scholarly journals Effect of pharmacological agents on relapse following orthodontic tooth movement:

2020 ◽  
Vol 90 (4) ◽  
pp. 598-606
Author(s):  
Prabhakar Veginadu ◽  
Santosh Rahul Tavva ◽  
Vizia Muddada ◽  
Suresh Gorantla
Keyword(s):  
Animal Studies ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Risk Of Bias ◽  
Evaluation Tool ◽  
Qualitative Synthesis ◽  
Pharmacological Agents ◽  
Orthodontic Force ◽  
Hand Search

ABSTRACT Objectives To investigate and synthesize systematically the evidence from animal studies pertaining to the effect of pharmacological agents on tooth movement relapse following cessation of orthodontic force application. Materials and Methods An electronic search was conducted in seven online databases (including gray sources) without restrictions until the third week of April 2019, followed by a hand search in the reference lists of eligible articles. Controlled animal studies investigating the effect of pharmacological agents on tooth movement relapse following orthodontic treatment were selected. Relevant data were extracted from eligible studies and the risk of bias assessment was done using SYRCLE's risk of bias tool. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation tool. Results The search identified 2354 records, of which 7 studies were deemed eligible for inclusion in the qualitative synthesis, with the majority presenting an unclear risk of bias. Orthodontic relapse was shown to decrease with the administration of pamidronate disodium, atorvastatin, aspirin, and chemically modified tetracycline-3. Inconsistent effects on relapse were observed after the use of simvastatin. The overall quality of retrieved evidence was assessed as low at best. Conclusions The available evidence shows that the investigated pharmacological agents may demonstrate variable effects on tooth movement relapse following cessation of orthodontic force. Additional evidence of higher quality is required to draw definitive conclusions on their effects and to make potential recommendations for clinical application.

scholarly journals Does exogenous female sex hormone administration affect the rate of tooth movement and root resorption? A systematic review of animal studies

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257778
Author(s):  
Eleftherios G. Kaklamanos ◽  
Miltiadis A. Makrygiannakis ◽  
Athanasios E. Athanasiou
Keyword(s):  
Sex Hormones ◽  
Animal Studies ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Risk Of Bias ◽  
Female Sex ◽  
Female Sex Hormones

Background The long-term use of contraceptive methods that contain estrogens, progestogens or combinations of the above among women aged 15 to 49 years is extensive. Both estrogens and progestogens affect bone metabolism. Objective To systematically investigate and appraise the quality of the available evidence from animal studies regarding the impact of exogenous administration of female sex hormones on the rate of orthodontic tooth movement and root resorption. Search methods Search without restriction in seven databases (including grey literature) and hand searching were performed until May 2021. Selection criteria We looked for controlled animal studies investigating the effect from exogenous administration of formulations containing female sex hormones on the rate of orthodontic tooth movement and root resorption. Data collection and analysis After study retrieval and selection, relevant data was extracted, and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool. The quality of available evidence was assessed with the Grades of Recommendation, Assessment, Development, and Evaluation. Results Three studies were identified, all being at unclear risk of bias. Overall, administration of progesterone and the combinations of estradiol with norgestrel and desogestrel were shown to significantly decrease the rate of orthodontic tooth movement when given for longer periods (>3 weeks). Inconsistent information was detected for shorter periods of consumption. Estradiol, with desogestrel use, resulted in less root resorption. The quality of the available evidence was considered to be low. Conclusions Exogenous administration of female sex hormones may decelerate in the long term the rate of tooth movement and decrease orthodontically induced root resorption in animals. Until more information becomes available, an orthodontist should be able to identify a patient consuming such substances and understand the potential clinical implications and adverse effects that may arise. Registration PROSPERO: CRD42017078208; https://clinicaltrials.gov/.

Does long-term use of pain relievers have an impact on the rate of orthodontic tooth movement? A systematic review of animal studies

2018 ◽  
Vol 41 (5) ◽  
pp. 468-477 ◽  
Author(s):  
Miltiadis A Makrygiannakis ◽  
Eleftherios G Kaklamanos ◽  
Athanasios E Athanasiou
Keyword(s):  
Pain Relief ◽  
Animal Studies ◽  
Tooth Movement ◽  
Grey Literature ◽  
Orthodontic Tooth Movement ◽  
Risk Of Bias ◽  
Data Collection And Analysis ◽  
High Doses

Summary Background Pain relief drugs are used and misused widely and may theoretically affect the events leading to orthodontic tooth movement. Objective To systematically investigate and appraise the quality of the available evidence regarding the effect of pain relief medications on the rate of orthodontic tooth movement. Search methods Search without restrictions in eight databases (including grey literature) and hand searching until October 2018. Selection criteria Animal controlled studies investigating the effect of pain relievers on the rate of orthodontic tooth movement. Data collection and analysis Following study retrieval and selection, relevant data were extracted and the risk of bias was assessed using the SYRCLE’s risk of bias tool. Results Fourteen studies were finally identified, most of which at unclear risk of bias. Ibuprofen and loxoprofen did not show any significant effects on the rate of orthodontic tooth movement, whereas indomethacin, ketorolac, morphine, and high doses of etoricoxib were found to decrease it. Inconsistent or conflicting effects were noted after the administration of acetaminophen, acetylsalicylic acid, celecoxib, meloxicam, and tramadol. The quality of the available evidence was considered at best as low. Conclusions Long-term consumption of pain relievers may affect the rate of orthodontic tooth movement. The orthodontist should be capable of identifying patients taking pain relievers independently of orthodontic treatment and consider the possible implications. Trial registration PROSPERO (CRD42017078208).

Effects of systemic medication on root resorption associated with orthodontic tooth movement: a systematic review of animal studies

2018 ◽  
Vol 41 (4) ◽  
pp. 346-359 ◽  
Author(s):  
Miltiadis A Makrygiannakis ◽  
Eleftherios G Kaklamanos ◽  
Athanasios E Athanasiou
Keyword(s):  
Animal Studies ◽  
Tooth Movement ◽  
Root Resorption ◽  
Arab World ◽  
Good Practice ◽  
Orthodontic Tooth Movement ◽  
Risk Of Bias ◽  
Control Group ◽  
Systemic Medication

SummaryBackgroundTheoretically, root resorption could be modulated by any medication taken that exhibits possible effects on the implicated molecular pathways.ObjectivesTo systematically investigate and appraise the quality of the available evidence from animal studies, regarding the effect of commonly prescribed systemic medication on root resorption associated with orthodontic tooth movement.Search methodsSearch without restrictions in eight databases (PubMed, Central, Cochrane Database of Systematic Reviews, SCOPUS, Web of Science, Arab World Research Source, ClinicalTrials.gov, ProQuest Dissertations and Theses Global) and hand searching until April 2018 took place. One author developed detailed search strategies for each database that were based on the PubMed strategy and adapted accordingly.Selection criteriaControlled studies investigating the effect of systemic medications on root resorption associated with orthodontic tooth movement.Data collection and analysisFollowing study retrieval and selection, relevant data were extracted and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool.ResultsTwenty-one studies were finally identified, most of which at unclear risk of bias. Root resorption was shown to increase in Vitamin C treated animals in comparison with the control group, whereas a comparative decrease was noted after the administration of the alendronate, ibuprofen, growth hormone, low doses of meloxicam, simvastatin, lithium chloride and strontium ranelate. No difference was noted for acetaminophen, aspirin, fluoxetine, atorvastatin, misoprostol, zoledronic acid and zinc. Finally, inconsistent effects were observed after the administration of celecoxib, prednisolone and L-thyroxine. The quality of the available evidence was considered at best as low.ConclusionsThe pharmaceutical substances investigated were shown to exhibit variable effects on root resorption. Although the overall quality of evidence provides the clinician with a cautious perspective on the strength of the relevant recommendations, good practice would suggest that it is important to identify patients consuming medications and consider the possible implications.RegistrationPROSPERO (CRD42017078208)

scholarly journals Predictability of rotational tooth movement with orthodontic aligners comparing software-based and achieved data: A systematic review and meta-analysis of observational studies

2021 ◽  
pp. 146531252110272
Author(s):  
Despina Koletsi ◽  
Anna Iliadi ◽  
Theodore Eliades
Keyword(s):  
Effect Size ◽  
Tooth Movement ◽  
Data Extraction ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Patient Treatment ◽  
Qualitative Synthesis ◽  
Meta Analyses ◽  
Enamel Reduction

Objective: To evaluate all available evidence on the prediction of rotational tooth movements with aligners. Data sources: Seven databases of published and unpublished literature were searched up to 4 August 2020 for eligible studies. Data selection: Studies were deemed eligible if they included evaluation of rotational tooth movement with any type of aligner, through the comparison of software-based and actually achieved data after patient treatment. Data extraction and data synthesis: Data extraction was done independently and in duplicate and risk of bias assessment was performed with the use of the QUADAS-2 tool. Random effects meta-analyses with effect sizes and their 95% confidence intervals (CIs) were performed and the quality of the evidence was assessed through GRADE. Results: Seven articles were included in the qualitative synthesis, of which three contributed to meta-analyses. Overall results revealed a non-accurate prediction of the outcome for the software-based data, irrespective of the use of attachments or interproximal enamel reduction (IPR). Maxillary canines demonstrated the lowest percentage accuracy for rotational tooth movement (three studies: effect size = 47.9%; 95% CI = 27.2–69.5; P < 0.001), although high levels of heterogeneity were identified (I2: 86.9%; P < 0.001). Contrary, mandibular incisors presented the highest percentage accuracy for predicted rotational movement (two studies: effect size = 70.7%; 95% CI = 58.9–82.5; P < 0.001; I2: 0.0%; P = 0.48). Risk of bias was unclear to low overall, while quality of the evidence ranged from low to moderate. Conclusion: Allowing for all identified caveats, prediction of rotational tooth movements with aligner treatment does not appear accurate, especially for canines. Careful selection of patients and malocclusions for aligner treatment decisions remain challenging.

scholarly journals Does the rate of orthodontic tooth movement change during the estrus cycle? A systematic review based on animal studies

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Noura Saeed Sultan Almidfa ◽  
Athanasios E. Athanasiou ◽  
Miltiadis A. Makrygiannakis ◽  
Eleftherios G. Kaklamanos
Keyword(s):  
Animal Studies ◽  
Tooth Movement ◽  
Citation Index ◽  
Cochrane Review ◽  
Orthodontic Tooth Movement ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Hormonal Changes ◽  
Estrus Cycle ◽  
Russian Science Citation Index

Abstract Background As the fluctuation of sex hormone levels in menstruating women results in periodical effects in bone metabolism, understanding the implications for tooth movement could be of benefit to the orthodontist. This type of research presents practical and ethical problems in humans, but animal models could provide useful information. Our objective was to systematically investigate the available evidence on the question whether the rate of orthodontic tooth movement varies between the different stages of the estrus cycle in animals. Methods Unrestricted searches in 7 databases and manual searching of the reference lists in relevant studies were performed up to February 2021 (Medline [PubMed], CENTRAL [Cochrane Library; includes records from Embase, CINAHL, ClinicalTrials.gov, WHO's ICTRP, KoreaMed, Cochrane Review Groups’ Specialized Registers, and records identified by handsearching], Cochrane Database of Systematic Reviews [Cochrane Library], Scopus, Web of Knowledge [including Web of Science Core Collection, KCI Korean Journal Database, Russian Science Citation Index, SciELO Citation Index and Zoological Record], Arab World Research Source [EBSCO] and ProQuest Dissertation and Theses [ProQuest]). Our search focused on prospective controlled animal studies, whose samples included female subjects of any species that were quantitatively comparing the amount of tooth movement in the different stages of the estrus cycle. Following study retrieval and selection, relevant data was extracted, and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool. Results From the finally assessed records, 3 studies met the inclusion criteria. Two of the studies experimented on Wistar rats, whereas the other on cats. Tooth movement was induced by expansion or coil springs. The rate of orthodontic tooth movement was increased during the stages of the estrus cycle when oestrogen and/or progesterone levels were lower. The risk of bias in the retrieved studies was assessed to be unclear. Conclusion Hormonal changes during the estrus cycle may affect the rate of orthodontic tooth movement. Although these animal experiment results should be approached cautiously regarding their translational potential, it could be useful to consider the possible impact of these physiological changes in the clinical setting until more information becomes available. Registration: PROSPERO (CRD42021158069).

The effects of orthodontic tooth movement in endodontically treated teeth

2019 ◽  
pp. 12-15
Author(s):  
Sabrina Haque ◽  
Mehreen Zakir
Keyword(s):  
Root Canal ◽  
Orthodontic Treatment ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Dental Tissue ◽  
Endodontically Treated Teeth ◽  
Orthodontic Force ◽  
Treatment Application

There are no relevant contraindications to orthodontic treatment of previously endodontically treated teeth, considering the quality of the obturated teeth, the health of the periodontal membrane, along with careful application of orthodontic force. Although, there is usually some degree of reversible or transient pulpal inflammation  even  in  healthy  teeth  during  orthodontic  treatment,  application  of  light  and  intermittent orthodontic force will reduce the risks provided sufficient time is given to allow proper repair of the dental tissue.  However,  there  may  be  a  few  hazards  associated  with  the  treatment  of  endodontically  involved teeth, some of which mainly include root resorption and ankylosis. This article will show some cases of teeth which had undergone  root canal treatment prior to orthodontic management and further observed whether orthodontic tooth movement had caused any resorption in the root filled teeth.  Root canal treated teeth can be moved orthodontically to the same extent as vital teeth, providing, a controlled force applica- tion to avoid risk of inflammatory root resorption. Ban J Orthod & Dentofac Orthop, April 2017; Vol-7 (1-2), P.12-15

Does medication administration affect the rate of orthodontic tooth movement and root resorption development in humans? A systematic review

2019 ◽  
Vol 42 (4) ◽  
pp. 407-414 ◽  
Author(s):  
Eleftherios G Kaklamanos ◽  
Miltiadis A Makrygiannakis ◽  
Athanasios E Athanasiou
Keyword(s):  
Animal Studies ◽  
Tooth Movement ◽  
Root Resorption ◽  
Human Subjects ◽  
Data Extraction ◽  
Grey Literature ◽  
Orthodontic Tooth Movement ◽  
Medication Administration ◽  
Risk Of Bias ◽  
Local Injections

Summary Background Recently, the potential impact of different medications on the rate of orthodontic tooth movement and the associated root resorption has been systematically reviewed in animal studies and various effects have been shown. However, animal data cannot be extrapolated to human clinical situations directly. Objectives To systematically investigate the most up to date available evidence from controlled human studies regarding the effect of medication administration on the rate of orthodontic tooth movement and associated root resorption development. Search methods We searched eight databases (covering also grey literature) without restrictions and we performed hand searching up until October 2018. Selection criteria Controlled studies in humans assessing the effect of various medications on the rate of orthodontic tooth movement and root resorption development. Data collection and analysis Study selection was followed by data extraction and risk of bias assessment using the ROBINS-I tool for non-randomized and the Cochrane Risk of Bias Tool for randomized studies. Results Eight studies, at various risk of bias, were finally identified. With regard to the rate of orthodontic tooth movement, local injections of prostaglandin E1 were found to exert an increasing effect, whereas systemic intake of nabumetone decreased it. Following tenoxicam administration, drinking water with fluoride or local injections of calcitriol (vitamin D metabolite), no significant effects were demonstrated. Concerning root resorption development, nabumetone administration was shown to reduce it, whereas fluoride, overall, was not observed to exert any effect. Only in individuals subjected to heavy orthodontic forces, did fluoride show a protective effect for the period of force application, but not in the longer term during retention. Conclusions The aforementioned substances may show varying effects on the rate of orthodontic tooth movement and root resorption development in human subjects. Despite the observed limitations, the orthodontist should be able to identify patients taking pharmaceuticals and consider any implications related to orthodontic treatment. Registration PROSPERO (CRD42017078208).

scholarly journals Effect of orthodontic forces on levels of enzymes in gingival crevicular fluid (GCF): A systematic review

2019 ◽  
Vol 24 (2) ◽  
pp. 40.e1-40.e22 ◽  
Author(s):  
Priyanka Kapoor ◽  
Nitika Monga ◽  
Om Prakash Kharbanda ◽  
Sunil Kapila ◽  
Ragini Miglani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acid Phosphatase ◽  
Tooth Movement ◽  
Gingival Crevicular Fluid ◽  
Orthodontic Tooth Movement ◽  
Tartrate Resistant Acid Phosphatase ◽  
Orthodontic Force ◽  
Hand Search ◽  
Force Application ◽  
Crevicular Fluid

Abstract Objective: Orthodontic force application releases multiple enzymes in gingival crevicular fluid (GCF) for activation, resorption, reversal, deposition of osseous elements and extracellular matrix degradation. The current systematic review critically evaluated all existing evidence on enzymes in orthodontic tooth movement. Methods: Literature was searched with predetermined search strategy on electronic databases (PubMed, Scopus, Embase), along with hand search. Results: Initial search identified 652 studies, shortlisted to 52 studies based on PRISMA. Quality assessment further led to final inclusion of 48 studies (13 moderately and 35 highly sensitive studies). Primary outcomes are significant upregulation in GCF levels of enzymes-aspartate aminotransferase (AST), alkaline phosphatase (ALP), matrix metalloproteinases (MMPs), lactate dehydrogenase (LDH), β-glucuronidase (βG), tartrate resistant acid phosphatase (TRAP), acid phosphatase (ACP) and down regulation in cathepsin B (Cb). Site specificity is shown by ALP, TRAP, AST, LDH, MMP9 with levels at compression site increasing earlier and in higher quantities compared with tension site. ALP levels are higher at tension site only in retention. A positive correlation of LDH, ALP and AST is also observed with increasing orthodontic force magnitude. Conclusions: A strong evidence of variation in enzymes (ALP, AST, ACP TRAP, LDH, MMPs, Cb) in GCF is found in association with different magnitude, stages and sites of orthodontic force application.

scholarly journals The effectiveness of locally injected platelet-rich plasma on orthodontic tooth movement acceleration:

2021 ◽  
Author(s):  
Ziyu Li ◽  
Jialiang Zhou ◽  
Song Chen
Keyword(s):  
Systematic Review ◽  
Animal Studies ◽  
Tooth Movement ◽  
Platelet Rich Plasma ◽  
Orthodontic Tooth Movement ◽  
Risk Of Bias ◽  
Current Evidence ◽  
Secondary Outcome ◽  
Histological Changes ◽  
Significant Difference

ABSTRACT Objectives To critically appraise the current evidence available from animal studies pertaining to the effectiveness of platelet-rich plasma (PRP) in accelerating orthodontic tooth movement. Materials and Methods Electronic searches of nine databases were conducted up to June 2020, followed by a hand search of the reference list of eligible studies. The study design required was prospective controlled animal studies. The primary outcome assessed was the rate of orthodontic tooth movement. The secondary outcome evaluated was histological changes after PRP application. Following study retrieval and selection, relevant data were extracted. Risk-of-bias (RoB) assessment was done using the Systematic Review Center for Laboratory Animal Experimentation's Risk of Bias Tool (SYRCLE's Risk of Bias Tool). Two review authors conducted the work of searching, study selection, and quality assessment independently and in duplicate. Results Of 193 studies, 5 animal studies were included in this systematic review. Three studies found a positive correlation between PRP injection and tooth movement acceleration, along with corresponding histological changes. Two studies detected no significant difference in tooth movement rate after PRP application. Conclusions Based on the current limited evidence, the efficacy of PRP on tooth movement acceleration remains debatable. More well-designed randomized controlled trials involving humans are called for to obtain more clinically significant conclusions.

scholarly journals Platelet-rich plasma: Its applications in orthodontics – A systematic review

2021 ◽  
Vol 11 ◽  
pp. 235-246
Author(s):  
Kanchan Prafulla Narkhede ◽  
Wasundhara Bhad ◽  
Santosh J. Chavan
Keyword(s):  
Systematic Review ◽  
Animal Studies ◽  
Tooth Movement ◽  
Platelet Rich Plasma ◽  
Human Subjects ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Non Invasive ◽  
Invasive Method

Objectives: The aim of this systematic review was to assess the available literature for the effects of platelet-rich plasma (PRP) in orthodontics. Material and Methods: This review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines (PRISMA). The following databases were searched up to May 2020: Medline (through PubMed), Cochrane, and Google Scholar, and reference lists of the included studies were screened. Randomized controlled trials (RCTs) and controlled clinical trials using PRP an adjunct with the standard orthodontic procedures including animal and human subjects as participants were included in the study. The quality of the included human RCTs was assessed per the revised Cochrane risk-of-bias tool for randomized trials (RoB 2.0), whereas the risk of bias of the included animal studies was assessed using SYRCLES’s RoB tool. Results: Eight studies, six animal and two human studies, fulfilled the inclusion criteria. Three animal studies and one human RCT reported that PRP increased the rate of tooth movement when used as an adjunct along with orthodontic treatment. Conclusion: According to the currently available literature, PRP is an efficient non-invasive method of tooth acceleration, but as most of the studies carried are on animals and cannot be applied to humans indistinctly.

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