study was conducted in the Department of Obstetrics and Gynecology, School of Medicine, Gazi University between January-2015 and December-2018. Patients were divided into two groups; endometriosis and non-endometriosis according to their pathology report and ultrasound examination. In both groups, miscarriage rates and in vitro fertilization pregnancy ratios were analyzed. Miscarriage rates in in vitro fertilization pregnancies and in endometriosis group who had and didn't have surgery also analyzed.</p><p><strong>RESULTS:</strong> Sixty-two patients in the study group and 65 patients in the control group were included. There was no significant difference in miscarriage rates between endometriosis and non-endometriosis group (20/62 (32%) and 13/65 (20%), respectively, p=0.124). There was a statistically significant difference in miscarriage rates between in vitro fertilization and non-in vitro fertilization group (p=0.004). Apart from that, in in vitro fertilization group, the miscarriage rate was higher in the endometrioma subgroup than non-endometrioma (p=0.008).</p><p><strong>CONCLUSION:</strong> There was an only significant difference in miscarriage rate in the in vitro fertilization group between endometrioma and non-endometrioma patients. In the future, there should be more studies to define the actual pathophysiology for miscarriage with endometriosis.</p>

Predictive Model for Live Birth at 12 Months After Starting In-Vitro Fertilization Treatment

MedPharmRes ◽  
2018 ◽  
Vol 2 (2) ◽  
pp. 5-20
Author(s):  
Vu Ho ◽  
Toan Pham ◽  
Tuong Ho ◽  
Lan Vuong
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Cox Regression ◽  
Financial Burden ◽  
Oocyte Retrieval ◽  
Operating Characteristics ◽  
Vitro Fertilization ◽  
Cox Regression Analysis ◽  
Significant Difference

IVF carries a considerable physical, emotional and financial burden. Therefore, it would be useful to be able to predict the likelihood of success for each couple. The aim of this retrospective cohort study was to develop a prediction model to estimate the probability of a live birth at 12 months after one completed IVF cycle (all fresh and frozen embryo transfers from the same oocyte retrieval). We analyzed data collected from 2600 women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) at a single center in Vietnam between April 2014 and December 2015. All patients received gonadotropin-releasing hormone (GnRH) antagonist stimulation, followed by fresh and/or frozen embryo transfer (FET) on Day 3. Using Cox regression analysis, five predictive factors were identified: female age, total dose of recombinant follicle stimulating hormone used, type of trigger, fresh or FET during the first transfer, and number of subsequent FET after the first transfer. The area under the receiver operating characteristics curve for the final model was 0.63 (95% confidence interval [CI] 0.60‒0.65) and 0.60 (95% CI 0.57‒0.63) for the validation cohort. There was no significant difference between the predicted and observed probabilities of live birth (Hosmer-Lemeshow test, p > 0.05). The model developed had similar discrimination to existing models and could be implemented in clinical practice.

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