MICROWAVE TOMOGRAPHY FOR ASSESSMENT OF EXTREMITY SOFT TISSUE BLOOD PERFUSION. INITIAL MULTI-FRAME IMAGING RESULTS

2010 ◽  
Author(s):  
Serguei Semenov ◽  
James Kellam ◽  
Thomas Williams ◽  
Michael Quinn
Keyword(s):  
Soft Tissue ◽  
Blood Perfusion ◽  
Microwave Tomography ◽  
Imaging Results

Microwave Tomography for Assessment of Extremity Soft Tissue Blood Perfusion: Initial Multi-Frame Imaging Resuls

2011 ◽  
Author(s):  
Serguei Semenov ◽  
James Kellam ◽  
Thomas Williams ◽  
Michael Quinn
Keyword(s):  
Soft Tissue ◽  
Blood Perfusion ◽  
Microwave Tomography

Imaging metastatic prostate cancer with 18F-DCFBC PET/CT (DCFBC) and 18F-NaF PET/CT (NaF).

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 231-231
Author(s):  
Farhad Fakhrejahani ◽  
Maria Liza Lindenberg ◽  
Ethan S. Bargvall ◽  
Esther Mena ◽  
Baris Turkbey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Soft Tissue ◽  
Functional Imaging ◽  
Metastatic Prostate Cancer ◽  
Whole Body ◽  
Inverse Association ◽  
Non Invasive ◽  
Imaging Results ◽  
Pet Ct ◽  
Antiandrogen Therapy

231 Background: Conventional imaging of advanced prostate cancer (computerized tomography and nuclear bone scintigraphy) is limited and indicates a need for a more specific molecular imaging probe. DCFBC is a radiolabeled PET agent that binds with high affinity to prostate specific membrane antigen (PSMA), which is overexpressed in almost all prostate cancers and through whole-body non-invasive functional imaging, may provide new information on the expression of PSMA. We compare the uptake of DCFBC in bone with respect to NaF PET/CT in metastatic prostate cancer patients. DCFBC has added capability to detect soft tissue metastasis whereas NaF is confined to secondary effects of bone disease. Methods: Subjects with known or suspected prostate cancer metastasis underwent DCFBC PET/CT imaging performed at 1 hour and 2 hours after IV bolus injection of 8 mCi of DCFBC. Patients also underwent a whole body NaF PET/CT scan within 3 weeks of DCFBC PET/CT to assess for bone metastases. Patients received 3 mCi of NaF IV bolus and then were imaged 1hour post injection. PSA levels and antiandrogen therapy status were obtained at the time of DCFBC imaging. Results: Fifteen patients have been preliminarily analyzed. PSA ranged from < .01 to 4379 ng/mL. NaF identified bone lesions in 10 patients but matching focal DCFBC uptake was only seen in 3 patients. DCFBC additionally showed lymph node metastasis in 1of these 3 patient. There were 5 patients without focal abnormal bone uptake on NaF or DCFBC. In this group, 4 of 5 patients had focal DCFBC uptake in lymph nodes or soft tissue lesions. Ten patients were on some form of androgen deprivation therapy (ADT). For those on ADT, 7 of 10 patients had positive findings on NaF, compared to 2 of 10 patients on DCFBC. Conclusions: DCFBC uptake in bone metastasis does not routinely correspond to focal NaF uptake which could be due to distinct mechanisms of tracer uptake and tumor biology. There is an inverse association in focal bone findings when comparing each tracer on antiandrogen therapy. Through whole-body non-invasive functional imaging and further study, DCFBC may prove useful in characterizing prostate cancer based on PSMA expression. Clinical trial information: NCT02190279.

Cochlear Soft Tissue Imaging Using In-Line Phase Contrast

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P100-P100
Author(s):  
Andrew J Fishman ◽  
Rau Christoph ◽  
Fan Lixin ◽  
Claus-Peter Richter
Keyword(s):  
Soft Tissue ◽  
Spatial Resolution ◽  
Specimen Preparation ◽  
X Rays ◽  
Imaging Methods ◽  
Imaging Results ◽  
In Situ Experiments ◽  
Grating Interferometer ◽  
Tissue Structures ◽  
Photon Source

Problem Most contemporary imaging methods require invasive specimen preparation and/or are time consuming, or lack sufficient spatial resolution. Methods Experiments were made at the Advanced Photon Source (APS), Argonne National Laboratory. The APS is a synchrotron radiation source of the third generation, for which the particular characteristic is the highly coherent X-ray radiation. X-rays are generated with an undulator, inserted in a straight section of the storage ring. Images taken with hard X-rays and the grating interferometer were compared with images from the same specimen acquired with light microscopy. Results The results show that imaging of cochlear soft tissue structures is possible with hard X-rays and a grating interferometer. Conclusion Imaging of cochlear soft tissue structures is possible with hard X-rays and a grating interferometer. Significance It is important to examine cochlear morphology from many points of view, including comparative anatomy, cochlear developmental changes, malformation caused by genetic defects, changes related to diseases, sensory physiology, and cochlear modeling. Best imaging results were obtained from in situ experiments in the absence of tissue distortion. However, most contemporary imaging methods require invasive specimen preparation and/or are time consuming, or lack sufficient spatial resolution. A method that potentially overcomes these shortcomings is presented in this paper and it uses hard X-rays and a grating interferometer. Furthermore, hard X-rays would allow imaging cochlear soft tissue structures without opening the cochlea itself. Support The UNICAT facility at the Advanced Photon Source is supported by the U.S. DOE under Award No. DEFG02-91ER45439, through the Frederick Seitz Materials Research Laboratory at the University of Illinois at Urbana-Champaign, the ORNL (U.S. DOE contract DE-AC.

scholarly journals Microwave Tomography for Brain Imaging: Feasibility Assessment for Stroke Detection

2008 ◽  
Vol 2008 ◽  
pp. 1-8 ◽  
Author(s):  
Serguei Y. Semenov ◽  
Douglas R. Corfield
Keyword(s):  
Brain Imaging ◽  
High Performance ◽  
Imaging Modality ◽  
Imaging Techniques ◽  
Head Model ◽  
Microwave Tomography ◽  
Feasibility Assessment ◽  
Imaging Results ◽  
High Dielectric ◽  
The Brain

There is a need for a medical imaging technology, that supplements current clinical brain imaging techniques, for the near-patient and mobile assessment of cerebral vascular disease. Microwave tomography (MWT) is a novel imaging modality that has this potential. The aim of the study was to assess the feasibility, and potential performance characteristics, of MWT for brain imaging with particular focus on stroke detection. The study was conducted using MWT computer simulations and 2D head model with stroke. A nonlinear Newton reconstruction approach was used. The MWT imaging of deep brain tissues presents a significant challenge, as the brain is an object of interest that is located inside a high dielectric contrast shield, comprising the skull and CSF. However, high performance, nonlinear MWT inversion methods produced biologically meaningful images of the brain including images of stroke. It is suggested that multifrequency MWT has the potential to significantly improve imaging results.

Feasibility study of gallium-68 citrate PET as a bone-tropic imaging biomarker in mCRPC.

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 31-31
Author(s):  
Ivan de Kouchkovsky ◽  
Spencer Behr ◽  
Li Zhang ◽  
Adam Foye ◽  
Henry Vanbrocklin ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Pet Imaging ◽  
Metabolic Response ◽  
Imaging Biomarker ◽  
Conventional Imaging ◽  
Castration Resistance ◽  
Imaging Results ◽  
Significant Difference ◽  
Gallium 68 ◽  
Early Metabolic Response

31 Background: Transferrin receptor (TFRC) expression is controlled by the PI3K and MYC signaling pathways, which are frequently dysregulated in prostate cancer (PC). Gallium-68 citrate (68Ga-citrate) is an iron biomimetic, which can be used to image PC in a TFRC dependent fashion. We performed a single-center pilot imaging study to investigate the use of 68Ga-citrate PET in patients with metastatic castration-resistant PC (mCRPC). Methods: Following written informed consent, mCRPC patients were prospectively enrolled and underwent 68Ga-citrate PET imaging. Optional metastatic tumor biopsies were undertaken at the time of imaging. Results: 34 mCRPC patients underwent 68Ga-citrate PET imaging. The median age was 67.5 years old. Median duration of castration resistance was 17.5 months; 14.7% of patients were post-docetaxel. Median serum PSA was 35.2 ng/dL. A total of 483 lesions were detected on conventional imaging (CT, 99mTc-HDP) or 68Ga-citrate PET, including 420 osseous and 63 soft tissue (nodal and visceral) lesions (Table). 67.3% of all lesions were detected on 68Ga-citrate PET, including 74.5% of all osseous lesions but only 19.0% of all soft tissue lesions (p<0.0001). Eight (1.7%) lesions were detected on 68Ga-citrate PET imaging only. Per-lesion average SUVmax (SUVmax,avg) was 6.7. Metastatic biopsies of PET avid lesions were performed in 20 patients (59%); adenocarcinoma histology was confirmed in 14 (70%) cases, treatment-emergent small cell neuroendocrine cancer (t-SCNC) in 6 (30%). There was no significant difference in SUVmax,avg between patients with adenocarcinoma or t-SCNC (SUVmax,avg 7.3 vs 7.6, respectively; Table). Serial 68Ga-citrate PET perfomed in a patient with biopsy-confirmed t-SCNC after 2 cycles of carboplatin/cabazitaxel demonstrated an early metabolic response (28.5% decrease in average SUVmax) confirmed on subsequent conventional imaging. Conclusions: 68Ga-citrate PET detects mCRPC bone metastases in patients with biopsy-proven prostatic adenocarcinoma or t-SCNC, distinguishing it from lineage dependent agents such as PSMA tracers. Detection of an early metabolic response in the bone of a treated t-SCNC patient was observed. Further prospective studies are ongoing coupling serial Ga-citrate PET with investigational agents targeting the MYC signaling pathway. Clinical trial information: NCT02391025. [Table: see text]

scholarly journals Microwave tomography: review of the progress towards clinical applications

2009 ◽  
Vol 367 (1900) ◽  
pp. 3021-3042 ◽  
Author(s):  
Serguei Semenov
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Imaging Modality ◽  
Three Dimensional ◽  
Clinical Applications ◽  
Microwave Tomography ◽  
Non Invasive ◽  
Dielectric Contrast ◽  
High Dielectric ◽  
Tissue Abnormalities

Microwave tomography (MWT) is an emerging biomedical imaging modality with great potential for non-invasive assessment of functional and pathological conditions of soft tissues. This paper presents a review of research results obtained by the author and his colleagues and focuses on various potential clinical applications of MWT. Most clinical applications of MWT imaging have complicated, nonlinear, high dielectric contrast inverse problems of three-dimensional diffraction tomography. There is a very high dielectric contrast between bones and fatty areas compared with soft tissues. In most cases, the contrast between soft-tissue abnormalities (the target imaging areas) is less pronounced than between bone (fat) and soft tissue. This additionally complicates the imaging problem. In spite of the difficulties mentioned, it has been demonstrated that MWT is applicable for extremities imaging, breast cancer detection, diagnostics of lung cancer, brain imaging and cardiac imaging.

Localization of Gallium-67 in Peritoneal Cells by Electron Microscopic Autoradiography

1973 ◽  
Vol 31 ◽  
pp. 404-405
Author(s):  
D. C. Swartzendruber ◽  
Norma L. Idoyaga-Vargas
Keyword(s):  
Clinical Trials ◽  
Soft Tissue ◽  
Tumor Tissue ◽  
Soft Tissue Tumors ◽  
Clinical Usefulness ◽  
Electron Microscopic ◽  
Normal Cells ◽  
Electron Microscopic Autoradiography ◽  
Peritoneal Cells ◽  
Gallium 67

The radionuclide gallium-67 (67Ga) localizes preferentially but not specifically in many human and experimental soft-tissue tumors. Because of this localization, 67Ga is used in clinical trials to detect humar. cancers by external scintiscanning methods. However, the fact that 67Ga does not localize specifically in tumors requires for its eventual clinical usefulness a fuller understanding of the mechanisms that control its deposition in both malignant and normal cells. We have previously reported that 67Ga localizes in lysosomal-like bodies, notably, although not exclusively, in macrophages of the spocytaneous AKR thymoma. Further studies on the uptake of 67Ga by macrophages are needed to determine whether there are factors related to malignancy that might alter the localization of 67Ga in these cells and thus provide clues to discovering the mechanism of 67Ga localization in tumor tissue.

Morphological Examination of a Herpes-type Virus Indigenous for Tree Shrews

1970 ◽  
Vol 28 ◽  
pp. 160-161
Author(s):  
J. P. Brunschwig ◽  
R. M. McCombs ◽  
R. Mirkovic ◽  
M. Benyesh-Melnick
Keyword(s):  
Electron Microscopy ◽  
Soft Tissue ◽  
Chick Embryo ◽  
Soft Tissue Sarcoma ◽  
Cell Cultures ◽  
Tree Shrew ◽  
Type Virus ◽  
Morphological Examination ◽  
Tree Shrews ◽  
Embryo Cells

A new virus, established as a member of the herpesvirus group by electron microscopy, was isolated from spontaneously degenerating cell cultures derived from the kidneys and lungs of two normal tree shrews. The virus was found to replicate best in cells derived from the homologous species. The cells used were a tree shrew cell line, T-23, which was derived from a spontaneous soft tissue sarcoma. The virus did not multiply or did so poorly for a limited number of passages in human, monkey, rodent, rabbit or chick embryo cells. In the T-23 cells, the virus behaved as members of the subgroup B of herpesvirus, in that the virus remained primarily cell associated.

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