scholarly journals Inflammatory myofibroblastic tumours of the respiratory tract: A series of three cases with varying clinical presentations and treatment

2015 ◽  
Vol 143 (7-8) ◽  
pp. 458-463
Author(s):  
Dragana Tegeltija ◽  
Aleksandra Lovrenski ◽  
Goran Stojanovic ◽  
Milorad Bijelovic ◽  
Ivana Jelicic ◽  
...  
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Plasma Cells ◽  
Lower Lobe ◽  
Inflammatory Cells ◽  
Complete Removal ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Clinical Presentations ◽  
Choice Of Treatment ◽  
The Right

Introduction. Inflammatory myofibroblastic tumor in the respiratory system is a rare and controversial disease. It is macroscopically well-circumscribed, non-encapsulated, firm and usually a yellowish-white mass. Histologically it is composed of the following spindled and inflammatory cells: lymphocytes, plasma cells, and histiocytes, including Touton type multinucleated giant cells. Case Outline. The series included a 49-year-old man with a tracheal inflammatory myofibroblastic tumor who complained of hoarseness; a 42-year-old man who was coughing and had a blood-stained sputum, and inflammatory myofibroblastic tumor was in the right main and intermediate bronchus; and a 32-yearold man with chest pain and inflammatory myofibroblastic tumor as a solitary peripheral nodule in the left lower lobe. In all the cases, the tumor was resected bronchoscopically and surgically. Conclusion. Inflammatory myofibroblastic tumor of the lung and the trachea is rare. Complete resection, when possible, should be the choice of treatment. After the complete removal, prognosis is generally excellent and recurrences are rare.

Abstract 288: Distribution of Pathological Features and Inflammatory Cells in Patients With Giant Cell Myocarditis

2020 ◽  
Vol 127 (Suppl_1) ◽  
Author(s):  
LIU SHANGYU ◽  
Yao Yan
Keyword(s):  
T Cells ◽  
Immune Cells ◽  
Giant Cells ◽  
Ventricular Septum ◽  
Free Wall ◽  
Pathological Features ◽  
Multinucleated Giant Cells ◽  
Giant Cell Myocarditis ◽  
Cardiac Lesions ◽  
The Right

Background: Giant-cell myocarditis (GCM) is a rare disease with a poor prognosis. The typical pathological features of GCM include an infiltration of multinucleated giant cells accompanied by numerous inflammatory immune cells. However, the etiology and pathophysiology of GCM remain largely unclear. Methods: Eight patients with pathological diagnoses with GCM underwent heart transplantation at our center. Hematoxylin- eosin (H-E) and Masson’s tri-chrome staining were performed on biopsies of the free walls of the right and left ventricles and interventricular septa of the original hearts to determine the characteristic distribution of cardiac lesions and the composition of infiltrating immune cells. A multiplex immunohistochemistry and multispectral imaging analysis were applied to further classify the specific types of inflammatory immune cells. Results: Inflammation found in a descending frequency gradually from the epicardium to the endocardium in the free wall of the left ventricle, but concentrated on the surface of right ventricular septum. Typical inflammatory infiltration and pathological changes were observed in the right-sided ventricular septum samples from all 8 patients. Numerous inflammatory immune cells, particularly CD4 + T cells, were detected in the lesion, which surrounded the emerging multinucleated giant cells. CD8 + T cells and a small number of regulatory T cells were scattered in the periphery. Conclusions: In GCM, cardiac lesions appear to concentrate particularly beneath the epicardium of the left ventricular free wall and the right side of the ventricular septum. These findings provide a rationale for the diagnostic use of conventional endocardial biopsy. The findings further suggest that myocardial injury is mediated by a variety of lymphocytes, especially CD4 + T cells.

Hepatic Lesions in Rabbits Infected with Encephalitozoon cuniculi Administered per Rectum

1992 ◽  
Vol 29 (6) ◽  
pp. 536-540 ◽  
Author(s):  
I. C. Fuentealba ◽  
N. T. Mahoney ◽  
J. A. Shadduck ◽  
J. Harvill ◽  
V. Wicher ◽  
...  
Keyword(s):  
New York ◽  
Plasma Cells ◽  
Inflammatory Cells ◽  
Giant Cells ◽  
Encephalitozoon Cuniculi ◽  
Acquired Immunodeficiency ◽  
Portal Veins ◽  
Hepatic Lesions ◽  
Hepatic Portal ◽  
Immunodeficiency Syndrome

Microsporidia have been recognized recently as opportunistic pathogens in acquired immunodeficiency syndrome patients. In an attempt to develop an animal model of enteric microsporidiosis, adult (5 to 6 months old) male Flemish Giant rabbits from a closed New York colony were administered 5 × 103, 5 × 105, and 5 × 107 Encephalitozoon cuniculi per rectum. Rabbits given 5 × 105 and 5 × 107 E. cuniculi had moderate granulomatous periportal infiltrates, characterized by the presence of numerous macrophages, epithelioid cells, and a few multinucleated giant cells, lymphocytes, and plasma cells. Inflammatory cells also were seen infiltrating the tunica adventitia and tunica media of hepatic portal veins and branches of the hepatic artery. This study demonstrates that administration of E. cuniculi per rectum to rabbits results in infection that is characterized by high frequency and severity of hepatic lesions.

Osseoinduction Evaluation of Hydroxyapatite and Zinc Containing Hydroxyapatite Granules in Rabbits

2011 ◽  
Vol 493-494 ◽  
pp. 252-257 ◽  
Author(s):  
L. Nascimento ◽  
M. Medeiros ◽  
J. Calasans-Maia ◽  
A. Alves ◽  
Antonella M. Rossi ◽  
...  
Keyword(s):  
Histological Analysis ◽  
Bone Matrix ◽  
Fibrous Tissue ◽  
Particle Diameter ◽  
Inflammatory Cells ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Ethics Commission

This study investigated the osteoinductive potential of granules of stoichiometric hydroxyapatite (HA) and 0.5% zinc containing hydroxyapatite (ZnHA) in intramuscular (IM) site of rabbit’s abdomen. The biomaterials were both used in granular form, with 75% porosity and particle diameter between 450 and 500μm, sintered at 1100°C. Both materials performed adequately on a multiparametric in vitro cytocompatibility assay, indicating their suitability for in vivo testing. After approval by the Ethics Commission on Teaching and Research in Animals, fifteen rabbits were submitted to general anesthesia, incision and tissue dilatation, and a small site was created for HA (right incision) and ZnHA (left incision) intramuscular implantation. The animals were killed after 2, 4 and 12 weeks for biomaterials and surrounding tissues removal. Histological analysis after 2 weeks revealed the presence of granulation tissue surrounding biomaterials with multinucleated giant cells and no newly formed bone for both materials. After 4 weeks there was fibrous tissue involving the material and few inflammatory cells. Following 12 weeks it was observed the presence of connective tissue surrounding the biomaterial, cellularized enough for the two experimental groups, but it was not observed the presence of bone matrix associated with the biomaterials. We conclude that both biomaterials are cytocompatible and did not present the property of osseoinduction after 12 weeks of implantation.

Calcium oxalate granuloma of the nose of a chronically dialysed nephritic patient

2001 ◽  
Vol 115 (6) ◽  
pp. 514-516 ◽  
Author(s):  
Andrej Böör ◽  
Ivan Jurkovič ◽  
Imrich Friedmann ◽  
Marian Benický ◽  
Pavol Kočan
Keyword(s):  
Calcium Oxalate ◽  
Nasal Cavity ◽  
Interstitial Nephritis ◽  
Granulation Tissue ◽  
Plasma Cells ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Polypoid Mass ◽  
Left Nasal Cavity ◽  
Crystalline Deposits

The patient was a 54-year-old woman who had been suffering from chronic tubulo-interstitial nephritis for about seven years, requiring haemodialysis. More recently, she developed a polypoid mass in the left nasal cavity causing discomfort on breathing and slight epistaxis. The tumour was of gritty consistency and measured 28 × 8 × 5 mm. Microscopy showed a lobulated almost cystic structure composed of granulation tissue with comparatively few plasma cells and many multinucleated giant cells lining the spaces filled with crystalline deposits of calcium oxalate.

scholarly journals Inflammatory Pseudotumor/Inflammatory Myofibroblastic Tumor of Spleen – A Case Report

2020 ◽  
Vol 8 (C) ◽  
pp. 66-70
Author(s):  
Rubens Jovanovic ◽  
Aleksandar Eftimov ◽  
Svetozar Antovic ◽  
Ognen Kostovski ◽  
Bojan Labachevski ◽  
...  
Keyword(s):  
Case Report ◽  
Microscopic Examination ◽  
Inflammatory Myofibroblastic Tumor ◽  
Inflammatory Pseudotumor ◽  
Plasma Cells ◽  
Unknown Origin ◽  
Inflammatory Cells ◽  
Genetic Changes ◽  
Secondary Neoplasm ◽  
Primary Neoplasm

BACKGROUND: Splenic inflammatory pseudotumor (IPT)/inflammatory myofibroblastic tumor (IMT) is a rare pseudotumor/tumor of unknown origin, which is usually benign, although atypical and aggressive cases have been reported. It is a lesion composed of proliferated myofibroblastic cells (hence IMT by some authors) with admixed pleomorphic inflammatory cells of varying proportions. CASE REPORT: Herein, we report a case of 61-year-old male patient with ill-defined abdominal discomfort and no other symptoms and signs. Clinical and imaging investigations revealed a mass in the spleen that was equivocally interpreted as secondary neoplasm, although primary neoplasm of the spleen was not excluded by the radiologists. Splenectomy was performed and on gross examination a well demarcated greyish-livid tumor measuring 3.5 cm × 3 cm × 3 cm was discovered. Microscopic examination showed proliferation of loosely arranged spindle cells admixed with inflammatory cells (histiocytes, lymphocytes, neutrophils, eosinophils, occasional plasma cells, and/or plasmacytoid cells) with varying density and multifocal clustering, multifocal hemorrhage, and fibrinoid-like deposition. We performed additional histochemical and immunohistochemical stainings which were consistent with the diagnosis of IPT/IMT. Next-generation sequencing (TruSight Tumor 15) showed common TP53 polymorphism (c.215C>G; p.Pro72Arg) along with several intronic and synonymous single nucleotide variations (SNVs), as well as five low confidence missense SNVs. Sixteen months after the operation the patient has uneventful follow-up. CONCLUSION: Although the incidence of IPT/IMT is low, awareness of its existence is necessary. The prognosis is favorable following splenectomy in most cases. Careful microscopic examination of the specimen is mandatory, due to possible misdiagnosis. We believe that extensive NGS analysis on archive samples would provide more data about the spectrum of possible genetic changes in lesions like IPM/IMT.

scholarly journals Inflammatory Cells in Tissues of Gout Patients and Their Correlations with Comorbidities

2013 ◽  
Vol 7 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Syeling Lai ◽  
Xiaodong Zhou
Keyword(s):  
Diabetes Mellitus ◽  
T Cells ◽  
Uric Acid ◽  
B Cells ◽  
Uric Acid Level ◽  
Acid Level ◽  
Plasma Cells ◽  
Pathological Finding ◽  
Inflammatory Cells ◽  
Giant Cells

Background: The major pathological finding of gout is the deposition of monosodium urate monohydrate (MSU) crystals with inflammatory infiltrate in the tissue. There have been many reports of in vitro analysis of inflammatory mechanism and comorbidities in gout. However, the associations of immune response cells and comorbidities of gout have not been well documented. Our studies aimed to examine the immune cell types and quantity in gout tissues, and to define the association of individual cell type with comorbidities. Methods: Surgically resected or biopsied tissues from 48 patients diagnosed as gout were used for this study. Cell count was performed on Hemotoxylin and Eosin stained sections for macrophages, plasma cells, neutrophils and on immunostained slides for T and B lymphocytes. Results: Hyperlipidemia, hypertension and diabetes mellitus were seen in 70.8%, 87.5% and 37.5% of patients, respectively. There were 35.6% and 37.8% of patients who admitted history of smoking and alcohol intake, respectively. Mean serum uric acid level was 8.5 mg/dl. The average body mass index was 30.1 kg/m2. H&E stained tissue sections demonstrated the crystalline deposits rimmed by palisading multinucleated giant cells, macrophages, neutrophils, plasma cells, T and B cells. Significant correlations between the clinical features and tissue inflammatory cells were observed in hyperlipidemia with number of T cells (p = 0.0363), hypertension with number of T cells and B cells (p = 0.0138 and 0.0033, respectively), diabetes mellitus with macrophages (p = 0.0016), and uric acid level with giant cells (p = 0.0088). Conclusion: Comorbidity factors including hyperlipidemia, hypertension and diabetes are significantly associated with the inflammatory cells in the tissues.

scholarly journals Intralobar pulmonary sequestrations in adults

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Lower Lobe ◽  
Pulmonary Sequestration ◽  
Military Hospital ◽  
Lateral Side ◽  
Intralobar Sequestration ◽  
Arterial Blood ◽  
Systemic Artery ◽  
Clinical Presentations ◽  
Chest X Ray ◽  
The Right

Intralobar sequestration accounts for 75% of pulmonary sequestrations. It is characterized by the presence of nonfunctional parenchymal lung tissue, receiving systemic arterial blood supply. We conducted a retrospective medical records review of all patients evaluated and treated in our pulmonary department of military hospital of Tunisia with diagnosis of PS from January 2007 through December 2015. Among them, we report 5 cases of intralobar pulmonary sequestrations operated. There are three women and two men; the mean age is 27.6 years. The sequestration was intralobar in all cases. Clinical presentations were chest pain and productive cough in three cases. Chest X-ray showed left basal opacity in three cases, bilateral basal reticulonodular opacities in one case and round hydric opacity in the right lower lobe in one other case. Computed tomography was performed and revealed an aberrant systemic artery born from the lateral side of aorta supplying a left lower lobe sequestration in four cases and a right lower lobe mass in only one case. The confirmation was operative in all cases and histologic only in three cases. All patients were treated by lobectomy. Only one case presented with a pulmonary sequestration combined with tuberculosis and he was treated firstly by antituberculous chemotherapy. The results were excellent with a favorable clinical course and the mortality was nil.

Location and structure of fibrous sheath formed after placing a tunneled hemodialysis catheter in a large pig model

2018 ◽  
Vol 19 (5) ◽  
pp. 484-491 ◽  
Author(s):  
Marius C Florescu ◽  
Joseph Runge ◽  
Maurino Flora ◽  
George Nio ◽  
John Lof ◽  
...  
Keyword(s):  
Plasma Cells ◽  
Superior Vena ◽  
Vena Cava ◽  
Giant Cells ◽  
External Jugular Vein ◽  
Entire Length ◽  
Entry Site ◽  
Fibrous Sheath ◽  
Hemodialysis Catheter ◽  
The Right

Background and objectives: We evaluated the location and structure of the fibrous sheath formed after the placement of tunneled, cuffed hemodialysis catheters in large animals, 70 kg pigs. We focused on describing the location of the fibrous sheath in relation to the catheter. Its location explains the fibrous sheath’s ability to cause catheter dysfunction by covering the catheter exit ports located at the catheter’s tip. Design: We used three animals. Each animal had a tunneled, cuffed, 15-French diameter hemodialysis catheter placed in the external jugular vein, with the tip at the junction of the superior vena cava and the right atrium. Two animals were sacrificed at 5 weeks and one animal at 17 weeks after catheter placement. The catheter and surrounding tissues were removed in one block. The fibrous sheath was dissected and longitudinally cut along the catheter to evaluate its extension in relation to the catheter. Relevant portions of the fibrous sheath were sent for pathology examination. Results: The fibrous sheath covered the catheter in its entire length and circumference. It started at the entry site and continued without any interruption along the entire length of the catheter, including the tip. Its average thickness is 1 mm and has an inner cellular/inflammatory layer comprising lymphocytes, plasma cells, neutrophils, macrophages, multinucleated giant cells, and spindled cells and an outer layer comprising a mixture of collagen and fibroblasts. Conclusion: Our model showed that the fibrous sheath forms around all catheters and covers them in their entire length and circumference without any gaps.

Lipodystrophia Centrifugalis Abdominalis Infantilis

2016 ◽  
Vol 20 (4) ◽  
pp. 349-351
Author(s):  
Daniel Paluzzi ◽  
Tess Peters ◽  
Richard M. Haber
Keyword(s):  
Plasma Cells ◽  
Age Of Onset ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Fat Necrosis ◽  
Lower Abdomen ◽  
Ipsilateral Side ◽  
First Case ◽  
Dermatological Condition ◽  
Inguinal Lymphadenopathy

Background: Lipodystrophia centrifugalis abdominalis infantilis (LCAI) is an uncommon dermatological condition characterized by a centrifugally expanding area of lipoatrophy involving the lower abdominal area and is frequently associated with inguinal lymphadenopathy. The average age of onset is 4 years and female individuals from Japan, China, and Korea are affected more often. Objectives: To report the first case of LCAI in a Vietnamese patient. Methods: A complete clinical assessment was done and a biopsy from the affected area was performed. Results: There was an atrophic, slightly hyperpigmented patch at the lower abdomen with prominent underlying vasculature. Inguinal lymphadenopathy was noted on the ipsilateral side. A biopsy showed a lobular panniculitis with fat necrosis and lymphohistiocytic infiltrate with scattered plasma cells and multinucleated giant cells. Conclusion: To our knowledge, this is the first reported case of LCAI in a Vietnamese patient.

scholarly journals Histopathological Features of Cutaneous Tuberculoid Granuloma Disorders

2021 ◽  
Vol 5 (3) ◽  
pp. 797-808
Author(s):  
Odelia Jovita Jusuf Fantoni ◽  
Inda Astri Aryani ◽  
Yuli Kurniawati ◽  
Raden Pamudji
Keyword(s):  
Foreign Bodies ◽  
Plasma Cells ◽  
Clinical Manifestations ◽  
Giant Cells ◽  
Cutaneous Tuberculosis ◽  
Histopathological Features ◽  
Caseous Necrosis ◽  
Appropriate Treatment ◽  
Inflammatory Pattern ◽  
The Right

Tuberculoid granulomas consist of epithelioid histiocytes, Langhans giant cells and rarely foreign bodies with lymphocytes, plasma cells and caseous necrosis. The granulomatous reaction pattern is defined as a typical inflammatory pattern that is characterized by granulomas. Various etiologies can lead to granulomatous reactions. The histopathological features of cutaneous disorders with tuberculoid granuloma include cutaneous tuberculosis, tuberculids, Morbus Hansen, syphilis and rosacea. There are various clinical manifestations of tuberculoid granuloma with similar appearances which makes it difficult to establish a definitive diagnosis. The histopathological features of cutaneous tuberculoid granuloma disorders can support the diagnosis. Therefore, the clinician can determine the appropriate treatment with the right diagnosis.

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