scholarly journals Antioxidant and cytotoxic activities of curly dock (Rumex crispus L., Polygonaceae) fruit extract

2020 ◽  
Vol 77 (3) ◽  
pp. 308-316
Author(s):  
Tatjana Cebovic ◽  
Dunja Jakovljevic ◽  
Zoran Maksimovic ◽  
Snezana Djordjevic ◽  
Sanja Jakovljevic ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pregnant Women ◽  
Congenital Anomalies ◽  
Diagnostic Methods ◽  
Cytotoxic Activities ◽  
Fetal Anomalies ◽  
Organ Systems ◽  
Increased Risk ◽  
Fetal Malformations

Background/Aim. Congenital malformations still represent one of the most important causes of prenatal and infant death. The study aim was to analyze occurrence, outcomes and risk factors of different types of congenital anomalies. Methods. The study included all pregnant women directed to Clinic of Obstetrics and Gynecology, Clinical Center of Serbia, Belgrade due to prenatally diagnosed congenital fetal anomalies during past ten years (January 1, 2008?December 31, 2017). Upon admission to our Clinic a detailed general medical and obstetrical history were taken from every patient. All women underwent genetic testing. Ultrasonography and magnetic resonance were diagnostic methods for fetal malformations confirmation. Results. The study included 773 pregnant women aged from 18 to 46 years. Out of registered nine different groups of fetal anomalies/malformations, the most common were malformations of the central nervous system, while majority of fetuses had combined multiple anomalies. Genetic cause for congenital anomalies was present in 25.2% of pregnancies. Medical pregnancy abortion was performed in 71.8% of cases. Only 10.2% of pregnancies ended in term. The best outcome for children was obtained in case of gastrointestinal anomalies (52% live born). Contrary, only one child with neck and thorax malformations could be saved. According to logistic regression the most important predictor of having a child with combined multiple anomalies was mother?s age, while predictor of central nervous system anomalies was gestational diabetes. The significant predictor of genetic anomalies was mother?s age. Conclusion. In our sample neurological congenital anomalies were the most common, although abnormalities of all organ systems were registered. Majority of pregnancies had to be discontinued due to combined multiple anomalies caused by genetic disorders. Older mother?s age and diabetes can imply on the increased risk for fetal malformations.

scholarly journals Congenital anomalies: Occurrence and potential risk factors

2020 ◽  
Vol 77 (3) ◽  
pp. 317-323
Author(s):  
Ivan Pavlovic ◽  
Darko Plecas ◽  
Snezana Plesinac ◽  
Jelena Dotlic ◽  
Nemanja Stojanovic
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pregnant Women ◽  
Congenital Anomalies ◽  
Diagnostic Methods ◽  
Fetal Anomalies ◽  
Tertiary Referral Center ◽  
Organ Systems ◽  
Increased Risk ◽  
Fetal Malformations

Background/Aim: Congenital malformations still represent one of the most important causes of prenatal and infant death. The study goal was to analyze occurrence and outcomes of different types of congenital anomalies from the tertiary referral center during a ten-year period. Moreover, study aimed at examining potential predictors of congenital anomalies based on patients? characteristics and medical history data. Methods: Study included all pregnant women directed to Clinic of Obstetrics and Gynecology Clinical Center of Serbia due to prenatally diagnosed congenital fetal anomalies during past ten years. Upon admission to our clinic a detailed general medical and obstetrical history were taken from every patient. All women underwent genetic testing. Ultrasonography and magnetic resonance were diagnostic methods for fetal malformations confirmation. Results: Study included 773 pregnant women aged from 18 to 46 years. Out of registered nine different groups of fetal anomalies/malformations, the most common were malformations of the central nervous system, while majority of fetuses had combined multiple anomalies. Genetic cause for congenital anomalies was present in 25.2% of pregnancies. Medical pregnancy abortion was performed in 71.8% of cases. Only 10.2% of pregnancies ended in term. The best outcome for children was obtained in case of gastrointestinal anomalies (52% live-born). Contrary only one child with neck and thorax malformations could be saved. According to logistic regression the most important predictor of having a child with combined multiple anomalies was mother?s age, while predictor of central nervous system anomalies was gestational diabetes. The significant predictor of genetic anomalies was mother?s age. Conclusion: In our sample neurological congenital anomalies were the most common, although abnormalities of all organ systems were registered. Majority of pregnancies had to be discontinued due to combined multiple anomalies caused by genetic disorders. Older mother?s age and diabetes can imply on the increased risk for fetal malformations.

scholarly journals Prevalence of Congenital Anomalies in Polyhydramnios: A hospital based study from Western Nepal

2018 ◽  
Vol 8 (1) ◽  
pp. 25-29
Author(s):  
Subita Lalchan ◽  
Prakash Sharma ◽  
Sangeeta Devi Gurung
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Gestational Age ◽  
Congenital Anomalies ◽  
Excessive Amount ◽  
Amniotic Fluid Index ◽  
Skeletal Anomalies ◽  
Increased Risk

Introduction: Polyhydramnios is excessive amount of amniotic fluid in relation to gestational age. It is frequently associated with congenital anomalies of the fetus. The aim of this study was to see the prevalence of congenital anomalies in polyhydramnios.Methods: Singleton pregnant irrespective of gestational age with amniotic fluid index more than 25 were included in the study. Degree of polyhydramnios was graded as mild, moderate and severe. Detail study of fetus was done for possible congenital anomalies. Congenital anomalies were confirmed with post-natal findings.Results: There were 39 pregnant women with amniotic fluid index (AFI) > 25 cm. Prevalence of polyhydramnios was 0.3%. Congenital anomalies were present in 31.6 % of pregnant women with polyhydramnios. In pregnant women with severe polyhydramnios; 66.6 % had congenital anomalies. Central nervous system, gastrointestinal and skeletal anomalies were the frequent anomalies associated with polyhydramnios.Conclusion: Polyhydramnios is associated with increased risk of congenital anomalies hence a detail survey of fetus should be done for possible congenital anomalies.

scholarly journals Central Nervous System Birth Defects in Surgically Treated Infants in Sarajevo Region of Bosnia and Herzegovina

2007 ◽  
Vol 7 (4) ◽  
pp. 294-300 ◽  
Author(s):  
Selma Aličelebić ◽  
Alma Arslanagić ◽  
Zakira Mornjaković
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Spina Bifida ◽  
Bosnia And Herzegovina ◽  
Birth Defects ◽  
Arachnoid Cyst ◽  
Congenital Anomalies ◽  
Organ Systems ◽  
Pes Equinovarus ◽  
Clinical Records

Congenital anomalies of the central nervous system (CNS) are common. The prevalence of these anomalies shows considerable geographical variation and female predominance. The aim of this work was to obtain the frequency of different CNS congenital anomalies types and their sex distribution among cases hospitalized in a Department of Neurosurgery, University of Sarajevo Clinics Center, Bosnia and Herzegovina, during the period January 2001 to December 2004. Retrospective study was carried out on the basis of the clinical records. Standard methods of descriptive statistics were performed for the data analysis. A total of 103 cases were surgically treated in the period from 2001 through 2004. Out of that number 56 (54,4%) were female patients, while 47 (46,6%) were male patients. Seven different CNS birth defect types were found in this investigation. These were: spina bifida (42 cases or 40,78%), congenital hydrocephalus (35 cases or 33,98%), arachnoid cyst (15 cases or 14,56%), Dandy-Walker syndrome (5 cases or 4,85%), dermoid cyst (4 cases or 3,88%), one of Arnold-Chiari syndrome (0,98%) and one of encefalocele (0,98%). According to this investigation, CNS congenital birth defects were slightly higher in females (54,4%). The most frequent types were spina bifida (40,78%) both in females (22,33%) and in males (18,45%), hydrocephalus (33,98%) and arachnoid cyst (14,56%). The anomalies of the other organ systems, associated with CNS anomalies obtained in this investigation, were pes equinovarus, cheiloshisis, cardiomegalia and palatoshisis. They were found in six cases (5,82%), equal in both sexes.

scholarly journals Congenital anomalies of the central nervous system: prevalence in a fetal medicine service in the Brazilian Midwest

2021 ◽  
Author(s):  
Carolina Leão de Moraes ◽  
Fernanda Sardinha de Abreu Tacon ◽  
Andréa de Faria Rezende Matos ◽  
Natália Cruz e Melo ◽  
Michelle Hermínia Mesquita de Castro ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Prenatal Care ◽  
Pregnant Women ◽  
Congenital Anomalies ◽  
Fetal Medicine ◽  
Medicine Service ◽  
The Central Nervous System ◽  
Prospective Longitudinal ◽  
Cns Anomalies

Introduction: Approximately 21% of congenital anomalies (CA) involve the Central Nervous System (CNS), constituting one of the most common birth defects, affecting 1 to 10: 1,000 of live births. Objective: To analyze the prevalence of CNS anomalies diagnosed by obstetric ultrasound. Methods: Prospective longitudinal cohort study carried out in a public fetal medicine service in Goiânia with pregnant women who were attended in high-risk prenatal care. The patients were followed up during the ultrasound exams from March 2018 to March 2019. Results: 225 cases of pregnant women with ultrasound diagnoses of CA were surveyed during the investigated period. CNS anomalies were the most prevalent, being present in 34.22% (77/225) of the cases. The mean maternal age of pregnant women was 25.55 years and mean gestational age was 28.84 weeks. Hydrocephalus was identified in 23 pregnant women (29.87%), being the most prevalent CNS anomalie. Anencephaly was present in 24.68% (19/77) and holoprosencephaly in 18.18% (14/77). Other CA were also diagnosed (21/77), such as meningocele, spina bifida, acrania, among others. However, they showed a lower prevalence in relation to hydrocephalus, anencephaly and holoprosencephaly. Conclusion: The findings are essential for the planning and allocation of hospital resources and investment in health. Besides that, to adequate and specific prenatal care, is indispensable in the search for reducing the incidence of these malformations, morbidity and improving survival rates of the affected population.

scholarly journals Major congenital malformations of foetus: a bane in pregnancy

2020 ◽  
Vol 9 (11) ◽  
pp. 4521
Author(s):  
D. M. Christe ◽  
D. Mohana ◽  
S. Shobha
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Congenital Anomalies ◽  
Umbilical Artery ◽  
Poor People ◽  
Age Group ◽  
Renal Anomalies ◽  
Fetal Malformations ◽  
The Central Nervous System ◽  
Major Congenital Malformations

Background: The aim of the study was to find out the numbers of women presenting with pregnancy complicating with major congenital anomalies of the fetus.Methods: This study was conducted over a period of fifteen months in the year 2018-2019. The types of congenital anomalies were that of the central nervous system, cardiac, renal, gastrointestinal, skeleto-muscular, hydrops foetalis, chromosomal, single umbilical artery and other multiple anomalies. Other variables regarding the age group of the mother, gravida, parity and gestational age at which the pregnancy was terminated was also noted.Results: A total of 212 pregnancies were diagnosed with major congenital anomalies of fetus and opted for termination. Malformations of the central nervous system (CNS) of fetus, formed the largest group of 56.6%, and fetal gastrointestinal malformations and fetal renal anomalies occupied the second major groups forming 11.8% and 11.3% respectively. The age group of women ranged between 23 years to 38 years. The largest group of pregnant women with fetal malformations were aged between 23-27 years. Primigravida with zero parity women were 60.4% of the total group of women with major fetal anomalies.Conclusions: Maximum number of congenital anomalies were seen in primigravida and para one mothers. Genetic counseling should be offered for women at clinics, before planning further pregnancy. Facilities should be made available for poor people from remote areas for early detection of congenital anomalies.

scholarly journals Predominance of fetal malformations among pregnant women: A multi-centric observational study

2021 ◽  
Vol 4 (2) ◽  
pp. 055-059
Author(s):  
Sayed Sayed Mohamed ◽  
Khalifa Ahmed Khedr ◽  
Abd Allah Shehata Nesreen Abd El Fattah ◽  
AM Eweis Mohamed ◽  
M Shawky Sherwet
Keyword(s):  
Observational Study ◽  
Pregnant Women ◽  
Congenital Anomalies ◽  
Prospective Observational Study ◽  
Past History ◽  
University Hospital ◽  
Fetal Anomalies ◽  
Fetal Medicine ◽  
Fetal Malformations ◽  
History Of

Objective: To observe the predominance of fetal anomalies in pregnant women in a multi-centric setting. Methods: This prospective observational study included 20225 pregnant women who came for antenatal care in University Hospital and fetal medicine units from 2016 to 2019. Fetal anatomical scanning was done for all participants. Results: One hundred eighty-three cases had fetal congenital anomalies, yielding a prevalence of around 0.9%. Third of cases had positive consanguinity, this increased in cases of skeletal and thoracic anomalies. The presence of past history of anomalies was evident in 8.2% mostly with skeletal and heart anomalies. History of drug intake was only verified in 1.6% of cases. Sixty-three women out of 183 (34.4%) were diagnosed to have anomalies in fetal nervous system. Conclusion: Prenatal diagnosis are recommended for early detection of congenital anomalies and counselling.

scholarly journals Congenital anomalies in antenatal ultrasound scan at a tertiary care teaching hospital

2018 ◽  
Vol 5 (1) ◽  
pp. 26-30
Author(s):  
Shreejana Shrestha ◽  
Yogita Dwa ◽  
Pooja Jaiswal ◽  
Binod Parmar
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Congenital Anomalies ◽  
Descriptive Analysis ◽  
Tertiary Care ◽  
Fetal Anomalies ◽  
Cross Sectional ◽  
Antenatal Ultrasound ◽  
Previous Child ◽  
The Central Nervous System

Introductions: Early detection of congenital fetal anomalies by ultrasonography (USG) helps to identify the severity and termination of pregnancy in severe cases. Anomalies cause significant perinatal morbidity and mortality. Aim of this study was to analyse real-time USG detection of prenatal anomalies. Methods: This was a cross-sectional descriptive study of fetal anomalies detected during 2nd and 3rd trimester antenatal USG scan done from 2011 to 2015, in Patan Hospital. Age of mother, parity, gestational age when anomalies detected and, anomalies of previous child, use of folic acid were analysed. Descriptive analysis was done. Results: There were 35,571 deliveries in four years period with 134 (0.37%) congenital anomalies, 99 (79.2%) detected during antenatal USG during 2nd and 3rd trimester. Among 99 anomalies, 29 (29.29%) were detected before 22 weeks. Central nervous system (CNS) anomalies were 47, gastrointestinal 23, renal 12, skin and fetal compartment 8 and rest were less common. Young mothers of less than 30 years were 109 (81.34%) and primi were 85 (63.4%). Conclusions: Antenatal ultrasound can detect fetal anomalies in 2nd and 3rd trimester with higher frequencies belonging to the central nervous system followed by gastrointestinal tract anomalies and renal.

Sonography of the fetal neural axis: a practical approach

1995 ◽  
Vol 7 (1) ◽  
pp. 47-60 ◽  
Author(s):  
Ruth B Goldstein
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Prenatal Diagnosis ◽  
Fetal Brain ◽  
Fetal Anomalies ◽  
Financial Responsibility ◽  
Increased Risk ◽  
Neural Axis ◽  
The Central Nervous System ◽  
Cns Malformations

Among serious fetal anomalies currently detectable with ultrasound, defects of the central nervous system (CNS) are among the most common. These congenital anomalies are especially likely to burden not only affected children with severely limiting handicaps, but also their families with long-lasting anguish and financial responsibility. It is appropriate that interest in methods for improving prenatal detection of these abnormalities has intensified. Alphafetoprotein screening programmes are now widely available, and many papers have been written describing useful sonographic observations that enhance prenatal diagnosis. As a consequence, the majority of the most common serious neural axis defects including fetal hydrocephalus, anencephaly, myelomeningocele and encephalocele, previously detected almost exclusively at birth, today can be accurately detected prenatally. A few observations in the fetal brain and spine have proven to be especially useful in this task. This article presents a simplified and effective approach to the general sonographic survey of the neural axis in fetuses at average and increased risk for these anomalies. The aim is to improve not only accuracy of diagnosis of CNS malformations, but the efficiency and confidence of the examiner.

scholarly journals Prevalence and Spectrum of Fetal Congenital Anomalies: A Hospital Based Study from Mid-Western Part of Nepal

2019 ◽  
Vol 9 (2) ◽  
pp. 2-9
Author(s):  
Gopal Prasad Khanal ◽  
Prakash Sharma ◽  
Prakash Kayastha ◽  
Anju Poudel
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pregnant Women ◽  
Congenital Anomalies ◽  
Cleft Lip ◽  
Cystic Hygroma ◽  
Conjoined Twins ◽  
Regional Hospital ◽  
Radiology Department ◽  
Cross Sectional

Introduction: To estimate the prevalence and pattern of congenital anomalies through obstetric ultrasound on pregnant women visiting Rapti sub-regional hospital, Ghorahi, Dang, Nepal. Methods: A descriptive cross sectional study was conducted among 10,380 pregnant women visiting Radiology department of Rapti sub-regional hospital from January 2016 to July 2017. The findings of transabdominal ultrasonography (USG) performed by Radiologist and information regarding women’sage and gestational age were recorded. The images of any significant cases were also saved. Data wereanalyzed based on study objectives using descriptive statistics such as frequency, percentage, mean, rangeand standard deviation. The classification of the malformation was done based on the anatomical system. Results: Out of 10,380 ultrasound performed during the study period, 106 (1.02%) pregnant women presented with different congenital anomalies. The antenatal prevalence of congenital anomalies was 10.21 per 1000 pregnant women. The mean maternal age was 25.9 ± 4.80 years. Regarding gestation age, 87 (82.1%) anomalies were detected at second trimester of pregnancy. Most commonly involved body system was central nervous system 51 (48.1%), followed by cardiovascular system 12 (11.3%), musculoskeletal system 10 (9.4%), gastrointestinal system 5 (4.7%), respiratory system 5 (4.7%), genitourinary system 4 (3.8%). Other anomalies were cystic hygroma 9 (8.4%), hydrops fetalis 4 (3.8%), cleft lip 3 (2.8%), pelvic cystic lesion 2 (1.8%) and conjoined twins 1 (0.9%). Conclusion: The prevalence of congenital anomalies is high in mid-western part of Nepal.  Central nervous system anomalies were more common than other anomalies.

scholarly journals Prevalence of Congenital Anomalies in Oligohydramnios: A Hospital Based Study in Western Nepal

2019 ◽  
Vol 9 (1) ◽  
pp. 7-11
Author(s):  
Subash K.C ◽  
Ramesh Poudel ◽  
Sagar Khadka ◽  
Ashish Shrestha
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Congenital Anomalies ◽  
Congenital Malformations ◽  
Ultrasound Scan ◽  
Amniotic Fluid Index ◽  
Singleton Pregnancy ◽  
Renal Anomalies

Introduction: Amniotic fluid serves as a cushion for growing fetus. Oligohydramnios is decreased amount of amniotic fluid and is associated with increased incidence of congenital anomalies. The aim of this study was to detect the prevalence of congenital anomalies in oligohydramnios Methods: Singleton pregnancy irrespective of gestational age with amniotic fluid deepest vertical pocket (DVP) of less than two centimeters was included in the study. Grading of oligohydramnios was done as mild and severe. Detailed anomaly scan was done to look for any congenital malformations. Congenital anomalies were confirmed with post natal findings. Results: There were 60 pregnant women with amniotic fluid index less than two centimeters with respect to deepest vertical pocket. Congenital anomalies were detected in 18.33% pregnant women with oligohydramnios. In patients with severe oligohydramnios 33.33% had congenital anomalies. Renal anomalies were the most common anomalies in our study followed by musculoskeletal anomalies. Central nervous system, gastrointestinal and cardiac and anomalies were also common in association with oligohydramnios. Conclusion: Our study showed that various congenital anomalies are associated with oligohydramnios and incidence of anomalies increases with increased severity of oligohydramnios. Hence, detailed ultrasound scan should be done to look for congenital malformations whenever oligohydramnios is encountered.

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