In-vitro experimental analysis of magnetic fluid hyperthermia in soft tissue with artificial blood perfusion

2017 ◽  
Vol 31 (1) ◽  
pp. 465-472 ◽  
Author(s):  
Mohammad Mahdi Attar ◽  
Farzan Barati ◽  
Gita Rezaei ◽  
Behroz Adelinia
Keyword(s):  
Soft Tissue ◽  
Magnetic Fluid ◽  
Experimental Analysis ◽  
Blood Perfusion ◽  
Magnetic Fluid Hyperthermia ◽  
Artificial Blood

On the in Vitro Hyperthermia of Magnetic Fluid in AC Magnetic Field

2009 ◽  
Author(s):  
Junfeng Jiang ◽  
Ruoyu Hong ◽  
Xiaohui Zhang ◽  
Hongzhong Li
Keyword(s):  
Magnetic Field ◽  
Magnetic Fluid ◽  
Volume Fraction ◽  
Maximum Temperature ◽  
Magnetic Fluid Hyperthermia ◽  
Ac Magnetic Field ◽  
Hyperthermia Therapy ◽  
Good Biocompatibility ◽  
High Chemical Stability

Hyperthermia therapy for cancer has attracted much attention nowadays. The study on the heat transfer in the magnetic fluid and the tumor is crucial for the successful application of magnetic fluid hyperthermia (MFH). Water-based Fe3O4 magnetic fluid is expected to be a most appropriate candidate for MFH due to the good biocompatibility, high saturation magnetization, super-paramagnetization and high chemical stability. In this paper, we explore the heat generation and transfer in magnetic fluid which is placed under an AC magnetic field. It is found that the amplitude and the frequency of alternating magnetic field, particle size and volume fraction have a pronounce influence on maximum temperature of hyperthermia.

Heat transfer of PEGylated cobalt ferrite nanofluids for magnetic fluid hyperthermia therapy: In vitro cellular study

2018 ◽  
Vol 462 ◽  
pp. 185-194 ◽  
Author(s):  
Shadie Hatamie ◽  
Benymin Parseh ◽  
Mohammad Mahdi Ahadian ◽  
Fatemeh Naghdabadi ◽  
Reza Saber ◽  
...  
Keyword(s):  
Heat Transfer ◽  
Magnetic Fluid ◽  
Cobalt Ferrite ◽  
Magnetic Fluid Hyperthermia ◽  
Hyperthermia Therapy

MAGNETIC FLUID HYPERTHERMIA IN A CYLINDRICAL GEL CONTAINS WATER FLOW

2015 ◽  
Vol 15 (05) ◽  
pp. 1550088 ◽  
Author(s):  
MORTEZA HEYDARI ◽  
MEHRDAD JAVIDI ◽  
MOHAMMAD MAHDI ATTAR ◽  
ALIREZA KARIMI ◽  
MAHDI NAVIDBAKHSH ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Experimental Data ◽  
Fluid Flow ◽  
Magnetic Fluid ◽  
Blood Perfusion ◽  
Temperature Function ◽  
Magnetic Fluid Hyperthermia ◽  
Frequency Magnetic Field ◽  
Complicated Part ◽  
Cancerous Cells

In magnetic fluid hyperthermia (MFH), nanoparticles are injected into a diseased tissue and then subjected to an alternating high frequency magnetic field. The produced heat may have a key asset to destroy the cancerous cells. The blood flow in a tissue is considered as the most complicated part of the MFH which should be taken into account in the analysis of the MFH. This study was aimed to perform an experimental study to investigate the heat transfer of agar gel which contains fluid flow. Fe 3 O 4 as a nanoparticle was injected into the center of a cylindrical gel. It was also embedded with other cylindrical gels and subjected to an alternating magnetic field of 7.3 (kA/m) and a frequency of 50 (kHz) for 3600 (s). The temperature of the gel was measured at three points. The temperature distribution was measured via the experimental data. Moreover, specific absorption rate (SAR) was quantified with time differential temperature function at t = 0 by means of experimental data. Finite element method (FEM) was employed to establish a model to validate the SAR function. Results revealed the effects of fluid flow and accuracy of the SAR function for heat production in gel. The proposed function have implications in hyperthermia studies as a heat generation source. Finally, the condition of experimental setup was simulated to find the blood perfusion.

Cisplatin-loaded carbon-encapsulated iron nanoparticles and their in vitro effects in magnetic fluid hyperthermia

Carbon ◽  
2010 ◽  
Vol 48 (8) ◽  
pp. 2327-2334 ◽  
Author(s):  
Arthur Taylor ◽  
Yulia Krupskaya ◽  
Kai Krämer ◽  
Susanne Füssel ◽  
Rüdiger Klingeler ◽  
...  
Keyword(s):  
Magnetic Fluid ◽  
Iron Nanoparticles ◽  
Magnetic Fluid Hyperthermia ◽  
In Vitro Effects

scholarly journals In vitro Ultrasonic Potentiation of 2-Phenylethynesulfonamide/Magnetic Fluid Hyperthermia Combination Treatments for Ovarian Cancer

2020 ◽  
Vol Volume 15 ◽  
pp. 419-432 ◽  
Author(s):  
Fernando Merida ◽  
Carlos Rinaldi ◽  
Eduardo J. Juan ◽  
Madeline Torres-Lugo
Keyword(s):  
Ovarian Cancer ◽  
Magnetic Fluid ◽  
Magnetic Fluid Hyperthermia ◽  
Combination Treatments

Evaluation of 99mTc-Label led Vitamin K4 as an Agent for Testicular Imaging

1991 ◽  
Vol 30 (01) ◽  
pp. 35-39 ◽  
Author(s):  
H. S. Durak ◽  
M. Kitapgi ◽  
B. E. Caner ◽  
R. Senekowitsch ◽  
M. T. Ercan
Keyword(s):  
Soft Tissue ◽  
Room Temperature ◽  
Normal Subjects ◽  
Left Testis ◽  
Wide Range ◽  
Activity Ratios ◽  
The Right ◽  
Radioactivity Levels

Vitamin K4 was labelled with 99mTc with an efficiency higher than 97%. The compound was stable up to 24 h at room temperature, and its biodistribution in NMRI mice indicated its in vivo stability. Blood radioactivity levels were high over a wide range. 10% of the injected activity remained in blood after 24 h. Excretion was mostly via kidneys. Only the liver and kidneys concentrated appreciable amounts of radioactivity. Testis/soft tissue ratios were 1.4 and 1.57 at 6 and 24 h, respectively. Testis/blood ratios were lower than 1. In vitro studies with mouse blood indicated that 33.9 ±9.6% of the radioactivity was associated with RBCs; it was washed out almost completely with saline. Protein binding was 28.7 ±6.3% as determined by TCA precipitation. Blood clearance of 99mTc-l<4 in normal subjects showed a slow decrease of radioactivity, reaching a plateau after 16 h at 20% of the injected activity. In scintigraphic images in men the testes could be well visualized. The right/left testis ratio was 1.08 ±0.13. Testis/soft tissue and testis/blood activity ratios were highest at 3 h. These ratios were higher than those obtained with pertechnetate at 20 min post injection.99mTc-l<4 appears to be a promising radiopharmaceutical for the scintigraphic visualization of testes.

scholarly journals Oxygen-Sensitivity and Pulmonary Selectivity of Vasodilators as Potential Drugs for Pulmonary Hypertension

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 155
Author(s):  
Daniel Morales-Cano ◽  
Bianca Barreira ◽  
Beatriz De Olaiz Navarro ◽  
María Callejo ◽  
Gema Mondejar-Parreño ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Gas Exchange ◽  
Pulmonary Circulation ◽  
Pulmonary Arteries ◽  
Blood Perfusion ◽  
Mesenteric Arteries ◽  
Oxygen Sensitivity ◽  
Low Oxygen ◽  
Oxygen Selectivity

Current approved therapies for pulmonary hypertension (PH) aim to restore the balance between endothelial mediators in the pulmonary circulation. These drugs may exert vasodilator effects on poorly oxygenated vessels. This may lead to the derivation of blood perfusion towards low ventilated alveoli, i.e., producing ventilation-perfusion mismatch, with detrimental effects on gas exchange. The aim of this study is to analyze the oxygen-sensitivity in vitro of 25 drugs currently used or potentially useful for PH. Additionally, the study analyses the effectiveness of these vasodilators in the pulmonary vs. the systemic vessels. Vasodilator responses were recorded in pulmonary arteries (PA) and mesenteric arteries (MA) from rats and in human PA in a wire myograph under different oxygen concentrations. None of the studied drugs showed oxygen selectivity, being equally or more effective as vasodilators under conditions of low oxygen as compared to high oxygen levels. The drugs studied showed low pulmonary selectivity, being equally or more effective as vasodilators in systemic than in PA. A similar behavior was observed for the members within each drug family. In conclusion, none of the drugs showed optimal vasodilator profile, which may limit their therapeutic efficacy in PH.

Sign in / Sign up

Export Citation Format

Share Document