The effect of heterocyclic S,S’-ligands on the electrochemical properties of some cobalt(III) complexes in acid

Eight mixed-ligand cobalt(III) complexes with the macrocyclic amine 1,4,8,11-tetraazacyclotetradecane (cyclam) and a heterocyclic dithiocarbamate (Rdtc-)i.e., morpholine-(Morphdtc), thiomorpholine- (Timdtc), piperazine-(Pzdtc), N-methylpiperazine-(Mepzdtc), piperidine- (Pipdtc), 2-, 3- or 4-methylpiperidine-(2-, 3- and 4-Mepipdtc) carbodithionato-S,S ions, of the general formula [Co(cyclam)Rdtc](ClO4)2, were investigated in deoxygenated 0.1 MHClO4 solutions. Cyclic voltammetry data at a glassy carbon (GC) electrode demonstrate a redox reaction of cobalt(III) from the complexes at potentials strongly influenced by the presence of different heterocyclic Rdtc- ligands. In this respect, the complexes were separated into two groups: the first, with a heteroatom O, S or N in the heterocyclic ring, and the second, with a methyl group on the piperidine ring of the Rdtc- ligand. Anodic polarization of an Fe electrode in the presence of the complexes shows their influence not only on the dissolution of iron but also on the hydrogen evolution reactions and on this basis complexes the complexes could be divided into the same two groups. It was found that the weaker the inhibiting effect of the free heterocyclic amines is, the significantly higher is the efficiency of the corresponding complexes.

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New Amine and Aromatic Substituted Analogues of Phencyclidine: Synthesis and Determination of Acute and Chronic Pain Activities

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207322666191016152157 ◽

2019 ◽

Vol 22 (8) ◽

pp. 570-576

Author(s):

Maryam Shokrollahi ◽

Marjaneh Samadizadeh ◽

Mohsen Khalili ◽

Seyed A. Sobhanian ◽

Abbas Ahmadi

Keyword(s):

Nmda Receptors ◽

Phenyl Ring ◽

Piperidine Ring ◽

Methyl Group ◽

Physiological Properties ◽

Antinociceptive Effects ◽

The Central Nervous System ◽

Analgesic Activities ◽

Compound Ii ◽

New Compounds

Background: Phencyclidine (PCP, I) is a synthetic drug with remarkable physiological properties. PCP and its analogues exert many pharmacological activities and interact with some neurotransmitter systems in the central nervous system like particular affinity for PCP sites in NMDA receptors or dopamine uptake blocking or even both. Aim and Objective: The following research, methyl group with electron-donating and dipole moment characters was added in different positions of phenyl ring along with the substitution of benzylamine (with many pharmacological effects) instead of piperidine ring of I to produce new compounds (II-V) of this family with more analgesic activities. Materials and Methods: Analgesic activities of these new compounds were measured by tail immersion and formalin tests for acute and chronic pains, respectively. Also, the outcomes were compared with control and PCP (10 mg/kg) groups. Results: The results indicate that compounds III, IV, and V have more acute and chronic antinociceptive effects than PCP and compound II which may be concerned with more antagonizing activities of these new painkillers for the blockage of dopamine reuptake as well as high affinity for NMDA receptors PCP binding site. Conclusion: It can be concluded that the benzylamine derivative of phencyclidine with a methyl group on the benzyl position on phenyl ring (V) is a more appropriate candidate to reduce acute and chronic (thermal and chemical) pains compared to other substituted phenyl analogs (II-IV) and PCP.

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Chemical Space Mapping for Multicomponent Gas Mixtures

10.26434/chemrxiv.14061047.v1 ◽

2021 ◽

Author(s):

Airat Kotliar-Shapirov ◽

Fedor S. Fedorov ◽

Henni Ouerdane ◽

Stanislav Evlashin ◽

Albert G. Nasibulin ◽

...

Keyword(s):

Cyclic Voltammetry ◽

Data Processing ◽

Electrochemical Sensors ◽

Chemical Space ◽

Chemical Species ◽

Single Species ◽

Data Driven ◽

Multicomponent Gas ◽

Data Driven Approach ◽

Cyclic Voltammetry Data

In our manuscript, we present our protocol for data processing to mitigate the effects of interfering analytes on the identification of the chemical species detected by sensors. Considering NO2 and CO2, we designed electrochemical sensors whose response yielded the cyclic voltammetry data that we analyzed to classify single-species components and their mixtures using a data-driven approach to generate a chemical space where their mixtures can be deconvoluted.<br>

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Synthesis of Novel 1,2,3-Triazole-Dihydropyrimidinone Hybrids Using Multicomponent 1,3-Dipolar Cycloaddition (Click)–Biginelli Reactions: Anticancer Activity

Synlett ◽

10.1055/s-0039-1690781 ◽

2020 ◽

Vol 31 (06) ◽

pp. 615-621

Author(s):

Elisabete P. Carreiro ◽

Ana M. Sena ◽

Adrián Puerta ◽

José M. Padrón ◽

Anthony J. Burke

Keyword(s):

Breast Cancer ◽

Lung Cancer ◽

Heterocyclic Ring ◽

Small Cell ◽

Dipolar Cycloaddition ◽

Cancer Cervix ◽

Small Cell Lung ◽

Methyl Group ◽

Cancer Breast ◽

Biginelli Reactions

In this work, 21 novel (1,4-disubstituted 1,2,3-triazole)-dihydropyrimidinone (1,2,3-trzl-DHPM) type hybrids were synthesized and characterized. These were divided into two types: hybrids A (5 in total) containing the dihydropyrimidinone heterocyclic ring decorated with a 1,4-disubstituted 1,2,3-triazole in the C-5 position [these compounds were accessed by a multicomponent copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) (or click)–Biginelli reactions with satisfactory yields (39–57%)] and hybrids B (16 in total) containing two 1,2,3-triazole units in the C-5 and C-6 methyl position of the DHPM. Hybrids B were synthesized via functionalization of the C-6 methyl group of hybrids A, a multistep sequence of reactions was used that included bromination, azidation, and a CuAAC. Hybrids B were obtained in very good to excellent yields (up to 99%). Some hybrids A and B were evaluated for their antiproliferative activity against different cancer cell lines that included A549 and SW1573 (non-small-cell lung), HBL-100 and T-47D (breast), HeLa (cervix) and WiDr (colon). Three of these hybrids were potent cell proliferation inhibitors of non-small-cell lung cancer, cervix cancer, breast cancer, and colon cancer.

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Assessment of Antimicrobial Features of Selenium Nanoparticles (SeNPs) Using Cyclic Voltammetric Strategy

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2019.16627 ◽

2019 ◽

Vol 19 (11) ◽

pp. 7363-7368 ◽

Cited By ~ 3

Author(s):

Madiha Saeed ◽

M. Tayyab Ansari ◽

Imdad Kaleem ◽

Sadia Zafar Bajwa ◽

Asma Rehman ◽

...

Keyword(s):

Cyclic Voltammetry ◽

Biomedical Applications ◽

Selenium Nanoparticles ◽

Size Distributions ◽

Cyclic Voltammetric ◽

Microwave Assisted ◽

Straightforward Method ◽

Microwave Assisted Method ◽

Controllable Size ◽

Cyclic Voltammetry Data

The emerging biomedical applications of selenium nanoparticles (SeNPs) require facile and efficient strategy to assess its interactions with cell membrane. In this study, an efficient and reproducible microwave assisted method was used to synthesize SeNPs with controllable size distributions. The physical properties of the emergent structures, such as morphology, structure, and size were studied. The antimicrobial applications of SeNPs were assessed by electrochemical analyses that entailed the systematic acquisition of cyclic voltammetry data. Our results demonstrate a straightforward method to predict the integrity of bacterial cell membranes following the administration of SeNP treatments.

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Three-Component Chlorophosphinoylation of Alkenes via Anodically Coupled Electrolysis

Synlett ◽

10.1055/s-0039-1689934 ◽

2019 ◽

Vol 30 (10) ◽

pp. 1199-1203 ◽

Cited By ~ 7

Author(s):

Lingxiang Lu ◽

Niankai Fu ◽

Song Lin

Keyword(s):

Cyclic Voltammetry ◽

High Efficiency ◽

Radical Intermediates ◽

Cyclic Voltammetry Data

We report the development of an electrocatalytic protocol for the chlorophosphinoylation of simple alkenes. Driven by electricity and mediated by a Mn catalyst, the heterodifunctionalization reaction takes place with high efficiency and regioselectivity. Cyclic voltammetry data are consistent with a mechanistic scenario based on anodically coupled electrolysis in which the generation of two distinct radical intermediates occur simultaneously on the anode and are both mediated by the Mn catalyst.

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Synthesis, Characterization and Antibacterial Activity of Mixed Ligand Complexes of Pd(II) Ions with Oxalic Acid and Heterocyclic Amines

Bangladesh Pharmaceutical Journal ◽

10.3329/bpj.v17i1.22314 ◽

2015 ◽

Vol 17 (1) ◽

pp. 46-50

Author(s):

Md Belayet Hossain ◽

Md Abdus Salam ◽

Farzana Siddiquee ◽

MA Yousuf

Keyword(s):

Antibacterial Activity ◽

Oxalic Acid ◽

Metal Ion ◽

Pathogenic Bacteria ◽

Magnetic Measurements ◽

Spectroscopic Studies ◽

Mixed Ligand ◽

Heterocyclic Amines ◽

Mixed Ligand Complexes ◽

Diffusion Method

The present work has been designed for the characterization and antibacterial studies of mixed ligand complexes of Pd(II) ions with phthalic acid and heterocyclic amines. The general formula of the complexes is (MLL/) [where, M = Pd(II); L = Oxalic acid, C2O4, L/ = Quinoline, C9H7N(1); iso-Quinoline, C9H7N(2)]. The complexes were prepared in the solid form and characterized by elemental analysis, conductivity & magnetic measurements and infrared & electronic spectroscopic studies. The infrared spectra of the complexes confirmed the coordination of metal ion with ligands. Their antibacterial activity has been evaluated by the disc diffusion method against seven pathogenic bacteria (three gram positive and four gram negative). The complexes were shown to exhibit mild to moderate antibacterial activity against the tested bacteria. DOI: http://dx.doi.org/10.3329/bpj.v17i1.22314 Bangladesh Pharmaceutical Journal 17(1): 46-50, 2014

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Unusual chemistry of Cu(ii) salan complexes: synthesis, characterization and superoxide dismutase activity

New Journal of Chemistry ◽

10.1039/d0nj01892a ◽

2020 ◽

Vol 44 (27) ◽

pp. 11457-11470

Author(s):

Satabdi Roy ◽

Atanu Banerjee ◽

Sudhir Lima ◽

Adolfo Horn Jr ◽

Raquel M. S. N. Sampaio ◽

...

Keyword(s):

Superoxide Dismutase ◽

Cyclic Voltammetry ◽

Spectral Characterization ◽

Superoxide Dismutase Activity ◽

Steric Effects ◽

Ring Cleavage ◽

Cyclic Voltammetry Data

Cu(ii)-salan complexes: structural and spectral characterization, solvent assisted ring cleavage and correlation of superoxide dismutase activity with cyclic voltammetry data and steric effects.

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