scholarly journals Ameliorating effects of antioxidative compounds from four plant extracts in experimental models of diabetes

2013 ◽  
Vol 78 (3) ◽  
pp. 365-380 ◽  
Author(s):  
Svetlana Dinic ◽  
Aleksandra Uskokovic ◽  
Mirjana Mihailovic ◽  
Nevena Grdovic ◽  
Jelena Arambasic ◽  
...  
Keyword(s):  
Plant Extracts ◽  
Diabetes Management ◽  
Higher Plants ◽  
Antioxidant Activities ◽  
Castanea Sativa ◽  
Experimental Models ◽  
Antioxidant Defenses ◽  
Antioxidant Compounds ◽  
Important Place ◽  
Pancreatic Cell

Given that oxidative stress plays a major role in pancreatic ?-cell dysfunction and ultimate destruction, as well as in different complications of diabetes, therapy with antioxidants has assumed an important place in diabetes management. The relatively limited effects of established antioxidant compounds have stimulated efforts to develop new therapeutic strategies, e.g. to increase the endogenous antioxidant defenses through pharmacological modulation of key antioxidant enzymes. Plant extracts are gaining popularity in treating diabetes because many substances synthesized by higher plants and fungi possess antioxidant activities and can prevent or protect tissues against the damaging effects of free radicals. This review summarizes experimental models of diabetes and possible mechanisms that lie behind the antioxidative effects of ?-lipoic acid (LA), a powerful antioxidant and compound that stimulates cellular glucose uptake, as well as of plant extracts from sweet chestnut (Castanea sativa), edible mushroom (Lactarius deterrimus) and natural products containing ?-glucans in the treatment of diabetes. Their roles in preventing pancreatic ?-cell death and in ameliorating the effects of severe diabetic complications are discussed.

scholarly journals Antimicrobial and Antioxidant Activities of Extracts and Compounds From Trifolium Baccarinii With Their Mechanisms of Antibacterial Action

2020 ◽  
Author(s):  
Léonel Feugap ◽  
Irene Kengne ◽  
Jean-De-Dieu Tamokou ◽  
Claudia Ngnokam ◽  
Mahamat Djamalladine ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Bacterial Resistance ◽  
Antimicrobial Agents ◽  
Higher Plants ◽  
Antioxidant Activities ◽  
Antioxidant Defenses ◽  
Biochanin A ◽  
Antibacterial Action ◽  
Bacterial Cells ◽  
Whole Plant

Abstract The treatment of infectious diseases with antimicrobial agents continues to present problems in modern-day medicine with many studies showing significant increase in the incidence of bacterial resistance to several antibiotics. The screening of plant extracts and natural compounds for antimicrobial activity has demonstrated that higher plants represent a potential source of new anti-infective agents. The aim of this study was to evaluate the antimicrobial and antioxidant activities of extracts and compounds from the whole plant Trifolium baccarinii Chiov. with their mechanisms of antibacterial action. Biochanin A (1), formononetin (2), luteolin (3), luteolin-4'-O-β-D-glucopyranoside (4), 4,7,2'-trihydroxy-4'-methoxyisoflavanol (5), sissotrin (6), 1-méthyl-β-D-glucopyranoside (7), ononin (8), D-mannitol (9) and 3-O-β-D-glucuronopyranosylsoyasapogenol B (10) were isolated from T. baccarinii. The MeOH, EtOAc and n-BuOH extracts as well as compounds 1–6 from T. baccarinii displayed the most antimicrobial and antioxidant activities. The MeOH extract and compound 5 exhibited antibacterial activity through bacteriolytic effect and reduction of the antioxidant defenses in the bacterial cells. Interestingly, none of the tested samples showed cytotoxic activity against normal cells; highlighting their good selectivity toward pathogenic bacteria and yeasts. Hence, they are promising lead candidates with antibacterial potential against methicillin resistant S. aureus (MRSA).

scholarly journals Antimicrobial and insecticidal effects of essential oil and plant extracts of Myrcia oblongata DC in pathogenic bacteria and Alphitobius diaperinus

2022 ◽  
Vol 82 ◽  
Author(s):  
C. B. Santana ◽  
J. G. L. Souza ◽  
A. G. Toledo ◽  
L. F. A. Alves ◽  
D. S. Alves ◽  
...  
Keyword(s):  
Plant Extracts ◽  
Pathogenic Bacteria ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Adult Mortality ◽  
Chemical Diversity ◽  
Antioxidant Compounds ◽  
Alphitobius Diaperinus ◽  
Insecticidal Effect ◽  
Acetone Extracts

Abstract The secondary metabolism products of plants have influenced great economic interest, given their chemical diversity and biological activities. Because of this, this study evaluates the phytochemical composition, antimicrobial activity, insecticidal, and antioxidant activity of plant extracts and oil of Myrcia oblongata. Saponins, steroids, triterpenoids, tannins, and flavonoids were detected. The extracts showed antimicrobial capacity on the tested microorganisms, except for the methanolic extract, which showed no activity for P. mirabilis and S. enteritidis. Regarding the analysis of antioxidant compounds, the hexanic, ethyl acetate and acetone extracts showed higher antioxidant activities and also higher insecticidal performance on Alphitobius diaperinus larvae, resulting in 80% adult mortality. The results reported here show that there may be a relationship between antioxidant potential and the insecticidal effect of Myrcia oblongata DC. The components present in both the extract and the oil can be used as natural alternative to synthetic compounds in the biological control of parasites and pathogenic microorganisms.

scholarly journals Phytochemical Screening and Antioxidant Activities of Different Organic Extracts of Three Algerian Plants

2020 ◽  
Vol 10 (2-s) ◽  
pp. 75-79
Author(s):  
Maria Rezzoug ◽  
Boulanouar Bakchiche ◽  
Abdelaziz Gherib ◽  
Ouahid Elasri
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Ethanolic Extract ◽  
Ocimum Basilicum ◽  
Antioxidant Compounds ◽  
Mentha Spicata ◽  
Important Place ◽  
Important Species ◽  
Thymus Algeriensis ◽  
Phytochemical Constituents

We compared the phytochemical constituents and antioxidant activities of three important species of Lamiaceae in Algeria (Mentha spicata, Ocimum basilicum and Thymus algeriensis). We noticed that the M. spicata species contains the largest fraction of phenolic and flavonoid products (231 and 22 mg / g) than the other two species studied. Other hand we founded that the two species M. spicata and T. algeriensis show excellent antioxidant activity in the ethanolic extract according to the two tests (DPPH and ABTS) compared to the ascorbic acid of reference. But the specie O. basilicum has good antioxidant activity in aqueous extraction. This Lamiaceae family takes an important place in the lives of Algerians citizens, so this species are very good source of natural antioxidant compounds in algerian traditional medicine. Keywords: Antioxidant activity, Lamiaceae, Mentha spicata, Ocimum basilicum and Thymus algeriensis, DPPH.

Antioxidant Activities and Antioxidant Compounds of Some Specialty Rices

2008 ◽  
Vol 37 (2) ◽  
pp. 129-135 ◽  
Author(s):  
Sun-Jung Seo ◽  
Young-Min Choi ◽  
Seon-Mi Lee ◽  
Su-Hyun Kong ◽  
Jun-Soo Lee
Keyword(s):  
Antioxidant Activities ◽  
Antioxidant Compounds

Antioxidant Compounds and Antioxidant Activities of Ethanol Extracts from Milling By-products of Rice Cultivars

2010 ◽  
Vol 39 (4) ◽  
pp. 624-630 ◽  
Author(s):  
Sea-Kwan Oh ◽  
Dae-Jung Kim ◽  
A-Reum Chun ◽  
Mi-Ra Yoon ◽  
Kee-Jong Kim ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Antioxidant Compounds ◽  
Rice Cultivars ◽  
Ethanol Extracts ◽  
By Products

Effects of Cultivated Area on Antioxidant Compounds and Antioxidant Activities of Sorghum (Sorghum bicolor L. Moench)

2011 ◽  
Vol 40 (11) ◽  
pp. 1512-1517 ◽  
Author(s):  
Koan-Sik Woo ◽  
Jae-Saeng Lee ◽  
Jong-Rae Kang ◽  
Jee-Yeon Ko ◽  
Seuk-Bo Song ◽  
...  
Keyword(s):  
Sorghum Bicolor ◽  
Antioxidant Activities ◽  
Antioxidant Compounds ◽  
Sorghum Bicolor L

Study of antioxidant potential in leaves, stems, nuts of Juglans regia L.

2012 ◽  
Vol 1 (10) ◽  
pp. 79 ◽  
Author(s):  
G. Raja* ◽  
Ivvala Anand Shaker ◽  
Inampudi Sailaja ◽  
R. Swaminathan ◽  
S. Saleem Basha ◽  
...  
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Juglans Regia ◽  
Radical Scavenging ◽  
Antioxidant Compounds ◽  
Free Radical Damage ◽  
Radical Damage

Natural antioxidants can protect the human body from free radicals and retard the progress of many chronic diseases as well as lipid oxidative rancidity in foods. The role of antioxidants has protected effect against free radical damage that may cause many diseases including cancer. Primary sources of naturally occurring antioxidants are known as whole grains, fruits, and vegetables. Several studies suggest that regular consumption of nuts, mostly walnuts, may have beneficial effects against oxidative stress mediated diseases such as cardiovascular disease and cancer. The role of antioxidants has attracted much interest with respect to their protective effect against free radical damage that may cause many diseases including cancer. Juglans regia L. (walnut) contains antioxidant compounds, which are thought to contribute to their biological properties. Polyphenols, flavonoids and flavonols concentrations and antioxidant activity of Leaves, Stems and Nuts extract of Juglans regia L. as evaluated using DPPH, ABTS, Nitric acid, hydroxyl and superoxide radical scavenging activity, lipid peroxidation and total oxidation activity were determined. The antioxidant activities of Leaves, Stems and Nuts extract of Juglans regia L. were concentration dependent in different experimental models and it was observed that free radicals were scavenged by the test compounds in all the models.

scholarly journals Determination of Chemical Constituents and Antioxidant Activities of Leaves and Stems from Jatropha cinerea (Ortega) Müll. Arg and Jatropha cordata (Ortega) Müll. Arg

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 212
Author(s):  
Yeimi Cecilia Vega-Ruiz ◽  
Corina Hayano-Kanashiro ◽  
Nohemí Gámez-Meza ◽  
Luis Angel Medina-Juárez
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Biological Effects ◽  
Chemical Constituents ◽  
Weather Conditions ◽  
Antioxidant Compounds ◽  
Leaf Extracts ◽  
Methanolic Extracts ◽  
Northwestern Region ◽  
High Concentrations

Jatropha species have been shown to be an important source of secondary metabolites with different biological effects. Jatropha cinerea (Ortega) Müll. Arg and Jatropha cordata (Ortega) Müll. Arg are distributed in the Northwestern region of Mexico, are adapted to extreme weather conditions and are widely used (stems, leaves, and sap) in traditional medicine. The aim of the present study was to carry out the phytochemical characterization and the evaluation of the antioxidant activity in methanolic extracts of stems and leaves from J. cinerea and J. cordata. The compounds present in the extracts of both species were characterized by ESI-IT-MS/MS and quantified by HPLC-DAD. The results showed that the stem extracts of both species are rich in phenolic acids, while the leaf extracts are rich in flavonoids. Some of the main compounds found were gallic acid, gentisic acid, 3,4-Dihydroxybenzoic acid, vitexin, isovitexin, and catechol. Both species showed high concentrations of phenols and total flavonoids and antioxidant activity. J. cordata showed the highest antioxidant capacity and the highest concentration of phenolic compounds. Overall, both Jatropha species are a natural source of antioxidant compounds with potential biotechnological uses.

Hydrothermal treatment of chestnut shells (Castanea sativa) to produce oligosaccharides and antioxidant compounds

2018 ◽  
Vol 192 ◽  
pp. 75-83 ◽  
Author(s):  
Beatriz Gullón ◽  
Gemma Eibes ◽  
Izaskun Dávila ◽  
María Teresa Moreira ◽  
Jalel Labidi ◽  
...  
Keyword(s):  
Hydrothermal Treatment ◽  
Castanea Sativa ◽  
Antioxidant Compounds

scholarly journals Antioxidant Compounds, Mineral Content and Antioxidant Activity of Several Tomato Cultivars Grown in Southwestern Romania

2013 ◽  
Vol 41 (1) ◽  
pp. 136 ◽  
Author(s):  
Violeta NOUR ◽  
Ion TRANDAFIR ◽  
Mira E. IONICA
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Trace Elements ◽  
Phenolic Compounds ◽  
Total Phenolics ◽  
Antioxidant Activities ◽  
Fruit Shape ◽  
Total Phenolic ◽  
Antioxidant Compounds ◽  
Tomato Cultivars

Ten indeterminate tomato cultivars differing in fruit shape and typology, grown simultaneously in a greenhouse from Oltenia (Southwestern Romania) and harvested at red ripe stage, were investigated for the contents in ascorbic acid, lycopene, β-carotene, total phenolics, minerals (K, Na, Ca and Mg) and trace elements (Fe, Cu, Mn, Cr, Zn and B). In addition, their antioxidant activities were determined. Significant differences were found among tomato cultivars in all studied antioxidant compounds, as well as in the antioxidant activity. Ascorbic acid ranged from 91.9 to 329.7 mg kg-1 fw, lycopene ranged from 19.7 to 49.0 mg kg-1 fw, while total phenolic compounds varied between 300.2 and 557.8 mg kg-1 fw. Antioxidant activity ranged from 0.81 mmol Trolox kg-1 fw to 1.74 mmol Trolox kg-1 fw and it was significantly correlated to total phenolics content (r = 0.91; p< 0.05). The cocktail type cultivar ‘Tiger’ and the cherry type cultivar ‘Belle’ proved to be the most powerful in antioxidant activity and phenolic compounds while the rectangular plum shaped cultivar ‘Porto’ recorded the highest average lycopene content. A valuable cultivar proved to be the brownish red ‘Sacher’ which registered among the highest contents of phenolics, lycopene and ascorbic acid. Mineral and trace elements contents were also significantly affected by cultivars. Values recorded for K, Ca and Mg ranged from 2139.6 to 3056.9 mg kg-1, 137.7 to 325.8 mg kg-1 and 27.3 to 168.7 mg kg-1 respectively.

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