scholarly journals A Comparison on Impact of HIV/AIDS Patients Characteristics On Their Blood Pressure in Nigeria

2020 ◽  
Vol 5 (8) ◽  
pp. 884-890
Author(s):  
Chinazo Anthonia Ezeokeke ◽  
Cecilia Nchedo Okoli
Keyword(s):  
Blood Pressure ◽  
General Hospital ◽  
Significant Relationship ◽  
Multivariate Regression ◽  
Cd4 Count ◽  
Coefficient Of Determination ◽  
Initial Weight ◽  
Aids Patients ◽  
Level Of Significance ◽  
Hiv Aids

The study focused on comparison on impact of HIV/AIDS patient’s characteristics on their blood pressure in Nigeria: a case of NAUTH, COOUTH and Onitsha general hospital in Anambra State. The blood pressure being the response variables are systolic blood pressure & diastolic blood pressure, while the predictor variables being the HIV/AIDS patient’s characteristics are age, baseline count, initial weight, present weight and CD4 count of HIV/AIDS patients. The R software package was employed to facilitate the data analysis. The Multivariate Regression Model of the two response variables (Systolic PB and Diastolic PB) was first fitted with the coefficient of determination of 31.88% and 46.80% respectively for NAUTH data, 27.9% and 37.98% respectively for COOUTH data and 97.35% and 57.15% respectively for general hospital, Onitsha data. The test on the significance of the parameters for the multivariate regression for NAUTH data revealed that age and baseline count of HIV/AIDS patients have significant relationship with systolic BP at 5% level of significance, whereas other predictor variables (initial weight, present weight and CD4 count of HIV/AIDS patients) are not significant, while in the second model, only age has a significant relationship with diastolic BP, whereas initial weight, present weight, baseline count and CD4 count of HIV/AIDS patients do not have significant relationship with diastolic BP at 5% level of significance. The test on the significance of the parameters for the multivariate regression also revealed that only age has significant relationship with systolic and diastolic BP at 5% level of significance, whereas other predictor variables are not significant for both COOUTH and general hospital Onitsha data. It was further  revealed that the data collected from the general hospital Onitsha has the highest coefficient of determination (0.9735) with the lowest AIC (1348.944), BIC (1374.462) and residual standard error (2.587) for systolic blood pressure model which makes the data used in this study the most suitable for the model employed under the stipulated year of study. Also observed that the same data collected from the general hospital Onitsha has the highest coefficient of determination (0.5715) with the lowest AIC (1825.917), BIC (1851.435) and residual standard error (6.008) for diastolic blood pressure model which equally makes the data used in this study the most suitable. It is clear from the result obtained in this study that the data set collected from general hospital, Onitsha from 2003 to 2017 is most appropriate for the multivariate multiple linear regression models.

scholarly journals Predictors of improved nutritional status among HIV/AIDS patients who received antiretroviral therapy (ART) at Sanglah General Hospital Denpasar

2017 ◽  
Vol 5 (2) ◽  
pp. 147
Author(s):  
Gusti Ayu Eka Utarini ◽  
Anak Agung Sagung Sawitri ◽  
Tuti Parwati Merati
Keyword(s):  
Antiretroviral Therapy ◽  
Nutritional Status ◽  
General Hospital ◽  
Incidence Rate ◽  
Median Time ◽  
Opportunistic Infections ◽  
Cd4 Count ◽  
Aids Patients ◽  
Art Initiation ◽  
Hiv Aids

Background and purpose: Antiretroviral therapy (ART) is associated with improved nutritional status among HIV/AIDS patients. This study aims to examine proportion, median time, incidence rate, and predictors of improved nutritional status among HIV/AIDS patients who received ART at Sanglah General Hospital Denpasar.Methods: A restrospective cohort study was conducted in Denpasar City. A total of 207 medical records of HIV/AIDS patients who received ART between 1st of January 2012 and 30th of June 2015 were included in the study. Kaplan Meier analysis was performed to calculate incidence rate and median time of improved nutritional status among HIV/AIDS patients. Sociodemographic characteristics and clinical variables included body mass index (BMI), body weight, haemoglobin level, CD4 count, HIV clinical stadium, ART regiments, and opportunistic infections (OIs). Data were analysed using cox proportional hazard model to identify predictors of improved nutritional status among HIV/AIDS patients.Results: As many as 65.22% of HIV/AIDS patients who received ART experienced an improvement in their nutritional status with the incidence rate of 9.1 per 100 person months and median time of 6.1 months. Multivariate analysis showed that predictors of improved nutritional status were BMI at ART initiation (AHR=1.34; 95%CI: 1.16-1.5), HIV clinical stadium (AHR=1.45; 95%CI: 1.02-2.06), CD4 count at ART initiation (AHR=0.89; 95%CI: 0.81-0.99) and the presence of diarrhoea (AHR=1.83; 95%CI: 1.06-3.14).Conclusions: Predictors of improved nutritional status among HIV/AIDS patients who received ART were BMI, HIV clinical stadium, CD4 count and diarrhoea.

scholarly journals Risk Factors for Mortality among HIV/AIDS Patients

2021 ◽  
Vol 2 (1) ◽  
pp. 20-19
Author(s):  
Zaki Mita Kusumaadhi ◽  
Nur Farhanah ◽  
Muchlis Achsan Udji Sofro
Keyword(s):  
Risk Factors ◽  
Pulmonary Tuberculosis ◽  
General Hospital ◽  
Clinical Stage ◽  
Significant Risk ◽  
Cd4 Count ◽  
Aids Patients ◽  
Male Sex ◽  
Compliance To Treatment ◽  
Hiv Aids

Background: Morbidity and mortality of HIV/AIDS infections is still high and as  a global health problem particularly in Low-Middle Income Countries (LMICs). Indonesia ranks third in Asia Pacific in increasing HIV infection. A Study on risk factors for mortality in HIV/AIDS patients in Dr. Kariadi General Hospital has never been conducted. This study analyzed the risk factors for mortality among HIV/AIDS patients.Methods: Case control study, data from medical records of inpatients and outpatients in Dr. Kariadi General Hospital from January 2015 to December 2017.Results: Study subject: Two hundred and ten HIV/AIDS patients, were included; 105 (56.75%) as cases and 105 (9.65%) control patients. The significant risk factors for mortality were as follow: male sex (p = 0.030); age ≥ 45 years (p = 0.035); non compliance to treatment (p = 0,000); WHO clinical stage III and IV (p = 0,000); co-infection of pulmonary tuberculosis (p = 0,000); CD4 cell count < 200 cells/mm3 (p = 0,000); eGFR < 60 mL/minute/1.72 m2 (p = 0.001) and Haemoglobin level < 10 g/dL (p = 0.008). The non-significant risk factors for mortality were as follow: level of education (p = 0.650); Hepatitis B co-infection (p = 0.153) and Hepatitis C co-infection (p = 0.506). The most important risk factors for mortality in this study in were non compliance to treatment (p = 0.003; OR = 3.285) and CD4 count < 200 cells/mm3 (p = 0.014; OR = 5.480).Conclusion: In this study, the risk factors for mortality in HIV/AIDS patients were male sex; age ≥ 45 years; non compliance to treatment; WHO clinical stage III and IV; co-infection of pulmonary tuberculosis, CD4 count < 200 cells/mm3; eGFR < 60 mL/minute/1.72 m2 and Hb level < 10 g/dL. The most important risk factors for mortality were non compliance to treatment and CD4 count < 200 cells / mm3.

scholarly journals Body mass index increases CD4+ count in HIV/AIDS patients on first-line therapy

2020 ◽  
Vol 39 (2) ◽  
pp. 121
Author(s):  
Mirna Widiyanti ◽  
Moch Irfan Hadi ◽  
Mei Lina Fitri Kumalasari ◽  
Evi Iriani Natalia ◽  
Dedi Ananta Purba ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Antiretroviral Therapy ◽  
Body Mass ◽  
Influencing Factor ◽  
Clinical Stage ◽  
Cd4 Count ◽  
First Line ◽  
Aids Patients ◽  
Cd4 Counts ◽  
Hiv Aids

Background<br />The body mass index (BMI) may contribute somewhat to drug metabolism, thus affecting the efficacy of antiretroviral therapy (ART). CD4+ counts   in people infected with HIV are essential in determining the stage of the disease, initiation of antiretroviral therapy, opportunistic infections and evaluating treatment outcomes. The aim of this study was to determine the association of BMI and clinical stage with CD4+ counts in HIV patients seeking treatment using first-line antiretroviral therapy (ART).<br /><br />Methods<br />An analytic study with a cross-sectional approach was conducted involving 251 HIV/AIDS patients who had received first-line antiretrovirals over six months. BMI, clinical staging according to WHO and CD4 + were collected. Multiple linear regression was used to evaluate the relationship between BMI, clinical stage and CD4+.<br /><br />Results<br />Among the enrolled patients, the median age was 36 years, 135 (55%) of the patients was female, 102 (40.6%) was overweight/obese, 161 (64.1%) was in stage 3 of the disease, and the median CD4+ count was 389 cells/mm3. Multiple linear regression test showed two variables with a significant effect on CD4+ count, namely BMI (B=69.247; 95 % CI : 42.886-95.608) and clinical stage (B=61.590; 28.910-94.270). BMI was the most influencing factor for CD4+ count (β=0.307) compared to clinical stage (β=0.216). <br /><br />Conclusions<br />Body mass index was the most influencing factor for CD4 + counts of HIV/AIDS patients. Regular ART can increase CD4+ counts and maintain the health of HIV/AIDS patients.

The Epidemiological Analysis of HIV/AIDS Patients: Sexually Transmitted Diseases Department VS. Other Departments in A General Hospital of Shanghai, China

2021 ◽  
Vol 19 ◽  
Author(s):  
Yue Yu ◽  
Liangliang Shen ◽  
Yufei Li ◽  
Jingjun Zhao ◽  
Heping Liu
Keyword(s):  
Sexually Transmitted Diseases ◽  
General Hospital ◽  
Demographic Characteristics ◽  
Hiv Screening ◽  
Aids Patients ◽  
Important Place ◽  
Sexually Transmitted ◽  
Positive Rate ◽  
Social Demographic ◽  
Hiv Aids

Background: Hospital is an important place for HIV/AIDS screening, and a general hospital is composed of multiple departments. Different departments have different levels of understanding of HIV/AIDS, especially the sexually transmitted diseases (STD) department is the main place for HIV/AIDS screening. Objective: The study aims to validate the common knowledge that the STD department is an important place for HIV/AIDS screening by comparing the epidemiological characteristics of HIV/AIDS patients in the STD department and other departments in Tongji Hospital, which can provide a theoretical basis for the precise and differentiated control of HIV/AIDS. Methods: A total of 283,525 HIV screening cases were analyzed from January 1st 2006 to December 31st 2018 in the STD department and other departments. The epidemiological data of 226 HIV/AIDS cases were retrospectively analyzed. Results : Firstly, the incidence of HIV/AIDS in the population served by Tongji Hospital was higher than that in Shanghai and China. Secondly, the positive rate of HIV screening test in the STD department was ten times higher than that of other departments. Thirdly, the social-demographic characteristics of HIV/AIDS patients in the STD department were different from those in other departments. Fourthly, there were differences in age, education, marital status and number of sex partners between men who have sex with men (MSM) and men who have sex with women (MSW). Fifthly, there was no difference except age in social-demographic characteristics of MSM between the STD department and other departments. Sixthly, compared with other departments, the majority of HIV/AIDS patients in the STD department were MSM. Seventhly, syphilis and HIV co-infection were not statistically significant in HIV/AIDS patients between the STD department and other departments. Conclusion: Firstly, the significantly higher positive rate of an HIV screening test in the STD department emphasizes its importance as a place for screening HIV/AIDS patients. Secondly, HIV/AIDS patients diagnosed in the general hospital were mainly transmitted by sexual contact, and MSM accounted for the most part of these patients. More attention should be paid to screen outpatients, especially in the STD department and young men.

scholarly journals Undernutrition and associated factors among adult HIV/AIDS patients receiving antiretroviral therapy in eastern zone of Tigray, Northern Ethiopia: a cross-sectional study

2020 ◽  
Vol 78 (1) ◽  
Author(s):  
Tsegu Hailu Gebru ◽  
Haftea Hagos Mekonen ◽  
Kbrom Gemechu Kiros
Keyword(s):  
Antiretroviral Therapy ◽  
Associated Factors ◽  
Preventive Therapy ◽  
Cd4 Count ◽  
Clinical Staging ◽  
Northern Ethiopia ◽  
Aids Patients ◽  
Cross Sectional ◽  
Eastern Zone ◽  
Hiv Aids

Abstract Background Undernutrition and HIV/AIDS are highly prevalent in sub-Saharan Africa, Ethiopia inclusive as linked in a vicious cycle. Thus, several studies have documented that undernutrition among HIV/AIDS patients increases the risk of mortality, decrease survival rates, affect the overall clinical outcome and quality of life. Despite this fact, information about the burden of undernutrition and associated factors among adults receiving antiretroviral therapy is lacking in the particular study area. Hence, this study aimed to examine the prevalence of undernutrition and associated factors among adult HIV/AIADS patients receiving antiretroviral therapy patients in Eastern Zone of Tigray, Northern Ethiopia. Methods A cross-sectional research design was adopted in data collection while systematic sampling technique was employed to sample and select the study subjects. A structured questionnaire was used to collect information from 394 study subjects through face to face method. Also, data on demographics, laboratory and anthropometric variables were collected from each selected patients sampled. The data collected were entered and analyzed using SPSS version 22.. Bivariate and multivariable logistic regression analysis with 95% confidence interval were used to find factors associated with undernutrition. The adjusted odds ratio was calculated to show the strength of the association. Variables with p-value of < 0.05 were considered statically significant. Results The mean age of the respondents was 41 (± 10). Out of 394 study respondents, about 42.9% of them were undernourished (95% CI: 37.8–47.7). Respondents who had CD4+ count less than 200 cells/μl (AOR = 1.84; 95% CI: 1–3.36), being advanced clinical staging (AOR = 3.6; 95% CI: 2.11–6.18), and not taking co-trimoxazole preventive therapy (AOR = 2.38; 95% CI: 1.21–4.6) were independently associated with undernutrition. Conclusion The result of this study indicated that the prevalence of undernutrition was high. Respondents with advanced clinical stage of CD4+ count less than 200 cells/ul and those that were not taking co-trimoxazole preventive therapy was found to be positively associated with undernutrition. Therefore, the implementation of nutritional programs is very crucial to improve the nutritional status of HIV/AIDS patients in the particular study.

scholarly journals Manifestations of tuberculosis in HIV/AIDS patients and its relationship with CD4 count

Lung India ◽  
2011 ◽  
Vol 28 (4) ◽  
pp. 263 ◽  
Author(s):  
Ashok Sharma ◽  
Rajeev Raina ◽  
Ajay Jaryal ◽  
Malay Sarkar
Keyword(s):  
Cd4 Count ◽  
Aids Patients ◽  
Hiv Aids

Manifestation of tuberculosis in HIV/AIDS patients and its relationship with CD4 count

2014 ◽  
Vol 3 (2) ◽  
pp. 215 ◽  
Author(s):  
Ashok Gagiya ◽  
Nilesh Doctor ◽  
Shailendre Gamit ◽  
Ankur Patel ◽  
Khusbu Patel ◽  
...  
Keyword(s):  
Cd4 Count ◽  
Aids Patients ◽  
Hiv Aids

scholarly journals Cardiovascular manifestations of People Newly Diagnosed HIV/AIDS and their Correlation with CD4 Count: Report from Northern India

2021 ◽  
pp. 17-22
Author(s):  
Ritu Attri ◽  
Arashbir Kaur ◽  
Satish Sachdeva ◽  
Mandip Singh Bhatia
Keyword(s):  
Pericardial Effusion ◽  
Diastolic Dysfunction ◽  
Systolic Dysfunction ◽  
Cd4 Count ◽  
Newly Diagnosed ◽  
Colour Doppler ◽  
Aids Patients ◽  
X Ray ◽  
Doppler Study ◽  
Hiv Aids

Introduction: About 21.17 lakhs people in India and about 0.49 lakh people in Punjab are living with HIV according to National AIDS Control Organization Annual Report (2015-16). Cardiovascular complications of HIV infection tend to occur late in the disease and are therefore becoming more prevalent in our society as therapy and longevity improve. Aims of this Study: To study incidence of cardiovascular morbidity in newly diagnosed HIV/AIDS patients and their correlation with CD4 count. To study the types of cardiovascular morbidities in newly diagnosed HIV /AIDS patients and their correlation with CD4 count. Methods: 100 HIV patients newly diagnosed by ELISA technique were selected for the study. All patients were subjected to cardiovascular investigations like ECG, ECHO using Philips iE33 Ultrasound Machine with X-MATRIX Technology with X5-1, supports 3D,2D colour flow, M-mode, Pulsed Wave/Continuous Wave (PW/CW) Doppler, Tissue Doppler imaging and chest x-ray. Results: Majority of the patients were asymptomatic (84%). Commonest being Chest pain(1%). 7% patients had ECG abnormalities. Commonest being sinus tachycardia (4), one patient had atrial fibrillation and 2 had LVH.Two patients had Cardiomegaly on X ray examination while remaining 98 patients had normal cardiac size. Out of the 100 patients studied, 27% patients had cardiac involvement on Echocardiography / Colour Doppler study. Out of these 27 patients, 22(80.65%) had CD4 count less than 200, 4(12.90%) had CD4 count between 201-350 and 1(6.45%) had CD4 count>350.Diastolic Dysfunction was most common abnormality followed by tricuspid regurgitation and systolic dysfunction and pericardial effusion on echocardiography / colour Doppler study. 20 patients had Diastolic Dysfunction, out of which 19 had Grade 1 diastolic dysfunction and 1 had Grade 2 diastolic dysfunction. Grade 3 and Grade 4 diastolic dysfunction was not seen in any patient. All patients with Diastolic Dysfunction had CD4 counts less than 200.Six patients had Mild Systolic Dysfunction, out of them 4 were males and 2 were females, all the males had an EF=50%, while females had EF of 50% and 52% respectively. 4 patients had CD4 count less than 200, 1 had CD4 count between 201-350 and remaining 1 CD4 count more than 350.Two patients had Pericardial Effusion and their CD4 count was less than 200. Conclusion: The commonest cardiac abnormality being detected diastolic dysfunction and least common being pericardial effusion. Diastolic dysfunction is directly related to CD4 count.

scholarly journals Pulmonary Tuberculosis in HIV/AIDS Patients Attending Art Clinic in Bududa General Hospital, Bududa District, Uganda

2019 ◽  
Vol 07 (03) ◽  
pp. 135-142
Author(s):  
Kalyetsi Rogers ◽  
Nafungo Gertrude ◽  
Muwanguzi Enoch
Keyword(s):  
Pulmonary Tuberculosis ◽  
General Hospital ◽  
Aids Patients ◽  
Hiv Aids
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