Microalbuminuria Is Common in Japanese Type 2 Diabetic Patients: A nationwide survey from the Japan Diabetes Clinical Data Management Study Group (JDDM 10)

Background: Hypothyroidism is an endocrine disorder resulting from deficiency of thyroid hormones, and Diabetes is a metabolic disorder that share the phenotype of hyperglycaemia. Both the endocrinopathies have been found to be associated with dyslipidaemia and atherosclerosis that result into various complications. Our aim was to assess the difference of dyslipidaemia in patients suffering from hypothyroidism with diabetes as compared to diabetes alone.Methods: Study was conducted in department of medicine in SGRDIMSR, Sri Amritsar. A total of 120 patients were enrolled for the present study, the one who presented to hospital from January 2018 to August 2019 diagnosed with diabetes mellitus type 2. The patients were divided into two groups. 60 patients having type 2 diabetes without hypothyroidism (control group). 60 patients having type 2 diabetes with hypothyroidism (study group). Fasting lipid profile were performed in both the groups and were analysed for the study.Results: Dyslipidaemia was seen more in study group as compared to control group with mean cholesterol of 488.3(±144.43) and mean triglyceride levels of 354.30(±128.57) in study group as compared to control group with mean cholesterol and triglyceride levels of 179.7(±81.47) and 177.08(±118.18) with p-value of 0.001 and 0.01 respectively which were significant. Also, obesity and diabetic complication were more in patients of dual endocrinopathies as compared to diabetes alone which were also significant statistically.Conclusions: From our study it is concluded that type 2 diabetes with hypothyroidism causes more dyslipidaemia as compare to type 2 diabetes alone. So proper screening of thyroid profile of type 2 diabetic patients and its correction helps in achieving better lipidemic control which further prevent complications.

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HDL & LDL Status in Untreated Newly Detected Type 2 Diabetic Patients

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v14i1.22877 ◽

2015 ◽

Vol 14 (1) ◽

pp. 31-33

Author(s):

Abu Tarek Iqbal ◽

M Jalal Uddin ◽

Md Salehuddin ◽

Hasan Murad

Keyword(s):

Type 2 Diabetes ◽

Risk Factor ◽

Microvascular Complications ◽

Diabetic Patients ◽

Study Group ◽

Type Ii ◽

Newly Diagnosed ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

Objective: The study was conducted with a view to find out HDL & LDL status in newly detected untreated Type II diabetic patients. Methods: Study was carried out on 116 (66 male & 50 female) newly diagnosed untreated type 2 diabetes patients aged 40 - 65 years and were selected randomly for study. Fifty (25 male & 25 female) non diabetic subjects aged 40 - 65 years were randomly selected as control. Results: LDL - C was significantly higher (P<.0001) and HDL -C was significantly lower (<.0001) in study group in comparison to control group.Conclusion: Dyslipidemia is commonly found in type - 2 diabetic patients. It is a risk factor for microvascular complications. So it should be controlled effectively. DOI: http://dx.doi.org/10.3329/cmoshmcj.v14i1.22877 Chatt Maa Shi Hosp Med Coll J; Vol.14 (1); Jan 2015; Page 31-33

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Role of Vitamin D as an Adjuvant to Oral Hypoglycemic Drugs in Treatment of Type-2 Diabetic Patients

Asian Journal of Medical Sciences ◽

10.3126/ajms.v11i2.26924 ◽

2020 ◽

Vol 11 (2) ◽

pp. 25-29

Author(s):

Sughandha Garg ◽

Debayan Mallik

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Control Group ◽

Diabetic Patients ◽

Study Group ◽

Type 2 Diabetic Patients ◽

Oral Hypoglycemic Drugs ◽

Type 2 Diabetic

Background: Type 2 diabetes mellitus (T2DM) is considered as one of the nonskeletal diseases related with deficiency of vitamin D. Both T2DM and vitamin D deficiency have similar risk factors, such as obesity, aging, and sedentary lifestyle. Cardiovascular diseases (CVDs) and metabolic syndrome disorders are also associated with vitamin D deficiency. Vitamin D plays an important functional role in glucose homeostasis through its effects on insulin secretion and sensitivity. It may reduce insulin resistance (IR) indirectly through its effect on calcium and phosphate metabolism and through upregulation of the insulin receptor gene. Thus, this study was designed to evaluate role of vitamin D as an adjuvant to oral hypoglycemic drugs in treatment of Type 2 diabetic patients. Aims and Objectives : Vitamin D deficiency appears to be related to the development of diabetes mellitus type 2 and the metabolic syndrome. Vitamin D may affect glucose homeostasis, vitamin D levels having been found to be inversely related to glycosylated hemoglobin levels in diabetes mellitus. The aim of the study was to evaluate role of vitamin D as an adjuvant to oral hypoglycemic drugs in treatment of Type 2 diabetic patients. Materials and Methods: The study was done on 60 patients diagnosed with T2DM. A total of 60 patients, control group were type 2 Diabetic patients on oral hypoglycemic drugs without vitamin D supplementation (n=30) and study group was type 2 Diabetic patients on oral hypoglycemic drugs with vitamin D supplementation (n=30). Results: The mean aged of patients was 43.27±8.80 in control group and 47.93±8.39 in study group. The family history of diabetes mellitus was 39 patients. HbA1C, FBG, Postprandial were decreased in study group as compared to control group from baseline (0 day) to 90 days, respectively. Other parameters like hemoglobin, Serum Creatinine serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase were slight changes in study group as compared to control group from baseline (0 day) to 90 days, respectively. Conclusion: The present study demonstrated that vitamin D as an adjuvant to oral hypoglycemic drugs in treatment in diabetic patients, vitamin D levels being related to glycemic control in diabetes mellitus type 2. These findings may have therapeutic implications as cautious vitamin D supplementation may improve glycemic control in diabetes mellitus type 2.

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Abstract #270 Knowledge; Attitude and Practice Among Cambodian Type 2 Diabetic Patients

Endocrine Practice ◽

10.1016/s1530-891x(20)47115-0 ◽

2018 ◽

Vol 24 ◽

pp. 66

Author(s):

Sum Satha ◽

Sophanara Min ◽

Sotharith Bory ◽

Yom An

Keyword(s):

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Attitude And Practice ◽

Knowledge Attitude And Practice ◽

Type 2 Diabetic

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Abstract #381 The Relation of Obesity, Insulin Resistance and Cardiovascular Risk in Type 2 Diabetic Patients in Sudan

Endocrine Practice ◽

10.1016/s1530-891x(20)46725-4 ◽

2019 ◽

Vol 25 ◽

pp. 174-175

Author(s):

Sulaf Abdelaziz ◽

Eltohami Dafalla

Keyword(s):

Insulin Resistance ◽

Cardiovascular Risk ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

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Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000673 ◽

2020 ◽

pp. 1-10

Author(s):

Giuseppe Derosa ◽

Angela D’Angelo ◽

Chiara Martinotti ◽

Maria Chiara Valentino ◽

Sergio Di Matteo ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Metabolic Control ◽

Vitamin D3 ◽

Therapy Group ◽

Hypoglycemic Agents ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

Abstract. Background: to evaluate the effects of Vitamin D3 on glyco-metabolic control in type 2 diabetic patients with Vitamin D deficiency. Methods: one hundred and seventeen patients were randomized to placebo and 122 patients to Vitamin D3. We evaluated anthropometric parameters, glyco-metabolic control, and parathormone (PTH) value at baseline, after 3, and 6 months. Results: a significant reduction of fasting, and post-prandial glucose was recorded in Vitamin D3 group after 6 months. A significant HbA1c decrease was observed in Vitamin D3 (from 7.6% or 60 mmol/mol to 7.1% or 54 mmol) at 6 months compared to baseline, and to placebo (p < 0.05 for both). At the end of the study period, we noticed a change in the amount in doses of oral or subcutaneous hypoglycemic agents and insulin, respectively. The use of metformin, acarbose, and pioglitazone was significantly lower (p = 0.037, p = 0.048, and p = 0.042, respectively) than at the beginning of the study in the Vitamin D3 therapy group. The units of Lispro, Aspart, and Glargine insulin were lower in the Vitamin D3 group at the end of the study (p = 0.031, p = 0.037, and p = 0.035, respectively) than in the placebo group. Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used.

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Evaluation of aortic arch calcification in type 2 diabetic patients

VASA ◽

10.1024/0301-1526.34.2.113 ◽

2005 ◽

Vol 34 (2) ◽

pp. 113-117 ◽

Cited By ~ 4

Author(s):

Papanas ◽

Symeonidis ◽

Maltezos ◽

Giannakis ◽

Mavridis ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Aortic Arch ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Insulin Dependence ◽

Artery Disease ◽

Type 2 Diabetic ◽

Aortic Arch Calcification

Background: The purpose of this study is to evaluate the severity of aortic arch calcification among type 2 diabetic patients in association with diabetes duration, diabetic complications, coronary artery disease and presence of cardiovascular risk factors. Patients and methods: This study included 207 type 2 diabetic patients (101 men) with a mean age of 61.5 ± 8.1 years and a mean diabetes duration of 13.9 ± 6.4 years. Aortic arch calcification was assessed by means of posteroanterior chest X-rays. Severity of calcification was graded as follows: grade 0 (no visible calcification), grade 1 (small spots of calcification or single thin calcification of the aortic knob), grade 2 (one or more areas of thick calcification), grade 3 (circular calcification of the aortic knob). Results: Severity of calcification was grade 0 in 84 patients (40.58%), grade 1 in 64 patients (30.92%), grade 2 in 43 patients (20.77%) and grade 3 in 16 patients (7.73%). In simple regression analysis severity of aortic arch calcification was associated with age (p = 0.032), duration of diabetes (p = 0.026), insulin dependence (p = 0.042) and presence of coronary artery disease (p = 0.039), hypertension (p = 0.019), dyslipidaemia (p = 0.029), retinopathy (p = 0.012) and microalbuminuria (p = 0.01). In multiple regression analysis severity of aortic arch calcification was associated with age (p = 0.04), duration of diabetes (p = 0.032) and presence of hypertension (p = 0.024), dyslipidaemia (p = 0.031) and coronary artery disease (p = 0.04), while the association with retinopathy, microalbuminuria and insulin dependence was no longer significant. Conclusions: Severity of aortic arch calcification is associated with age, diabetes duration, diabetic complications (retinopathy, microalbuminuria), coronary artery disease, insulin dependence, and presence of hypertension and dyslipidaemia.

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