Effects of systemic medication on root resorption associated with orthodontic tooth movement: a systematic review of animal studies

2018 ◽  
Vol 41 (4) ◽  
pp. 346-359 ◽  
Author(s):  
Miltiadis A Makrygiannakis ◽  
Eleftherios G Kaklamanos ◽  
Athanasios E Athanasiou
Keyword(s):  
Animal Studies ◽  
Tooth Movement ◽  
Root Resorption ◽  
Arab World ◽  
Good Practice ◽  
Orthodontic Tooth Movement ◽  
Risk Of Bias ◽  
Control Group ◽  
Systemic Medication

SummaryBackgroundTheoretically, root resorption could be modulated by any medication taken that exhibits possible effects on the implicated molecular pathways.ObjectivesTo systematically investigate and appraise the quality of the available evidence from animal studies, regarding the effect of commonly prescribed systemic medication on root resorption associated with orthodontic tooth movement.Search methodsSearch without restrictions in eight databases (PubMed, Central, Cochrane Database of Systematic Reviews, SCOPUS, Web of Science, Arab World Research Source, ClinicalTrials.gov, ProQuest Dissertations and Theses Global) and hand searching until April 2018 took place. One author developed detailed search strategies for each database that were based on the PubMed strategy and adapted accordingly.Selection criteriaControlled studies investigating the effect of systemic medications on root resorption associated with orthodontic tooth movement.Data collection and analysisFollowing study retrieval and selection, relevant data were extracted and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool.ResultsTwenty-one studies were finally identified, most of which at unclear risk of bias. Root resorption was shown to increase in Vitamin C treated animals in comparison with the control group, whereas a comparative decrease was noted after the administration of the alendronate, ibuprofen, growth hormone, low doses of meloxicam, simvastatin, lithium chloride and strontium ranelate. No difference was noted for acetaminophen, aspirin, fluoxetine, atorvastatin, misoprostol, zoledronic acid and zinc. Finally, inconsistent effects were observed after the administration of celecoxib, prednisolone and L-thyroxine. The quality of the available evidence was considered at best as low.ConclusionsThe pharmaceutical substances investigated were shown to exhibit variable effects on root resorption. Although the overall quality of evidence provides the clinician with a cautious perspective on the strength of the relevant recommendations, good practice would suggest that it is important to identify patients consuming medications and consider the possible implications.RegistrationPROSPERO (CRD42017078208)

scholarly journals Does exogenous female sex hormone administration affect the rate of tooth movement and root resorption? A systematic review of animal studies

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257778
Author(s):  
Eleftherios G. Kaklamanos ◽  
Miltiadis A. Makrygiannakis ◽  
Athanasios E. Athanasiou
Keyword(s):  
Sex Hormones ◽  
Animal Studies ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Risk Of Bias ◽  
Female Sex ◽  
Female Sex Hormones

Background The long-term use of contraceptive methods that contain estrogens, progestogens or combinations of the above among women aged 15 to 49 years is extensive. Both estrogens and progestogens affect bone metabolism. Objective To systematically investigate and appraise the quality of the available evidence from animal studies regarding the impact of exogenous administration of female sex hormones on the rate of orthodontic tooth movement and root resorption. Search methods Search without restriction in seven databases (including grey literature) and hand searching were performed until May 2021. Selection criteria We looked for controlled animal studies investigating the effect from exogenous administration of formulations containing female sex hormones on the rate of orthodontic tooth movement and root resorption. Data collection and analysis After study retrieval and selection, relevant data was extracted, and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool. The quality of available evidence was assessed with the Grades of Recommendation, Assessment, Development, and Evaluation. Results Three studies were identified, all being at unclear risk of bias. Overall, administration of progesterone and the combinations of estradiol with norgestrel and desogestrel were shown to significantly decrease the rate of orthodontic tooth movement when given for longer periods (>3 weeks). Inconsistent information was detected for shorter periods of consumption. Estradiol, with desogestrel use, resulted in less root resorption. The quality of the available evidence was considered to be low. Conclusions Exogenous administration of female sex hormones may decelerate in the long term the rate of tooth movement and decrease orthodontically induced root resorption in animals. Until more information becomes available, an orthodontist should be able to identify a patient consuming such substances and understand the potential clinical implications and adverse effects that may arise. Registration PROSPERO: CRD42017078208; https://clinicaltrials.gov/.

Does medication administration affect the rate of orthodontic tooth movement and root resorption development in humans? A systematic review

2019 ◽  
Vol 42 (4) ◽  
pp. 407-414 ◽  
Author(s):  
Eleftherios G Kaklamanos ◽  
Miltiadis A Makrygiannakis ◽  
Athanasios E Athanasiou
Keyword(s):  
Animal Studies ◽  
Tooth Movement ◽  
Root Resorption ◽  
Human Subjects ◽  
Data Extraction ◽  
Grey Literature ◽  
Orthodontic Tooth Movement ◽  
Medication Administration ◽  
Risk Of Bias ◽  
Local Injections

Summary Background Recently, the potential impact of different medications on the rate of orthodontic tooth movement and the associated root resorption has been systematically reviewed in animal studies and various effects have been shown. However, animal data cannot be extrapolated to human clinical situations directly. Objectives To systematically investigate the most up to date available evidence from controlled human studies regarding the effect of medication administration on the rate of orthodontic tooth movement and associated root resorption development. Search methods We searched eight databases (covering also grey literature) without restrictions and we performed hand searching up until October 2018. Selection criteria Controlled studies in humans assessing the effect of various medications on the rate of orthodontic tooth movement and root resorption development. Data collection and analysis Study selection was followed by data extraction and risk of bias assessment using the ROBINS-I tool for non-randomized and the Cochrane Risk of Bias Tool for randomized studies. Results Eight studies, at various risk of bias, were finally identified. With regard to the rate of orthodontic tooth movement, local injections of prostaglandin E1 were found to exert an increasing effect, whereas systemic intake of nabumetone decreased it. Following tenoxicam administration, drinking water with fluoride or local injections of calcitriol (vitamin D metabolite), no significant effects were demonstrated. Concerning root resorption development, nabumetone administration was shown to reduce it, whereas fluoride, overall, was not observed to exert any effect. Only in individuals subjected to heavy orthodontic forces, did fluoride show a protective effect for the period of force application, but not in the longer term during retention. Conclusions The aforementioned substances may show varying effects on the rate of orthodontic tooth movement and root resorption development in human subjects. Despite the observed limitations, the orthodontist should be able to identify patients taking pharmaceuticals and consider any implications related to orthodontic treatment. Registration PROSPERO (CRD42017078208).

scholarly journals Effect of pharmacological agents on relapse following orthodontic tooth movement:

2020 ◽  
Vol 90 (4) ◽  
pp. 598-606
Author(s):  
Prabhakar Veginadu ◽  
Santosh Rahul Tavva ◽  
Vizia Muddada ◽  
Suresh Gorantla
Keyword(s):  
Animal Studies ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Risk Of Bias ◽  
Evaluation Tool ◽  
Qualitative Synthesis ◽  
Pharmacological Agents ◽  
Orthodontic Force ◽  
Hand Search

ABSTRACT Objectives To investigate and synthesize systematically the evidence from animal studies pertaining to the effect of pharmacological agents on tooth movement relapse following cessation of orthodontic force application. Materials and Methods An electronic search was conducted in seven online databases (including gray sources) without restrictions until the third week of April 2019, followed by a hand search in the reference lists of eligible articles. Controlled animal studies investigating the effect of pharmacological agents on tooth movement relapse following orthodontic treatment were selected. Relevant data were extracted from eligible studies and the risk of bias assessment was done using SYRCLE's risk of bias tool. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation tool. Results The search identified 2354 records, of which 7 studies were deemed eligible for inclusion in the qualitative synthesis, with the majority presenting an unclear risk of bias. Orthodontic relapse was shown to decrease with the administration of pamidronate disodium, atorvastatin, aspirin, and chemically modified tetracycline-3. Inconsistent effects on relapse were observed after the use of simvastatin. The overall quality of retrieved evidence was assessed as low at best. Conclusions The available evidence shows that the investigated pharmacological agents may demonstrate variable effects on tooth movement relapse following cessation of orthodontic force. Additional evidence of higher quality is required to draw definitive conclusions on their effects and to make potential recommendations for clinical application.

Does long-term use of pain relievers have an impact on the rate of orthodontic tooth movement? A systematic review of animal studies

2018 ◽  
Vol 41 (5) ◽  
pp. 468-477 ◽  
Author(s):  
Miltiadis A Makrygiannakis ◽  
Eleftherios G Kaklamanos ◽  
Athanasios E Athanasiou
Keyword(s):  
Pain Relief ◽  
Animal Studies ◽  
Tooth Movement ◽  
Grey Literature ◽  
Orthodontic Tooth Movement ◽  
Risk Of Bias ◽  
Data Collection And Analysis ◽  
High Doses

Summary Background Pain relief drugs are used and misused widely and may theoretically affect the events leading to orthodontic tooth movement. Objective To systematically investigate and appraise the quality of the available evidence regarding the effect of pain relief medications on the rate of orthodontic tooth movement. Search methods Search without restrictions in eight databases (including grey literature) and hand searching until October 2018. Selection criteria Animal controlled studies investigating the effect of pain relievers on the rate of orthodontic tooth movement. Data collection and analysis Following study retrieval and selection, relevant data were extracted and the risk of bias was assessed using the SYRCLE’s risk of bias tool. Results Fourteen studies were finally identified, most of which at unclear risk of bias. Ibuprofen and loxoprofen did not show any significant effects on the rate of orthodontic tooth movement, whereas indomethacin, ketorolac, morphine, and high doses of etoricoxib were found to decrease it. Inconsistent or conflicting effects were noted after the administration of acetaminophen, acetylsalicylic acid, celecoxib, meloxicam, and tramadol. The quality of the available evidence was considered at best as low. Conclusions Long-term consumption of pain relievers may affect the rate of orthodontic tooth movement. The orthodontist should be capable of identifying patients taking pain relievers independently of orthodontic treatment and consider the possible implications. Trial registration PROSPERO (CRD42017078208).

scholarly journals Effect of nicotine exposure on the rate of orthodontic tooth movement: A meta-analysis based on animal studies

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247011
Author(s):  
Sanjay Jyothish ◽  
Athanasios E. Athanasiou ◽  
Miltiadis A. Makrygiannakis ◽  
Eleftherios G. Kaklamanos
Keyword(s):  
Animal Studies ◽  
Cell Function ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Risk Of Bias ◽  
Control Group ◽  
Nicotine Exposure ◽  
Force Application ◽  
Clinical Scenarios ◽  
Meta Regression

Background Nicotine exposure has been reported to modify bone cell function and the osseous metabolism with potential effects on the rate of orthodontic tooth movement. Objectives To systematically investigate and quantitively synthesize the most recent available evidence from animal studies regarding the effect of nicotine exposure on the rate of orthodontic tooth movement. Search methods Unrestricted searches in 7 databases and hand searching were performed until July 2020 (PubMed, Central, Cochrane Database of Systematic Reviews, SCOPUS, Web of Science, Arab World Research Source, ProQuest Dissertations and Theses Global). Selection criteria We searched for controlled studies on healthy animals investigating the effect of nicotine on the rate of orthodontic tooth movement. Data collection and analysis Following study retrieval and selection, relevant data was extracted and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool. Exploratory synthesis and meta-regression were carried out using the random effects model. Results From the initially identified records, 5 articles meeting the inclusion criteria were selected and no specific concerns regarding bias were identified. Quantitative data synthesis showed that the rate of orthodontic tooth movement in the nicotine exposed rats was higher than in the control group animals (2 weeks of force application; 0.317 mm more movement in nicotine exposed rats; 95% Confidence Interval: 0.179–0.454; p = 0.000). No effect of the concentration or the duration force application was demonstrated following exploratory meta-regression. Conclusion Rats administered with nicotine showed accelerated rates of orthodontic tooth movement. Although, information from animal studies cannot be fully translated to human clinical scenarios, safe practice would suggest that the orthodontist should be able to identify patients exposed to nicotine and consider the possible implications for everyday clinical practice.

scholarly journals Does the rate of orthodontic tooth movement change during the estrus cycle? A systematic review based on animal studies

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Noura Saeed Sultan Almidfa ◽  
Athanasios E. Athanasiou ◽  
Miltiadis A. Makrygiannakis ◽  
Eleftherios G. Kaklamanos
Keyword(s):  
Animal Studies ◽  
Tooth Movement ◽  
Citation Index ◽  
Cochrane Review ◽  
Orthodontic Tooth Movement ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Hormonal Changes ◽  
Estrus Cycle ◽  
Russian Science Citation Index

Abstract Background As the fluctuation of sex hormone levels in menstruating women results in periodical effects in bone metabolism, understanding the implications for tooth movement could be of benefit to the orthodontist. This type of research presents practical and ethical problems in humans, but animal models could provide useful information. Our objective was to systematically investigate the available evidence on the question whether the rate of orthodontic tooth movement varies between the different stages of the estrus cycle in animals. Methods Unrestricted searches in 7 databases and manual searching of the reference lists in relevant studies were performed up to February 2021 (Medline [PubMed], CENTRAL [Cochrane Library; includes records from Embase, CINAHL, ClinicalTrials.gov, WHO's ICTRP, KoreaMed, Cochrane Review Groups’ Specialized Registers, and records identified by handsearching], Cochrane Database of Systematic Reviews [Cochrane Library], Scopus, Web of Knowledge [including Web of Science Core Collection, KCI Korean Journal Database, Russian Science Citation Index, SciELO Citation Index and Zoological Record], Arab World Research Source [EBSCO] and ProQuest Dissertation and Theses [ProQuest]). Our search focused on prospective controlled animal studies, whose samples included female subjects of any species that were quantitatively comparing the amount of tooth movement in the different stages of the estrus cycle. Following study retrieval and selection, relevant data was extracted, and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool. Results From the finally assessed records, 3 studies met the inclusion criteria. Two of the studies experimented on Wistar rats, whereas the other on cats. Tooth movement was induced by expansion or coil springs. The rate of orthodontic tooth movement was increased during the stages of the estrus cycle when oestrogen and/or progesterone levels were lower. The risk of bias in the retrieved studies was assessed to be unclear. Conclusion Hormonal changes during the estrus cycle may affect the rate of orthodontic tooth movement. Although these animal experiment results should be approached cautiously regarding their translational potential, it could be useful to consider the possible impact of these physiological changes in the clinical setting until more information becomes available. Registration: PROSPERO (CRD42021158069).

scholarly journals Effect of Methotrexate Injection on Orthodontic Tooth Movement: An Experimental Study on Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Amin Golshah ◽  
Khaled Omidi ◽  
Nafiseh Nikkerdar ◽  
Hedaiat Moradpoor ◽  
Fatemeh Ghorbani
Keyword(s):  
Blood Vessels ◽  
Orthodontic Treatment ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Volume Ratio ◽  
Negative Control Group ◽  
Negative Control ◽  
Bone Volume ◽  
Control Group

Introduction. Knowledge about the effects of medications, vitamins, and various supplements on orthodontic tooth movement (OTM) is imperative for orthodontists. This study aimed to assess the effect of methotrexate (MTX) injection on OTM in rats. Materials and Methods. Twenty-eight male Wistar rats were randomized into four groups (n = 7). The first molar and central incisor were connected using a nickel-titanium (NiTi) coil spring with a 50 g load in each rat. The two experimental groups received 0.75 mg/kg and 1.5 mg/kg MTX, respectively, intraperitoneally for 21 days. The negative control group did not receive any injection and did not undergo orthodontic treatment. The positive control group underwent orthodontic treatment and received 0.9% saline (NaCl) injections for 21 days. All rats were sacrificed with chloroform inhalation after 21 days; their maxilla was resected, and the mean number of Howship’s lacunae, blood vessels, osteoclasts, and resorption lacunae was counted. The reduction in bone volume (bone volume to total volume ratio (BV/TV)) at the site of the maxillary molar was quantified by microcomputed tomography (micro-CT). Results. OTM, the number of osteoclasts, and the number of blood vessels significantly increased in rats treated with MTX ( P < 0.05 ). However, the increase in the number of Howship’s lacunae and resorption lacunae was not significant ( P > 0.05 ). Lower BV/TV in the MTX groups was in agreement with the increased number of osteoclasts. Conclusion. Injection of MTX can significantly increase OTM and decrease root resorption in rats.

scholarly journals Effects of Gradually Increasing Force Generated by Permanent Rare Earth Magnets for Orthodontic Tooth Movement

2006 ◽  
Vol 76 (6) ◽  
pp. 1004-1009 ◽  
Author(s):  
Ryo Tomizuka ◽  
Hiroyasu Kanetaka ◽  
Yoshinaka Shimizu ◽  
Akihiro Suzuki ◽  
Kaoru Igarashi ◽  
...  
Keyword(s):  
Rare Earth ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Male Rats ◽  
Control Group ◽  
Pathological Changes ◽  
Group I ◽  
Group Ii ◽  
Experimental Group

Abstract Objective: To examine the effects of gradually increasing force generated by permanent rare earth magnets for orthodontic tooth movement by using a novel experimental rat model and computer simulation. Materials and Methods: Fifty-five male rats (age 18 weeks) were used as animal experiments. Magnetic (experimental groups) or titanium (control group) cuboids (1.5 × 1.5 × 0.7 mm) were bonded to the lingual surface of the maxillary first molars. The initial distance between materials was 1.0 mm, generating 4.96 gf (experimental group I), or 1.5 mm, generating 2.26 gf (experimental group II). Tooth movement was measured and periodontal structures were observed with microfocus x-ray computed tomography radiographs. Results: The distance between the magnets decreased with time in experimental groups I and II (P &lt; .001), whereas there was no tooth displacement in the control group. Experimental group I showed rapid tooth movement in the initial phase followed by slower tooth movement. Experimental group II showed gradual tooth movement. Horizontal sections on microfocus computed tomgraphy radiographs revealed no pathological changes, such as root resorption, on the compressed side in the experimental groups. Conclusions: The initial light force and gradual increasing force in magnetic attractive force induced effective tooth movement in rats without inducing any pathological changes.

scholarly journals Effect of a DPP-4 Inhibitor on Orthodontic Tooth Movement and Associated Root Resorption

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Jiawei Qi ◽  
Hideki Kitaura ◽  
Wei-Ren Shen ◽  
Saika Ogawa ◽  
Fumitoshi Ohori ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Pcr Analysis ◽  
Control Group ◽  
Dipeptidyl Peptidase 4 ◽  
And Control ◽  
Phosphate Buffered Saline ◽  
Necrosis Factor

Objectives. Dipeptidyl peptidase-4 (DPP-4) inhibitors are used as a treatment for type 2 diabetes mellitus and have also recently been applied to enhance bone quality and density, and increase the expression of bone markers. This study aimed to investigate the effect of a DPP-4 inhibitor on orthodontic tooth movement (OTM) and related root resorption in a mouse model. Materials and Methods. Mice were randomly divided into three groups: those undergoing OTM with the addition of a DPP-4 inhibitor (30 μg), those undergoing OTM and receiving phosphate-buffered saline (PBS), and those without force loading (control group). OTM was achieved by means of a nickel–titanium closed coil spring that moved the first molar in a mesial direction for 12 days. The distance of OTM was measured using silicone impression. Maxillae were removed for histological analysis or real-time PCR analysis. Results. The distance of OTM and the number of osteoclasts were significantly decreased after administration of the DPP-4 inhibitor, which also significantly suppressed the number of odontoclasts and root resorption after OTM. Furthermore, the mRNA expression of tumour necrosis factor-α (TNF-α) and the receptor activator of nuclear factor kappa-B ligand (RANKL) were decreased in DPP-4 inhibitor-treated mice compared with those receiving PBS and control animals. Conclusion. The DPP-4 inhibitor inhibited tooth movement and associated root resorption by blocking the formation of osteoclasts and odontoclasts, respectively. It also appeared to inhibit osteoclastogenesis and odontoclastogenesis by suppressing the expression of TNF-α and/or RANKL.

The effects of orthodontic tooth movement in endodontically treated teeth

2019 ◽  
pp. 12-15
Author(s):  
Sabrina Haque ◽  
Mehreen Zakir
Keyword(s):  
Root Canal ◽  
Orthodontic Treatment ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Dental Tissue ◽  
Endodontically Treated Teeth ◽  
Orthodontic Force ◽  
Treatment Application

There are no relevant contraindications to orthodontic treatment of previously endodontically treated teeth, considering the quality of the obturated teeth, the health of the periodontal membrane, along with careful application of orthodontic force. Although, there is usually some degree of reversible or transient pulpal inflammation  even  in  healthy  teeth  during  orthodontic  treatment,  application  of  light  and  intermittent orthodontic force will reduce the risks provided sufficient time is given to allow proper repair of the dental tissue.  However,  there  may  be  a  few  hazards  associated  with  the  treatment  of  endodontically  involved teeth, some of which mainly include root resorption and ankylosis. This article will show some cases of teeth which had undergone  root canal treatment prior to orthodontic management and further observed whether orthodontic tooth movement had caused any resorption in the root filled teeth.  Root canal treated teeth can be moved orthodontically to the same extent as vital teeth, providing, a controlled force applica- tion to avoid risk of inflammatory root resorption. Ban J Orthod & Dentofac Orthop, April 2017; Vol-7 (1-2), P.12-15

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