scholarly journals Orthopedic Treatment Outcomes in Class III Malocclusion

2008 ◽  
Vol 78 (3) ◽  
pp. 561-573 ◽  
Author(s):  
Laura De Toffol ◽  
Chiara Pavoni ◽  
Tiziano Baccetti ◽  
Lorenzo Franchi ◽  
Paola Cozza
Keyword(s):  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Scientific Evidence ◽  
Quality Standard ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Medical Subject Headings ◽  
Orthopedic Treatment ◽  
High Quality Research ◽  
Facial Mask

Abstract Objective: To assess the scientific evidence on the effectiveness of early orthopedic treatment in Class III subjects. Materials and Methods: A literature survey was performed by applying the Medline database (Entrez PubMed). The survey covered the period from January 1966 to December 2005 and used the Medical Subject Headings (MeSH). The following study types that reported data on the effects of Class III treatment with orthopedic appliances (facial mask, chincup, FR-3) on intermaxillary sagittal and vertical relationships were included: randomized clinical trials (RCTs), and prospective and retrospective longitudinal controlled clinical trials (CCTs) with untreated Class III controls. Results: The search strategy resulted in 536 articles. After selection according to criteria for inclusion and exclusion, 19 articles qualified for the final review analysis. One RCT and 18 CCTs were retrieved. Conclusion: The quality standard of the retrieved investigations ranged from low (four studies) to medium/high (five studies). Data derived from medium/high quality research described over 75% of success of orthopedic treatment of Class III malocclusion (RME and facial mask therapy) at a follow-up observation 5 years after the end of orthopedic treatment.

scholarly journals Stability Factors After Double-Jaw Surgery in Class III Malocclusion

2008 ◽  
Vol 78 (6) ◽  
pp. 1141-1152 ◽  
Author(s):  
Manuela Mucedero ◽  
Antonella Coviello ◽  
Tiziano Baccetti ◽  
Lorenzo Franchi ◽  
Paola Cozza
Keyword(s):  
Clinical Trials ◽  
Treatment Strategies ◽  
Control Group ◽  
Quality Level ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Medical Subject Headings ◽  
Method Error ◽  
Skeletal Class ◽  
Jaw Surgery

Abstract Objective: To identify the stability factors of skeletal Class III malocclusion after double-jaw surgery by a systematic review of the literature. Materials and Methods: The survey covered the period from September 1959 to October 2007 and used the MeSH, Medical Subject Headings. The inclusion criteria were stability of bimaxillary surgery of the permanent dentition, adult patients with skeletal Class III malocclusion, a follow-up of at least 12 months, randomized and nonrandomized controlled clinical trials (RCCTs; CCTs), prospective and retrospective studies with and without concurrent untreated as well as normal controls, and clinical trials (CTs) comparing at least two treatment strategies without any untreated or normal control group. Results: The search strategy resulted in 1783 articles. After selection according to the inclusion/ exclusion criteria, 15 articles qualified for the final review analysis. Quality was low in two studies, medium in twelve, and medium/high in one article, which was represented by a RCT (randomized clinical trial). Most of the studies had sufficient sample size, method error analysis, and adequate statistical methods. Thus, the quality level of the studies was sufficient to draw evidence-based conclusions. Conclusions: Surgical correction of skeletal Class III malocclusion after combined maxillary and mandibular procedures appears to be stable for maxillary advancements up to 5 mm and for the correction of presurgical sagittal intermaxillary discrepancies smaller than 7 mm.

scholarly journals Protraction facial mask in early treatment of class III malocclusion

2017 ◽  
Vol 14 (2) ◽  
Author(s):  
Jesús Alberto Hernández ◽  
Libia Soto
Keyword(s):  
Early Treatment ◽  
Case Reports ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Orthopedic Treatment ◽  
Mandibular Bone ◽  
Facial Mask ◽  
Orthognatic Surgery ◽  
Facial Changes

Summary: Treatment of mild to moderate maloclussion class III with protraction facial maskcould reduce the need of orthognatic surgery at all or reduce the size of the orthognatic surgicalintervention. Objetive: To evaluate the effect of early treatment with facial mask in angle classIII patients. Methods: Two class III patientes were estudied beinf treated with facial masthe firstpatient used the facial mask 12 hours at day 3 months periods then the patient was switched todental orthopedic treatment controlled by Rx lateral perfilogram . The second patient used facialmask 6 months ,then switched to dental orthopedic treatment 3 years.The patients were controleduntil patients were 14 years old. Discussion: This serie of 2 case reports reveal that the use of aprotactil facial mask is favourable ro treat patients suffering class III maloclussions. Theskeletal facial changes were positively significant in those patients according to the datadetectable changes of maxillar and mandibular bone size and the cefalometric points a and b thatoclussal plane. In follow up studies ,it and determend that even after reach the patients 18 yearsof age, 67% of the patients were in normal oclussion even longer than 8 years after treatment.Thisresuet indicates that only on third of the ortonagte surgeris may be truly needed to the treatmentof ,class III dental. Key words: Class III maloclussion. Facial mask. Early dentaltreatment.

Liraglutide for the Treatment of Obesity: Analyzing Published Reviews

2019 ◽  
Vol 25 (15) ◽  
pp. 1783-1790 ◽  
Author(s):  
Rosario Pastor ◽  
Josep A. Tur
Keyword(s):  
Weight Loss ◽  
Clinical Trials ◽  
Systematic Reviews ◽  
Randomized Clinical Trials ◽  
Statistical Tests ◽  
Overweight And Obesity ◽  
Cochrane Library ◽  
Medical Subject Headings ◽  
Mesh Terms ◽  
Treatment Of Obesity

Background: Several drugs have been currently approved for the treatment of obesity. The pharmacokinetic of liraglutide, as well as the treatment of type 2 diabetes mellitus, have been widely described. Objective: To analyze the published systematic reviews on the use of liraglutide for the treatment of obesity. Methods: Systematic reviews were found out through MEDLINE searches, through EBSCO host and the Cochrane Library based on the following terms: "liraglutide" as major term and using the following Medical Subject Headings (MesH) terms: "obesity", "overweight", "weight loss". A total of 3 systematic reviews were finally included to be analyzed. Results: From the three systematic reviews selected, only two included the randomized clinical trials, while the third study reviewed both randomized and non-randomized clinical trials. Only one review performed statistical tests of heterogeneity and a meta-analysis, combining the results of individual studies. Another review showed the results of individual studies with odds ratio and confidence interval, but a second one just showed the means and confidence intervals. In all studies, weight loss was registered in persons treated with liraglutide in a dose dependent form, reaching a plateau at 3.0 mg dose, which was reached just in men. Most usual adverse events were gastrointestinal. Conclusion: More powerful and prospective studies are needed to assess all aspects related to liraglutide in the overweight and obesity treatment.

scholarly journals Probiotics supplementation and insulin resistance: a systematic review

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Bárbara Izabel Moraes Salles ◽  
Débora Cioffi ◽  
Sandra Roberta G. Ferreira
Keyword(s):  
Systematic Review ◽  
Insulin Resistance ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Metabolic Diseases ◽  
Healthy Lifestyle ◽  
Intestinal Barrier ◽  
Short Chain Fatty Acids ◽  
Intestinal Barrier Function ◽  
Medical Subject Headings

Abstract Background Research on intestinal microbiota has grown considerably, as well as the interest on probiotics’ supplementation effects on metabolism. Considering high prevalence rates of metabolic diseases linked by insulin resistance, we performed a systematic review of existing literature which addressed the role of probiotics in modulating insulin sensitivity in animals and humans. Methods This systematic review was based on PRISMA guidelines. Searches for original articles published in English from 1990 to January 2020 were made in the electronic database of PubMed from the National Library of Medicine, using Medical Subject Headings to identify longitudinal studies conducted in animals and humans which reported effects of probiotics in a variety of insulin resistance parameters. Results Overall, results from 27 probiotic interventions (Lactobacillus, Bifidobacterium, Clostridium and Akkermansia) indicated significant beneficial changes in insulin resistance measures in animal studies. Additionally, they improved lipid profile, inflammatory and oxidative markers, short-chain fatty acids production and microbiota composition. In seven clinical trials, samples and designs were heterogeneous. Five showed benefits in insulin resistance parameters and in two others no effect was detected. Conclusion Available data regarding the effects of certain probiotics do not guarantee sustained amelioration of insulin resistance in humans. Consistent beneficial results for intestinal barrier function, immune system and metabolism were reported in animals may encourage long-term randomized clinical trials in people with obesity and cardiometabolic risk. Whether supplementation with probiotics in combination with medications and/or prebiotics, associated with a healthy lifestyle, will prove useful to attenuate insulin resistance requires further investigation.

scholarly journals Treatment and posttreatment effects of a facial mask combined with a bite-block appliance in Class III malocclusion

2010 ◽  
Vol 138 (3) ◽  
pp. 300-310 ◽  
Author(s):  
Paola Cozza ◽  
Tiziano Baccetti ◽  
Manuela Mucedero ◽  
Chiara Pavoni ◽  
Lorenzo Franchi
Keyword(s):  
Class Iii ◽  
Class Iii Malocclusion ◽  
Bite Block ◽  
Facial Mask

Mandibular propulsion appliance for adults with Class II malocclusion: a systematic review and meta-analysis

2019 ◽  
Vol 42 (2) ◽  
pp. 163-173 ◽  
Author(s):  
Daybelis González Espinosa ◽  
Milena Santos ◽  
Sissy Maria dos Anjos Mendes ◽  
David Normando
Keyword(s):  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Scientific Evidence ◽  
Class Ii ◽  
Class Ii Malocclusion ◽  
Herbst Appliance ◽  
Skeletal Changes ◽  
Before And After ◽  
Mandibular Retrusion

Summary Background The effects of mandibular propulsion appliances in adults have some controversial results. While some authors claim that its use in non-growing patients could produce some dentoskeletal effects, other studies indicate that Class II correction occurs only through significant dental effects. Objective To evaluate the effects in non-growing Class II patients with mandibular retrusion, promoted by the treatment with mandibular propulsion appliances and determine if they produce mandibular changes. Methods The research was carried out in nine electronic databases and additional manual searches up to July 2019. Selection criteria were no restriction was placed on date and publication language. Randomized or non-randomized clinical trials with/without control were included. They must evaluated non-growing patients with Class II malocclusion, treated with mandibular propulsion appliances; outcomes were assessed before and after treatment. Data collection and analysis Data were extracted by two independent examiners in duplicate. The ROBINS-I tool was used to assess the methodological quality of the included studies. Results Of the 2824 articles identified, 11 non-randomized clinical articles were selected for qualitative analysis and 8 for quantitative analysis. SNB (0.87°, CI 95% 0.08, 1.66), ANB (−0.82°, CI 95% −1.24 to 0.40) and Pg/OLp [2.3 to 1.2 mm (P < 0.001)] presented smallest but significant mandibular changes with some differences regarding the used appliance. The Herbst appliance showed the largest mandibular changes followed by the SUS appliance when evaluated through Ar-Pg. SNA showed non-significant changes. Overbite (−2.85. CI 95% −3.06, −2.64), Overjet (−5.00.CI 95% −5.45, −4.55) showed significant changes in all devices. Class II correction occurs through a significant labial movement of the mandibular incisors, some lingual inclination of the maxillary incisors and minor skeletal changes. Conclusions All mandibular propulsion appliances examined, showed efficiency in normalizing the Class II malocclusion in adult patients; however, changes were acquired mainly through dentoalveolar changes. Some minor mandibular forward changes was noted, mainly in patients treated with the Herbst appliance. Randomized clinical trials are needed to improve scientific evidence. Registration PROSPERO (code CRD42017067384).

Soft tissue facial profile in Class III malocclusion: long-term post-pubertal effects produced by the Face Mask Protocol

2019 ◽  
Vol 41 (5) ◽  
pp. 531-536 ◽  
Author(s):  
Chiara Pavoni ◽  
Francesca Gazzani ◽  
Lorenzo Franchi ◽  
Saveria Loberto ◽  
Roberta Lione ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Face Mask ◽  
Treated Group ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Lower Lip ◽  
Facial Profile ◽  
Facial Mask ◽  
The Face

SummaryObjectivesThe objective of this study was to analyze soft tissue changes produced by rapid maxillary expansion and facial mask therapy in growing Class III patients.MaterialsThe treated group consisted of 32 Caucasian patients (15 females and 17 males) with dentoskeletal Class III malocclusion treated with the Face Mask Protocol (FMP, rapid maxillary expander, facial mask, and removable lower bite-block). All patients were evaluated before treatment (T1; mean age, 8.4 years), at the end of active treatment (T2; mean age, 10.7 years), and at a post-pubertal follow-up observation (T3; mean age, 15.8 years). The treated group was compared with a matched control group of 20 untreated subjects (10 females and 10 males) with dentoskeletal Class III malocclusion. Statistical comparisons between two groups were performed with the independent samples t-test (P < 0.05).ResultsSignificant improvements were found during the long-term T1–T3 interval for profile facial angle (–5.8°), nasolabial angle (–4.4°), mandibular sulcus (–10.3°), upper lip protrusion (+0.7 mm), and lower lip protrusion (–1.1 mm) in the treated group. No significant post-pubertal effects were found in terms of lower face percentage between two groups.LimitationsThis study has a retrospective design and it used a historical control sample.ConclusionThe FMP induced positive effects on soft tissue facial profile with a good long-term post-pubertal stability.

scholarly journals A Focus on the Nowadays Potential Antiviral Strategies in Early Phase of Coronavirus Disease 2019 (Covid-19): A Narrative Review

Life ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 146
Author(s):  
Caterina Monari ◽  
Valeria Gentile ◽  
Clarissa Camaioni ◽  
Giulia Marino ◽  
Nicola Coppola ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Severe Acute Respiratory Syndrome ◽  
Randomized Clinical Trials ◽  
Scientific Evidence ◽  
Antiviral Agents ◽  
Narrative Review ◽  
Definitive Evidence ◽  
Treatment Regimens ◽  
Related Disease ◽  
Critical Issues

Background: The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the related disease (COVID-19) has rapidly spread to a pandemic proportion, increasing the demands on health systems for the containment and management of COVID-19. Nowadays, one of the critical issues still to be pointed out regards COVID-19 treatment regimens and timing: which drug, in which phase, for how long? Methods: Our narrative review, developed using MEDLINE and EMBASE, summarizes the main evidences in favor or against the current proposed treatment regimens for COVID-19, with a particular focus on antiviral agents. Results: Although many agents have been proposed as possible treatment, to date, any of the potential drugs against SARS-CoV-2 has shown to be safe and effective for treating COVID-19. Despite the lack of definitive evidence, remdesivir remains the only antiviral with encouraging effects in hospitalized patients with COVID-19. Conclusions: In such a complex moment of global health emergency, it is hard to demand scientific evidence. Nevertheless, randomized clinical trials aiming to identify effective and safe drugs against SARS-CoV-2 infection are urgently needed in order to confirm or reject the currently available evidence.

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