Incidence of Type I Diabetes in the Liguria Region, Italy: Results of a prospective study in a 0- to 14-year age-group

Diabetes Care ◽  
1994 ◽  
Vol 17 (10) ◽  
pp. 1193-1196 ◽  
Author(s):  
M. Mazzella ◽  
M. Cotellessa ◽  
S. Bonassi ◽  
R. Mulas ◽  
A. Caratozzolo ◽  
...  
2004 ◽  
Vol 10 (5) ◽  
pp. 575-581 ◽  
Author(s):  
L J Edwards ◽  
C S Constantinescu

The cause of multiple sclerosis (MS) remains unknown. It is largely regarded as being an inflammatory autoimmune disease and has been reported in association with other inflammatory/autoimmune diseases. We performed a prospective study in 658 consecutive patients diagnosed with MS attending our outpatient MS management clinic between June 2002 and June 2003. Prevalence of associated conditions in these patients was calculated and compared with values from population studies using chi-square tests, odds ratios and confidence intervals. The MS population had significantly increased rates of asthma, inflammatory bowel disease, type I diabetes mellitus, pernicious anaemia, autoimmune thyroid disease, uveitis, seronegative spondyloarthropathies, bipolar disorder and melanoma compared to the general population. Both T helper type 1 (Th1)-mediated and T helper type 2 (Th2)-mediated diseases were significantly increased compared to the general population. There were also interesting associations seen with polyglandular autoimmune syndrome and rare single case associations. MS is associated with several other conditions. This work does not give evidence for the hypothesis that MS and atopy, reflecting Th1 and Th2 polarization, respectively, are mutually exclusive. Further work, ideally with a matched control population, is indicated.


1988 ◽  
Vol 1 (3) ◽  
pp. 219-230 ◽  
Author(s):  
Werner Alfons Scherbaum ◽  
Helga Mogel ◽  
Bernhard Otto Boehm ◽  
Ullrich Hedderich ◽  
Michael Glück ◽  
...  

1985 ◽  
Vol 60 (1) ◽  
pp. 74-80 ◽  
Author(s):  
SIU L. HUI ◽  
SOLOMON EPSTEIN ◽  
C. CONRAD JOHNSTON

2002 ◽  
Vol 19 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Cindy Y. Li ◽  
Sorin Eremia

Objective: Throughout the 1990s, laser treatment of leg veins was a challenge. Newer, longer wavelength lasers capable of delivering high fluences with larger spot sizes with a variable pulse width have shown promising preliminary results. Experience with these lasers for treatment of facial telangiectasia and periorbital reticular veins is even more scant. To our knowledge this is the first prospective study to evaluate a variable pulse width, cryogen spray—equipped 1064 nm Nd:Yag laser for both the treatment of leg and face veins, including larger periorbital reticular veins. Materials and Methods: Forty-seven volunteers aged 32–67 years (30 with skin type I-V with leg telangiectasia and reticular veins, and 17 with skin type I-IV with face telangiectasia and reticular periorbital veins) were treated with the Nd:Yag laser. For leg vein patients, 2–3 sets of different leg veins were treated with a maximum of 3 treatments. Patients were examined 1 week after each treatment and at 1, 2, and 3 months after the last treatment. All face vein patients received 1 treatment and were examined at 1 month posttreatment. Treatment parameters for both leg and face veins varied with the size of vessels being treated. Pre- and posttreatment 35 mm photos were taken. Improvement was judged by 2 experienced physicians both visually on patients and by comparison of pre- and posttreatment photos. Results were graded as percent resolution in 5 groups: 0%, 0–25%, 25–50%, 50–75%, and 75–100%. Results: Twenty-three of 30 patients completed the leg vein segment of the study. A total of 41 leg vein sites were treated. Greater than 75% improvement was observed at 85% of the treated sites. Greater than 50% improvement was observed at 95% of the treated sites. Less than 25% improvement was observed at 5% of the treated sites. Seventeen of 17 patients completed the face vein segment of the study, and 32 sites were treated (24 cheeks, noses, and chin telangiectasia and 8 periorbital reticular veins). Greater than 75% improvement was observed at 97% of the treated sites. Greater than 50% improvement was observed at 100% of the treated sites. Notably, 100% of the facial reticular veins treated had essentially 100% resolution. Pain during treatment was variably perceived by patients, but was occasionally sufficient for patients to decline further treatment. Transient hemosiderin pigmentation, as seen with sclerotherapy, was common with larger vessels. Conclusion: The cryogen spray-equipped 1064 nm Nd: Yag laser was remarkably effective and safe for skin type I-V patients. Excellent results for leg veins, approaching sclerotherapy outcomes, were obtained for both 0.3–1.5 mm telangiectasia and larger 1.5–3.0 mm reticular veins. Furthermore, this 1064 Nd:Yag laser is also an outstanding tool for treatment of facial telangiectasia with little if any risk of purpura. For the first time we appear to have a safe and effective treatment for 1–2 mm periorbital reticular veins. The use of topical anesthesia may be needed for some patients.


Author(s):  
Ajay Sharma ◽  
Ashok Sharma ◽  
Pramod Jaret ◽  
Malay Sarkar ◽  
Sanjeev Sharma

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">The spontaneous pneumothorax has been classified as major cause of morbidity and mortality among respiratory diseases. The objectives of the study were to determine the incidence and aetiology of spontaneous pneumothorax and to assess the clinical profile of affected patients admitted in our institute</span>.</p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A hospital based prospective study was conducted in year 2011-12 in the Department of Medicine, IGMC Shimla (H.P.) India. During study period the total admissions were 7335 out of which 30 patients were diagnosed as spontaneous pneumothorax and treated as cases under study. The data was collected on proforma includes demographic profile, probable cause, clinical and outcome indicators of Spontaneous Pneumothorax, master chart framed and analysed into frequency percentage. </span><span lang="EN-IN"> </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Incidence of spontaneous pneumothorax was found to be 408.99/yr/100000 admissions in the department of medicine. Incidence of primary spontaneous pneumothorax was 81.79/yr/100000 admissions. Incidence of secondary spontaneous pneumothorax was 327.19/yr/100000 admissions. Majority of the patients of primary spontaneous pneumothorax were of the 20-29yrs age group. Higher proportions of cases were from male gender (93.33%). Secondary pneumothorax patients were mostly of 50 to 59 years age group. The predominant aetiology for secondary spontaneous pneumothorax was COPD (36.66%) followed by Pulmonary tuberculosis (33.33%)</span>.</p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Spontaneous pneumothorax was more common in men. The predominant aetiology for secondary spontaneous pneumothorax was COPD (36.66%) followed by pulmonary tuberculosis (33.33%). </span></p><p class="abstract"> </p>


Blood ◽  
1994 ◽  
Vol 84 (3) ◽  
pp. 934-940
Author(s):  
JT Wang ◽  
MT Lin ◽  
PJ Chen ◽  
JC Sheu ◽  
JT Lin ◽  
...  

To study the incidence of human T-cell lymphotropic virus (HTLV) after blood transfusion in Taiwan, serum samples from 699 patients in a prospective study were examined for seroreactivity of anti-HTLV. By an enzyme immunoassay, 9 of the 699 recipients were repeatedly positive. Serial serum samples of these 9 patients were then confirmed with a Western blot analysis and with a polymerase chain reaction (PCR) assay for HTLV-I genome. Four were already positive for anti-HTLV before transfusion, 1 carried antibodies to HTLV-I transiently after transfusion, and only 4 cases had de nova seroconversions. These patients and their family members were called back and tested for HTLV- I genome in the peripheral blood mononuclear cell (PBMC) and plasma. All the serologically positive patients, except the “transient one,” were positive for HTLV sequences in the PBMCs. Viral sequences could also be detected in several serum or plasma samples. In the family members, only the spouse of a pretransfusion-positive patient was infected. These results suggested that approximately 0.6% of the blood recipients were infected by HTLV-I through transfusion in Taiwan, and that the frequency of intrafamilial HTLV-I transmission is low. We also observed the unusual coinfection by both HTLV-I and hepatitis C virus in 2 patients, and superinfection of hepatitis C virus after blood transfusion in 1 HTLV-I carrier. Cases of coinfection suggest a prevalence of both viruses in blood donors and warrant further screening.


1991 ◽  
Vol 105 (10) ◽  
pp. 825-827 ◽  
Author(s):  
Maurice R. Hawthorne ◽  
Desmond A. Nunez ◽  
Graham P. Clarke ◽  
Desmond Robertshaw

AbstractA prospective study was designed in which General Practitioners were issued with a standard referral letter for hearing aid provision. Unknown to the General Practitioner an independent otolaryngologist assessment was obtained at the time of first attendance. Three hundred consecutive patients selected by General Practitioners applying these guidelines were seen in a designated hearing aid clinic staffed by audiological technicians of senior grade or above. Referral pro formata were incomplete in 75 patients who were not assessed. Ninety-four patients (31 per cent) (95 per cent confidence interval 29–36 per cent) were accepted by the audiologist. Obstructing wax was the most common criterion failed. Clinical agreement between audiologist and otolaryngologist was 57 per cent greater than chance. None of the cases of clinical disagreement altered treatment. A direct referral system as proposed could have processed only 31 per cent of 300 referrals. However, experienced technical staff reliably detected otological pathology and with aural toilet facilities 91 per cent of 225 patients (confidence interval 88–94 per cent) were aided.


Hypertension ◽  
1989 ◽  
Vol 13 (6_pt_2) ◽  
pp. 781-788 ◽  
Author(s):  
E P Paulsen ◽  
R L Seip ◽  
C R Ayers ◽  
B Y Croft ◽  
D L Kaiser

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